Role of metabolism by intestinal microbiota in pharmacokinetics of oral baicalin
Baicalin (baicalein-7-glucuronide) is a flavonoid purified from Scutellaria baicalensis Georgi that has traditionally been used for treatment of hypertension, cardiovascular diseases, and viral hepatitis. In this study, the effects of intestinal microbiota on the pharmacokinetics of baicalin were in...
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| Published in | Archives of pharmacal research Vol. 37; no. 3; pp. 371 - 378 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Heidelberg
Pharmaceutical Society of Korea
01.03.2014
대한약학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0253-6269 1976-3786 1976-3786 |
| DOI | 10.1007/s12272-013-0179-2 |
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| Abstract | Baicalin (baicalein-7-glucuronide) is a flavonoid purified from
Scutellaria baicalensis
Georgi that has traditionally been used for treatment of hypertension, cardiovascular diseases, and viral hepatitis. In this study, the effects of intestinal microbiota on the pharmacokinetics of baicalin were investigated in normal and antibiotic-pretreated rats following p.o. administration of 100 mg/kg baicalin by using liquid chromatography/ion trap mass spectrometry. When rats were pretreated orally with cefadroxil, oxytetracycline and erythromycin for 3 days to control the number of intestinal bacteria, the pharmacokinetic parameters of oral baicalin were significantly affected by antibiotics: C
max
, T
1/2(β)
, K
el
and AUC values were significantly changed compared to those in normal rats. These results indicate that intestinal microbiota might play a key role in the oral pharmacokinetics of baicalin. |
|---|---|
| AbstractList | Baicalin (baicalein-7-glucuronide) is a flavonoid purified from Scutellaria baicalensis Georgi that has traditionally been used for treatment of hypertension, cardiovascular diseases, and viral hepatitis. In this study, the effects of intestinal microbiota on the pharmacokinetics of baicalin were investigated in normal and antibiotic-pretreated rats following p.o. administration of 100 mg/kg baicalin by using liquid chromatography/ion trap mass spectrometry. When rats were pretreated orally with cefadroxil, oxytetracycline and erythromycin for 3 days to control the number of intestinal bacteria, the pharmacokinetic parameters of oral baicalin were significantly affected by antibiotics: Cmax, T1/2(β), Kel and AUC values were significantly changed compared to those in normal rats. These results indicate that intestinal microbiota might play a key role in the oral pharmacokinetics of baicalin. Baicalin (baicalein-7-glucuronide) is a flavonoid purified from Scutellaria baicalensis Georgi that has traditionally been used for treatment of hypertension, cardiovascular diseases, and viral hepatitis. In this study, the effects of intestinal microbiota on the pharmacokinetics of baicalin were investigated in normal and antibiotic-pretreated rats following p.o. administration of 100 mg/kg baicalin by using liquid chromatography/ion trap mass spectrometry. When rats were pretreated orally with cefadroxil, oxytetracycline and erythromycin for 3 days to control the number of intestinal bacteria, the pharmacokinetic parameters of oral baicalin were significantly affected by antibiotics: Cmax, T1/2(β), Kel and AUC values were significantly changed compared to those in normal rats. These results indicate that intestinal microbiota might play a key role in the oral pharmacokinetics of baicalin.Baicalin (baicalein-7-glucuronide) is a flavonoid purified from Scutellaria baicalensis Georgi that has traditionally been used for treatment of hypertension, cardiovascular diseases, and viral hepatitis. In this study, the effects of intestinal microbiota on the pharmacokinetics of baicalin were investigated in normal and antibiotic-pretreated rats following p.o. administration of 100 mg/kg baicalin by using liquid chromatography/ion trap mass spectrometry. When rats were pretreated orally with cefadroxil, oxytetracycline and erythromycin for 3 days to control the number of intestinal bacteria, the pharmacokinetic parameters of oral baicalin were significantly affected by antibiotics: Cmax, T1/2(β), Kel and AUC values were significantly changed compared to those in normal rats. These results indicate that intestinal microbiota might play a key role in the oral pharmacokinetics of baicalin. Baicalin (baicalein-7-glucuronide) is a flavonoidpurified from Scutellaria baicalensis Georgi that hastraditionally been used for treatment of hypertension, cardiovasculardiseases, and viral hepatitis. In this study, theeffects of intestinal microbiota on the pharmacokinetics ofbaicalin were investigated in normal and antibiotic-pretreatedrats following p.o. administration of 100 mg/kgbaicalin by using liquid chromatography/ion trap massspectrometry. When rats were pretreated orally with cefadroxil,oxytetracycline and erythromycin for 3 days