A novel soluble β-1,3- d -glucan Salecan reduces adiposity and improves glucose tolerance in high-fat diet-fed mice
Salecan is a recently identified water-soluble viscous extracellular β-1,3- d -glucan polysaccharide from an Agrobacterium species. It is a high-molecular-mass polymer (about 2 × 10 6 Da) and composed of a linear chain of glucosyl residues linked through a repeat unit of seven β-(1,3) and two α-(1,3...
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Published in | British journal of nutrition Vol. 109; no. 2; pp. 254 - 262 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Cambridge
Cambridge University Press
28.01.2013
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Subjects | |
Online Access | Get full text |
ISSN | 0007-1145 1475-2662 1475-2662 |
DOI | 10.1017/S0007114512000980 |
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Abstract | Salecan is a recently identified water-soluble viscous extracellular β-1,3-
d
-glucan polysaccharide from an
Agrobacterium
species. It is a high-molecular-mass polymer (about 2 × 10
6
Da) and composed of a linear chain of glucosyl residues linked through a repeat unit of seven β-(1,3) and two α-(1,3) glucosidic bonds. In the present study, we examined the effects of dietary Salecan fed at 2 and 5 % in a high-fat diet (64 % energy) in C57BL/6J mice. After 6 weeks, mice fed 2 and 5 % Salecan had significantly lower body weight, fat mass and percentage of body fat mass compared with those fed a high-fat cellulose (control) diet. Both the Salecan groups significantly and dose-dependently improved glucose tolerance, with a 9 and 26 % reduction of glucose AUC, respectively. Liver and adipose tissue weights were also significantly decreased by the Salecan treatment. Supplementation with 5 % Salecan led to lower serum TAG, total cholesterol (TC) and HDL-cholesterol (52, 18 and 19 %, respectively) and lower hepatic TAG by 56 % and TC by 22 % compared with the high-fat cellulose control group. Dietary Salecan intake caused an obvious elevation of fat in the faeces. Supplementation with Salecan disturbed bile acid-promoted emulsification and reduced the size of emulsion droplets
in vitro.
These results indicate that Salecan decreases fat absorption, improves glucose tolerance and has biologically important, dose-related effects on reducing high-fat diet-induced obesity. |
---|---|
AbstractList | Salecan is a recently identified water-soluble viscous extracellular β-1,3-D-glucan polysaccharide from an Agrobacterium species. It is a high-molecular-mass polymer (about 2 × 10⁶ Da) and composed of a linear chain of glucosyl residues linked through a repeat unit of seven β-(1,3) and two α-(1,3) glucosidic bonds. In the present study, we examined the effects of dietary Salecan fed at 2 and 5 % in a high-fat diet (64 % energy) in C57BL/6J mice. After 6 weeks, mice fed 2 and 5 % Salecan had significantly lower body weight, fat mass and percentage of body fat mass compared with those fed a high-fat cellulose (control) diet. Both the Salecan groups significantly and dose-dependently improved glucose tolerance, with a 9 and 26 % reduction of glucose AUC, respectively. Liver and adipose tissue weights were also significantly decreased by the Salecan treatment. Supplementation with 5 % Salecan led to lower serum TAG, total cholesterol (TC) and HDL-cholesterol (52, 18 and 19 %, respectively) and lower hepatic TAG by 56 % and TC by 22 % compared with the high-fat cellulose control group. Dietary Salecan intake caused an obvious elevation of fat in the faeces. Supplementation with Salecan disturbed bile acid-promoted emulsification and reduced the size of emulsion droplets in vitro. These results indicate that Salecan decreases fat absorption, improves glucose tolerance and has biologically important, dose-related effects on reducing high-fat diet-induced obesity. Salecan is a recently identified water-soluble viscous extracellular β-1,3- d -glucan polysaccharide from an Agrobacterium species. It is a high-molecular-mass polymer (about 2 × 10 6 Da) and composed of a linear chain of glucosyl residues linked through a repeat unit of seven β-(1,3) and two α-(1,3) glucosidic bonds. In the