Abnormalities of Hippocampal Subfields in Individuals With Acute Carbon Monoxide Poisoning
ABSTRACT Objective To investigate alterations in hippocampal subfields in patients with acute carbon monoxide poisoning (ACMP) and explore their relationship with neurocognitive function. Materials and Methods Forty‐seven ACMP patients and 29 age‐ and sex‐matched healthy controls (HCs) were recruite...
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| Published in | CNS neuroscience & therapeutics Vol. 31; no. 6; pp. e70482 - n/a |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
John Wiley & Sons, Inc
01.06.2025
John Wiley and Sons Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1755-5930 1755-5949 1755-5949 |
| DOI | 10.1111/cns.70482 |
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| Abstract | ABSTRACT
Objective
To investigate alterations in hippocampal subfields in patients with acute carbon monoxide poisoning (ACMP) and explore their relationship with neurocognitive function.
Materials and Methods
Forty‐seven ACMP patients and 29 age‐ and sex‐matched healthy controls (HCs) were recruited. All ACMP patients underwent carboxyhemoglobin (COHb) assessment at admission and acquired MRI scans within 3 days post‐exposure. Cognitive functions were assessed using the mini‐mental state examination (MMSE) and Montreal Cognitive Assessment (MoCA), and activities of daily living were evaluated using the Functional Independence Measure (FIM) and Barthel Index (BI). Differences in hippocampal volume between groups were analyzed using Analysis of Covariance (ANCOVA), and correlations with cognitive and functional scores were evaluated.
Results
After follow‐up, 27.66% (13/47) of ACMP patients developed Delayed Encephalopathy After Carbon Monoxide Poisoning (DEACMP). The COHb concentration was significantly higher in the DEACMP group (median 17.70% vs. 11.95%, z = −2.225, p = 0.026) compared to the Recovery group. The cognitive function scores, delayed memory‐related sub‐items scores derived from cognitive assessments, and activities of daily living scores in the DEACMP group were lower than those in the Recovery group (all p < 0.05). The ACMP group showed significant volume reduction in the bilateral whole hippocampus, cornu ammonis (CA) cornu ammonis 3, CA4, GC.ML.DG, Moleculat_layer, and right subiculum compared to HCs. The right subiculum and right CA4 volumes were smaller in the DEACMP group than in the Recovery group. The ROC curve analysis indicated that the combination of COHb concentration, MoCA, and FIM scores had good predictive value for DEACMP(the area under the ROC curve = 0.887, p < 0001). Correlation analysis showed that MoCA‐delayed recall was positively associated with the volume of the left CA1 subfield (r = 0.357, p = 0.020), and MMSE‐delayed recall was positively associated with the volume of the left presubiculum (r = 0.323, p = 0.037).
Conclusion
This study is the first to report specific hippocampal subfield alterations in ACMP patients, suggesting their potential as non‐invasive markers of hippocampal injury. The hippocampal subfields may contribute to the development of DEACMP by modulating cognitive processes. These findings may improve understanding of the neurological impact of hypoxic injuries in human subject research.
This study investigated the relationship between hippocampal subfield volumes and cognitive impairments in patients with ACMP. We found significant volume reductions in the bilateral CA3, CA4, GC.ML.DG, Moleculat_layer, and right subiculum in ACMP patients. Among ACMP patients, patients who developed DEACMP had smaller volumes in the right CA4 and right subiculum. Specific hippocampal subfields may be involved in the development of DEACMP by potentially modulating cognitive processes. |
|---|---|
| AbstractList | To investigate alterations in hippocampal subfields in patients with acute carbon monoxide poisoning (ACMP) and explore their relationship with neurocognitive function.
Forty-seven ACMP patients and 29 age- and sex-matched healthy controls (HCs) were recruited. All ACMP patients underwent carboxyhemoglobin (COHb) assessment at admission and acquired MRI scans within 3 days post-exposure. Cognitive functions were assessed using the mini-mental state examination (MMSE) and Montreal Cognitive Assessment (MoCA), and activities of daily living were evaluated using the Functional Independence Measure (FIM) and Barthel Index (BI). Differences in hippocampal volume between groups were analyzed using Analysis of Covariance (ANCOVA), and correlations with cognitive and functional scores were evaluated.
