Blood pressure levels in patients with subclinical thyroid dysfunction : a meta-analysis of cross-sectional data

The relationship between subclinical thyroid dysfunction and blood pressure is controversial and has received insufficient attention. The aim of this study was to assess whether blood pressure levels in patients with subclinical thyroid dysfunction differ from those of euthyroid subjects. A meta-ana...

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Published inHypertension research Vol. 34; no. 10; pp. 1098 - 1105
Main Authors Cai, Yunfei, Ren, Yongkui, Shi, Jingpu
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.10.2011
Subjects
692/699/2743/1841
692/699/75/243
692/700/478/174
Adult
Blood Pressure
Cross-Sectional Studies
Female
Geriatrics/Gerontology
Health Promotion and Disease Prevention
Humans
Hypertension - epidemiology
Hypertension - physiopathology
hyperthyroidism
hypothyroidism
Hypothyroidism - epidemiology
Hypothyroidism - physiopathology
Internal Medicine
Male
Medicine
Medicine & Public Health
meta-analysis
Middle Aged
Obstetrics/Perinatology/Midwifery
original-article
Public Health
thyroid disease
thyroid disease
meta-analysis
blood pressure
hyperthyroidism
hypothyroidism
Online AccessGet full text
ISSN0916-9636
1348-4214
1348-4214
DOI10.1038/hr.2011.91

