Clinical evaluation of photoprotective effect by a topical antioxidants combination (tocopherols and tocotrienols)
Background Vitamin E is among the earliest recognized antioxidants. Recent findings suggested that tocotrienols have superior activity than tocopherols. Moreover, vitamin A is well‐known in dermatology for its actions, including the ultraviolet radiation absorbing property. Objectives In view of e...
Saved in:
| Published in | Journal of the European Academy of Dermatology and Venereology Vol. 26; no. 11; pp. 1449 - 1453 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing Ltd
01.11.2012
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0926-9959 1468-3083 1468-3083 |
| DOI | 10.1111/j.1468-3083.2011.04219.x |
Cover
| Abstract | Background Vitamin E is among the earliest recognized antioxidants. Recent findings suggested that tocotrienols have superior activity than tocopherols. Moreover, vitamin A is well‐known in dermatology for its actions, including the ultraviolet radiation absorbing property.
Objectives In view of experimental evidence for the photoprotective properties of these antioxidants, we evaluated in 30 patients with photosensitivity, the prophylactic efficacy of a new topical agent, containing tocopherols 10% and tocotrienols 0.3%, compared with retinol, simple vehicle and untreated areas.
Methods After determination of the minimal UVB erythema dose (MED), two areas of 2 × 2 cm were selected on the buttocks of each subject, one of which was treated with the antioxidant formulation whereas the other field did not undergo any treatment. Therefore, both areas were irradiated with a twofold MED. As further controls, other two similar areas, selected on the forearm of 15 patients, were photo‐irradiated similarly, 30 min after application of the simple vehicle to a field and of vitamin A in the same vehicle to the other. Reactions (erythema/oedema/itch/vesciculation) assessment was carried out assigning scores indicative of their intensity; then, mean values +DS of scores were calculated.
Results The pre‐treatment with the vitamin E formulation highly protects against photosensitivity, and all reactions to irradiation were significantly lower in the areas treated with the topical vitamin E formulation compared to those treated with the simple vehicle or vitamin A.
Conclusions The use of a new topical formulation containing significant concentrations of tocotrienols and tocopherols represents a promising strategy to reduce the photo‐induced skin damage. |
|---|---|
| AbstractList | Vitamin E is among the earliest recognized antioxidants. Recent findings suggested that tocotrienols have superior activity than tocopherols. Moreover, vitamin A is well-known in dermatology for its actions, including the ultraviolet radiation absorbing property.BACKGROUNDVitamin E is among the earliest recognized antioxidants. Recent findings suggested that tocotrienols have superior activity than tocopherols. Moreover, vitamin A is well-known in dermatology for its actions, including the ultraviolet radiation absorbing property.In view of experimental evidence for the photoprotective properties of these antioxidants, we evaluated in 30 patients with photosensitivity, the prophylactic efficacy of a new topical agent, containing tocopherols 10% and tocotrienols 0.3%, compared with retinol, simple vehicle and untreated areas.OBJECTIVESIn view of experimental evidence for the photoprotective properties of these antioxidants, we evaluated in 30 patients with photosensitivity, the prophylactic efficacy of a new topical agent, containing tocopherols 10% and tocotrienols 0.3%, compared with retinol, simple vehicle and untreated areas.After determination of the minimal UVB erythema dose (MED), two areas of 2 × 2 cm were selected on the buttocks of each subject, one of which was treated with the antioxidant formulation whereas the other field did not undergo any treatment. Therefore, both areas were irradiated with a twofold MED. As further controls, other two similar areas, selected on the forearm of 15 patients, were photo-irradiated similarly, 30 min after application of the simple vehicle to a field and of vitamin A in the same vehicle to the other. Reactions (erythema/oedema/itch/vesciculation) assessment