Long Non-coding RNA MEG3 Induces Renal Cell Carcinoma Cells Apoptosis by Activating the Mitochondrial Pathway
Summary： This study aimed to examine the effect of long non-coding RNA （LncRNA） MEG3 on the biological behaviors of renal cell carcinoma （RCC） cells 786-0 and the possible mechanism. MEG3 expression levels were detected by RT-qPCR in Rmaor tissues and adjacent non-tumor tissues from 29 RCC patients...
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| Published in | Journal of Huazhong University of Science and Technology. Medical sciences Vol. 35; no. 4; pp. 541 - 545 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Wuhan
Huazhong University of Science and Technology
01.08.2015
Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022,China%Department of Urology, The First Hospital of Wuhan, Wuhan 430022, China |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1672-0733 1993-1352 1993-1352 |
| DOI | 10.1007/s11596-015-1467-5 |
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| Abstract | Summary： This study aimed to examine the effect of long non-coding RNA （LncRNA） MEG3 on the biological behaviors of renal cell carcinoma （RCC） cells 786-0 and the possible mechanism. MEG3 expression levels were detected by RT-qPCR in Rmaor tissues and adjacent non-tumor tissues from 29 RCC patients and in RCC lines 786-0 and SN12 and human embryonic kidney cell line 293T. Plasmids GV144-MEG3 （MEG3 overexpression plasmid） and GV144 （control plasmid） were stably transfected into 786-0 cells by using lipofectamine 2000. Cell viabilities were determined by MTT, cell apoptosis rates by flow cytometry following PE Annexin V and 7AAD staining, apoptosis-related protein expressions by Western blotting, and Bcl-2 mRNA by RT-qPCR in the transfected cells. The results showed that MEG3 was evidently downregulated in RCC tissues （P〈0.05） and RCC cell lines （P〈0.05）. The viabilities of 786-0 cells were decreased significantly after transfection with GV144-MEG3 for over 24 h （P〈0.05）. Consistently, the apoptosis rate was significantly increased in 786-0 cells transfected with GV144-MEG3 for 48 h （P〈0.05）. Furthermore, overexpression of MEG3 could reduce the expression of Bcl-2 and procaspase-9 proteins, enhance the expression of cleaved caspase-9 protein, and promote the release of cytochrome c protein to cytoplasm （P〈0.05）. Additionally, Bcl-2 mRNA level was declined by MEG3 overexpression （P〈0.05）. It was concluded that MEG3 induces the apoptosis of RCC cells possibly by activating the mitochondrial pathway. |
|---|---|
| AbstractList | Summary： This study aimed to examine the effect of long non-coding RNA （LncRNA） MEG3 on the biological behaviors of renal cell carcinoma （RCC） cells 786-0 and the possible mechanism. MEG3 expression levels were detected by RT-qPCR in Rmaor tissues and adjacent non-tumor tissues from 29 RCC patients and in RCC lines 786-0 and SN12 and human embryonic kidney cell line 293T. Plasmids GV144-MEG3 （MEG3 overexpression plasmid） and GV144 （control plasmid） were stably transfected into 786-0 cells by using lipofectamine 2000. Cell viabilities were determined by MTT, cell apoptosis rates by flow cytometry following PE Annexin V and 7AAD staining, apoptosis-related protein expressions by Western blotting, and Bcl-2 mRNA by RT-qPCR in the transfected cells. The results showed that MEG3 was evidently downregulated in RCC tissues （P〈0.05） and RCC cell lines （P〈0.05）. The viabilities of 786-0 cells were decreased significantly after transfection with GV144-MEG3 for over 24 h （P〈0.05）. Consistently, the apoptosis rate was significantly increased in 786-0 cells transfected with GV144-MEG3 for 48 h （P〈0.05）. Furthermore, overexpression of MEG3 could reduce the expression of Bcl-2 and procaspase-9 proteins, enhance the expression of cleaved caspase-9 protein, and promote the release of cytochrome