Computational Ensemble Gene Co-Expression Networks for the Analysis of Cancer Biomarkers
Gene networks have become a powerful tool for the comprehensive examination of gene expression patterns. Thanks to these networks generated by means of inference algorithms, it is possible to study different biological processes and even identify new biomarkers for such diseases. These biomarkers ar...
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| Published in | Informatics (Basel) Vol. 11; no. 2; p. 14 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Basel
MDPI AG
01.06.2024
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| Subjects | |
| Online Access | Get full text |
| ISSN | 2227-9709 2227-9709 |
| DOI | 10.3390/informatics11020014 |
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| Abstract | Gene networks have become a powerful tool for the comprehensive examination of gene expression patterns. Thanks to these networks generated by means of inference algorithms, it is possible to study different biological processes and even identify new biomarkers for such diseases. These biomarkers are essential for the discovery of new treatments for genetic diseases such as cancer. In this work, we introduce an algorithm for genetic network inference based on an ensemble method that improves the robustness of the results by combining two main steps: first, the evaluation of the relationship between pairs of genes using three different co-expression measures, and, subsequently, a voting strategy. The utility of this approach was demonstrated by applying it to a human dataset encompassing breast and prostate cancer-associated stromal cells. Two gene networks were computed using microarray data, one for breast cancer and one for prostate cancer. The results obtained revealed, on the one hand, distinct stromal cell behaviors in breast and prostate cancer and, on the other hand, a list of potential biomarkers for both diseases. In the case of breast tumor, ST6GAL2, RIPOR3, COL5A1, and DEPDC7 were found, and in the case of prostate tumor, the genes were GATA6-AS1, ARFGEF3, PRR15L, and APBA2. These results demonstrate the usefulness of the ensemble method in the field of biomarker discovery. |
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| AbstractList | Gene networks have become a powerful tool for the comprehensive examination of gene expression patterns. Thanks to these networks generated by means of inference algorithms, it is possible to study different biological processes and even identify new biomarkers for such diseases. These biomarkers are essential for the discovery of new treatments for genetic diseases such as cancer. In this work, we introduce an algorithm for genetic network inference based on an ensemble method that improves the robustness of the results by combining two main steps: first, the evaluation of the relationship between pairs of genes using three different co-expression measures, and, subsequently, a voting strategy. The utility of this approach was demonstrated by applying it to a human dataset encompassing breast and prostate cancer-associated stromal cells. Two gene networks were computed using microarray data, one for breast cancer and one for prostate cancer. The results obtained revealed, on the one hand, distinct stromal cell behaviors in breast and prostate cancer and, on the other hand, a list of potential biomarkers for both diseases. In the case of breast tumor, ST6GAL2, RIPOR3, COL5A1, and DEPDC7 were found, and in the case of prostate tumor, the genes were GATA6-AS1, ARFGEF3, PRR15L, and APBA2. These results demonstrate the usefulness of the ensemble method in the field of biomarker discovery. |
| Audience | Academic |
| Author | Figueroa-Martínez, Julia Saz-Navarro, Dulcenombre M. Gómez-Vela, Francisco A. López-Fernández, Aurelio Rodríguez-Baena, Domingo S. |
| Author_xml | – sequence: 1 givenname: Julia orcidid: 0009-0009-1461-4365 surname: Figueroa-Martínez fullname: Figueroa-Martínez, Julia – sequence: 2 givenname: Dulcenombre M. orcidid: 0000-0003-1551-5341 surname: Saz-Navarro fullname: Saz-Navarro, Dulcenombre M. – sequence: 3 givenname: Aurelio orcidid: 0000-0001-5986-5437 surname: López-Fernández fullname: López-Fernández, Aurelio – sequence: 4 givenname: Domingo S. orcidid: 0000-0001-9801-9364 surname: Rodríguez-Baena fullname: Rodríguez-Baena, Domingo S. – sequence: 5 givenname: Francisco A. orcidid: 0000-0001-7376-5790 surname: Gómez-Vela fullname: Gómez-Vela, Francisco A. |
