Prognostic impact of mitochondrial DNA D-loop variations in pediatric acute myeloid leukemia
The role of mitochondrial DNA (mt-DNA) changes, especially those in the regulatory D-loop region in Acute Myeloid Leukemia (AML) remains investigational. Consecutive 151 pediatric AML patients, (≤18 yr) were prospectively enrolled from June 2013-August 2016, to assess the prognostic impact of mt-DNA...
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| Published in | Oncotarget Vol. 10; no. 13; pp. 1334 - 1343 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Impact Journals, LLC
12.02.2019
Impact Journals LLC |
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| Online Access | Get full text |
| ISSN | 1949-2553 1949-2553 |
| DOI | 10.18632/oncotarget.26665 |
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| Abstract | The role of mitochondrial DNA (mt-DNA) changes, especially those in the regulatory D-loop region in Acute Myeloid Leukemia (AML) remains investigational. Consecutive 151
pediatric AML patients, (≤18 yr) were prospectively enrolled from June 2013-August 2016, to assess the prognostic impact of mt-DNA D-loop variations (somatic/germline) on survival. For each patient, D-loop region was sequenced on baseline bone marrow and buccal swab, and mother's blood sample. In 151 AML subjects, 1490 variations were found at 237 positions; 80.9% were germline and 19.1% somatic. The mean number of variations per position was 6.3. Variations with frequency ≥6 were analyzed for their impact on survival and 4 categories were created, namely "somatic-protective", "somatic-hazardous", "germline-protective" and "germline- hazardous". Although, somatic-protective could not predict event free survival (EFS) or overall survival (OS), somatic-hazardous [(OS) HR = 2.33,
= 0.06] and germline-hazardous [(OS) HR = 2.85,
< 0.01] significantly predicted OS and EFS. Notably, the germline-protective, could significantly predict EFS (HR = 0.31,
= 0.03) and OS (HR = 0.19,
< 0.01), only when variations at ≥2 positions were present. On multivariate analysis, three positions namely 16111, 16126, 16362 and karyotype were found to be predictive of EFS. A prognostic index (PI) was developed using nomogram PI = (0.8*karyotype) + (1.0*c16111) + (0.7*t16362) + (1.2*t16126). Hazard ratio for EFS increased significantly with increasing PI reaching to a maximum of 3.3 (
< 0.01). In conclusion, the impact of mt-DNA D-loop variations on outcomes in pediatric AML depends on their nature (germline/somatic), position and mutational burden, highlighting their potential role as evolving prognostic biomarkers. |
|---|---|
| AbstractList | The role of mitochondrial DNA (mt-DNA) changes, especially those in the regulatory D-loop region in Acute Myeloid Leukemia (AML) remains investigational. Consecutive 151
de novo
pediatric AML patients, (≤18 yr) were prospectively enrolled from June 2013-August 2016, to assess the prognostic impact of mt-DNA D-loop variations (somatic/germline) on survival. For each patient, D-loop region was sequenced on baseline bone marrow and buccal swab, and mother’s blood sample. In 151 AML subjects, 1490 variations were found at 237 positions; 80.9% were germline and 19.1% somatic. The mean number of variations per position was 6.3. Variations with frequency ≥6 were analyzed for their impact on survival and 4 categories were created, namely “somatic-protective”, “somatic-hazardous”, “germline-protective” and “germline- hazardous”. Although, somatic-protective could not predict event free survival (EFS) or overall survival (OS), somatic-hazardous [(OS) HR = 2.33,
p
= 0.06] and germline-hazardous [(OS) HR = 2.85,
p
< 0.01] significantly predicted OS and EFS. Notably, the germline-protective, could significantly predict EFS (HR = 0.31,
p
= 0.03) and OS (HR = 0.19,
p