c protein to cytoplasm （P〈0.05）. Additionally, Bcl-2 mRNA level was declined by MEG3 overexpression （P〈0.05）. It was concluded that MEG3 induces the apoptosis of RCC cells possibly by activating the mitochondrial pathway. This study aimed to examine the effect of long non-coding RNA (LncRNA) MEG3 on the biological behaviors of renal cell carcinoma (RCC) cells 786-0 and the possible mechanism. MEG3 expression levels were detected by RT-qPCR in tumor tissues and adjacent non-tumor tissues from 29 RCC patients and in RCC lines 786-0 and SN12 and human embryonic kidney cell line 293T. Plasmids GV144-MEG3 (MEG3 overexpression plasmid) and GV144 (control plasmid) were stably transfected into 786-0 cells by using lipofectamine 2000. Cell viabilities were determined by MTT, cell apoptosis rates by flow cytometry following PE Annexin V and 7AAD staining, apoptosis-related protein expressions by Western blotting, and Bcl-2 mRNA by RT-qPCR in the transfected cells. The results showed that MEG3 was evidently downregulated in RCC tissues (P<0.05) and RCC cell lines (P<0.05). The viabilities of 786-0 cells were decreased significantly after transfection with GV144-MEG3 for over 24 h (P<0.05). Consistently, the apoptosis rate was significantly increased in 786-0 cells transfected with GV144-MEG3 for 48 h (P<0.05). Furthermore, overexpression of MEG3 could reduce the expression of Bcl-2 and procaspase-9 proteins, enhance the expression of cleaved caspase-9 protein, and promote the release of cytochrome c protein to cytoplasm (P<0.05). Additionally, Bcl-2 mRNA level was declined by MEG3 overexpression (P<0.05). It was concluded that MEG3 induces the apoptosis of RCC cells possibly by activating the mitochondrial pathway.This study aimed to examine the effect of long non-coding RNA (LncRNA) MEG3 on the biological behaviors of renal cell carcinoma (RCC) cells 786-0 and the possible mechanism. MEG3 expression levels were detected by RT-qPCR in tumor tissues and adjacent non-tumor tissues from 29 RCC patients and in RCC lines 786-0 and SN12 and human embryonic kidney cell line 293T. Plasmids GV144-MEG3 (MEG3 overexpression plasmid) and GV144 (control plasmid) were stably transfected into 786-0 cells by using lipofectamine 2000. Cell viabilities were determined by MTT, cell apoptosis rates by flow cytometry following PE Annexin V and 7AAD staining, apoptosis-related protein expressions by Western blotting, and Bcl-2 mRNA by RT-qPCR in the transfected cells. The results showed that MEG3 was evidently downregulated in RCC tissues (P<0.05) and RCC cell lines (P<0.05). The viabilities of 786-0 cells were decreased significantly after transfection with GV144-MEG3 for over 24 h (P<0.05). Consistently, the apoptosis rate was significantly increased in 786-0 cells transfected with GV144-MEG3 for 48 h (P<0.05). Furthermore, overexpression of MEG3 could reduce the expression of Bcl-2 and procaspase-9 proteins, enhance the expression of cleaved caspase-9 protein, and promote the release of cytochrome c protein to cytoplasm (P<0.05). Additionally, Bcl-2 mRNA level was declined by MEG3 overexpression (P<0.05). It was concluded that MEG3 induces the apoptosis of RCC cells possibly by activating the mitochondrial pathway. This study aimed to examine the effect of long non-coding RNA (LncRNA) MEG3 on the biological behaviors of renal cell carcinoma (RCC) cells 786-0 and the possible mechanism. MEG3 expression levels were detected by RT-qPCR in tumor tissues and adjacent non-tumor tissues from 29 RCC patients and in RCC lines 786-0 and SN12 and human embryonic kidney cell line 293T. Plasmids GV144-MEG3 (MEG3 overexpression plasmid) and GV144 (control plasmid) were stably transfected into 786-0 cells by using lipofectamine 2000. Cell viabilities were determined by MTT, cell apoptosis rates by flow cytometry following PE Annexin V and 