Pharmacokinetic characterization of 2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone, a novel 11β-hydroxysteroid dehydrogenase type 1 inhibitor in rats - Zheng, Zhi; Seo, Hyewon; Kwak, Hyun Jung; Kim, Ki Young; Ahn, Jin Hee; Bae, Myung Ae; Song, Jin Sook (Archives of pharmacal research, 2016)
Keywords: 11-beta-Hydroxysteroid Dehydrogenase Type 1 - antagonists & inhibitors; Administration, Oral; Animals; bioavailability; Biological Availability; blood proteins; Blood Proteins - metabolism; Caco-2 Cells; Cell Membrane Permeability; Cyclic S-Oxides - administration & dosage; Cyclic S-Oxides - chemistry; Cyclic S-Oxides - pharmacokinetics; Cyclic S-Oxides - pharmacology; Dogs; Drug Evaluation, Preclinical; Enzyme Inhibitors - administration & dosage; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - pharmacokinetics; Enzyme Inhibitors - pharmacology; Half-Life; human cell lines; Humans; Hypoglycemic Agents - administration & dosage; Hypoglycemic Agents - chemistry; Hypoglycemic Agents - pharmacokinetics; Hypoglycemic Agents - pharmacology; Injections, Intravenous; intravenous injection; liver; Male; Medicine; Mice; Microsomes, Liver - metabolism; Molecular Structure; noninsulin-dependent diabetes mellitus; obesity; oral administration; permeability; pharmacokinetics; Pharmacology/Toxicology; Pharmacy; Protein Binding; rats; Rats, Sprague-Dawley; Research Article; Solubility; Thiazines - administration & dosage; Thiazines - chemistry; Thiazines - pharmacokinetics; Thiazines - pharmacology; Tissue Distribution; 약학; 11β-hydroxysteroid dehydrogenase type 1; Metabolic stability; Plasma protein binding; Caco-2 cell permeability; Pharmacokinetics