< 0.01), only when variations at ≥2 positions were present. On multivariate analysis, three positions namely 16111, 16126, 16362 and karyotype were found to be predictive of EFS. A prognostic index (PI) was developed using nomogram PI = (0.8*karyotype) + (1.0*c16111) + (0.7*t16362) + (1.2*t16126). Hazard ratio for EFS increased significantly with increasing PI reaching to a maximum of 3.3 (
p
< 0.01). In conclusion, the impact of mt-DNA D-loop variations on outcomes in pediatric AML depends on their nature (germline/somatic), position and mutational burden, highlighting their potential role as evolving prognostic biomarkers. The role of mitochondrial DNA (mt-DNA) changes, especially those in the regulatory D-loop region in Acute Myeloid Leukemia (AML) remains investigational. Consecutive 151 pediatric AML patients, (≤18 yr) were prospectively enrolled from June 2013-August 2016, to assess the prognostic impact of mt-DNA D-loop variations (somatic/germline) on survival. For each patient, D-loop region was sequenced on baseline bone marrow and buccal swab, and mother's blood sample. In 151 AML subjects, 1490 variations were found at 237 positions; 80.9% were germline and 19.1% somatic. The mean number of variations per position was 6.3. Variations with frequency ≥6 were analyzed for their impact on survival and 4 categories were created, namely "somatic-protective", "somatic-hazardous", "germline-protective" and "germline- hazardous". Although, somatic-protective could not predict event free survival (EFS) or overall survival (OS), somatic-hazardous [(OS) HR = 2.33, = 0.06] and germline-hazardous [(OS) HR = 2.85, < 0.01] significantly predicted OS and EFS. Notably, the germline-protective, could significantly predict EFS (HR = 0.31, = 0.03) and OS (HR = 0.19, < 0.01), only when variations at ≥2 positions were present. On multivariate analysis, three positions namely 16111, 16126, 16362 and karyotype were found to be predictive of EFS. A prognostic index (PI) was developed using nomogram PI = (0.8*karyotype) + (1.0*c16111) + (0.7*t16362) + (1.2*t16126). Hazard ratio for EFS increased significantly with increasing PI reaching to a maximum of 3.3 ( < 0.01). In conclusion, the impact of mt-DNA D-loop variations on outcomes in pediatric AML depends on their nature (germline/somatic), position and mutational burden, highlighting their potential role as evolving prognostic biomarkers. The role of mitochondrial DNA (mt-DNA) changes, especially those in the regulatory D-loop region in Acute Myeloid Leukemia (AML) remains investigational. Consecutive 151 de novo pediatric AML patients, (≤18 yr) were prospectively enrolled from June 2013-August 2016, to assess the prognostic impact of mt-DNA D-loop variations (somatic/germline) on survival. For each patient, D-loop region was sequenced on baseline bone marrow and buccal swab, and mother's blood sample. In 151 AML subjects, 1490 variations were found at 237 positions; 80.9% were germline and 19.1% somatic. The mean number of variations per position was 6.3. Variations with frequency ≥6 were analyzed for their impact on survival and 4 categories were created, namely "somatic-protective", "somatic-hazardous", "germline-protective" and "germline- hazardous". Although, somatic-protective could not predict event free survival (EFS) or overall survival (OS), somatic-hazardous [(OS) HR = 2.33, p = 0.06] and germline-hazardous [(OS) HR = 2.85, p < 0.01] significantly predicted OS and EFS. Notably, the germline-protective, could significantly predict EFS (HR = 0.31, p = 0.03) and OS (HR = 0.19, p < 0.01), only when variations at ≥2 positions were present. On multivariate analysis, three positions namely 16111, 16126, 16362 and karyotype were found to be predictive of EFS. A prognostic index (PI) was developed using nomogram PI = (0.8*karyotype) + (1.0*c16111) + (0.7*t16362) + (1.2*t16126). Hazard ratio for EFS increased significantly with increasing PI reaching to a maximum of 3.3 (p < 0.01). In conclusion, the impact of mt-DNA D-loop variations on outcomes in pediatric AML depends on their nature (germline/somatic), position and mutational