7AAD staining, apoptosis-related protein expressions by Western blotting, and Bcl-2 mRNA by RT-qPCR in the transfected cells. The results showed that MEG3 was evidently downregulated in RCC tissues (P<0.05) and RCC cell lines (P<0.05). The viabilities of 786-0 cells were decreased significantly after transfection with GV144-MEG3 for over 24 h (P<0.05). Consistently, the apoptosis rate was significantly increased in 786-0 cells transfected with GV144-MEG3 for 48 h (P<0.05). Furthermore, overexpression of MEG3 could reduce the expression of Bcl-2 and procaspase-9 proteins, enhance the expression of cleaved caspase-9 protein, and promote the release of cytochrome c protein to cytoplasm (P<0.05). Additionally, Bcl-2 mRNA level was declined by MEG3 overexpression (P<0.05). It was concluded that MEG3 induces the apoptosis of RCC cells possibly by activating the mitochondrial pathway. Summary This study aimed to examine the effect of long non-coding RNA (LncRNA) MEG3 on the biological behaviors of renal cell carcinoma (RCC) cells 786-0 and the possible mechanism. MEG3 expression levels were detected by RT-qPCR in tumor tissues and adjacent non-tumor tissues from 29 RCC patients and in RCC lines 786-0 and SN12 and human embryonic kidney cell line 293T. Plasmids GV144-MEG3 (MEG3 overexpression plasmid) and GV144 (control plasmid) were stably transfected into 786-0 cells by using lipofectamine 2000. Cell viabilities were determined by MTT, cell apoptosis rates by flow cytometry following PE Annexin V and 7AAD staining, apoptosis-related protein expressions by Western blotting, and Bcl-2 mRNA by RT-qPCR in the transfected cells. The results showed that MEG3 was evidently downregulated in RCC tissues ( P <0.05) and RCC cell lines ( P <0.05). The viabilities of 786-0 cells were decreased significantly after transfection with GV144-MEG3 for over 24 h ( P <0.05). Consistently, the apoptosis rate was significantly increased in 786-0 cells transfected with GV144-MEG3 for 48 h ( P <0.05). Furthermore, overexpression of MEG3 could reduce the expression of Bcl-2 and procaspase-9 proteins, enhance the expression of cleaved caspase-9 protein, and promote the release of cytochrome c protein to cytoplasm ( P <0.05). Additionally, Bcl-2 mRNA level was declined by MEG3 overexpression ( P <0.05). It was concluded that MEG3 induces the apoptosis of RCC cells possibly by activating the mitochondrial pathway. |
| Author | Miao WANG TaoHUANG Gang LUO Chao HUANG Xing-yuan XIAO Liang WANG Guo-song JIANG Fu-qing ZENG |
| AuthorAffiliation | Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022,China Department of Urology, The First Hospital of Wuhan, Wuhan 430022, China |
| AuthorAffiliation_xml | – name: Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022,China%Department of Urology, The First Hospital of Wuhan, Wuhan 430022, China |
| Author_xml | – sequence: 1 givenname: Miao surname: Wang fullname: Wang, Miao organization: Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology – sequence: 2 givenname: Tao surname: Huang fullname: Huang, Tao organization: Department of Urology, The First Hospital of Wuhan – sequence: 3 givenname: Gang surname: Luo fullname: Luo, Gang organization: Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology – sequence: 4 givenname: Chao surname: Huang fullname: Huang, Chao organization: Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology – sequence: 5 givenname: Xing-yuan surname: Xiao fullname: Xiao, Xing-yuan organization: Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology – sequence: 6 givenname: Liang surname: Wang fullname: Wang, Liang organization: Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology – sequence: 7 givenname: Guo-song surname: Jiang fullname: Jiang, Guo-song organization: Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology – sequence: 8 givenname: