Soluble CD40 ligand and soluble P-selectin levels in Gilbert's syndrome: A link to protection against atherosclerosis?
To investigate the role of CD40 ligand and P-selectin in the mechanism of decreased incidence of cardiovascular disease in Gilbert's syndrome (GS). The soluble forms of CD40 ligand (sCD40L) and P-selectin (sP-selectin), and high sensitive C reactive protein (hs-CRP) levels were investigated in...
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| Published in | Clinical biochemistry Vol. 42; no. 9; pp. 791 - 795 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.06.2009
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0009-9120 1873-2933 1873-2933 |
| DOI | 10.1016/j.clinbiochem.2009.02.005 |
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| Abstract | To investigate the role of CD40 ligand and P-selectin in the mechanism of decreased incidence of cardiovascular disease in Gilbert's syndrome (GS).
The soluble forms of CD40 ligand (sCD40L) and P-selectin (sP-selectin), and high sensitive C reactive protein (hs-CRP) levels were investigated in subjects with GS (
n
=
25) and compared to healthy controls (
n
=
53).
sCD40L and hs-CRP levels were significantly lower in GS compared to the controls (0.33
±
0.27 vs 0.71
±
0.37 ng/mL,
p
<
0.001 and 0.51
±
0.45 vs 1.16
±
1.31 mg/L,
p
=
0.046, respectively). Both sCD40L and hs-CRP were negatively correlated with total bilirubin (
r
=
−
0.5,
p
<
0.001 and
r
=
−
0.34,
p
=
0.002, respectively). sP-selectin levels were lower in GS when compared to the controls but the difference did not reach statistical significance (
p
=
0.052). No correlation was found between the plasma levels of sCD40L, sP-selectin and hs-CRP.
These novel findings suggest that reduced sCD40L and hs-CRP concentrations may have a role in the mechanism of protection against atherosclerosis in GS. |
|---|---|
| AbstractList | Objective - To investigate the role of CD40 ligand and P-selectin in the mechanism of decreased incidence of cardiovascular disease in Gilbert's syndrome (GS). Design and methods - The soluble forms of CD40 ligand (sCD40L) and P-selectin (sP-selectin), and high sensitive C reactive protein (hs-CRP) levels were investigated in subjects with GS (n = 25) and compared to healthy controls (n = 53). Results - sCD40L and hs-CRP levels were significantly lower in GS compared to the controls (0.33 +/- 0.27 vs 0.71 +/- 0.37 ng/mL, p < 0.001 and 0.51 +/- 0.45 vs 1.16 +/- 1.31 mg/L, p = 0.046, respectively). Both sCD40L and hs-CRP were negatively correlated with total bilirubin (r = - 0.5, p < 0.001 and r = - 0.34, p = 0.002, respectively). sP-selectin levels were lower in GS when compared to the controls but the difference did not reach statistical significance (p = 0.052). No correlation was found between the plasma levels of sCD40L, sP-selectin and hs-CRP. Conclusion - These novel findings suggest that reduced sCD40L and hs-CRP concentrations may have a role in the mechanism of protection against atherosclerosis in GS. To investigate the role of CD40 ligand and P-selectin in the mechanism of decreased incidence of cardiovascular disease in Gilbert's syndrome (GS).OBJECTIVETo investigate the role of CD40 ligand and P-selectin in the mechanism of decreased incidence of cardiovascular disease in Gilbert's syndrome (GS).The soluble forms of CD40 ligand (sCD40L) and P-selectin (sP-selectin), and high sensitive C reactive protein (hs-CRP) levels were investigated in subjects with GS (n=25) and compared to healthy controls (n=53).DESIGN AND METHODSThe soluble forms of CD40 ligand (sCD40L) and P-selectin (sP-selectin), and high sensitive C reactive protein (hs-CRP) levels were investigated in subjects with GS (n=25) and compared to healthy controls (n=53).sCD40L and hs-CRP levels were significantly lower in GS compared to the controls (0.33+/-0.27 vs 0.71+/-0.37 ng/mL, p<0.001 and 0.51+/-0.45 vs 1.16+/-1.31 mg/L, p=0.046, respectively). Both sCD40L and hs-CRP were negatively correlated with total bilirubin (r=-0.5, p<0.001 and r=-0.34, p=0.002, respectively). sP-selectin levels were lower in GS when compared to the controls but the difference did not reach statistical significance (p=0.052). No correlation was found between the plasma levels of sCD40L, sP-selectin and hs-CRP.RESULTSsCD40L and hs-CRP levels were significantly lower in GS compared to the controls (0.33+/-0.27 vs 0.71+/-0.37 ng/mL, p<0.001 and 0.51+/-0.45 vs 1.16+/-1.31 mg/L, p=0.046, respectively). Both sCD40L and hs-CRP were negatively correlated with total bilirubin (r=-0.5, p<0.001 and r=-0.34, p=0.002, respectively). sP-selectin levels were lower in GS when compared to the controls but the difference did not reach statistical significance (p=0.052). No correlation was found between the plasma levels of sCD40L, sP-selectin and hs-CRP.These novel findings suggest that reduced sCD40L and hs-CRP concentrations may have a role in the mechanism of protection against atherosclerosis in GS.CONCLUSIONThese novel