After follow-up, 27.66% (13/47) of ACMP patients developed Delayed Encephalopathy After Carbon Monoxide Poisoning (DEACMP). The COHb concentration was significantly higher in the DEACMP group (median 17.70% vs. 11.95%, z = -2.225, p = 0.026) compared to the Recovery group. The cognitive function scores, delayed memory-related sub-items scores derived from cognitive assessments, and activities of daily living scores in the DEACMP group were lower than those in the Recovery group (all p < 0.05). The ACMP group showed significant volume reduction in the bilateral whole hippocampus, cornu ammonis (CA) cornu ammonis 3, CA4, GC.ML.DG, Moleculat_layer, and right subiculum compared to HCs. The right subiculum and right CA4 volumes were smaller in the DEACMP group than in the Recovery group. The ROC curve analysis indicated that the combination of COHb concentration, MoCA, and FIM scores had good predictive value for DEACMP(the area under the ROC curve = 0.887, p < 0001). Correlation analysis showed that MoCA-delayed recall was positively associated with the volume of the left CA1 subfield (r = 0.357, p = 0.020), and MMSE-delayed recall was positively associated with the volume of the left presubiculum (r = 0.323, p = 0.037).
This study is the first to report specific hippocampal subfield alterations in ACMP patients, suggesting their potential as non-invasive markers of hippocampal injury. The hippocampal subfields may contribute to the development of DEACMP by modulating cognitive processes. These findings may improve understanding of the neurological impact of hypoxic injuries in human subject research. ABSTRACT Objective To investigate alterations in hippocampal subfields in patients with acute carbon monoxide poisoning (ACMP) and explore their relationship with neurocognitive function. Materials and Methods Forty‐seven ACMP patients and 29 age‐ and sex‐matched healthy controls (HCs) were recruited. All ACMP patients underwent carboxyhemoglobin (COHb) assessment at admission and acquired MRI scans within 3 days post‐exposure. Cognitive functions were assessed using the mini‐mental state examination (MMSE) and Montreal Cognitive Assessment (MoCA), and activities of daily living were evaluated using the Functional Independence Measure (FIM) and Barthel Index (BI). Differences in hippocampal volume between groups were analyzed using Analysis of Covariance (ANCOVA), and correlations with cognitive and functional scores were evaluated. Results After follow‐up, 27.66% (13/47) of ACMP patients developed Delayed Encephalopathy After Carbon Monoxide Poisoning (DEACMP). The COHb concentration was significantly higher in the DEACMP group (median 17.70% vs. 11.95%, z = −2.225, p = 0.026) compared to the Recovery group. The cognitive function scores, delayed memory‐related sub‐items scores derived from cognitive assessments, and activities of daily living scores in the DEACMP group were lower than those in the Recovery group (all p < 0.05). The ACMP group showed significant volume reduction in the bilateral whole hippocampus, cornu ammonis (CA) cornu ammonis 3, CA4, GC.ML.DG, Moleculat_layer, and right subiculum compared to HCs. The right subiculum and right CA4 volumes were smaller in the DEACMP group than in the Recovery group. The ROC curve analysis indicated that the combination of COHb concentration, MoCA, and FIM scores had good predictive value for DEACMP(the area under the ROC curve = 0.887, p < 0001). Correlation analysis showed that MoCA‐delayed recall was positively associated with the volume of the left CA1 subfield (r = 0.357, p = 0.020), and MMSE‐delayed recall was positively associated with the volume of the left presubiculum (r = 0.323, p = 0.037). Conclusion This study is the first to report specific hippocampal subfield alterations in ACMP patients, suggesting their potential as non‐invasive markers of hippocampal injury. The hippocampal subfields may contribute to the development of DEACMP by modulating cognitive processes. These findings may improve understanding of the neurological impact of hypoxic injuries in human subject research. This study investigated the relationship between hippocampal subfield volumes and cognitive impairments in patients with ACMP. We found significant volume reductions in the bilateral CA3, CA4, GC.ML.DG, Moleculat_layer, and