Fu-qing surname: Zeng fullname: Zeng, Fu-qing email: zengfuqingpro@hotmail.com organization: Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26223924$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/emboj.2013.134 10.1074/jbc.274.21.15237 10.1002/jcb.25004 10.4149/neo_2013_063 10.1016/S0022-5347(05)65382-7 10.1101/gad.13.15.1899 10.1002/jcb.24055 10.1016/j.canlet.2014.11.005 10.1093/bfgp/elp037 10.1038/onc.2010.330 10.1007/s00432-014-1690-7 10.1007/s00262-003-0474-8 10.4111/kju.2012.53.4.217 10.1046/j.1365-2443.2000.00320.x 10.1186/1476-4598-10-38 10.1186/1471-2407-13-461 10.1002/(SICI)1097-0177(199806)212:2<214::AID-AJA6>3.0.CO;2-K 10.1155/2014/591703 10.1016/j.devcel.2011.06.017 10.1038/onc.2011.193 10.1186/s13148-015-0047-7 10.1007/s00280-009-0983-z 10.1093/hmg/ddl001 10.1038/20959 10.1016/j.bbadis.2014.08.015 10.1126/science.1142447 |
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| Copyright | Huazhong University of Science and Technology and Springer-Verlag Berlin Heidelberg 2015 Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
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| Notes | long non-coding RNA （LncRNA）; MEG3; renal cell carcinoma; apoptosis Summary： This study aimed to examine the effect of long non-coding RNA （LncRNA） MEG3 on the biological behaviors of renal cell carcinoma （RCC） cells 786-0 and the possible mechanism. MEG3 expression levels were detected by RT-qPCR in Rmaor tissues and adjacent non-tumor tissues from 29 RCC patients and in RCC lines 786-0 and SN12 and human embryonic kidney cell line 293T. Plasmids GV144-MEG3 （MEG3 overexpression plasmid） and GV144 （control plasmid） were stably transfected into 786-0 cells by using lipofectamine 2000. Cell viabilities were determined by MTT, cell apoptosis rates by flow cytometry following PE Annexin V and 7AAD staining, apoptosis-related protein expressions by Western blotting, and Bcl-2 mRNA by RT-qPCR in the transfected cells. The results showed that MEG3 was evidently downregulated in RCC tissues （P〈0.05） and RCC cell lines （P〈0.05）. The viabilities of 786-0 cells were decreased significantly after transfection with GV144-MEG3 for over 24 h （P〈0.05）. Consistently, the apoptosis rate was significantly increased in 786-0 cells transfected with GV144-MEG3 for 48 h （P〈0.05）. Furthermore, overexpression of MEG3 could reduce the expression of Bcl-2 and procaspase-9 proteins, enhance the expression of cleaved caspase-9 protein, and promote the release of cytochrome c protein to cytoplasm （P〈0.05）. Additionally, Bcl-2 mRNA level was declined by MEG3 overexpression （P〈0.05）. It was concluded that MEG3 induces the apoptosis of RCC cells possibly by activating the mitochondrial pathway. 42-1679/R ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
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| Publisher | Huazhong University of Science and Technology Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022,China%Department of Urology, The First Hospital of Wuhan, Wuhan 430022, China |
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| References | Liu, Wan, Lu (CR15) 2015; 10 van Bakel, Hughes (CR5) 2009; 8 Gibb, Brown, Lam (CR9) 2011; 10 Schuster-Gossler, Bilinski, Sado (CR13) 1998; 212 Wang, Ren, Sun (CR16) 2012; 113 Martinou, Youle (CR27) 2011; 21 McPherson, Pertsemlidis, Kavaslar (CR6) 2007; 316 Ronnau, Verhaegh, Luna-Velez (CR12) 2014; 2014 Zhang, Zou, Wang (CR23) 2015; 116 Blondeau, Deng, Syring (CR20) 2015; 7 Fang, Pan, Leng (CR11) 2015; 356 Qin, Chen, Ding (CR21) 2013; 60 Reeves, Liu (CR1) 2009; 64 Chen, Ruan, Wang (CR2) 2014; 140 Budhram-Mahadeo, Morris, Smith (CR28) 1999; 274 Gross, McDonnell, Korsmeyer (CR26) 1999; 13 Braconi, Kogure, Valeri (CR18) 2011; 30 Yang, Deng (CR10) 2014; 7 Kawakami, Chano, Minami (CR24) 2006; 15 Shimizu, Narita, Tsujimoto (CR25) 1999; 399 Cho, Chung (CR4) 2012; 