findings suggest that reduced sCD40L and hs-CRP concentrations may have a role in the mechanism of protection against atherosclerosis in GS. To investigate the role of CD40 ligand and P-selectin in the mechanism of decreased incidence of cardiovascular disease in Gilbert's syndrome (GS). The soluble forms of CD40 ligand (sCD40L) and P-selectin (sP-selectin), and high sensitive C reactive protein (hs-CRP) levels were investigated in subjects with GS (n=25) and compared to healthy controls (n=53). sCD40L and hs-CRP levels were significantly lower in GS compared to the controls (0.33+/-0.27 vs 0.71+/-0.37 ng/mL, p<0.001 and 0.51+/-0.45 vs 1.16+/-1.31 mg/L, p=0.046, respectively). Both sCD40L and hs-CRP were negatively correlated with total bilirubin (r=-0.5, p<0.001 and r=-0.34, p=0.002, respectively). sP-selectin levels were lower in GS when compared to the controls but the difference did not reach statistical significance (p=0.052). No correlation was found between the plasma levels of sCD40L, sP-selectin and hs-CRP. These novel findings suggest that reduced sCD40L and hs-CRP concentrations may have a role in the mechanism of protection against atherosclerosis in GS. To investigate the role of CD40 ligand and P-selectin in the mechanism of decreased incidence of cardiovascular disease in Gilbert's syndrome (GS). The soluble forms of CD40 ligand (sCD40L) and P-selectin (sP-selectin), and high sensitive C reactive protein (hs-CRP) levels were investigated in subjects with GS ( n = 25) and compared to healthy controls ( n = 53). sCD40L and hs-CRP levels were significantly lower in GS compared to the controls (0.33 ± 0.27 vs 0.71 ± 0.37 ng/mL, p < 0.001 and 0.51 ± 0.45 vs 1.16 ± 1.31 mg/L, p = 0.046, respectively). Both sCD40L and hs-CRP were negatively correlated with total bilirubin ( r = − 0.5, p < 0.001 and r = − 0.34, p = 0.002, respectively). sP-selectin levels were lower in GS when compared to the controls but the difference did not reach statistical significance ( p = 0.052). No correlation was found between the plasma levels of sCD40L, sP-selectin and hs-CRP. These novel findings suggest that reduced sCD40L and hs-CRP concentrations may have a role in the mechanism of protection against atherosclerosis in GS. |
| Author | Tasci, Ilker Ozgurtas, Taner Erbil, Mehmet Kemal Ercin, Cemal Nuri Tapan, Serkan Dogru, Teoman |
| Author_xml | – sequence: 1 givenname: Serkan surname: Tapan fullname: Tapan, Serkan email: serkantapan7@yahoo.com organization: Department of Medical Biochemistry, Gulhane School of Medicine, 06108 Etlik, Ankara, Turkey – sequence: 2 givenname: Teoman surname: Dogru fullname: Dogru, Teoman organization: Department of Gastroenterology, Gulhane School of Medicine, Etlik, Ankara, Turkey – sequence: 3 givenname: Ilker surname: Tasci fullname: Tasci, Ilker organization: Department of Internal Medicine, Gulhane School of Medicine, Etlik, Ankara, Turkey – sequence: 4 givenname: Cemal Nuri surname: Ercin fullname: Ercin, Cemal Nuri organization: Department of Gastroenterology, Gulhane School of Medicine, Etlik, Ankara, Turkey – sequence: 5 givenname: Taner surname: Ozgurtas fullname: Ozgurtas, Taner organization: Department of Medical Biochemistry, Gulhane School of Medicine, 06108 Etlik, Ankara, Turkey – sequence: 6 givenname: Mehmet Kemal surname: Erbil fullname: Erbil, Mehmet Kemal organization: Department of Medical Biochemistry, Gulhane School of Medicine, 06108 Etlik, Ankara, Turkey |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19232335$$D View this record in MEDLINE/PubMed |
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| Keywords | sCD40L Bilirubin Gilbert's syndrome sP-selectin hs-CRP Atherosclerosis |
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| Snippet | To investigate the role of CD40 ligand and P-selectin in the mechanism of decreased incidence of cardiovascular disease in Gilbert's syndrome (GS).
The soluble... Objective - To investigate the role of CD40 ligand and P-selectin in the mechanism of decreased incidence of cardiovascular disease in Gilbert's syndrome (GS).... To investigate the role of CD40 ligand and P-selectin in the mechanism of decreased incidence of cardiovascular disease in Gilbert's syndrome (GS).OBJECTIVETo... |
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| SubjectTerms | Adult Atherosclerosis Atherosclerosis - blood Atherosclerosis - prevention & control Bilirubin C-Reactive Protein - metabolism CD40 Ligand - blood Enzyme-Linked Immunosorbent Assay Female Gilbert Disease - blood Gilbert's syndrome hs-CRP Humans Male P-Selectin - blood sCD40L sP-selectin Young Adult |
| Title | Soluble CD40 ligand and soluble P-selectin levels in Gilbert's syndrome: A link to protection against atherosclerosis? |
| URI | https://dx.doi.org/10.1016/j.clinbiochem.2009.02.005 https://www.ncbi.nlm.nih.gov/pubmed/19232335 https://www.proquest.com/docview/20084331 https://www.proquest.com/docview/67273100 |
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