was carried out assigning scores indicative of their intensity; then, mean values +DS of scores were calculated.METHODSAfter determination of the minimal UVB erythema dose (MED), two areas of 2 × 2 cm were selected on the buttocks of each subject, one of which was treated with the antioxidant formulation whereas the other field did not undergo any treatment. Therefore, both areas were irradiated with a twofold MED. As further controls, other two similar areas, selected on the forearm of 15 patients, were photo-irradiated similarly, 30 min after application of the simple vehicle to a field and of vitamin A in the same vehicle to the other. Reactions (erythema/oedema/itch/vesciculation) assessment was carried out assigning scores indicative of their intensity; then, mean values +DS of scores were calculated.The pre-treatment with the vitamin E formulation highly protects against photosensitivity, and all reactions to irradiation were significantly lower in the areas treated with the topical vitamin E formulation compared to those treated with the simple vehicle or vitamin A.RESULTSThe pre-treatment with the vitamin E formulation highly protects against photosensitivity, and all reactions to irradiation were significantly lower in the areas treated with the topical vitamin E formulation compared to those treated with the simple vehicle or vitamin A.The use of a new topical formulation containing significant concentrations of tocotrienols and tocopherols represents a promising strategy to reduce the photo-induced skin damage.CONCLUSIONSThe use of a new topical formulation containing significant concentrations of tocotrienols and tocopherols represents a promising strategy to reduce the photo-induced skin damage. Background Vitamin E is among the earliest recognized antioxidants. Recent findings suggested that tocotrienols have superior activity than tocopherols. Moreover, vitamin A is well‐known in dermatology for its actions, including the ultraviolet radiation absorbing property. Objectives In view of experimental evidence for the photoprotective properties of these antioxidants, we evaluated in 30 patients with photosensitivity, the prophylactic efficacy of a new topical agent, containing tocopherols 10% and tocotrienols 0.3%, compared with retinol, simple vehicle and untreated areas. Methods After determination of the minimal UVB erythema dose (MED), two areas of 2 × 2 cm were selected on the buttocks of each subject, one of which was treated with the antioxidant formulation whereas the other field did not undergo any treatment. Therefore, both areas were irradiated with a twofold MED. As further controls, other two similar areas, selected on the forearm of 15 patients, were photo‐irradiated similarly, 30 min after application of the simple vehicle to a field and of vitamin A in the same vehicle to the other. Reactions (erythema/oedema/itch/vesciculation) assessment was carried out assigning scores indicative of their intensity; then, mean values +DS of scores were calculated. Results The pre‐treatment with the vitamin E formulation highly protects against photosensitivity, and all reactions to irradiation were significantly lower in the areas treated with the topical vitamin E formulation compared to those treated with the simple vehicle or vitamin A. Conclusions The use of a new topical formulation containing significant concentrations of tocotrienols and tocopherols represents a promising strategy to reduce the photo‐induced skin damage. Background Vitamin E is among the earliest recognized antioxidants. Recent findings suggested that tocotrienols have superior activity than tocopherols. Moreover, vitamin A is well‐known in dermatology for its actions, including the ultraviolet radiation absorbing property. Objectives In view of experimental evidence for the photoprotective properties of these antioxidants, we evaluated in 30 patients with photosensitivity, the prophylactic efficacy of a new topical agent, containing tocopherols 10% and tocotrienols 0.3%, compared with retinol, simple vehicle and untreated areas. Methods After determination of the minimal UVB erythema dose (MED), two areas of 2 × 2 cm were selected on the buttocks of each subject, one of which was treated with the antioxidant