right subiculum in ACMP patients. Among ACMP patients, patients who developed DEACMP had smaller volumes in the right CA4 and right subiculum. Specific hippocampal subfields may be involved in the development of DEACMP by potentially modulating cognitive processes. To investigate alterations in hippocampal subfields in patients with acute carbon monoxide poisoning (ACMP) and explore their relationship with neurocognitive function.OBJECTIVETo investigate alterations in hippocampal subfields in patients with acute carbon monoxide poisoning (ACMP) and explore their relationship with neurocognitive function.Forty-seven ACMP patients and 29 age- and sex-matched healthy controls (HCs) were recruited. All ACMP patients underwent carboxyhemoglobin (COHb) assessment at admission and acquired MRI scans within 3 days post-exposure. Cognitive functions were assessed using the mini-mental state examination (MMSE) and Montreal Cognitive Assessment (MoCA), and activities of daily living were evaluated using the Functional Independence Measure (FIM) and Barthel Index (BI). Differences in hippocampal volume between groups were analyzed using Analysis of Covariance (ANCOVA), and correlations with cognitive and functional scores were evaluated.MATERIALS AND METHODSForty-seven ACMP patients and 29 age- and sex-matched healthy controls (HCs) were recruited. All ACMP patients underwent carboxyhemoglobin (COHb) assessment at admission and acquired MRI scans within 3 days post-exposure. Cognitive functions were assessed using the mini-mental state examination (MMSE) and Montreal Cognitive Assessment (MoCA), and activities of daily living were evaluated using the Functional Independence Measure (FIM) and Barthel Index (BI). Differences in hippocampal volume between groups were analyzed using Analysis of Covariance (ANCOVA), and correlations with cognitive and functional scores were evaluated.After follow-up, 27.66% (13/47) of ACMP patients developed Delayed Encephalopathy After Carbon Monoxide Poisoning (DEACMP). The COHb concentration was significantly higher in the DEACMP group (median 17.70% vs. 11.95%, z = -2.225, p = 0.026) compared to the Recovery group. The cognitive function scores, delayed memory-related sub-items scores derived from cognitive assessments, and activities of daily living scores in the DEACMP group were lower than those in the Recovery group (all p < 0.05). The ACMP group showed significant volume reduction in the bilateral whole hippocampus, cornu ammonis (CA) cornu ammonis 3, CA4, GC.ML.DG, Moleculat_layer, and right subiculum compared to HCs. The right subiculum and right CA4 volumes were smaller in the DEACMP group than in the Recovery group. The ROC curve analysis indicated that the combination of COHb concentration, MoCA, and FIM scores had good predictive value for DEACMP(the area under the ROC curve = 0.887, p < 0001). Correlation analysis showed that MoCA-delayed recall was positively associated with the volume of the left CA1 subfield (r = 0.357, p = 0.020), and MMSE-delayed recall was positively associated with the volume of the left presubiculum (r = 0.323, p = 0.037).RESULTSAfter follow-up, 27.66% (13/47) of ACMP patients developed Delayed Encephalopathy After Carbon Monoxide Poisoning (DEACMP). The COHb concentration was significantly higher in the DEACMP group (median 17.70% vs. 11.95%, z = -2.225, p = 0.026) compared to the Recovery group. The cognitive function scores, delayed memory-related sub-items scores derived from cognitive assessments, and activities of daily living scores in the DEACMP group were lower than those in the Recovery group (all p < 0.05). The ACMP group showed significant volume reduction in the bilateral whole hippocampus, cornu ammonis (CA) cornu ammonis 3, CA4, GC.ML.DG, Moleculat_layer, and right subiculum compared to HCs. The right subiculum and right CA4 volumes were smaller in the DEACMP group than in the Recovery group. The ROC curve analysis indicated that the combination of COHb concentration, MoCA, and FIM scores had good predictive value for DEACMP(the area under the ROC curve = 0.887, p < 0001). Correlation analysis showed that MoCA-delayed recall was positively associated with the volume of the left CA1 subfield (r = 0.357, p = 0.020), and MMSE-delayed recall was positively associated