Britanin attenuates ovalbumin-induced airway inflammation in a murine asthma model

• Published in: Archives of pharmacal research Vol. 39; no. 7; pp. 1006 - 1012
• Main Authors: Kim, Sun-Gun, Lee, Eujin, Park, Na-Young, Park, Hyo-Hyun, Jeong, Kyu-Tae, Kim, Keuk-Jun, Lee, Youn Ju, Jin, Meihua, Lee, Eunkyung
• Format: Journal Article
• Language: English
• Published: Seoul Pharmaceutical Society of Korea 01.07.2016; 대한약학회
• Subjects: animal disease models; Animals; asthma; Asthma - chemically induced; Asthma - metabolism; Asthma - prevention & control; cytokines; Disease Models, Animal; eosinophilia; Female; histopathology; immunoglobulin E; inflammation; Inflammation - chemically induced; Inflammation - metabolism; Inflammation - prevention & control; Inflammation Mediators - antagonists & inhibitors; Inflammation Mediators - metabolism; Lactones - pharmacology; Lactones - therapeutic use; Medicine; Mice; Mice, Inbred BALB C; mucus; ovalbumin; Ovalbumin - toxicity; Pharmacology/Toxicology; Pharmacy; Research Article; secretion; Sesquiterpenes - pharmacology; Sesquiterpenes - therapeutic use; sesquiterpenoids; splenocytes; 약학; Airway hyperresponsiveness (AHR); Britanin; Bronchoalveolar lavage fluids (BALF); Inulae flos; Eosinophils
• ISSN: 0253-6269; 1976-3786; 1976-3786
• DOI: 10.1007/s12272-016-0783-z

We previously demonstrated the alleviation of ovalbumin (OVA)-induced airway inflammation by Inulae flos. In the present study, the effects of britanin, a sesquiterpene compound isolated from Inulae flos, were evaluated in an in vivo animal model for anti-asthma activity through observation of airway hyperresponsiveness (AHR), eosinophil recruitment, Th2 cytokine and IgE levels, and lung histopathology. Britanin administration effectively reduced AHR induced by aerosolized methacholine, airway eosinophilia, Th2 cytokines in bronchoalveolar lavage fluids and the supernatant of cultured splenocytes compared with OVA-induced mice. Histological studies showed that increased inflammatory cell infiltration and mucus secretion were reduced by britanin administration. Thus, britanin may have therapeutic potential for treating allergic asthma.