53 He, Wu, Huang (CR22) 2014; 1842 Lu, Li, Liu (CR17) 2013; 13 Okamoto, Hirata, Chen (CR7) 2010; 29 Debatin (CR19) 2004; 53 Hock, Lynch, Balaji (CR3) 2002; 167 Miyoshi, Wagatsuma, Wakana (CR14) 2000; 5 Scheuermann, Boyer (CR8) 2013; 32 X Chen (1467_CR2) 2014; 140 KM Debatin (1467_CR19) 2004; 53 DJ Reeves (1467_CR1) 2009; 64 R Qin (1467_CR21) 2013; 60 Y Zhang (1467_CR23) 2015; 116 H Bakel van (1467_CR5) 2009; 8 JC Scheuermann (1467_CR8) 2013; 32 JC Martinou (1467_CR27) 2011; 21 QQ Yang (1467_CR10) 2014; 7 CG Ronnau (1467_CR12) 2014; 2014 Y He (1467_CR22) 2014; 1842 JJ Blondeau (1467_CR20) 2015; 7 T Kawakami (1467_CR24) 2006; 15 J Okamoto (1467_CR7) 2010; 29 XY Fang (1467_CR11) 2015; 356 LM Hock (1467_CR3) 2002; 167 EA Gibb (1467_CR9) 2011; 10 N Miyoshi (1467_CR14) 2000; 5 IC Cho (1467_CR4) 2012; 53 V Budhram-Mahadeo (1467_CR28) 1999; 274 A Gross (1467_CR26) 1999; 13 K Schuster-Gossler (1467_CR13) 1998; 212 KH Lu (1467_CR17) 2013; 13 P Wang (1467_CR16) 2012; 113 C Braconi (1467_CR18) 2011; 30 R McPherson (1467_CR6) 2007; 316 S Shimizu (1467_CR25) 1999; 399 J Liu (1467_CR15) 2015; 10 9626496 - Dev Dyn. 1998 Jun;212(2):214-28 14749900 - Cancer Immunol Immunother. 2004 Mar;53(3):153-9 10444588 - Genes Dev. 1999 Aug 1;13(15):1899-911 19833698 - Brief Funct Genomic Proteomic. 2009 Nov;8(6):424-36 22234798 - J Cell Biochem. 2012 Jun;113(6):1868-74 20697358 - Oncogene. 2010 Nov 4;29(44):5969-75 10759892 - Genes Cells. 2000 Mar;5(3):211-20 23790166 - Neoplasma. 2013;60(5):486-92 16439445 - Hum Mol Genet. 2006 Mar 15;15(6):821-30 11743275 - J Urol. 2002 Jan;167(1):57-60 25201080 - Biochim Biophys Acta. 2014 Nov;1842(11):2204-15 21489289 - Mol Cancer. 2011 Apr 13;10:38 24098911 - BMC Cancer. 2013 Oct 07;13:461 17478681 - Science. 2007 Jun 8;316(5830):1488-91 19343348 - Cancer Chemother Pharmacol. 2009 Jun;64(1):11-25 25444905 - Cancer Lett. 2015 Jan 28;356(2 Pt B):357-66 23756463 - EMBO J. 2013 Jul 3;32(13):1805-16 10329733 - J Biol Chem. 1999 May 21;274(21):15237-44 24817925 - Int J Clin Exp Pathol. 2014 Mar 15;7(4):1286-92 21625215 - Oncogene. 2011 Nov 24;30(47):4750-6 25358633 - J Cell Biochem. 2015 Apr;116(4):542-50 22536463 - Korean J Urol. 2012 Apr;53(4):217-28 25243154 - Biomed Res Int. 2014;2014:591703 25685243 - Clin Epigenetics. 2015 Feb 08;7:10 21763611 - Dev Cell. 2011 Jul 19;21(1):92-101 25992654 - PLoS One. 2015 May 20;10(5):e0114586 24802708 - J Cancer Res Clin Oncol. 2014 Aug;140(8):1295-304 10365962 - Nature. 1999 Jun 3;399(6735):483-7 |
| References_xml | – volume: 32 start-page: 1805 issue: 13 year: 2013 end-page: 1816 ident: CR8 article-title: Getting to the heart of the matter: long non-coding RNAs in cardiac development and disease publication-title: Embo J doi: 10.1038/emboj.2013.134 – volume: 274 start-page: 15237 issue: 21 year: 1999 end-page: 15244 ident: CR28 article-title: p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor publication-title: J Biol Chem doi: 10.1074/jbc.274.21.15237 – volume: 116 start-page: 542 issue: 4 year: 2015 end-page: 550 ident: CR23 article-title: Down-regulated long non-coding RNA MEG3 and its effect on promoting apoptosis and suppressing migration of trophoblast cells publication-title: J Cell Biochem doi: 10.1002/jcb.25004 – volume: 60 start-page: 486 issue: 5 year: 2013 end-page: 492 ident: CR21 article-title: Long non-coding RNA MEG3 inhibits the proliferation of cervical carcinoma cells through the induction of cell cycle arrest and apoptosis publication-title: Neoplasma doi: 10.4149/neo_2013_063 – volume: 167 start-page: 57 issue: 1 year: 2002 end-page: 60 ident: CR3 article-title: Increasing incidence of all stages of kidney cancer in the last 2 decades in the United States: an analysis of surveillance, epidemiology and end results program data publication-title: J Urol doi: 10.1016/S0022-5347(05)65382-7 – volume: 13 start-page: 1899 issue: 15 year: 