formulation whereas the other field did not undergo any treatment. Therefore, both areas were irradiated with a twofold MED. As further controls, other two similar areas, selected on the forearm of 15 patients, were photo‐irradiated similarly, 30 min after application of the simple vehicle to a field and of vitamin A in the same vehicle to the other. Reactions (erythema/oedema/itch/vesciculation) assessment was carried out assigning scores indicative of their intensity; then, mean values +DS of scores were calculated. Results The pre‐treatment with the vitamin E formulation highly protects against photosensitivity, and all reactions to irradiation were significantly lower in the areas treated with the topical vitamin E formulation compared to those treated with the simple vehicle or vitamin A. Conclusions The use of a new topical formulation containing significant concentrations of tocotrienols and tocopherols represents a promising strategy to reduce the photo‐induced skin damage. Vitamin E is among the earliest recognized antioxidants. Recent findings suggested that tocotrienols have superior activity than tocopherols. Moreover, vitamin A is well-known in dermatology for its actions, including the ultraviolet radiation absorbing property. In view of experimental evidence for the photoprotective properties of these antioxidants, we evaluated in 30 patients with photosensitivity, the prophylactic efficacy of a new topical agent, containing tocopherols 10% and tocotrienols 0.3%, compared with retinol, simple vehicle and untreated areas. After determination of the minimal UVB erythema dose (MED), two areas of 2 × 2 cm were selected on the buttocks of each subject, one of which was treated with the antioxidant formulation whereas the other field did not undergo any treatment. Therefore, both areas were irradiated with a twofold MED. As further controls, other two similar areas, selected on the forearm of 15 patients, were photo-irradiated similarly, 30 min after application of the simple vehicle to a field and of vitamin A in the same vehicle to the other. Reactions (erythema/oedema/itch/vesciculation) assessment was carried out assigning scores indicative of their intensity; then, mean values +DS of scores were calculated. The pre-treatment with the vitamin E formulation highly protects against photosensitivity, and all reactions to irradiation were significantly lower in the areas treated with the topical vitamin E formulation compared to those treated with the simple vehicle or vitamin A. The use of a new topical formulation containing significant concentrations of tocotrienols and tocopherols represents a promising strategy to reduce the photo-induced skin damage. |
| Author | Pedrelli, V.F. Pigatto, P.D. Lauriola, M.M. |
| Author_xml | – sequence: 1 givenname: V.F. surname: Pedrelli fullname: Pedrelli, V.F. organization: Dermatological Clinic, Department of Technology for Health, IRCCS Galeazzi Hospital, University of Milan, Milan, Italy – sequence: 2 givenname: M.M. surname: Lauriola fullname: Lauriola, M.M. organization: Policlinico San Marco, Dermatology Department, Zingonia-Osio Sotto (Bg), Italy – sequence: 3 givenname: P.D. surname: Pigatto fullname: Pigatto, P.D. email: paolo.pigatto@unimi.it organization: Dermatological Clinic, Department of Technology for Health, IRCCS Galeazzi Hospital, University of Milan, Milan, Italy |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21917024$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkcFu3CAQhlGVqtmkfYWKY3qwC8Y2cGilatOkjaL2kjZHhPFYYcuaLbDJ7tsXr5McegqXgZn_-9HMnKCj0Y-AEKakpPl8XJW0bkXBiGBlRSgtSV1RWe5eocVz4QgtiKzaQspGHqOTGFeEZGkj3qDjLKacVPUChaWzozXaYbjXbquT9SP2A97c-eQ3wScwyd4DhmHIN9ztsca5cCD0mNU72-cYsfHrzo4zf5a88Zs7CN7FrOrx9E7BwpgTH96i14N2Ed49xlP06-LrzfJbcf3z8vvyy3VhasJlIQdNNGtZJ7lsqG6k7nugpuZ9n3OEi4bWhnWsl4ZIYLwWAA0fCJMioxTYKTqbfXMbf7cQk1rbaMA5PYLfRpUHWbWCCsKy9P2jdNutoVebYNc67NXTnLLg8ywwwccYYFDGpkOzKWjrFCWTHVUrNc1fTfNX02LUYTFqlw3EfwZPf7wA_TSjD9bB_sWcujr_Pd0yX8y8jQl2z7wOf1TLGW_U7Y9LdXVL6psLcq44-wfKOrXm |
