β-Adrenergic blockade enhances coronary vasoconstrictor response to forehead cooling
Forehead cooling activates the sympathetic nervous system and can trigger angina pectoris in susceptible individuals. However, the effect of forehead cooling on coronary blood flow velocity (CBV) is not well understood. In this human experiment, we tested the hypotheses that forehead cooling reduces...
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| Published in | American journal of physiology. Heart and circulatory physiology Vol. 306; no. 6; pp. H910 - H917 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Physiological Society
01.03.2014
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0363-6135 1522-1539 1522-1539 |
| DOI | 10.1152/ajpheart.00787.2013 |
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| Abstract | Forehead cooling activates the sympathetic nervous system and can trigger angina pectoris in susceptible individuals. However, the effect of forehead cooling on coronary blood flow velocity (CBV) is not well understood. In this human experiment, we tested the hypotheses that forehead cooling reduces CBV (i.e., coronary vasoconstriction) and that this vasoconstrictor effect would be enhanced under systemic β-adrenergic blockade. A total of 30 healthy subjects (age range, 23–79 years) underwent Doppler echocardiography evaluation of CBV in response to 60 s of forehead cooling (1°C ice bag on forehead). A subset of subjects (n = 10) also underwent the procedures after an intravenous infusion of propranolol. Rate pressure product (RPP) was used as an index of myocardial oxygen demand. Consistent with our first hypothesis, forehead cooling reduced CBV from 19.5 ± 0.7 to 17.5 ± 0.8 cm/s ( P < 0.001), whereas mean arterial pressure increased by 11 ± 2 mmHg (P < 0.001). Consistent with our second hypothesis, forehead cooling reduced CBV under propranolol despite a significant rise in RPP. The current studies indicate that forehead cooling elicits a sympathetically mediated pressor response and a reduction in CBV, and this effect is augmented under β-blockade. The results are consistent with sympathetic activation of β-receptor coronary vasodilation in humans, as has been demonstrated in animals. |
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| AbstractList | Forehead cooling activates the sympathetic nervous system and can trigger angina pectoris in susceptible individuals. However, the effect of forehead cooling on coronary blood flow velocity (CBV) is not well understood. In this human experiment, we tested the hypotheses that forehead cooling reduces CBV (i.e., coronary vasoconstriction) and that this vasoconstrictor effect would be enhanced under systemic β-adrenergic blockade. A total of 30 healthy subjects (age range, 23–79 years) underwent Doppler echocardiography evaluation of CBV in response to 60 s of forehead cooling (1°C ice bag on forehead). A subset of subjects (n = 10) also underwent the procedures after an intravenous infusion of propranolol. Rate pressure product (RPP) was used as an index of myocardial oxygen demand. Consistent with our first hypothesis, forehead cooling reduced CBV from 19.5 ± 0.7 to 17.5 ± 0.8 cm/s (
P
< 0.001), whereas mean arterial pressure increased by 11 ± 2 mmHg (P < 0.001). Consistent with our second hypothesis, forehead cooling reduced CBV under propranolol despite a significant rise in RPP. The current studies indicate that forehead cooling elicits a sympathetically mediated pressor response and a reduction in CBV, and this effect is augmented under β-blockade. The results are consistent with sympathetic activation of β-receptor coronary vasodilation in humans, as has been demonstrated in animals. Forehead cooling activates the sympathetic nervous system and can trigger angina pectoris in susceptible individuals. However, the effect of forehead cooling on coronary blood flow velocity (CBV) is not well understood. In this human experiment, we tested the hypotheses that forehead cooling reduces CBV (i.e., coronary vasoconstriction) and that this vasoconstrictor effect would be enhanced under systemic β-adrenergic blockade. A total of 30 healthy subjects (age range, 23-79 years) underwent Doppler echocardiography evaluation of CBV in response to 60 s of forehead cooling (1°C ice bag on forehead). A subset of subjects (n = 10) also underwent the procedures after an intravenous infusion of propranolol. Rate pressure product (RPP) was used as an index of myocardial oxygen demand. Consistent with our first hypothesis, forehead cooling reduced CBV from 19.5 ± 0.7 to 17.5 ± 0.8 cm/s (P < 0.001), whereas mean arterial pressure increased by 11 ± 2 mmHg (P < 0.001). Consistent with our second hypothesis, forehead cooling reduced CBV under propranolol despite a significant rise in RPP. The current studies indicate that forehead cooling elicits a sympathetically mediated pressor response and a reduction in CBV, and this effect is augmented under β-blockade. The results are consistent with sympathetic activation of β-receptor coronary vasodilation in humans, as has been demonstrated in animals.Forehead cooling activates the sympathetic nervous system and can trigger angina pectoris in susceptible individuals. However, the effect of forehead cooling on coronary blood flow velocity (CBV) is not well understood. In this human experiment, we tested the hypotheses that forehead cooling reduces CBV (i.e., coronary vasoconstriction) and that this vasoconstrictor effect would be enhanced under systemic β-adrenergic blockade. A total of 30 healthy subjects (age range, 23-79 years) underwent