present study, we examined the effects of dietary Salecan fed at 2 and 5 % in a high-fat diet (64 % energy) in C57BL/6J mice. After 6 weeks, mice fed 2 and 5 % Salecan had significantly lower body weight, fat mass and percentage of body fat mass compared with those fed a high-fat cellulose (control) diet. Both the Salecan groups significantly and dose-dependently improved glucose tolerance, with a 9 and 26 % reduction of glucose AUC, respectively. Liver and adipose tissue weights were also significantly decreased by the Salecan treatment. Supplementation with 5 % Salecan led to lower serum TAG, total cholesterol (TC) and HDL-cholesterol (52, 18 and 19 %, respectively) and lower hepatic TAG by 56 % and TC by 22 % compared with the high-fat cellulose control group. Dietary Salecan intake caused an obvious elevation of fat in the faeces. Supplementation with Salecan disturbed bile acid-promoted emulsification and reduced the size of emulsion droplets in vitro. These results indicate that Salecan decreases fat absorption, improves glucose tolerance and has biologically important, dose-related effects on reducing high-fat diet-induced obesity. Salecan is a recently identified water-soluble viscous extracellular β-1,3-d-glucan polysaccharide from an Agrobacterium species. It is a high-molecular-mass polymer (about 2 × 10⁶Da) and composed of a linear chain of glucosyl residues linked through a repeat unit of seven β-(1,3) and two α-(1,3) glucosidic bonds. In the present study, we examined the effects of dietary Salecan fed at 2 and 5 % in a high-fat diet (64 % energy) in C57BL/6J mice. After 6 weeks, mice fed 2 and 5 % Salecan had significantly lower body weight, fat mass and percentage of body fat mass compared with those fed a high-fat cellulose (control) diet. Both the Salecan groups significantly and dose-dependently improved glucose tolerance, with a 9 and 26 % reduction of glucose AUC, respectively. Liver and adipose tissue weights were also significantly decreased by the Salecan treatment. Supplementation with 5 % Salecan led to lower serum TAG, total cholesterol (TC) and HDL-cholesterol (52, 18 and 19 %, respectively) and lower hepatic TAG by 56 % and TC by 22 % compared with the high-fat cellulose control group. Dietary Salecan intake caused an obvious elevation of fat in the faeces. Supplementation with Salecan disturbed bile acid-promoted emulsification and reduced the size of emulsion droplets in vitro. These results indicate that Salecan decreases fat absorption, improves glucose tolerance and has biologically important, dose-related effects on reducing high-fat diet-induced obesity. Salecan is a recently identified water-soluble viscous extracellular β-1,3-D-glucan polysaccharide from an Agrobacterium species. It is a high-molecular-mass polymer (about 2 × 10⁶ Da) and composed of a linear chain of glucosyl residues linked through a repeat unit of seven β-(1,3) and two α-(1,3) glucosidic bonds. In the present study, we examined the effects of dietary Salecan fed at 2 and 5 % in a high-fat diet (64 % energy) in C57BL/6J mice. After 6 weeks, mice fed 2 and 5 % Salecan had significantly lower body weight, fat mass and percentage of body fat mass compared with those fed a high-fat cellulose (control) diet. Both the Salecan groups significantly and dose-dependently improved glucose tolerance, with a 9 and 26 % reduction of glucose AUC, respectively. Liver and adipose tissue weights were also significantly decreased by the Salecan treatment. Supplementation with 5 % Salecan led to lower serum TAG, total cholesterol (TC) and HDL-cholesterol (52, 18 and 19 %, respectively) and lower hepatic TAG by 56 % and TC by 22 % compared with the high-fat cellulose control group. Dietary Salecan intake caused an obvious elevation of fat in the faeces. Supplementation with Salecan disturbed bile acid-promoted emulsification and reduced the size of emulsion droplets in vitro. These results indicate that Salecan decreases fat absorption, improves glucose tolerance and has biologically important, dose-related effects on reducing high-fat diet-induced obesity.Salecan is a recently identified water-soluble viscous extracellular β-1,3-D-glucan