| CitedBy_id | crossref_primary_10_56782_pps_256 crossref_primary_10_2147_IJN_S276355 crossref_primary_10_3390_molecules190811679 crossref_primary_10_23736_S2784_8671_24_07861_7 crossref_primary_10_1016_j_freeradbiomed_2014_03_035 crossref_primary_10_3390_antiox12010138 crossref_primary_10_3390_app14146236 crossref_primary_10_1177_1091581818794455 crossref_primary_10_1111_jocd_12421 crossref_primary_10_3390_ijms17111682 crossref_primary_10_1016_j_drudis_2017_08_001 crossref_primary_10_1016_j_ijpharm_2023_122781 crossref_primary_10_3389_fphar_2022_1006198 crossref_primary_10_3390_antiox10050634 crossref_primary_10_3390_antiox12081503 crossref_primary_10_1016_j_foodres_2022_111175 crossref_primary_10_3389_fphar_2025_1559139 |
| Cites_doi | 10.1016/S0009-3084(02)00164-0 10.1111/j.1751-1097.1997.tb08610.x 10.1016/0304-3940(95)11812-B 10.1021/jf100691g 10.1016/0891-5849(91)90033-Y 10.1016/S0009-9120(99)00027-2 10.1111/j.1524-4725.2005.31724 10.1016/S0163-7827(99)00008-9 10.1002/mc.10055 10.1111/1523-1747.ep12605921 10.1046/j.1523-1747.2003.12519.x 10.1021/bi00091a020 10.1111/j.1600-0536.1997.tb00224.x 10.1111/1523-1747.ep12371744 10.1111/j.1600-0536.1991.tb01878.x 10.1093/carcin/18.8.1617 |
| ContentType | Journal Article |
| Copyright | 2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology 2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology. |
| Copyright_xml | – notice: 2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology – notice: 2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology. |
| DBID | BSCLL AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1111/j.1468-3083.2011.04219.x |
| DatabaseName | Istex CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic CrossRef MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1468-3083 |
| EndPage | 1453 |
| ExternalDocumentID | 21917024 10_1111_j_1468_3083_2011_04219_x JDV4219 ark_67375_WNG_JW04TF0D_7 |
| Genre | shortCommunication Clinical Trial Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- --K .3N .GA .Y3 05W 0R~ 10A 1B1 1OB 1OC 1~5 29L 31~ 33P 36B 3SF 4.4 4G. 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5VS 66C 7-5 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAEDT AAESR AAEVG AAHQN AAIPD AALRI AAMMB AAMNL AANHP AANLZ AAONW AAQFI AAQXK AASGY AAXRX AAXUO AAYCA AAZKR ABCQN ABCUV ABEML ABJNI ABQWH ABWVN ABXGK ACAHQ ACBWZ ACCZN ACGFS ACGOF ACMXC ACPOU ACRPL ACSCC ACVFH ACXBN ACXQS ACYXJ ADBBV ADBTR ADCNI ADEOM ADIZJ ADKYN ADMGS ADMUD ADNMO ADOZA ADZMN AE3 AEFGJ AEIGN AEIMD AENEX AEUPX AEUYR AEYWJ AFBPY AFEBI AFFPM AFGKR AFPUW AFTJW AFWVQ AFZJQ AGHNM AGQPQ AGXDD AGYGG AHBTC AHEFC AIACR AIDQK AIDYY AIGII AIQQE AITYG AIURR ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BSCLL BY8 C45 CAG CO8 COF CS3 CYRXZ D-6 D-7 D-E D-F DC6 DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DU5 EBS EJD EX3 F00 F01 F04 F5P FDB FEDTE FGOYB FUBAC FZ0 G-S G.N GODZA H.X HF~ HGLYW HVGLF HZI HZ~ IHE IX1 J0M K48 KBYEO LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES M41 MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 NF~ NQ- O66 O9- OIG OVD OZT P2P P2W P2X P2Z P4B P4D PALCI Q.N Q11 QB0 R.K R2- RIWAO RJQFR ROL RPZ RX1 SAMSI SEW SUPJJ TEORI UB1 UHS W8V W99 WBKPD WHWMO WIH WIJ WIK WOHZO WOW WQJ WVDHM WXI WXSBR XG1 YFH ZZTAW ~IA ~WT AAHHS ACCFJ AEEZP AEQDE AEUQT AFPWT AIWBW AJBDE ESX RIG WRC WUP AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c4079-9fa0a363b97951a59adde1c47dd3b9078514c3b3d9c09e3748ee57f03989fa1e3 |
| IEDL.DBID | DR2 |
| ISSN | 0926-9959 1468-3083 |
| IngestDate | Thu Jul 10 18:23:50 EDT 2025 Mon Jul 21 05:47:16 EDT 2025 Wed Oct 01 03:00:04 EDT 2025 Thu Apr 24 23:01:23 EDT 2025 Wed Jan 22 17:04:37 EST 2025 Sun Sep 21 06:21:39 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 11 |
| Language | English |
| License | http://onlinelibrary.wiley.com/termsAndConditions#vor 2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4079-9fa0a363b97951a59adde1c47dd3b9078514c3b3d9c09e3748ee57f03989fa1e3 |
| Notes | ark:/67375/WNG-JW04TF0D-7 istex:CD6B9E0DFD25F8D7709B6BD78268CE9EDAD128AE ArticleID:JDV4219 Funding sources Conflict of interest This study was carried out with the financial support of Vermont Italia Srl, Italy. The Authors declare that they have not other potential conflict of interest (personal relationship). All the authors have participated sufficiently to take public responsibility for appropriate portions of the work. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
| PMID | 21917024 |
| PQID | 1112681803 |
| PQPubID | 23479 |