with the volume of the left presubiculum (r = 0.323, p = 0.037).This study is the first to report specific hippocampal subfield alterations in ACMP patients, suggesting their potential as non-invasive markers of hippocampal injury. The hippocampal subfields may contribute to the development of DEACMP by modulating cognitive processes. These findings may improve understanding of the neurological impact of hypoxic injuries in human subject research.CONCLUSIONThis study is the first to report specific hippocampal subfield alterations in ACMP patients, suggesting their potential as non-invasive markers of hippocampal injury. The hippocampal subfields may contribute to the development of DEACMP by modulating cognitive processes. These findings may improve understanding of the neurological impact of hypoxic injuries in human subject research. This study investigated the relationship between hippocampal subfield volumes and cognitive impairments in patients with ACMP. We found significant volume reductions in the bilateral CA3, CA4, GC.ML.DG, Moleculat_layer, and right subiculum in ACMP patients. Among ACMP patients, patients who developed DEACMP had smaller volumes in the right CA4 and right subiculum. Specific hippocampal subfields may be involved in the development of DEACMP by potentially modulating cognitive processes. ABSTRACT Objective To investigate alterations in hippocampal subfields in patients with acute carbon monoxide poisoning (ACMP) and explore their relationship with neurocognitive function. Materials and Methods Forty‐seven ACMP patients and 29 age‐ and sex‐matched healthy controls (HCs) were recruited. All ACMP patients underwent carboxyhemoglobin (COHb) assessment at admission and acquired MRI scans within 3 days post‐exposure. Cognitive functions were assessed using the mini‐mental state examination (MMSE) and Montreal Cognitive Assessment (MoCA), and activities of daily living were evaluated using the Functional Independence Measure (FIM) and Barthel Index (BI). Differences in hippocampal volume between groups were analyzed using Analysis of Covariance (ANCOVA), and correlations with cognitive and functional scores were evaluated. Results After follow‐up, 27.66% (13/47) of ACMP patients developed Delayed Encephalopathy After Carbon Monoxide Poisoning (DEACMP). The COHb concentration was significantly higher in the DEACMP group (median 17.70% vs. 11.95%, z = −2.225, p = 0.026) compared to the Recovery group. The cognitive function scores, delayed memory‐related sub‐items scores derived from cognitive assessments, and activities of daily living scores in the DEACMP group were lower than those in the Recovery group (all p < 0.05). The ACMP group showed significant volume reduction in the bilateral whole hippocampus, cornu ammonis (CA) cornu ammonis 3, CA4, GC.ML.DG, Moleculat_layer, and right subiculum compared to HCs. The right subiculum and right CA4 volumes were smaller in the DEACMP group than in the Recovery group. The ROC curve analysis indicated that the combination of COHb concentration, MoCA, and FIM scores had good predictive value for DEACMP(the area under the ROC curve = 0.887, p < 0001). Correlation analysis showed that MoCA‐delayed recall was positively associated with the volume of the left CA1 subfield (r = 0.357, p = 0.020), and MMSE‐delayed recall was positively associated with the volume of the left presubiculum (r = 0.323, p = 0.037). Conclusion This study is the first to report specific hippocampal subfield alterations in ACMP patients, suggesting their potential as non‐invasive markers of hippocampal injury. The hippocampal subfields may contribute to the development of DEACMP by modulating cognitive processes. These findings may improve understanding of the neurological impact of hypoxic injuries in human subject research. |
| Author | Zhang, Xiaoming Tang, Mengyue Wang, Siyue Liu, Nian Li, Ting Deng, Yan Ji, Yifan Huang, Xiaohua |
| AuthorAffiliation | 1 Sichuan Key Laboratory of Medical Imaging, Department of Radiology Nanchong Sichuan PR China |
| AuthorAffiliation_xml | – name: 1 Sichuan Key Laboratory of Medical Imaging, Department of Radiology Nanchong Sichuan PR China |
