Clinical application of an enzyme immunoassay for cholecystokinin-like immunoreactive substance for determination of the human plasma levels: the effect of metoclopramide on gastrointestinal peptides and stress-related hormones

Metoclopramide, a prokinetic drug, is widely used to treat vomiting and nausea. Delayed gastric emptying and continual stress are considered important factors, among others, that induce nausea and vomiting. One gastrointestinal motility regulatory factor has been assumed to be the induction of chang...

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Published inJournal of Peptide Science Vol. 12; no. 5; pp. 311 - 320
Main Authors Katagiri, Fumihiko, Inoue, Shin, Itoh, Hiroki, Takeyama, Masaharu
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Ltd 01.05.2006
Wiley
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Online AccessGet full text
ISSN1075-2617
1099-1387
DOI10.1002/psc.726

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Abstract Metoclopramide, a prokinetic drug, is widely used to treat vomiting and nausea. Delayed gastric emptying and continual stress are considered important factors, among others, that induce nausea and vomiting. One gastrointestinal motility regulatory factor has been assumed to be the induction of changes in the levels of peptides such as gastrin, somatostatin, motilin, and cholecystokinin (CCK) in plasma. In contrast, adrenocorticotropic hormone (ACTH) and cortisol are used as indicators of stress. Here, we studied the effects of metoclopramide on human plasma gastrin‐, somatostatin‐, motilin‐, and CCK‐like immunoreactive substances (ISs) and ACTH‐IS and cortisol under stress conditions using repetitive blood sampling in healthy subjects. Metoclopramide hydrochloride at a dose of 30 mg or placebo was orally administered to five healthy male volunteers. Blood samples were taken before and 20, 40, 60, 90, 120, 180, and 240 min after administration, subject to extracting procedures, and submitted to a highly sensitive enzyme immunoassay system. A single administration of metoclopramide caused significant increases in plasma somatostatin‐IS levels compared with the placebo. Metoclopramide significantly decreased plasma gastrin‐ and suppressed ACTH‐IS and cortisol levels compared with the placebo. We hypothesize that metoclopramide might have an accelerating gastric‐emptying effect and a modulatory effect on the hypothalamo‐pituitary‐adrenal (HPA) axis and the autonomic nervous function. These effects might be beneficial in stress‐related diseases, which suggest that this medicine has clinicopharmacological activities. Copyright © 2005 European Peptide Society and John Wiley & Sons, Ltd.
AbstractList Metoclopramide, a prokinetic drug, is widely used to treat vomiting and nausea. Delayed gastric emptying and continual stress are considered important factors, among others, that induce nausea and vomiting. One gastrointestinal motility regulatory factor has been assumed to be the induction of changes in the levels of peptides such as gastrin, somatostatin, motilin, and cholecystokinin (CCK) in plasma. In contrast, adrenocorticotropic hormone (ACTH) and cortisol are used as indicators of stress. Here, we studied the effects of metoclopramide on human plasma gastrin‐, somatostatin‐, motilin‐, and CCK‐like immunoreactive substances (ISs) and ACTH‐IS and cortisol under stress conditions using repetitive blood sampling in healthy subjects. Metoclopramide hydrochloride at a dose of 30 mg or placebo was orally administered to five healthy male volunteers. Blood samples were taken before and 20, 40, 60, 90, 120, 180, and 240 min after administration, subject to extracting procedures, and submitted to a highly sensitive enzyme immunoassay system. A single administration of metoclopramide caused significant increases in plasma somatostatin‐IS levels compared with the placebo. Metoclopramide significantly decreased plasma gastrin‐ and suppressed ACTH‐IS and cortisol levels compared with the placebo. We hypothesize that metoclopramide might have an accelerating gastric‐emptying effect and a modulatory effect on the hypothalamo‐pituitary‐adrenal (HPA) axis and the autonomic nervous function. These effects might be beneficial in stress‐related diseases, which suggest that this medicine has clinicopharmacological activities. Copyright © 2005 European Peptide Society and John Wiley & Sons, Ltd.
Metoclopramide, a prokinetic drug, is widely used to treat vomiting and nausea. Delayed gastric emptying and continual stress are considered important factors, among others, that induce nausea and vomiting. One gastrointestinal motility regulatory factor has been assumed to be the induction of changes in the levels of peptides such as gastrin, somatostatin, motilin, and cholecystokinin (CCK) in plasma. In contrast, adrenocorticotropic hormone (ACTH) and cortisol are used as indicators of stress. Here, we studied the effects of metoclopramide on human plasma gastrin-, somatostatin-, motilin-, and CCK-like immunoreactive substances (ISs) and ACTH-IS and cortisol under stress conditions using repetitive blood sampling in healthy subjects. Metoclopramide hydrochloride at a dose of 30 mg or placebo was orally administered to five healthy male volunteers. Blood samples were taken before and 20, 40, 60, 90, 120, 180, and 240 min after administration, subject to extracting procedures, and submitted to a highly sensitive enzyme immunoassay system. A single administration of metoclopramide caused significant increases in plasma somatostatin-IS levels compared with the placebo. Metoclopramide significantly decreased plasma gastrin- and suppressed ACTH-IS and cortisol levels compared with the placebo. We hypothesize that metoclopramide might have an accelerating gastric-emptying effect and a modulatory effect on the hypothalamo-pituitary-adrenal (HPA) axis and the autonomic nervous function. These effects might be beneficial in stress-related diseases, which suggest that this medicine has clinicopharmacological activities.Metoclopramide, a