| PageCount | 5 |
| ParticipantIDs | proquest_miscellaneous_1112681803 pubmed_primary_21917024 crossref_citationtrail_10_1111_j_1468_3083_2011_04219_x crossref_primary_10_1111_j_1468_3083_2011_04219_x wiley_primary_10_1111_j_1468_3083_2011_04219_x_JDV4219 istex_primary_ark_67375_WNG_JW04TF0D_7 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2012-11 November 2012 2012-11-00 2012-Nov 20121101 |
| PublicationDateYYYYMMDD | 2012-11-01 |
| PublicationDate_xml | – month: 11 year: 2012 text: 2012-11 |
| PublicationDecade | 2010 |
| PublicationPlace | Oxford, UK |
| PublicationPlace_xml | – name: Oxford, UK – name: England |
| PublicationTitle | Journal of the European Academy of Dermatology and Venereology |
| PublicationTitleAlternate | J Eur Acad Dermatol Venereol |
| PublicationYear | 2012 |
| Publisher | Blackwell Publishing Ltd |
| Publisher_xml | – name: Blackwell Publishing Ltd |
| References | Vertuani S, Manfredini S. Phyto-tocotrienols - vitamin E in the third millennium. Cosmetic Technology 2001; 4: 21-23. Antille C, Tran C, Sorg O et al. Vitamin A exerts a photoprotective action in skin by absorbing ultraviolet B radiation. J Invest Dermatol 2003; 121: 1163-1167. Wang X, Quinn PJ. Vitamin E and its function in membranes. Prog Lipid Res 1999; 38: 309-336. Shibata A, Nakagawa K, Kawakami Y et al. Suppression of gamma-tocotrienol on UVB induced inflammation in HaCaT keratinocytes and HR-1 hairless mice via inflammatory mediators multiple signaling. J Agric Food Chem 2010; 58: 7013-7020. Fisher AA. Three faces of vitamin E topical allergy. Cutis 1991; 48: 272-274. de Groot AC, Berretty PJ, van Ginkel CJ et al. Allergic contact dermatitis from tocopheryl acetate in cosmetic creams. Contact Dermatitis 1991; 25: 302-304. Jurkiewicz BA, Bissett DL, Buettner GR. Effect of topically applied tocopherol on ultraviolet radiation-mediated free radical damage in skin. J Invest Dermatol 1995; 104: 484-488. Yoshida Y, Niki E, Noguchi N. Comparative study on the action of tocopherols and tocotrienols as antioxidant: chemical and physical effects. Chem Phys Lipids 2003; 123: 63-75. Shindo Y, Witt E, Han D et al. Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin. J Invest Dermatol 1994; 102: 122-124. Suzuki YJ, Tsuchiya M, Wassall SR et al. Structural and dynamic membrane properties of α-tocopherol and α-tocotrienol: implications to the molecular mechanism of their antioxidant potency. Biochemistry 1993; 32: 10692-10699. Yuen KS, Halliday GM. alpha-Tocopherol, an inhibitor of epidermal lipid peroxidation, prevents ultraviolet radiation from suppressing the skin immune system. Photochem Photobiol 1997; 65: 587-592. McVean M, Liebler DC. Inhibition of UVB induced DNA photodamage in mouse epidermis by topically applied alpha-tocopherol. Carcinogenesis 1997; 18: 1617-1622. Serbinova E, Kagan V, Han D, Packer L. Free radical recycling and intramembrane mobility in the antioxidant properties of α-tocopherol and α-tocotrienol. Free Radic Biol Med 1991; 10: 263-275. Theriault A, Chao JT, Wang Q et al. Tocotrienol: a review of its therapeutic potential. Clin Biochem 1999; 32: 309-319. Maalouf S, El-Sabban M, Darwiche N, Gali-Muhtasib H. Protective effect of vitamin E on ultraviolet B light-induced damage in keratinocytes. Mol Carcinog 2002; 34: 121-130. Harris BD, Taylor JS. Contact allergy to vitamin E capsules: false negative patch tests to vitamin E. Contact Dermatitis 1997; 36: 273. Thiele JJ, Hsieh SN, Ekanayake-Mudiyanselage S. Vitamin E: critical review of its current use in cosmetic and clinical dermatology. Dermatol Surg 2005; 31: 805-813. Kamat JP, Devasagayam TPA. Tocotrienols from palm oil as potent inhibitors of lipid peroxidation and protein oxidation in rat brain mitochondria. Neuro Lett 1995; 195: 179-182. Dubakiene R, Kupriene M. Scientific problems of photosensitivity. Medicina (Kaunas) 2006; 42: 619-624. 1994; 102 2006; 42 2010; 58 1991; 25 1991; 48 1997; 65 2010 1991; 10 2001; 4 2002; 34 1999; 38 1993; 32 1997; 36 1997; 18 2005; 31 1995; 104 1999; 32 1995; 195 2003; 123 2003; 121 e_1_2_5_14_2 Dubakiene R (e_1_2_5_16_2) 2006; 42 e_1_2_5_13_2 e_1_2_5_9_2 e_1_2_5_8_2 e_1_2_5_15_2 e_1_2_5_7_2 e_1_2_5_10_2 e_1_2_5_6_2 e_1_2_5_12_2 e_1_2_5_4_2 e_1_2_5_11_2 e_1_2_5_21_2 e_1_2_5_3_2 Vertuani S (e_1_2_5_5_2) 2001; 4 e_1_2_5_2_2 Fisher AA (e_1_2_5_20_2) 1991; 48 e_1_2_5_18_2 e_1_2_5_17_2 e_1_2_5_19_2 |