polysaccharide from an Agrobacterium species. It is a high-molecular-mass polymer (about 2 × 10⁶ Da) and composed of a linear chain of glucosyl residues linked through a repeat unit of seven β-(1,3) and two α-(1,3) glucosidic bonds. In the present study, we examined the effects of dietary Salecan fed at 2 and 5 % in a high-fat diet (64 % energy) in C57BL/6J mice. After 6 weeks, mice fed 2 and 5 % Salecan had significantly lower body weight, fat mass and percentage of body fat mass compared with those fed a high-fat cellulose (control) diet. Both the Salecan groups significantly and dose-dependently improved glucose tolerance, with a 9 and 26 % reduction of glucose AUC, respectively. Liver and adipose tissue weights were also significantly decreased by the Salecan treatment. Supplementation with 5 % Salecan led to lower serum TAG, total cholesterol (TC) and HDL-cholesterol (52, 18 and 19 %, respectively) and lower hepatic TAG by 56 % and TC by 22 % compared with the high-fat cellulose control group. Dietary Salecan intake caused an obvious elevation of fat in the faeces. Supplementation with Salecan disturbed bile acid-promoted emulsification and reduced the size of emulsion droplets in vitro. These results indicate that Salecan decreases fat absorption, improves glucose tolerance and has biologically important, dose-related effects on reducing high-fat diet-induced obesity. |
Author | Pang, Wenqiang Zhang, Jianfa Chen, Peng Zhu, Bin Zhang, Ying Xia, Lin Wang, Tao |
Author_xml | – sequence: 1 givenname: Ying surname: Zhang fullname: Zhang, Ying – sequence: 2 givenname: Lin surname: Xia fullname: Xia, Lin – sequence: 3 givenname: Wenqiang surname: Pang fullname: Pang, Wenqiang – sequence: 4 givenname: Tao surname: Wang fullname: Wang, Tao – sequence: 5 givenname: Peng surname: Chen fullname: Chen, Peng – sequence: 6 givenname: Bin surname: Zhu fullname: Zhu, Bin – sequence: 7 givenname: Jianfa surname: Zhang fullname: Zhang, Jianfa |
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Keywords | Obesity β-Glucans Salecan Rodentia Nutrition disorder Tolerance Glucose Feeding Glucan Glucose tolerance Vertebrata Mammalia Adiposity Diet Mouse Animal High-fat diet Fat Nutritional status |
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Snippet | Salecan is a recently identified water-soluble viscous extracellular β-1,3-
d
-glucan polysaccharide from an
Agrobacterium
species. It is a high-molecular-mass... Salecan is a recently identified water-soluble viscous extracellular β-1,3-D-glucan polysaccharide from an Agrobacterium species. It is a high-molecular-mass... Salecan is a recently identified water-soluble viscous extracellular β-1,3-d-glucan polysaccharide from an Agrobacterium species. It is a high-molecular-mass... |
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SubjectTerms | absorption Adiposity Agrobacterium Animals Anti-Obesity Agents - administration & dosage Anti-Obesity Agents - chemistry Anti-Obesity Agents - therapeutic use beta-Glucans - administration & dosage beta-Glucans - chemistry beta-Glucans - therapeutic use bile Biological and medical sciences blood serum Cell Size cellulose Diet, High-Fat - adverse effects Dietary Fats - analysis Dietary Fats - metabolism Dietary Supplements droplets emulsifying Emulsifying Agents - administration & dosage Emulsifying Agents - chemistry Emulsifying Agents - therapeutic use emulsions energy fat body feces Feces - chemistry Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology glucose Glucose Intolerance - etiology Glucose Intolerance - prevention & control glucose tolerance high density lipoprotein cholesterol high fat diet Intestinal Absorption Intra-Abdominal Fat - pathology Lipid Metabolism liver Liver - metabolism Liver - pathology Mice Mice, Inbred C57BL obesity Obesity - etiology Obesity - metabolism Obesity - pathology Obesity - prevention & control Organ Size polymers Solubility Vertebrates: anatomy and physiology, studies on body, several organs or systems Weight Gain |
Title | A novel soluble β-1,3- d -glucan Salecan reduces adiposity and improves glucose tolerance in high-fat diet-fed mice |
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