Selective Aurora A-TPX2 Interaction Inhibitors Have In Vivo Efficacy as Targeted Antimitotic Agents - Stockwell, Simon R.; Scott, Duncan E.; Fischer, Gerhard; Guarino, Estrella; Rooney, Timothy P. C.; Feng, Tzu-Shean; Moschetti, Tommaso; Srinivasan, Rajavel; Alza, Esther; Asteian, Alice; Dagostin, Claudio; Alcaide, Anna; et al. (Journal of medicinal chemistry, 2024)
Keywords: Animals; Antimitotic Agents - chemistry; Antimitotic Agents - pharmacology; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Aurora Kinase A - antagonists & inhibitors; Aurora Kinase A - metabolism; Cell Cycle Proteins - antagonists & inhibitors; Cell Cycle Proteins - metabolism; Cell Line, Tumor; Chemistry, Medicinal; Humans; Life Sciences & Biomedicine; Mice; Mice, Nude; Microtubule-Associated Proteins - metabolism; Nuclear Proteins - antagonists & inhibitors; Nuclear Proteins - metabolism; Paclitaxel - pharmacology; Pharmacology & Pharmacy; Protein Kinase Inhibitors - chemistry; Protein Kinase Inhibitors - pharmacology; Science & Technology; Structure-Activity Relationship; Xenograft Model Antitumor Assays; A ACTIVATION; TAXANE RESISTANCE; ALISERTIB MLN8237; STRUCTURAL BASIS; PANCREATIC-CANCER; SOLID TUMORS SAFETY; CELL-CYCLE; KINASE INHIBITOR; PHASE-I; SMALL-MOLECULE INHIBITOR