CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection - Yuki, Kyoko E.; Marei, Hadir; Fiskin, Evgenij; Eva, Megan M.; Gopal, Angelica A.; Schwartzentruber, Jeremy A.; Majewski, Jacek; Cellier, Mathieu; Mandl, Judith N.; Vidal, Silvia M.; Malo, Danielle; Dikic, Ivan (Nature microbiology, 2019)
Keywords: 14/63; 59/5; 631/326/41/2531; 631/326/41/2533; 631/326/421; 631/326/88; 631/80/128; 64/60; 82/29; 82/58; 82/80; 96/106; 96/109; 96/21; 96/31; 96/35; 96/95; Actin; Actins - metabolism; Animals; Bacteria; Bacterial infections; Bacterial Infections - metabolism; Bacterial Infections - microbiology; Bacterial Infections - prevention & control; Bacterial Load; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Biomedical and Life Sciences; Cell adhesion & migration; Cell migration; Cytoskeleton; Cytoskeleton - genetics; Cytoskeleton - metabolism; Disease Resistance - genetics; Genomes; Guanosine triphosphatases; HEK293 Cells; HeLa Cells; Host-Pathogen Interactions; Humans; Infections; Infectious Diseases; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - metabolism; Life Sciences; Listeria monocytogenes; Listeria monocytogenes - metabolism; Listeria monocytogenes - physiology; Macrophages - microbiology; Macrophages - pathology; Medical Microbiology; Mice; Microbiology; Microbiology and Parasitology; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; Mutagenesis; Mutation; Mycobacterium tuberculosis - metabolism; Mycobacterium tuberculosis - physiology; Parasitology; Pathogenicity; Pathogens; Phagocytes; Phagocytosis; Polymerization; Protein Binding; Proteins; Public health; rac1 GTP-Binding Protein - metabolism; Rac1 protein; Salmonella; Salmonella typhimurium - metabolism; Salmonella typhimurium - physiology; Signal Transduction; Survival Analysis; Tuberculosis; Virology