prokinetic drug, is widely used to treat vomiting and nausea. Delayed gastric emptying and continual stress are considered important factors, among others, that induce nausea and vomiting. One gastrointestinal motility regulatory factor has been assumed to be the induction of changes in the levels of peptides such as gastrin, somatostatin, motilin, and cholecystokinin (CCK) in plasma. In contrast, adrenocorticotropic hormone (ACTH) and cortisol are used as indicators of stress. Here, we studied the effects of metoclopramide on human plasma gastrin-, somatostatin-, motilin-, and CCK-like immunoreactive substances (ISs) and ACTH-IS and cortisol under stress conditions using repetitive blood sampling in healthy subjects. Metoclopramide hydrochloride at a dose of 30 mg or placebo was orally administered to five healthy male volunteers. Blood samples were taken before and 20, 40, 60, 90, 120, 180, and 240 min after administration, subject to extracting procedures, and submitted to a highly sensitive enzyme immunoassay system. A single administration of metoclopramide caused significant increases in plasma somatostatin-IS levels compared with the placebo. Metoclopramide significantly decreased plasma gastrin- and suppressed ACTH-IS and cortisol levels compared with the placebo. We hypothesize that metoclopramide might have an accelerating gastric-emptying effect and a modulatory effect on the hypothalamo-pituitary-adrenal (HPA) axis and the autonomic nervous function. These effects might be beneficial in stress-related diseases, which suggest that this medicine has clinicopharmacological activities.
Metoclopramide, a prokinetic drug, is widely used to treat vomiting and nausea. Delayed gastric emptying and continual stress are considered important factors, among others, that induce nausea and vomiting. One gastrointestinal motility regulatory factor has been assumed to be the induction of changes in the levels of peptides such as gastrin, somatostatin, motilin, and cholecystokinin (CCK) in plasma. In contrast, adrenocorticotropic hormone (ACTH) and cortisol are used as indicators of stress. Here, we studied the effects of metoclopramide on human plasma gastrin-, somatostatin-, motilin-, and CCK-like immunoreactive substances (ISs) and ACTH-IS and cortisol under stress conditions using repetitive blood sampling in healthy subjects. Metoclopramide hydrochloride at a dose of 30 mg or placebo was orally administered to five healthy male volunteers. Blood samples were taken before and 20, 40, 60, 90, 120, 180, and 240 min after administration, subject to extracting procedures, and submitted to a highly sensitive enzyme immunoassay system. A single administration of metoclopramide caused significant increases in plasma somatostatin-IS levels compared with the placebo. Metoclopramide significantly decreased plasma gastrin- and suppressed ACTH-IS and cortisol levels compared with the placebo. We hypothesize that metoclopramide might have an accelerating gastric-emptying effect and a modulatory effect on the hypothalamo-pituitary-adrenal (HPA) axis and the autonomic nervous function. These effects might be beneficial in stress-related diseases, which suggest that this medicine has clinicopharmacological activities.
Author Inoue, Shin
Katagiri, Fumihiko
Itoh, Hiroki
Takeyama, Masaharu
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1987; 35
1976; 42
1982; 35
1990; 12
1973; 50
2000; 6
1983; 131
1990; 38
1981; 123
2004; 27
1984; 101
1984; 87
1993; 42
1993; 41
1999; 25
1982; 243
1974
1981; 29
1969; 16
2001; 49
1978; 13
1985; 23
1999; 80
2001; 24
1998; 42
2001; 40
1978
1988; 1
1989; 30
2002; 25
1980; 15
1980; 36
1989; 34
1967; 53
1990; 26
1997; 11
2004; 18
1978; 87
2002; 23
1992; 134
2005; 51
1994; 15
1983; 28
1978; 106
1976; 39
1985; 32
1983; 25
2003; 23
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Nagano (10.1002/psc.726-BIB22) 1999; 25
Hostein (10.1002/psc.726-BIB35) 1984; 87
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Itoh (10.1002/psc.726-BIB39) 1976; 39
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Ling (10.1002/psc.726-BIB33) 1973; 50
Itoh (10.1002/psc.726-BIB10) 2000; 6
Anonymous (10.1002/psc.726-BIB2) 1988; 1
Crawley (10.1002/psc.726-BIB29) 1994; 15
Seal (10.1002/psc.726-BIB36) 1982; 243
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Fukudo (10.1002/psc.726-BIB48) 1998; 42
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Naito (10.1002/psc.726-BIB20) 2002; 25
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Snippet Metoclopramide, a prokinetic drug, is widely used to treat vomiting and nausea. Delayed gastric emptying and continual stress are considered important factors,...
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SubjectTerms Administration, Oral
Adrenocorticotropic Hormone
Adrenocorticotropic Hormone - blood
Adrenocorticotropic Hormone - immunology
Adult
Cholecystokinin
Cholecystokinin - blood
Cholecystokinin - drug effects
Cholecystokinin - immunology
Circadian Rhythm
cortisol
Domperidone
Domperidone - administration & dosage
Domperidone - pharmacology
Dopamine Antagonists
Dopamine Antagonists - administration & dosage
Dopamine Antagonists - pharmacology
enzyme immunoassay
Gastrins
Gastrins - blood
Gastrins - drug effects
Gastrointestinal Hormones
Gastrointestinal Hormones - blood
Humans
Hydrocortisone
Hydrocortisone - blood
Immunoenzyme Techniques
Immunoenzyme Techniques - methods
Immunoenzyme Techniques - standards
Male
Metoclopramide
Metoclopramide - administration & dosage
Metoclopramide - blood
Metoclopramide - pharmacology
Motilin
Motilin - blood
Motilin - drug effects
Reference Standards
Somatostatin
Somatostatin - blood
stress
Stress, Physiological
Stress, Physiological - blood
Stress, Physiological - physiopathology
Time Factors
Title Clinical application of an enzyme immunoassay for cholecystokinin-like immunoreactive substance for determination of the human plasma levels: the effect of metoclopramide on gastrointestinal peptides and stress-related hormones
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