| References_xml | – reference: Shindo Y, Witt E, Han D et al. Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin. J Invest Dermatol 1994; 102: 122-124. – reference: Antille C, Tran C, Sorg O et al. Vitamin A exerts a photoprotective action in skin by absorbing ultraviolet B radiation. J Invest Dermatol 2003; 121: 1163-1167. – reference: Dubakiene R, Kupriene M. Scientific problems of photosensitivity. Medicina (Kaunas) 2006; 42: 619-624. – reference: Thiele JJ, Hsieh SN, Ekanayake-Mudiyanselage S. Vitamin E: critical review of its current use in cosmetic and clinical dermatology. Dermatol Surg 2005; 31: 805-813. – reference: Suzuki YJ, Tsuchiya M, Wassall SR et al. Structural and dynamic membrane properties of α-tocopherol and α-tocotrienol: implications to the molecular mechanism of their antioxidant potency. Biochemistry 1993; 32: 10692-10699. – reference: Harris BD, Taylor JS. Contact allergy to vitamin E capsules: false negative patch tests to vitamin E. Contact Dermatitis 1997; 36: 273. – reference: Kamat JP, Devasagayam TPA. Tocotrienols from palm oil as potent inhibitors of lipid peroxidation and protein oxidation in rat brain mitochondria. Neuro Lett 1995; 195: 179-182. – reference: Theriault A, Chao JT, Wang Q et al. Tocotrienol: a review of its therapeutic potential. Clin Biochem 1999; 32: 309-319. – reference: Wang X, Quinn PJ. Vitamin E and its function in membranes. Prog Lipid Res 1999; 38: 309-336. – reference: Jurkiewicz BA, Bissett DL, Buettner GR. Effect of topically applied tocopherol on ultraviolet radiation-mediated free radical damage in skin. J Invest Dermatol 1995; 104: 484-488. – reference: de Groot AC, Berretty PJ, van Ginkel CJ et al. Allergic contact dermatitis from tocopheryl acetate in cosmetic creams. Contact Dermatitis 1991; 25: 302-304. – reference: Shibata A, Nakagawa K, Kawakami Y et al. Suppression of gamma-tocotrienol on UVB induced inflammation in HaCaT keratinocytes and HR-1 hairless mice via inflammatory mediators multiple signaling. J Agric Food Chem 2010; 58: 7013-7020. – reference: Yuen KS, Halliday GM. alpha-Tocopherol, an inhibitor of epidermal lipid peroxidation, prevents ultraviolet radiation from suppressing the skin immune system. Photochem Photobiol 1997; 65: 587-592. – reference: Maalouf S, El-Sabban M, Darwiche N, Gali-Muhtasib H. Protective effect of vitamin E on ultraviolet B light-induced damage in keratinocytes. Mol Carcinog 2002; 34: 121-130. – reference: McVean M, Liebler DC. Inhibition of UVB induced DNA photodamage in mouse epidermis by topically applied alpha-tocopherol. Carcinogenesis 1997; 18: 1617-1622. – reference: Fisher AA. Three faces of vitamin E topical allergy. Cutis 1991; 48: 272-274. – reference: Vertuani S, Manfredini S. Phyto-tocotrienols - vitamin E in the third millennium. Cosmetic Technology 2001; 4: 21-23. – reference: Yoshida Y, Niki E, Noguchi N. Comparative study on the action of tocopherols and tocotrienols as antioxidant: chemical and physical effects. Chem Phys Lipids 2003; 123: 63-75. – reference: Serbinova E, Kagan V, Han D, Packer L. Free radical recycling and intramembrane mobility in the antioxidant properties of α-tocopherol and α-tocotrienol. Free Radic Biol Med 1991; 10: 263-275. – volume: 10 start-page: 263 year: 1991 end-page: 275 article-title: Free radical recycling and intramembrane mobility in the antioxidant properties of α‐tocopherol and α‐tocotrienol publication-title: Free Radic Biol Med – volume: 123 start-page: 63 year: 2003 end-page: 75 article-title: Comparative study on the action of tocopherols and tocotrienols as antioxidant: chemical and physical effects publication-title: Chem Phys Lipids – volume: 195 start-page: 179 year: 1995 end-page: 182 article-title: Tocotrienols from palm oil as potent inhibitors of lipid peroxidation and protein oxidation in rat brain mitochondria publication-title: Neuro Lett – volume: 18 start-page: 1617 year: 1997 end-page: 1622 article-title: Inhibition of UVB induced DNA photodamage in mouse epidermis by topically applied alpha‐tocopherol publication-title: Carcinogenesis – volume: 42 start-page: 619 year: 2006 end-page: 624 article-title: Scientific problems of