1999 end-page: 1911 ident: CR26 article-title: BCL-2 family members and the mitochondria in apoptosis publication-title: Genes Dev doi: 10.1101/gad.13.15.1899 – volume: 113 start-page: 1868 issue: 6 year: 2012 end-page: 1874 ident: CR16 article-title: Overexpression of the long non-coding RNA MEG3 impairs in vitro glioma cell proliferation publication-title: J Cell Biochem doi: 10.1002/jcb.24055 – volume: 356 start-page: 357 issue: 2 year: 2015 end-page: 366 ident: CR11 article-title: Long noncoding RNAs: novel insights into gastric cancer publication-title: Cancer Lett doi: 10.1016/j.canlet.2014.11.005 – volume: 8 start-page: 424 issue: 6 year: 2009 end-page: 436 ident: CR5 article-title: Establishing legitimacy and function in the new transcriptome publication-title: Brief Funct Genomic Proteomic doi: 10.1093/bfgp/elp037 – volume: 29 start-page: 5969 issue: 44 year: 2010 end-page: 5975 ident: CR7 article-title: EMX2 is epigenetically silenced and suppresses growth in human lung cancer publication-title: Oncogene doi: 10.1038/onc.2010.330 – volume: 140 start-page: 1295 issue: 8 year: 2014 end-page: 1304 ident: CR2 article-title: miR-129-3p, as a diagnostic and prognostic biomarker for renal cell carcinoma, attenuates cell migration and invasion via downregulating multiple metastasis-related genes publication-title: J Cancer Res Clin Oncol doi: 10.1007/s00432-014-1690-7 – volume: 53 start-page: 153 issue: 3 year: 2004 end-page: 159 ident: CR19 article-title: Apoptosis pathways in cancer and cancer therapy publication-title: Cancer Immunol Immunother doi: 10.1007/s00262-003-0474-8 – volume: 53 start-page: 217 issue: 4 year: 2012 end-page: 228 ident: CR4 article-title: Current status of targeted therapy for advanced renal cell carcinoma publication-title: Korean J Urol doi: 10.4111/kju.2012.53.4.217 – volume: 5 start-page: 211 issue: 3 year: 2000 end-page: 220 ident: CR14 article-title: Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q publication-title: Genes Cells doi: 10.1046/j.1365-2443.2000.00320.x – volume: 10 start-page: 38 year: 2011 ident: CR9 article-title: The functional role of long non-coding RNA in human carcinomas publication-title: Mol Cancer doi: 10.1186/1476-4598-10-38 – volume: 10 start-page: 0114586 issue: 5 year: 2015 ident: CR15 article-title: The long noncoding RNA MEG3 contributes to cisplatin resistance of human lung adenocarcinoma publication-title: Plos One – volume: 13 start-page: 461 year: 2013 ident: CR17 article-title: Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression publication-title: BMC Cancer doi: 10.1186/1471-2407-13-461 – volume: 212 start-page: 214 issue: 2 year: 1998 end-page: 228 ident: CR13 article-title: The mouse Gtl2 gene is differentially expressed during embryonic development, encodes multiple alternatively spliced transcripts, and may act as an RNA publication-title: Dev Dyn doi: 10.1002/(SICI)1097-0177(199806)212:2<214::AID-AJA6>3.0.CO;2-K – volume: 2014 start-page: 591703 year: 2014 ident: CR12 article-title: Noncoding RNAs as novel biomarkers in prostate cancer publication-title: Biomed Res Int doi: 10.1155/2014/591703 – volume: 21 start-page: 92 issue: 1 year: 2011 end-page: 101 ident: CR27 article-title: Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics publication-title: Dev Cell doi: 10.1016/j.devcel.2011.06.017 – volume: 7 start-page: 1286 issue: 4 year: 2014 end-page: 1292 ident: CR10 article-title: Long non-coding RNAs as novel biomarkers and therapeutic targets in head and neck cancers publication-title: Int J Clin Exp Pathol – volume: 30 start-page: 4750 issue: 47 year: 2011 end-page: 4756 ident: CR18 article-title: microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer publication-title: Oncogene doi: 10.1038/onc.2011.193 – volume: 7 start-page: 10 issue: 1 year: 2015 ident: CR20 article-title: Identification of