Melatonin Protects N2a against Ischemia/Reperfusion Injury through Autophagy Enhancement

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 30; no. 1; pp. 1 - 7
• Main Author: 国艳春 王剑飞 王忠强 杨易 王西明 段秋红
• Format: Journal Article
• Language: English
• Published: Heidelberg Huazhong University of Science and Technology 01.02.2010; Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China%Department of Emergency Medicine,Wuhan General Hospital of Guangzhou Command,Wuhan 430070,China
• Subjects: Animals; Autophagy - physiology; Cell Hypoxia - physiology; Cell Line, Tumor; Medicine; Medicine & Public Health; Melatonin - pharmacology; Mice; Neuroblastoma - pathology; Neuroprotective Agents - pharmacology; Reperfusion Injury - physiopathology; Reperfusion Injury - prevention & control; ischemia/reperfusion; autophagy; PKB; 3-MA; Beclin1; melatonin; N2a; LC3; rapamycin
• ISSN: 1672-0733; 1993-1352
• DOI: 10.1007/s11596-010-0101-9

Researches have shown that melatonin is neuroprotectant in ischemia/reperfusion-mediated injury.Although melatonin is known as an effective antioxidant,the mechanism of the protection cannot be explained merely by antioxidation.This study was devoted to explore other existing mechanisms by investigating whether melatonin protects ischemia/reperfusion-injured neurons through elevating autophagy,since autophagy has been frequently suggested to play a crucial role in neuron survival.To find it out,an ischemia/...