Structural convergence of unstructured p53 family transactivation domains in MDM2 recognition - Shin, Jae-Sun; Ha, Ji-Hyang; Lee, Dong-Hwa; Ryu, Kyoung-Seok; Bae, Kwang-Hee; Park, Byoung Chul; Park, Sung Goo; Yi, Gwan-Su; Chi, Seung-Wook (Cell cycle (Georgetown, Tex.), 2015)
Keywords: Amino Acid Sequence; Circular Dichroism; DNA-Binding Proteins - genetics; Gene Components; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Multiprotein Complexes - genetics; Nuclear Proteins - genetics; Protein Binding; Protein Conformation; Proto-Oncogene Proteins c-mdm2 - genetics; Transcription Factors - genetics; Transcriptional Activation - genetics; Tumor Protein p73; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Proteins - genetics; HSQC, heteronuclear single quantum coherence; IDP, Intrinsically disordered protein; complex structure; transactivation domain; RDC, Residual dipolar coupling; NOESY, nuclear Overhauser effect spectroscopy; p73; ITC, Isothermal titration calorimetry; TAD, transactivation domain; NMR; AIRs, Ambiguous interaction restraints; NMR, nuclear magnetic resonance; MDM2; MDM2, mouse double minute 2; p53 family