photosensitivity publication-title: Medicina (Kaunas) – volume: 31 start-page: 805 year: 2005 end-page: 813 article-title: Vitamin E: critical review of its current use in cosmetic and clinical dermatology publication-title: Dermatol Surg – volume: 34 start-page: 121 year: 2002 end-page: 130 article-title: Protective effect of vitamin E on ultraviolet B light‐induced damage in keratinocytes publication-title: Mol Carcinog – volume: 25 start-page: 302 year: 1991 end-page: 304 article-title: Allergic contact dermatitis from tocopheryl acetate in cosmetic creams publication-title: Contact Dermatitis – volume: 48 start-page: 272 year: 1991 end-page: 274 article-title: Three faces of vitamin E topical allergy publication-title: Cutis – volume: 38 start-page: 309 year: 1999 end-page: 336 article-title: Vitamin E and its function in membranes publication-title: Prog Lipid Res – volume: 65 start-page: 587 year: 1997 end-page: 592 article-title: alpha‐Tocopherol, an inhibitor of epidermal lipid peroxidation, prevents ultraviolet radiation from suppressing the skin immune system publication-title: Photochem Photobiol – volume: 4 start-page: 21 year: 2001 end-page: 23 article-title: Phyto‐tocotrienols – vitamin E in the third millennium publication-title: Cosmetic Technology – volume: 32 start-page: 10692 year: 1993 end-page: 10699 article-title: Structural and dynamic membrane properties of α‐tocopherol and α‐tocotrienol: implications to the molecular mechanism of their antioxidant potency publication-title: Biochemistry – volume: 102 start-page: 122 year: 1994 end-page: 124 article-title: Enzymic and non‐enzymic antioxidants in epidermis and dermis of human skin publication-title: J Invest Dermatol – volume: 58 start-page: 7013 year: 2010 end-page: 7020 article-title: Suppression of gamma‐tocotrienol on UVB induced inflammation in HaCaT keratinocytes and HR‐1 hairless mice via inflammatory mediators multiple signaling publication-title: J Agric Food Chem – volume: 121 start-page: 1163 year: 2003 end-page: 1167 article-title: Vitamin A exerts a photoprotective action in skin by absorbing ultraviolet B radiation publication-title: J Invest Dermatol – volume: 36 start-page: 273 year: 1997 article-title: Contact allergy to vitamin E capsules: false negative patch tests to vitamin E publication-title: Contact Dermatitis – year: 2010 – volume: 32 start-page: 309 year: 1999 end-page: 319 article-title: Tocotrienol: a review of its therapeutic potential publication-title: Clin Biochem – volume: 104 start-page: 484 year: 1995 end-page: 488 article-title: Effect of topically applied tocopherol on ultraviolet radiation‐mediated free radical damage in skin publication-title: J Invest Dermatol – ident: e_1_2_5_2_2 – ident: e_1_2_5_11_2 doi: 10.1016/S0009-3084(02)00164-0 – ident: e_1_2_5_12_2 doi: 10.1111/j.1751-1097.1997.tb08610.x – ident: e_1_2_5_9_2 doi: 10.1016/0304-3940(95)11812-B – ident: e_1_2_5_10_2 doi: 10.1021/jf100691g – volume: 42 start-page: 619 year: 2006 ident: e_1_2_5_16_2 article-title: Scientific problems of photosensitivity publication-title: Medicina (Kaunas) – volume: 48 start-page: 272 year: 1991 ident: e_1_2_5_20_2 article-title: Three faces of vitamin E topical allergy publication-title: Cutis – ident: e_1_2_5_8_2 doi: 10.1016/0891-5849(91)90033-Y – ident: e_1_2_5_6_2 doi: 10.1016/S0009-9120(99)00027-2 – ident: e_1_2_5_3_2 doi: 10.1111/j.1524-4725.2005.31724 – ident: e_1_2_5_4_2 doi: 10.1016/S0163-7827(99)00008-9 – ident: e_1_2_5_13_2 doi: 10.1002/mc.10055 – ident: e_1_2_5_18_2 doi: 10.1111/1523-1747.ep12605921 – ident: e_1_2_5_15_2 doi: 10.1046/j.1523-1747.2003.12519.x – ident: e_1_2_5_7_2 doi: 10.1021/bi00091a020 – ident: e_1_2_5_21_2 doi: 10.1111/j.1600-0536.1997.tb00224.x – ident: e_1_2_5_17_2 doi: 10.1111/1523-1747.ep12371744 – ident: e_1_2_5_19_2 doi: 10.1111/j.1600-0536.1991.tb01878.x – volume: 4 start-page: 21 year: 2001 ident: e_1_2_5_5_2 article-title: Phyto‐tocotrienols – vitamin E in the third millennium publication-title: Cosmetic Technology – ident: e_1_2_5_14_2 doi: 10.1093/carcin/18.8.1617 |
| SSID | ssj0001158 |
| Score | 2.1102057 |