novel long non-coding RNAs in clear cell renal cell carcinoma publication-title: Clin Epigenetics doi: 10.1186/s13148-015-0047-7 – volume: 64 start-page: 11 issue: 1 year: 2009 end-page: 25 ident: CR1 article-title: Treatment of metastatic renal cell carcinoma publication-title: Cancer Chemother Pharmacol doi: 10.1007/s00280-009-0983-z – volume: 15 start-page: 821 issue: 6 year: 2006 end-page: 830 ident: CR24 article-title: Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma publication-title: Hum Mol Genet doi: 10.1093/hmg/ddl001 – volume: 399 start-page: 483 issue: 6735 year: 1999 end-page: 487 ident: CR25 article-title: Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC publication-title: Nature doi: 10.1038/20959 – volume: 1842 start-page: 2204 issue: 11 year: 2014 end-page: 2215 ident: CR22 article-title: Inhibitory effects of long noncoding RNA MEG3 on hepatic stellate cells activation and liver fibrogenesis publication-title: Biochim Biophys Acta doi: 10.1016/j.bbadis.2014.08.015 – volume: 316 start-page: 1488 issue: 5830 year: 2007 end-page: 1491 ident: CR6 article-title: A common allele on chromosome 9 associated with coronary heart disease publication-title: Science doi: 10.1126/science.1142447 – volume: 116 start-page: 542 issue: 4 year: 2015 ident: 1467_CR23 publication-title: J Cell Biochem doi: 10.1002/jcb.25004 – volume: 30 start-page: 4750 issue: 47 year: 2011 ident: 1467_CR18 publication-title: Oncogene doi: 10.1038/onc.2011.193 – volume: 274 start-page: 15237 issue: 21 year: 1999 ident: 1467_CR28 publication-title: J Biol Chem doi: 10.1074/jbc.274.21.15237 – volume: 316 start-page: 1488 issue: 5830 year: 2007 ident: 1467_CR6 publication-title: Science doi: 10.1126/science.1142447 – volume: 2014 start-page: 591703 year: 2014 ident: 1467_CR12 publication-title: Biomed Res Int doi: 10.1155/2014/591703 – volume: 60 start-page: 486 issue: 5 year: 2013 ident: 1467_CR21 publication-title: Neoplasma doi: 10.4149/neo_2013_063 – volume: 29 start-page: 5969 issue: 44 year: 2010 ident: 1467_CR7 publication-title: Oncogene doi: 10.1038/onc.2010.330 – volume: 13 start-page: 461 year: 2013 ident: 1467_CR17 publication-title: BMC Cancer doi: 10.1186/1471-2407-13-461 – volume: 7 start-page: 1286 issue: 4 year: 2014 ident: 1467_CR10 publication-title: Int J Clin Exp Pathol – volume: 32 start-page: 1805 issue: 13 year: 2013 ident: 1467_CR8 publication-title: Embo J doi: 10.1038/emboj.2013.134 – volume: 15 start-page: 821 issue: 6 year: 2006 ident: 1467_CR24 publication-title: Hum Mol Genet doi: 10.1093/hmg/ddl001 – volume: 212 start-page: 214 issue: 2 year: 1998 ident: 1467_CR13 publication-title: Dev Dyn doi: 10.1002/(SICI)1097-0177(199806)212:2<214::AID-AJA6>3.0.CO;2-K – volume: 356 start-page: 357 issue: 2 year: 2015 ident: 1467_CR11 publication-title: Cancer Lett doi: 10.1016/j.canlet.2014.11.005 – volume: 53 start-page: 217 issue: 4 year: 2012 ident: 1467_CR4 publication-title: Korean J Urol doi: 10.4111/kju.2012.53.4.217 – volume: 1842 start-page: 2204 issue: 11 year: 2014 ident: 1467_CR22 publication-title: Biochim Biophys Acta doi: 10.1016/j.bbadis.2014.08.015 – volume: 13 start-page: 1899 issue: 15 year: 1999 ident: 1467_CR26 publication-title: Genes Dev doi: 10.1101/gad.13.15.1899 – volume: 8 start-page: 424 issue: 6 year: 2009 ident: 1467_CR5 publication-title: Brief Funct Genomic Proteomic doi: 10.1093/bfgp/elp037 – volume: 140 start-page: 1295 issue: 8 year: 2014 ident: 1467_CR2 publication-title: J Cancer Res Clin Oncol doi: 10.1007/s00432-014-1690-7 – volume: 7 start-page: 10 issue: 1 year: 2015 ident: 1467_CR20 publication-title: Clin Epigenetics doi: 10.1186/s13148-015-0047-7 – volume: 10 start-page: 38 year: 2011 ident: 1467_CR9 publication-title: Mol Cancer doi: 10.1186/1476-4598-10-38 – volume: 21 start-page: 92 issue: 1 year: 2011 ident: 1467_CR27 publication-title: Dev Cell