| Author_xml | – sequence: 1 givenname: Mengyue surname: Tang fullname: Tang, Mengyue organization: Sichuan Key Laboratory of Medical Imaging, Department of Radiology – sequence: 2 givenname: Ting surname: Li fullname: Li, Ting organization: Sichuan Key Laboratory of Medical Imaging, Department of Radiology – sequence: 3 givenname: Yan surname: Deng fullname: Deng, Yan organization: Sichuan Key Laboratory of Medical Imaging, Department of Radiology – sequence: 4 givenname: Yifan surname: Ji fullname: Ji, Yifan organization: Sichuan Key Laboratory of Medical Imaging, Department of Radiology – sequence: 5 givenname: Siyue surname: Wang fullname: Wang, Siyue organization: Sichuan Key Laboratory of Medical Imaging, Department of Radiology – sequence: 6 givenname: Nian surname: Liu fullname: Liu, Nian organization: Sichuan Key Laboratory of Medical Imaging, Department of Radiology – sequence: 7 givenname: Xiaohua surname: Huang fullname: Huang, Xiaohua organization: Sichuan Key Laboratory of Medical Imaging, Department of Radiology – sequence: 8 givenname: Xiaoming orcidid: 0009-0003-3852-5742 surname: Zhang fullname: Zhang, Xiaoming email: zhangxm@nsmc.edu.cn organization: Sichuan Key Laboratory of Medical Imaging, Department of Radiology |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/40548357$$D View this record in MEDLINE/PubMed |
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| Copyright | 2025 The Author(s). published by John Wiley & Sons Ltd. 2025 The Author(s). CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd. 2025. This work is published under http://creativecommons.org/licenses/by/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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| Keywords | carbon monoxide poisoning subfield delayed encephalopathy hippocampus CO |
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| License | Attribution 2025 The Author(s). CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
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| Notes | Mengyue Tanga and Ting Li authors are equal contributions to this work. Funding This work was supported by the North Sichuan Medical College (CBY21‐QA43), Doctoral Research Start‐up Fund project of Affiliated Hospital of North Sichuan Medical College (2023‐2GC009) and Sichuan Science and Technology Program (2024ZYD0272). ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Funding: This work was supported by the North Sichuan Medical College (CBY21‐QA43), Doctoral Research Start‐up Fund project of Affiliated Hospital of North Sichuan Medical College (2023‐2GC009) and Sichuan Science and Technology Program (2024ZYD0272). |
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| Snippet | ABSTRACT
Objective
To investigate alterations in hippocampal subfields in patients with acute carbon monoxide poisoning (ACMP) and explore their relationship... To investigate alterations in hippocampal subfields in patients with acute carbon monoxide poisoning (ACMP) and explore their relationship with neurocognitive... ABSTRACT Objective To investigate alterations in hippocampal subfields in patients with acute carbon monoxide poisoning (ACMP) and explore their relationship... This study investigated the relationship between hippocampal subfield volumes and cognitive impairments in patients with ACMP. We found significant volume... |
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| SubjectTerms | Activities of Daily Living Adult Ammon's horn Analysis of covariance Brain research Carbon monoxide Carbon monoxide poisoning Carbon Monoxide Poisoning - complications Carbon Monoxide Poisoning - diagnostic imaging Carbon Monoxide Poisoning - pathology Carbon Monoxide Poisoning - psychology Carboxyhemoglobin Carboxyhemoglobin - metabolism Cognition Cognitive ability Consciousness Correlation analysis delayed encephalopathy Demographics Encephalitis Encephalopathy Female Hippocampus Hippocampus - diagnostic imaging Hippocampus - pathology Humans Hypoxia Magnetic Resonance Imaging Male Memory Mental disorders Middle Aged Neuropsychological Tests Neurosciences Normal distribution Original Patients Poisoning Presubiculum subfield Subiculum Systemic diseases Traumatic brain injury Variance analysis |
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| Title | Abnormalities of Hippocampal Subfields in Individuals With Acute Carbon Monoxide Poisoning |
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