burden, highlighting their potential role as evolving prognostic biomarkers.The role of mitochondrial DNA (mt-DNA) changes, especially those in the regulatory D-loop region in Acute Myeloid Leukemia (AML) remains investigational. Consecutive 151 de novo pediatric AML patients, (≤18 yr) were prospectively enrolled from June 2013-August 2016, to assess the prognostic impact of mt-DNA D-loop variations (somatic/germline) on survival. For each patient, D-loop region was sequenced on baseline bone marrow and buccal swab, and mother's blood sample. In 151 AML subjects, 1490 variations were found at 237 positions; 80.9% were germline and 19.1% somatic. The mean number of variations per position was 6.3. Variations with frequency ≥6 were analyzed for their impact on survival and 4 categories were created, namely "somatic-protective", "somatic-hazardous", "germline-protective" and "germline- hazardous". Although, somatic-protective could not predict event free survival (EFS) or overall survival (OS), somatic-hazardous [(OS) HR = 2.33, p = 0.06] and germline-hazardous [(OS) HR = 2.85, p < 0.01] significantly predicted OS and EFS. Notably, the germline-protective, could significantly predict EFS (HR = 0.31, p = 0.03) and OS (HR = 0.19, p < 0.01), only when variations at ≥2 positions were present. On multivariate analysis, three positions namely 16111, 16126, 16362 and karyotype were found to be predictive of EFS. A prognostic index (PI) was developed using nomogram PI = (0.8*karyotype) + (1.0*c16111) + (0.7*t16362) + (1.2*t16126). Hazard ratio for EFS increased significantly with increasing PI reaching to a maximum of 3.3 (p < 0.01). In conclusion, the impact of mt-DNA D-loop variations on outcomes in pediatric AML depends on their nature (germline/somatic), position and mutational burden, highlighting their potential role as evolving prognostic biomarkers. |
| Author | Radhika Bakhshi Sameer Bakhshi Anudishi Tyagi Raja Pramanik Sreenivas Vishnubhatla |
| Author_xml | – sequence: 1 givenname: Anudishi surname: Tyagi fullname: Tyagi, Anudishi organization: Department of Medical Oncology, Dr. B. R. A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India – sequence: 2 givenname: Raja surname: Pramanik fullname: Pramanik, Raja organization: Department of Medical Oncology, Dr. B. R. A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India – sequence: 3 givenname: Sreenivas surname: Vishnubhatla fullname: Vishnubhatla, Sreenivas organization: Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India – sequence: 4 givenname: Radhika surname: Bakhshi fullname: Bakhshi, Radhika organization: Department of Biomedical Sciences, Shaheed Rajguru College of Applied Sciences, University of Delhi, New Delhi, India – sequence: 5 givenname: Sameer surname: Bakhshi fullname: Bakhshi, Sameer organization: Department of Medical Oncology, Dr. B. R. A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India |
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| CitedBy_id | crossref_primary_10_1016_j_mito_2020_12_006 crossref_primary_10_3390_cancers16050960 crossref_primary_10_3389_fonc_2023_1109518 crossref_primary_10_1016_j_bcmd_2022_102662 crossref_primary_10_1080_10428194_2021_2010063 crossref_primary_10_4103_jfmpc_jfmpc_679_19 |
| Cites_doi | 10.1182/blood-2006-01-011007 10.1002/elps.1150180504 10.1056/NEJMoa1801946 10.1111/ejh.12090 10.1038/sj.leu.2403380 10.1016/j.gde.2016.03.005 10.1016/j.canlet.2005.08.008 10.1159/000114160 10.1111/j.1742-4658.2009.07269.x 10.4103/0971-5916.191740 10.4103/0971-5916.192027 10.1016/j.exphem.2008.01.004 10.6004/jnccn.2017.0116 10.1038/leu.2011.200 10.1126/science.287.5460.2017 10.1186/1471-2407-6-93 10.1309/GQFCCJMH5KHNVX73 10.5114/pm.2014.42717 10.1200/JCO.2005.07.044 10.1111/j.1365-2141.2010.08084.x 10.1038/leu.2008.69 10.1038/290457a0 10.1182/blood-2016-08-733196 10.1182/blood-2015-01-623447 10.1016/j.mrfmmm.2018.05.002 10.1016/0921-8734(92)90043-O 10.3892/ol.2017.6988 10.1038/sj.leu.2403146 10.1086/425871 10.1002/(SICI)1097-0215(19980518)76:4<495::AID-IJC9>3.0.CO;2-M |