Doppler echocardiography evaluation of CBV in response to 60 s of forehead cooling (1°C ice bag on forehead). A subset of subjects (n = 10) also underwent the procedures after an intravenous infusion of propranolol. Rate pressure product (RPP) was used as an index of myocardial oxygen demand. Consistent with our first hypothesis, forehead cooling reduced CBV from 19.5 ± 0.7 to 17.5 ± 0.8 cm/s (P < 0.001), whereas mean arterial pressure increased by 11 ± 2 mmHg (P < 0.001). Consistent with our second hypothesis, forehead cooling reduced CBV under propranolol despite a significant rise in RPP. The current studies indicate that forehead cooling elicits a sympathetically mediated pressor response and a reduction in CBV, and this effect is augmented under β-blockade. The results are consistent with sympathetic activation of β-receptor coronary vasodilation in humans, as has been demonstrated in animals. Forehead cooling activates the sympathetic nervous system and can trigger angina pectoris in susceptible individuals. However, the effect of forehead cooling on coronary blood flow velocity (CBV) is not well understood. In this human experiment, we tested the hypotheses that forehead cooling reduces CBV (i.e., coronary vasoconstriction) and that this vasoconstrictor effect would be enhanced under systemic β-adrenergic blockade. A total of 30 healthy subjects (age range, 23-79 years) underwent Doppler echocardiography evaluation of CBV in response to 60 s of forehead cooling (1°C ice bag on forehead). A subset of subjects (n = 10) also underwent the procedures after an intravenous infusion of propranolol. Rate pressure product (RPP) was used as an index of myocardial oxygen demand. Consistent with our first hypothesis, forehead cooling reduced CBV from 19.5 ± 0.7 to 17.5 ± 0.8 cm/s (P < 0.001), whereas mean arterial pressure increased by 11 ± 2 mmHg (P < 0.001). Consistent with our second hypothesis, forehead cooling reduced CBV under propranolol despite a significant rise in RPP. The current studies indicate that forehead cooling elicits a sympathetically mediated pressor response and a reduction in CBV, and this effect is augmented under β-blockade. The results are consistent with sympathetic activation of β-receptor coronary vasodilation in humans, as has been demonstrated in animals. |
| Author | Muller, Matthew D. Leuenberger, Urs A. Sinoway, Lawrence I. Gao, Zhaohui Patel, Hardikkumar M. Heffernan, Matthew J. |
| Author_xml | – sequence: 1 givenname: Matthew D. surname: Muller fullname: Muller, Matthew D. organization: Pennsylvania State University College of Medicine, Pennsylvania State Hershey Heart and Vascular Institute, Hershey, Pennsylvania – sequence: 2 givenname: Zhaohui surname: Gao fullname: Gao, Zhaohui organization: Pennsylvania State University College of Medicine, Pennsylvania State Hershey Heart and Vascular Institute, Hershey, Pennsylvania – sequence: 3 givenname: Hardikkumar M. surname: Patel fullname: Patel, Hardikkumar M. organization: Pennsylvania State University College of Medicine, Pennsylvania State Hershey Heart and Vascular Institute, Hershey, Pennsylvania – sequence: 4 givenname: Matthew J. surname: Heffernan fullname: Heffernan, Matthew J. organization: Pennsylvania State University College of Medicine, Pennsylvania State Hershey Heart and Vascular Institute, Hershey, Pennsylvania – sequence: 5 givenname: Urs A. surname: Leuenberger fullname: Leuenberger, Urs A. organization: Pennsylvania State University College of Medicine, Pennsylvania State Hershey Heart and Vascular Institute, Hershey, Pennsylvania – sequence: 6 givenname: Lawrence I. surname: Sinoway fullname: Sinoway, Lawrence I. organization: Pennsylvania State University College of Medicine, Pennsylvania State Hershey Heart and Vascular Institute, Hershey, Pennsylvania |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24441550$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1007_s00415_021_10514_9 crossref_primary_10_1007_s00421_023_05208_1 crossref_primary_10_14814_phy2_14070 crossref_primary_10_1152_ajpheart_00584_2014 crossref_primary_10_1002_brb3_1463 crossref_primary_10_1016_j_avsg_2016_05_135 crossref_primary_10_1152_japplphysiol_00940_2016 crossref_primary_10_1007_s00421_023_05267_4 crossref_primary_10_1152_ajpheart_00010_2018 crossref_primary_10_1152_ajpheart_00174_2014 crossref_primary_10_1152_japplphysiol_00106_2017 crossref_primary_10_14814_phy2_12806 |
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| Snippet | Forehead cooling activates the sympathetic nervous system and can trigger angina pectoris in susceptible individuals. However, the effect of forehead cooling... |
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| SubjectTerms | Adrenergic beta-Antagonists - administration & dosage Adrenergic beta-Antagonists - pharmacology Adult Aged Aging - physiology Blood Pressure - physiology Body Temperature - physiology Body Temperature Regulation - physiology Cold Temperature Coronary Vessels - diagnostic imaging Coronary Vessels - drug effects Coronary Vessels - physiology Echocardiography, Doppler Female Forehead - physiology Humans Infusions, Intravenous Integrative Cardiovascular Physiology and Pathophysiology Male Middle Aged Propranolol - administration & dosage Propranolol - pharmacology Regional Blood Flow - drug effects Regional Blood Flow - physiology Sympathetic Nervous System - physiology Vasoconstriction - drug effects Vasoconstriction - physiology |
| Title | β-Adrenergic blockade enhances coronary vasoconstrictor response to forehead cooling |
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