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Abstract The relationship between subclinical thyroid dysfunction and blood pressure is controversial and has received insufficient attention. The aim of this study was to assess whether blood pressure levels in patients with subclinical thyroid dysfunction differ from those of euthyroid subjects. A meta-analysis of all cross-sectional studies was performed to compare the blood pressure levels in patients with subclinical thyroid dysfunction with those of healthy controls. A computer-based online retrieval of databases (MEDLINE and EMBASE) and manual searches were undertaken to identify articles that addressed the association between subclinical thyroid dysfunction and blood pressure levels and were published through 2010, using no language restrictions. The meta-analysis was performed using STATA 11 (Stata). Seven cross-sectional studies were examined. In patients with subclinical hypothyroidism, the pooled estimate of the weighted mean difference (WMD) of increased blood pressure revealed a significant difference in both systolic blood pressure (SBP; WMD with 95% confidence interval (CI) 1.89 mm Hg (0.98–2.80), P <0.05) and diastolic blood pressure (DBP; WMD with 95% CI 0.75 mm Hg (0.24–1.27), P <0.05). However, in patients with subclinical hyperthyroidism, the pooled estimate of the WMD of increased blood pressure revealed no significant difference in SBP (WMD with 95% CI −0.75 mm Hg (−1.81 to 0.31)) or DBP (WMD with 95% CI −0.64 mm Hg (−2.36 to 1.08)). The present meta-analysis indicates that subclinical hypothyroidism is associated with increased SBP and DBP, whereas subclinical hyperthyroidism is not. Further investigation is needed to confirm blood pressure levels in patients with subclinical thyroid dysfunction.
AbstractList The relationship between subclinical thyroid dysfunction and blood pressure is controversial and has received insufficient attention. The aim of this study was to assess whether blood pressure levels in patients with subclinical thyroid dysfunction differ from those of euthyroid subjects. A meta-analysis of all cross-sectional studies was performed to compare the blood pressure levels in patients with subclinical thyroid dysfunction with those of healthy controls. A computer-based online retrieval of databases (MEDLINE and EMBASE) and manual searches were undertaken to identify articles that addressed the association between subclinical thyroid dysfunction and blood pressure levels and were published through 2010, using no language restrictions. The meta-analysis was performed using STATA 11 (Stata). Seven cross-sectional studies were examined. In patients with subclinical hypothyroidism, the pooled estimate of the weighted mean difference (WMD) of increased blood pressure revealed a significant difference in both systolic blood pressure (SBP; WMD with 95% confidence interval (CI) 1.89 mm Hg (0.98–2.80), P <0.05) and diastolic blood pressure (DBP; WMD with 95% CI 0.75 mm Hg (0.24–1.27), P <0.05). However, in patients with subclinical hyperthyroidism, the pooled estimate of the WMD of increased blood pressure revealed no significant difference in SBP (WMD with 95% CI −0.75 mm Hg (−1.81 to 0.31)) or DBP (WMD with 95% CI −0.64 mm Hg (−2.36 to 1.08)). The present meta-analysis indicates that subclinical hypothyroidism is associated with increased SBP and DBP, whereas subclinical hyperthyroidism is not. Further investigation is needed to confirm blood pressure levels in patients with subclinical thyroid dysfunction.
The relationship between subclinical thyroid dysfunction and blood pressure is controversial and has received insufficient attention. The aim of this study was to assess whether blood pressure levels in patients with subclinical thyroid dysfunction differ from those of euthyroid subjects. A meta-analysis of all cross-sectional studies was performed to compare the blood pressure levels in patients with subclinical thyroid dysfunction with those of healthy controls. A computer-based online retrieval of databases (MEDLINE and EMBASE) and manual searches were undertaken to identify articles that addressed the association between subclinical thyroid dysfunction and blood pressure levels and were published through 2010, using no language restrictions. The meta-analysis was performed using STATA 11 (Stata). Seven cross-sectional studies were examined. In patients with subclinical hypothyroidism, the pooled estimate of the weighted mean difference (WMD) of increased blood pressure revealed a significant difference in both systolic blood pressure (SBP; WMD with 95% confidence interval (CI) 1.89 mm Hg (0.98-2.80), P<0.05) and diastolic blood pressure (DBP; WMD with 95% CI 0.75 mm Hg (0.24-1.27), P<0.05). However, in patients with subclinical hyperthyroidism, the pooled estimate of the WMD of increased blood pressure revealed no significant difference in SBP (WMD with 95% CI -0.75 mm Hg (-1.81 to 0.31)) or DBP (WMD with 95% CI -0.64 mm Hg (-2.36 to 1.08)). The present meta-analysis indicates that subclinical hypothyroidism is associated with increased SBP and DBP, whereas subclinical hyperthyroidism is not. Further investigation is needed to confirm blood pressure levels in patients with subclinical thyroid dysfunction.The relationship between subclinical thyroid dysfunction and blood pressure is controversial and has received insufficient attention. The aim of this study was to assess whether blood pressure levels in patients with subclinical thyroid dysfunction differ from those of euthyroid subjects. A meta-analysis of all cross-sectional studies was performed to compare the blood pressure levels in patients with subclinical thyroid dysfunction with those of healthy controls. A computer-based online retrieval of databases (MEDLINE and EMBASE) and manual searches were undertaken to identify articles that addressed the association between subclinical thyroid dysfunction and blood pressure levels and were published through 2010, using no language restrictions. The meta-analysis was performed using STATA 11 (Stata). Seven cross-sectional studies were examined. In patients with subclinical hypothyroidism, the pooled estimate of the weighted mean difference (WMD) of increased blood pressure revealed a significant difference in both systolic blood pressure (SBP; WMD with 95% confidence interval (CI) 1.89 mm Hg (0.98-2.80), P<0.05) and diastolic blood pressure (DBP; WMD with 95% CI 0.75 mm Hg (0.24-1.27), P<0.05). However, in patients with subclinical hyperthyroidism, the pooled estimate of the WMD of increased blood pressure revealed no significant difference in SBP (WMD with 95% CI -0.75 mm Hg (-1.81 to 0.31)) or DBP (WMD with 95% CI -0.64 mm Hg (-2.36 to 1.08)). The present meta-analysis indicates that subclinical hypothyroidism is associated with increased SBP and DBP, whereas subclinical hyperthyroidism is not. Further investigation is needed to confirm blood pressure levels in patients with subclinical thyroid dysfunction.
The relationship between subclinical thyroid dysfunction and blood pressure is controversial and has received insufficient attention. The aim of this study was to assess whether blood pressure levels in patients with subclinical thyroid dysfunction differ from those of euthyroid subjects. A meta-analysis of all cross-sectional studies was performed to compare the blood pressure levels in patients with subclinical thyroid dysfunction with those of healthy controls. A computer-based online retrieval of databases (MEDLINE and EMBASE) and manual searches were undertaken to identify articles that addressed the association between subclinical thyroid dysfunction and blood pressure levels and were published through 2010, using no language restrictions. The meta-analysis was performed using STATA 11 (Stata). Seven cross-sectional studies were examined. In patients with subclinical hypothyroidism, the pooled estimate of the weighted mean difference (WMD) of increased blood pressure revealed a significant difference in both systolic blood pressure (SBP; WMD with 95% confidence interval (CI) 1.89 mm Hg (0.98-2.80), P<0.05) and diastolic blood pressure (DBP; WMD with 95% CI 0.75 mm Hg (0.24-1.27), P<0.05). However, in patients with subclinical hyperthyroidism, the pooled estimate of the WMD of increased blood pressure revealed no significant difference in SBP (WMD with 95% CI -0.75 mm Hg (-1.81 to 0.31)) or DBP (WMD with 95% CI -0.64 mm Hg (-2.36 to 1.08)). The present meta-analysis indicates that subclinical hypothyroidism is associated with increased SBP and DBP, whereas subclinical hyperthyroidism is not. Further investigation is needed to confirm blood pressure levels in patients with subclinical thyroid dysfunction.
Author CAI Yunfei
REN Yongkui
SHI Jingpu
Author_xml – sequence: 1
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  fullname: Cai, Yunfei
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  surname: Ren
  fullname: Ren, Yongkui
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  fullname: Shi, Jingpu
  email: jingpusepi@yahoo.com
  organization: Department of Clinical Epidemiology, The First Affiliated Hospital, China Medical University, Center of Evidence Based Medicine, The First Affiliated Hospital, China Medical University
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– reference: 21814205 - Hypertens Res. 2011 Oct;34(10):1071-2
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Snippet The relationship between subclinical thyroid dysfunction and blood pressure is controversial and has received insufficient attention. The aim of this study was...
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SubjectTerms 692/699/2743/1841
692/699/75/243
692/700/478/174
Adult
Blood Pressure
Cross-Sectional Studies
Female
Geriatrics/Gerontology
Health Promotion and Disease Prevention
Humans
Hypertension - epidemiology
Hypertension - physiopathology
hyperthyroidism
hypothyroidism
Hypothyroidism - epidemiology
Hypothyroidism - physiopathology
Internal Medicine
Male
Medicine
Medicine & Public Health
meta-analysis
Middle Aged
Obstetrics/Perinatology/Midwifery
original-article
Public Health
thyroid disease
Title Blood pressure levels in patients with subclinical thyroid dysfunction : a meta-analysis of cross-sectional data
URI https://cir.nii.ac.jp/crid/1573668925537492864
https://link.springer.com/article/10.1038/hr.2011.91
https://www.ncbi.nlm.nih.gov/pubmed/21796125
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