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| Keywords | leukemia D-loop pediatric AML prognosis mitochondrial DNA |
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| References | Gille (7) 1992; 275 Gattermann (17) 2008; 36 Zhang (25) 2004; 75 Wilczyński (9) 2014; 18 Alexeyev (2) 2009; 276 27 Wong (18) 2006; 6 Heuser (3) 2011; 26 Young (1) 2016; 38 Prathap Naidu (26) 2008; 66 Kumar (29) 2016; 143 Turnbull (4) 2003; 17 Nakao (19) 2002; 8 Bakhshi (28) 2016; 143 Guo (16) 2006; 239 Brahmer (23) 2018; 378 Bakhshi (13) 2018; 810 Young (5) 2007; 109 Laurent-Puig (8) 2019; 23 Clark (31) 2016; 125 Staden (6) 1981; 290 Plebani (24) 2006; 126 Naoe (30) 2017; 129 Charron (15) 1998; 76 Bakhshi (12) 2010; 149 Cobarello (14) 2000; 287 Lancet (32) 2017; 15 Sancho (21) 1997; 18 Morley (20) 2004; 18 Ying (11) 2017; 14 Nyvold (22) 2013; 90 Capitanio (10) 2008; 22 |
| References_xml | – volume: 109 start-page: 756 year: 2007 ident: 5 article-title: Mitochondrial DNA sequence variation in single cells from leukemia patients publication-title: Leukemia doi: 10.1182/blood-2006-01-011007 – volume: 18 start-page: 682 year: 1997 ident: 21 article-title: Detection of somatic mutations in the mitochondrial DNA control region of colorectal and gastric tumors by heteroduplex and single-strand conformation analysis publication-title: Electrophoresis doi: 10.1002/elps.1150180504 – volume: 378 start-page: 2093 year: 2018 ident: 23 article-title: Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden publication-title: N Engl J Med doi: 10.1056/NEJMoa1801946 – volume: 90 start-page: 385 year: 2013 ident: 22 article-title: Characterization and prognostic significance of mitochondrial DNA variations in acute myeloid leukemia publication-title: Eur J Haematol doi: 10.1111/ejh.12090 – volume: 18 start-page: 1313 year: 2004 ident: 20 article-title: Mitochondrial mutations in acute leukaemia publication-title: Leukemia doi: 10.1038/sj.leu.2403380 – volume: 8 start-page: 481 year: 2002 ident: 19 article-title: Mitochondrial D-loop mutations as clonal markers in multicentric hepatocellular carcinoma and plasma publication-title: Clin Cancer Res – volume: 38 start-page: 52 year: 2016 ident: 1 article-title: Human mitochondrial DNA replication machinery and disease publication-title: Curr Opin Genet Dev doi: 10.1016/j.gde.2016.03.005 – volume: 239 start-page: 151 year: 2006 ident: 16 article-title: Mutations in the mitochondrial DNA D-Loop region occur frequently in human osteosarcoma publication-title: Cancer Lett doi: 10.1016/j.canlet.2005.08.008 – volume: 66 start-page: 1 year: 2008 ident: 26 article-title: Maternal footprints of Southeast Asians in North India publication-title: Hum Hered doi: 10.1159/000114160 – volume: 276 start-page: 5768 year: 2009 ident: 2 article-title: Is there more to aging than mitochondrial DNA and reactive oxygen species? publication-title: FEBS J doi: 10.1111/j.1742-4658.2009.07269.x – volume: 143 start-page: S11 year: 2016 ident: 28 article-title: High fms-like tyrosine kinase-3 (FLT3) receptor surface expression predicts poor outcome in FLT3 internal tandem duplication (ITD) negative patients in adult acute myeloid leukaemia: A prospective pilot study from India publication-title: Indian J Med Res doi: 10.4103/0971-5916.191740 – volume: 143 start-page: 763 year: 2016 ident: 29 article-title: Nucleophosmin mutation analysis in acute myeloid leukaemia: Immunohistochemistry as a surrogate for molecular techniques publication-title: Indian J Med Res doi: 10.4103/0971-5916.192027 – volume: 36 start-page: 577 year: 2008 ident: 17 article-title: Analysis of mitochondrial DNA in 104 patients with myelodysplastic syndromes publication-title: Exp Hematol doi: 10.1016/j.exphem.2008.01.004 – volume: 15 start-page: 926 year: 2017 ident: 32 article-title: Acute Myeloid Clinical Practice Guidelines in Oncology publication-title: J Natl Compr Canc