doi: 10.1016/j.devcel.2011.06.017 – volume: 113 start-page: 1868 issue: 6 year: 2012 ident: 1467_CR16 publication-title: J Cell Biochem doi: 10.1002/jcb.24055 – volume: 167 start-page: 57 issue: 1 year: 2002 ident: 1467_CR3 publication-title: J Urol doi: 10.1016/S0022-5347(05)65382-7 – volume: 53 start-page: 153 issue: 3 year: 2004 ident: 1467_CR19 publication-title: Cancer Immunol Immunother doi: 10.1007/s00262-003-0474-8 – volume: 10 start-page: 0114586 issue: 5 year: 2015 ident: 1467_CR15 publication-title: Plos One – volume: 5 start-page: 211 issue: 3 year: 2000 ident: 1467_CR14 publication-title: Genes Cells doi: 10.1046/j.1365-2443.2000.00320.x – volume: 399 start-page: 483 issue: 6735 year: 1999 ident: 1467_CR25 publication-title: Nature doi: 10.1038/20959 – volume: 64 start-page: 11 issue: 1 year: 2009 ident: 1467_CR1 publication-title: Cancer Chemother Pharmacol doi: 10.1007/s00280-009-0983-z – reference: 14749900 - Cancer Immunol Immunother. 2004 Mar;53(3):153-9 – reference: 23790166 - Neoplasma. 2013;60(5):486-92 – reference: 24802708 - J Cancer Res Clin Oncol. 2014 Aug;140(8):1295-304 – reference: 10444588 - Genes Dev. 1999 Aug 1;13(15):1899-911 – reference: 24098911 - BMC Cancer. 2013 Oct 07;13:461 – reference: 22536463 - Korean J Urol. 2012 Apr;53(4):217-28 – reference: 24817925 - Int J Clin Exp Pathol. 2014 Mar 15;7(4):1286-92 – reference: 16439445 - Hum Mol Genet. 2006 Mar 15;15(6):821-30 – reference: 25992654 - PLoS One. 2015 May 20;10(5):e0114586 – reference: 10759892 - Genes Cells. 2000 Mar;5(3):211-20 – reference: 25685243 - Clin Epigenetics. 2015 Feb 08;7:10 – reference: 20697358 - Oncogene. 2010 Nov 4;29(44):5969-75 – reference: 21763611 - Dev Cell. 2011 Jul 19;21(1):92-101 – reference: 21489289 - Mol Cancer. 2011 Apr 13;10:38 – reference: 10329733 - J Biol Chem. 1999 May 21;274(21):15237-44 – reference: 9626496 - Dev Dyn. 1998 Jun;212(2):214-28 – reference: 11743275 - J Urol. 2002 Jan;167(1):57-60 – reference: 19833698 - Brief Funct Genomic Proteomic. 2009 Nov;8(6):424-36 – reference: 19343348 - Cancer Chemother Pharmacol. 2009 Jun;64(1):11-25 – reference: 25201080 - Biochim Biophys Acta. 2014 Nov;1842(11):2204-15 – reference: 10365962 - Nature. 1999 Jun 3;399(6735):483-7 – reference: 25444905 - Cancer Lett. 2015 Jan 28;356(2 Pt B):357-66 – reference: 21625215 - Oncogene. 2011 Nov 24;30(47):4750-6 – reference: 22234798 - J Cell Biochem. 2012 Jun;113(6):1868-74 – reference: 25243154 - Biomed Res Int. 2014;2014:591703 – reference: 25358633 - J Cell Biochem. 2015 Apr;116(4):542-50 – reference: 17478681 - Science. 2007 Jun 8;316(5830):1488-91 – reference: 23756463 - EMBO J. 2013 Jul 3;32(13):1805-16 |
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| Snippet | Summary： This study aimed to examine the effect of long non-coding RNA （LncRNA） MEG3 on the biological behaviors of renal cell carcinoma （RCC） cells 786-0... Summary This study aimed to examine the effect of long non-coding RNA (LncRNA) MEG3 on the biological behaviors of renal cell carcinoma (RCC) cells 786-0 and... This study aimed to examine the effect of long non-coding RNA (LncRNA) MEG3 on the biological behaviors of renal cell carcinoma (RCC) cells 786-0 and the... |
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| SubjectTerms | Apoptosis Bcl-2 Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - pathology Cell Line, Tumor Cell Survival Gene Expression Regulation, Neoplastic HEK293 Cells Humans Kidney Neoplasms - genetics Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Medicine Medicine & Public Health Mitochondria - genetics RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Signal Transduction 人胚肾细胞 凋亡途径 激活 癌细胞 线粒体 诱导 非编码RNA |
| Title | Long Non-coding RNA MEG3 Induces Renal Cell Carcinoma Cells Apoptosis by Activating the Mitochondrial Pathway |
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