Isolated diastolic hypertension is not associated with endothelial dysfunction

• Published in: Hypertension research Vol. 45; no. 4; pp. 698 - 707
• Main Authors: Han, Yiming, Maruhashi, Tatsuya, Kajikawa, Masato, Kishimoto, Shinji, Yamaji, Takayuki, Harada, Takahiro, Hashimoto, Yu, Yusoff, Farina Mohamad, Nakano, Yukiko, Chayama, Kazuaki, Nakashima, Ayumu, Goto, Chikara, Yoshimura, Kenichi, Higashi, Yukihito
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.04.2022
• Subjects: Adult; American Heart Association; Antihypertensive Agents - pharmacology; Antihypertensive Agents - therapeutic use; Antihypertensives; Blood Pressure; Cardiology; Female; Humans; Hypertension; Male; Middle Aged; Nitric oxide; Prevalence; Regression analysis; United States; United States; Flow-mediated vasodilation; Isolated diastolic hypertension; Endothelial function
• ISSN: 0916-9636; 1348-4214; 1348-4214
• DOI: 10.1038/s41440-022-00854-y

Hypertension is associated with an impairment of endothelial function. However, it is unclear whether isolated diastolic hypertension is associated with endothelial dysfunction. The purpose of this study was to investigate the association of endothelial function with isolated diastolic hypertension diagnosed by using two major hypertension guidelines: systolic blood pressure (BP) < 130 mmHg and diastolic BP ≥ 80 mmHg according to the 2017 American College of Cardiology/American Heart Association (ACC/AHA) hypertension guideline and systolic BP < 140 mmHg and diastolic BP ≥ 90 mmHg according to the 2018 European Society of Cardiology/European Society of Hypertension (ESC/ESH) hypertension guideline. We measured the flow-mediated vasodilation (FMD) of the brachial artery in subjects without systolic hypertension who were not treated with antihypertensive drugs. Of 3727 subjects (2813 men; mean age: 41.3 ± 10.9 years), 749 (20.1%) had isolated diastolic hypertension according to the 2017 ACC/AHA definition. Multiple logistic regression analysis revealed that isolated diastolic hypertension was not associated with endothelial dysfunction, defined as FMD < 7.0% (OR, 1.15; 95% CI, 0.98-1.35; P = 0.09). Of 4747 subjects (3727 men; mean age: 45.1 ± 10.8 years), 314 subjects (6.6%) had isolated diastolic hypertension according to the ESC/ESH definition. Multiple logistic regression analysis revealed that isolated diastolic hypertension was not associated with endothelial dysfunction after adjusting for age and sex (OR, 1.04; 95% CI, 0.82-1.32; P = 0.76). Isolated diastolic hypertension was not associated with endothelial dysfunction in individuals who were not treated with antihypertensive drugs regardless of the major hypertension guideline definition used.