Netw doi: 10.6004/jnccn.2017.0116 – volume: 26 start-page: 289 year: 2011 ident: 3 article-title: Prognostic implications and molecular associations of NADH dehydrogenase subunit 4 (ND4) mutations in acute myeloid leukemia publication-title: Leukemia doi: 10.1038/leu.2011.200 – volume: 287 start-page: 2017 year: 2000 ident: 14 article-title: Facile detection of mitochondrial DNA mutations in tumours and bodily fluids publication-title: Science doi: 10.1126/science.287.5460.2017 – volume: 6 start-page: 93 year: 2006 ident: 18 article-title: Significance of somatic mutations and content alteration of mitochondrial DNA in esophageal cancer publication-title: BMC Cancer doi: 10.1186/1471-2407-6-93 – volume: 126 start-page: 593 year: 2006 ident: 24 article-title: Mitochondrial DNA D-loop in pancreatic cancer: Somatic mutations are epiphenomena while the germline 16519T variant worsens metabolism and outcome publication-title: Am J Clin Pathol doi: 10.1309/GQFCCJMH5KHNVX73 – volume: 18 start-page: 136 year: 2014 ident: 9 article-title: Mitochondrial dysfunction in cancer publication-title: Prz Menopauzalny doi: 10.5114/pm.2014.42717 – volume: 23 start-page: 3517 year: 2019 ident: 8 article-title: Clinical Value of Mitochondrial Mutations in Colorectal Cancer publication-title: J Clin Oncol doi: 10.1200/JCO.2005.07.044 – volume: 149 start-page: 391 year: 2010 ident: 12 article-title: Mitochondrial D-loop variations in paediatric acute myeloid leukaemia: A potential prognostic marker publication-title: Br J Haematol doi: 10.1111/j.1365-2141.2010.08084.x – volume: 22 start-page: 1938 year: 2008 ident: 10 article-title: MtDNA mutation associated with mitochondrial dysfunction in megakaryoblastic leukaemic cells publication-title: Leukemia doi: 10.1038/leu.2008.69 – volume: 290 start-page: 457 year: 1981 ident: 6 article-title: Sequence and organization of the human mitochondrial genome publication-title: Nature doi: 10.1038/290457a0 – volume: 129 start-page: 424 year: 2017 ident: 30 article-title: Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel publication-title: Blood doi: 10.1182/blood-2016-08-733196 – volume: 125 start-page: 3878 year: 2016 ident: 31 article-title: A randomized comparison of daunorubicin 90 mg/mvs 60 mg/min AML induction: results from the UK NCRI AML17 trial in 1206 patients publication-title: Blood doi: 10.1182/blood-2015-01-623447 – volume: 810 start-page: 13 year: 2018 ident: 13 article-title: Pattern of mitochondrial D-loop variations and their relation with mitochondrial encoded genes in pediatric acute myeloid leukemia publication-title: Mutat Res doi: 10.1016/j.mrfmmm.2018.05.002 – volume: 275 start-page: 405 year: 1992 ident: 7 article-title: Cell culture models for oxidative stress: superoxide and hydrogen peroxide versus normobaric hyperoxia publication-title: Mutat Res doi: 10.1016/0921-8734(92)90043-O – volume: 14 start-page: 6269 year: 2017 ident: 11 article-title: Sequence variations of mitochondrial DNA D-loop region in patients with acute myeloid leukemia publication-title: Oncol Lett doi: 10.3892/ol.2017.6988 – volume: 17 start-page: 2487 year: 2003 ident: 4 article-title: Somatic mitochondrial DNA mutations in adult-onset leukaemia publication-title: Leukemia doi: 10.1038/sj.leu.2403146 – ident: 27 – volume: 75 start-page: 966 year: 2004 ident: 25 article-title: Phylogeny of Mitochondrial DNA Macrohaplogroup N in India, Based on Complete Sequencing: Implications for the Peopling of South Asia publication-title: Am J Hum Genet doi: 10.1086/425871 – volume: 76 start-page: 495 year: 1998 ident: 15 article-title: Mitochondrial DNA sequence variation in human leukemic cells publication-title: Int J Cancer doi: 10.1002/(SICI)1097-0215(19980518)76:4<495::AID-IJC9>3.0.CO;2-M |
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| Title | Prognostic impact of mitochondrial DNA D-loop variations in pediatric acute myeloid leukemia |
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