tocontrol the number of intestinal bacteria, the pharmacokineticparameters of oral baicalin were significantly affectedby antibiotics: Cmax, T1/2(b), Kel and AUC values weresignificantly changed compared to those in normal rats. These results indicate that intestinal microbiota might playa key role in the oral pharmacokinetics of baicalin. KCI Citation Count: 51 Baicalin (baicalein-7-glucuronide) is a flavonoid purified from Scutellaria baicalensis Georgi that has traditionally been used for treatment of hypertension, cardiovascular diseases, and viral hepatitis. In this study, the effects of intestinal microbiota on the pharmacokinetics of baicalin were investigated in normal and antibiotic-pretreated rats following p.o. administration of 100 mg/kg baicalin by using liquid chromatography/ion trap mass spectrometry. When rats were pretreated orally with cefadroxil, oxytetracycline and erythromycin for 3 days to control the number of intestinal bacteria, the pharmacokinetic parameters of oral baicalin were significantly affected by antibiotics: Cₘₐₓ, T₁/₂₍ᵦ₎, Kₑₗand AUC values were significantly changed compared to those in normal rats. These results indicate that intestinal microbiota might play a key role in the oral pharmacokinetics of baicalin. Baicalin (baicalein-7-glucuronide) is a flavonoid purified from Scutellaria baicalensis Georgi that has traditionally been used for treatment of hypertension, cardiovascular diseases, and viral hepatitis. In this study, the effects of intestinal microbiota on the pharmacokinetics of baicalin were investigated in normal and antibiotic-pretreated rats following p.o. administration of 100 mg/kg baicalin by using liquid chromatography/ion trap mass spectrometry. When rats were pretreated orally with cefadroxil, oxytetracycline and erythromycin for 3 days to control the number of intestinal bacteria, the pharmacokinetic parameters of oral baicalin were significantly affected by antibiotics: C max , T 1/2(β) , K el and AUC values were significantly changed compared to those in normal rats. These results indicate that intestinal microbiota might play a key role in the oral pharmacokinetics of baicalin. |
| Author | Kang, Mi Jeong Noh, Keumhan Oh, Do Gyeong Kim, Hyoung Chin Jeong, Tae Cheon Yoon, Won Ki Jeong, Hye Gwang Ko, Gyu Sub Kang, Wonku Kim, Jin Sung |
| Author_xml | – sequence: 1 givenname: Mi Jeong surname: Kang fullname: Kang, Mi Jeong organization: College of Pharmacy, Yeungnam University – sequence: 2 givenname: Gyu Sub surname: Ko fullname: Ko, Gyu Sub organization: College of Pharmacy, Yeungnam University – sequence: 3 givenname: Do Gyeong surname: Oh fullname: Oh, Do Gyeong organization: College of Pharmacy, Yeungnam University – sequence: 4 givenname: Jin Sung surname: Kim fullname: Kim, Jin Sung organization: College of Pharmacy, Yeungnam University – sequence: 5 givenname: Keumhan surname: Noh fullname: Noh, Keumhan organization: College of Pharmacy, Yeungnam University – sequence: 6 givenname: Wonku surname: Kang fullname: Kang, Wonku organization: College of Pharmacy, Yeungnam University – sequence: 7 givenname: Won Ki surname: Yoon fullname: Yoon, Won Ki organization: Korea Research Institute of Bioscience and Biotechnology – sequence: 8 givenname: Hyoung Chin surname: Kim fullname: Kim, Hyoung Chin organization: Korea Research Institute of Bioscience and Biotechnology – sequence: 9 givenname: Hye Gwang surname: Jeong fullname: Jeong, Hye Gwang organization: College of Pharmacy, Chungnam National University – sequence: 10 givenname: Tae Cheon surname: Jeong fullname: Jeong, Tae Cheon email: taecheon@yumail.ac.kr, taecheon@ynu.ac.kr organization: College of Pharmacy, Yeungnam University |
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| Snippet | Baicalin (baicalein-7-glucuronide) is a flavonoid purified from
Scutellaria baicalensis
Georgi that has traditionally been used for treatment of hypertension,... Baicalin (baicalein-7-glucuronide) is a flavonoid purified from Scutellaria baicalensis Georgi that has traditionally been used for treatment of hypertension,... Baicalin (baicalein-7-glucuronide) is a flavonoidpurified from Scutellaria baicalensis Georgi that hastraditionally been used for treatment of hypertension,... |
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| SubjectTerms | Administration, Oral Animals baicalin cefadroxil erythromycin Flavonoids - administration & dosage Flavonoids - pharmacokinetics Intestinal Absorption - drug effects Intestinal Absorption - physiology intestinal microorganisms Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism liquid chromatography Male mass spectrometry Medicine Microbiota - drug effects Microbiota - physiology oxytetracycline pharmacokinetics Pharmacology/Toxicology Pharmacy Rats Rats, Sprague-Dawley Research Article Scutellaria Scutellaria baicalensis 약학 |
| Title | Role of metabolism by intestinal microbiota in pharmacokinetics of oral baicalin |
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