Evidence-Based Review of Clinical Studies on Trauma
Clinical studies on trauma represent an important example of the ethical limitations of clinical research because patients cannot be randomized to "trauma" and "no trauma" groups. Instead, this important area of research includes preclinical studies, permitting more comprehensive...
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| Published in | Journal of endodontics Vol. 35; no. 8; pp. 1160 - 1162 |
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| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.08.2009
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0099-2399 1878-3554 1878-3554 |
| DOI | 10.1016/j.joen.2009.05.011 |
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| Abstract | Clinical studies on trauma represent an important example of the ethical limitations of clinical research because patients cannot be randomized to "trauma" and "no trauma" groups. Instead, this important area of research includes preclinical studies, permitting more comprehensive experimental designs, case series/retrospective studies, and randomized studies in which the intervention focuses on treatment delivered after occurrence of dental trauma. |
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| AbstractList | Clinical studies on trauma represent an important example of the ethical limitations of clinical research because patients cannot be randomized to "trauma" and "no trauma" groups. Instead, this important area of research includes preclinical studies, permitting more comprehensive experimental designs, case series/retrospective studies, and randomized studies in which the intervention focuses on treatment delivered after occurrence of dental trauma. Clinical studies on trauma represent an important example of the ethical limitations of clinical research because patients cannot be randomized to "trauma" and "no trauma" groups. Instead, this important area of research includes preclinical studies, permitting more comprehensive experimental designs, case series/retrospective studies, and randomized studies in which the intervention focuses on treatment delivered after occurrence of dental trauma.Clinical studies on trauma represent an important example of the ethical limitations of clinical research because patients cannot be randomized to "trauma" and "no trauma" groups. Instead, this important area of research includes preclinical studies, permitting more comprehensive experimental designs, case series/retrospective studies, and randomized studies in which the intervention focuses on treatment delivered after occurrence of dental trauma. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19631856$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/S0083-6729(03)01007-0 10.1111/j.1600-9657.2005.00330.x |
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| Copyright | 2009 American Association of Endodontists American Association of Endodontists |
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| References | Billich (bib2) 2002; 3 Hannappel, Huff (bib3) 2003; 66 Chappuis, von Arx (bib1) 2005; 21 Chappuis (10.1016/j.joen.2009.05.011_bib1) 2005; 21 Hannappel (10.1016/j.joen.2009.05.011_bib3) 2003; 66 Billich (10.1016/j.joen.2009.05.011_bib2) 2002; 3 |
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| SubjectTerms | Adjuvants, Immunologic - therapeutic use Dental Enamel Proteins - therapeutic use Dentistry Endocrinology & Metabolism Evidence-Based Dentistry Humans Pilot Projects Randomized Controlled Trials as Topic Root Canal Therapy - methods Root Resorption - prevention & control Thymosin - analogs & derivatives Thymosin - therapeutic use Tooth Avulsion - surgery Tooth Replantation Treatment Outcome |
| Title | Evidence-Based Review of Clinical Studies on Trauma |
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