| Snippet | Background Vitamin E is among the earliest recognized antioxidants. Recent findings suggested that tocotrienols have superior activity than tocopherols.... Background Vitamin E is among the earliest recognized antioxidants. Recent findings suggested that tocotrienols have superior activity than tocopherols.... Vitamin E is among the earliest recognized antioxidants. Recent findings suggested that tocotrienols have superior activity than tocopherols. Moreover, vitamin... |
| SourceID | proquest pubmed crossref wiley istex |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1449 |
| SubjectTerms | Administration, Topical Adult Aged Antioxidants - administration & dosage Female Humans Male Middle Aged Placebos Radiation-Protective Agents - administration & dosage Tocopherols - administration & dosage Tocotrienols - administration & dosage |
| Title | Clinical evaluation of photoprotective effect by a topical antioxidants combination (tocopherols and tocotrienols) |
| URI | https://api.istex.fr/ark:/67375/WNG-JW04TF0D-7/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1468-3083.2011.04219.x https://www.ncbi.nlm.nih.gov/pubmed/21917024 https://www.proquest.com/docview/1112681803 |
| Volume | 26 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVWIB databaseName: Wiley Online Library - Core collection (SURFmarket) issn: 0926-9959 databaseCode: DR2 dateStart: 19970101 customDbUrl: isFulltext: true eissn: 1468-3083 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001158 providerName: Wiley-Blackwell |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3fa9swEBajhbGXrfvtdRsajLE9KNiWLFmPY11WAu3DaNe-CUmW6UiwS-JA2r--d7KTktKHMvZmyz4hne7k76zTJ0I-KwVxVe4V06LiTAgtmFWuZFJoW6Y1r1yGe4ePjuXhqZicF-dD_hPuhen5ITY_3NAz4nyNDm7d4q6Tl4wDhhiYOAV43wjxZMZljK5-3zJJAfCJk7LOJUOKre2knnsr2vpS7aLSV_fB0G1UGz9L42dkuu5Qn40yHS07N_LXd7ge_0-P98jTAb3S7725PSePQvOCPD4a1udfkvlAMzqjtyzitK3p5UXbtQMlBEyvtM8ioe6KWgoPooTFvMvV3woTcyg0DUL2Xv5r1_rIftDOFvBWRfEezwFroODbK3I6_nny45ANpzowD8GjZrq2qYUBcloBurOFxhk280JVFZQBYgEI57njlfapDsiOE0Kh6pTrEkSzwF-TnaZtwltCLXdZHXjhclkJK7OydgB3ZOG8q1PlfELUegSNHyjP8eSNmdkKfUqDKjWoUhNValYJyTaSlz3txwNkvkQj2QjY-RTT5lRhzo5_mclZKk7G6YFRCfm0tiIDzowrNLYJ7XKB9ecSd9_zhLzpzWtTW46RNSCqhMhoJA9ul5kc_MGrd_8quE-eQHHe78B8T3a6-TJ8ACjWuY_RyW4AlHgjrg |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3Pb9MwFLbQJgEXGL8DGxgJITikSmLHjo9oo5Sy9oA6tptlO45Aq5KpS6XCX897Ttqp0w4T4pY4fpbtvGd_z37-TMg7KcGvypyMFS9ZzLnisZG2iAVXpkgqVtoUzw5PpmJ0wsdn-Vl_HRCehen4ITYLbmgZYbxGA8cF6etWXsQMQERPxcnB_AYAKHe5ALcFEdL3Ky4pgD5hWFaZiJFkazus58aStuaqXez21U1AdBvXholp-JDM103q4lHOB8vWDtyfa2yP_6nNe-RBD2Dpp07jHpE7vn5M7k76LfonZNEzjc7pFZE4bSp68bNpm54VAkZY2gWSUPubGgofgoTB0MvVrxJjcyjUDbz2Tv5D27hAgNDMLyFXSfEdrwKrIeHjU3Iy_Dw7HMX9xQ6xA_9RxaoyiWGCWSUB4Jlc4SCbOi7LEtIAtACKc8yyUrlEeSTI8T6XVcJUAaKpZ8_ITt3U_gWhhtm08iy3mSi5EWlRWUA8IrfOVom0LiJy_Qu161nP8fKNud7yfgqNXaqxS3XoUr2KSLqRvOiYP24h8z5oyUbALM4xck7m-nT6RY9PEz4bJkdaRuTtWo002DNu0pjaN8tLLD8TeACfReR5p1-b0jJ0rgFURUQELbl1vfT46Ac-vfxXwTfk3mg2OdbHX6ffXpH7kCXrDmTuk512sfQHgMxa-zpY3F_mryfP |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3Pb9MwFLbQJk1cGL_JxsBICMHBVRI7cXxEK2UUViG0sd0s23HEtCqpulQq_PW856SdOu0wIW6Jk2c5znv295LPnwl5KyXkVamTTImSMyGUYEbaguVCmSKueGkTXDt8PMmPTsX4PDvvtwPCtTCdPsT6gxtGRhivMcD9rKxuRnnBOICIXopTQPgNAFBui0wVyO8b_rjWkgLoE4ZlleYMRbY2aT231rQxV21jty9vA6KbuDZMTKNdMl09UsdHuRwsWjtwf26oPf6nZ35IHvQAln7sPO4Ruefrx2TnuP9F_4TMe6XRKb0WEqdNRWe_mrbpVSFghKUdkYTa39RQuBAsDFIvlxclcnMotA2y9s7-fdu4IIDQTK_grpLiOW4FVkPBh6fkdPTp5PCI9Rs7MAf5o2KqMrHhObdKAsAzmcJBNnFCliWUAWgBFOe45aVysfIokON9JquYqwJME8-fka26qf0LQg23SeV5ZtO8FCZPisoC4skz62wVS-siIlevULte9Rw335jqjeyn0NilGrtUhy7Vy4gka8tZp_xxB5t3wUvWBmZ-icw5memzyWc9PovFySgeahmRNys30hDP-JPG1L5ZXGH9aY4L8HlEnnf-ta4txeQaQFVE8uAld26XHg9_4tHevxq-JjvfhyP97cvk6z65nyKvJ7CXXpKtdr7wBwDMWvsqBNxfVrQnVQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Clinical+evaluation+of+photoprotective+effect+by+a+topical+antioxidants+combination+%28tocopherols+and+tocotrienols%29&rft.jtitle=Journal+of+the+European+Academy+of+Dermatology+and+Venereology&rft.au=Pedrelli%2C+V+F&rft.au=Lauriola%2C+M+M&rft.au=Pigatto%2C+P+D&rft.date=2012-11-01&rft.issn=1468-3083&rft.eissn=1468-3083&rft.volume=26&rft.issue=11&rft.spage=1449&rft_id=info:doi/10.1111%2Fj.1468-3083.2011.04219.x&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0926-9959&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0926-9959&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0926-9959&client=summon |