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| Cites_doi | 10.4049/jimmunol.1200583 10.1089/omi.2011.0118 10.1074/jbc.M400554200 10.1371/journal.pone.0156006 10.3390/cancers12040806 10.3389/fonc.2022.963617 10.1002/cam4.6481 10.12688/f1000research.9005.1 10.1038/s41419-018-0382-7 10.1002/pros.24360 10.1038/s41592-019-0686-2 10.1111/gbb.12106 10.1007/s11356-021-17355-z 10.3390/e21121139 10.1038/modpathol.3800676 10.1155/2007/79879 10.1007/s10555-012-9415-3 10.1371/journal.pone.0018640 10.1016/j.tranon.2020.100781 10.3389/fonc.2018.00374 10.1038/nrc3700 10.3390/genes10120962 10.1126/science.aaa6204 10.1016/j.ygeno.2019.01.010 10.2147/OTT.S256336 10.1186/1752-0509-6-145 10.3390/genes11070831 10.1186/1479-7364-4-3-202 10.18632/oncotarget.7313 10.1038/75556 10.1016/j.softx.2024.101634 10.4292/wjgpt.v5.i1.40 10.2202/1544-6115.1027 10.3389/fonc.2021.634075 10.4161/cc.20849 10.7554/eLife.27356 10.1016/j.biosystems.2018.01.007 10.1016/j.compbiolchem.2015.03.002 10.3389/fgene.2021.695399 10.1093/bib/bbt051 10.1093/bioinformatics/btw788 10.1074/jbc.M117.809657 10.1002/ijc.22434 10.1111/cei.13293 10.1016/j.gpb.2019.05.005 10.1093/bioinformatics/btq596 10.1186/s12859-022-04732-9 10.1186/1471-2105-12-436 10.1111/j.1349-7006.2009.01209.x 10.1186/s12920-022-01410-w 10.1186/1471-2105-9-559 10.3390/cancers14133244 10.3389/fgene.2022.944970 10.1002/cam4.495 10.1186/1471-2105-7-S1-S7 10.1080/1120009X.2022.2097431 10.1016/bs.mie.2016.09.016 10.1002/pro.3978 10.1093/nar/28.1.27 10.1111/j.1349-7006.2008.00996.x 10.1371/journal.pbio.0050008 10.1186/s13045-020-01005-x 10.1186/s43046-023-00181-4 10.3389/fgene.2019.00695 10.1371/journal.pone.0050411 10.1016/j.yexcr.2008.02.022 10.3892/ol.2021.12979 10.1016/j.breast.2022.08.010 10.1093/nar/gkv007 10.1073/pnas.90.15.7181 10.1186/1741-7007-9-54 10.1101/2022.05.06.490968 10.1371/journal.pone.0284284 10.18632/aging.102087 10.1007/s10555-008-9175-2 10.1007/s00432-019-02974-4 10.1016/j.pathol.2020.09.017 10.1007/s00428-019-02604-x 10.1096/fj.02-0773com 10.1109/EMBC48229.2022.9871422 10.1080/00031305.2021.2004922 10.1038/s41598-019-40826-w 10.1186/1752-0509-8-S4-S11 10.1158/0008-5472.CAN-05-3087 10.1371/journal.pone.0057180 10.18637/jss.v018.i02 |
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| References | ref_50 Tsuji (ref_78) 1993; 90 Xu (ref_24) 2021; 11 Hsu (ref_14) 2019; 9 ref_13 Jung (ref_69) 2007; 120 ref_10 Su (ref_51) 2010; 26 Liang (ref_92) 2022; 29 Ritchie (ref_40) 2015; 43 Pei (ref_57) 2017; Volume 585 ref_52 Zhan (ref_16) 2022; 76 Yu (ref_56) 2012; 16 Law (ref_41) 2016; 5 ref_17 Yu (ref_61) 2019; 197 ref_15 ref_59 Liu (ref_58) 2017; 33 (ref_46) 2018; 166 Matsumoto (ref_68) 2015; 4 Zhang (ref_82) 2022; 28 Ferraz (ref_37) 2023; 12 Sostres (ref_64) 2014; 5 Kawada (ref_6) 2009; 100 Kanehisa (ref_55) 2000; 28 Zhao (ref_66) 2018; 293 Katoh (ref_91) 2017; 40 Kim (ref_89) 2009; 100 ref_25 Mukherjee (ref_62) 2012; 11 Xu (ref_88) 2021; 22 Deng (ref_26) 2019; 10 Decker (ref_30) 2020; 13 Brugere (ref_12) 2018; 51 ref_29 Mizuguchi (ref_90) 2019; 475 Zhou (ref_20) 2019; 145 ref_28 Redekar (ref_9) 2023; 35 Lagares (ref_48) 2015; 56 Huang (ref_11) 2018; 19 Arnold (ref_1) 2022; 66 Meyer (ref_36) 2007; 2007 Joyce (ref_73) 2015; 348 Wang (ref_87) 2020; 13 Sund (ref_4) 2009; 28 ref_71 (ref_60) 2024; 25 Zhou (ref_72) 2016; 7 Tang (ref_19) 2018; 8 Bostwick (ref_79) 2021; 53 Zetser (ref_74) 2004; 279 Mevik (ref_31) 2007; 18 Wu (ref_70) 2021; 19 ref_35 ref_34 Ye (ref_22) 2023; 35 ref_33 ref_32 ref_76 Dauphinee (ref_63) 2013; 191 Ovens (ref_18) 2021; 12 Oughtred (ref_47) 2021; 30 Xia (ref_86) 2022; 12 Dong (ref_93) 2022; 13 Withrow (ref_2) 2022; 82 Mishra (ref_65) 2017; 6 ref_39 ref_38 Ashburner (ref_53) 2000; 25 Goldshmidt (ref_75) 2003; 17 ref_83 Tipney (ref_54) 2010; 4 Song (ref_23) 2019; 11 Li (ref_77) 2006; 66 Liao (ref_84) 2017; 14 Liang (ref_81) 2018; 9 ref_43 ref_42 Virtanen (ref_45) 2020; 17 Adhami (ref_21) 2020; 112 Takahashi (ref_44) 2014; 15 ref_3 Hale (ref_67) 2008; 314 Mao (ref_5) 2013; 32 ref_8 Zhu (ref_27) 2017; 33 Hong (ref_7) 2020; 13 Hansel (ref_80) 2007; 20 Gaiteri (ref_49) 2014; 13 Wang (ref_85) 2014; 14 |
| References_xml | – volume: 191 start-page: 892 year: 2013 ident: ref_63 article-title: SASH1 is a scaffold molecule in endothelial TLR4 signaling publication-title: J. Immunol. doi: 10.4049/jimmunol.1200583 – volume: 16 start-page: 284 year: 2012 ident: ref_56 article-title: clusterProfiler: An R package for comparing biological themes among gene clusters publication-title: Omics J. Integr. Biol. doi: 10.1089/omi.2011.0118 – volume: 19 start-page: 647 year: 2018 ident: ref_11 article-title: Bioinformatic Analysis Identifies Three Potentially Key Differentially Expressed Genes in Peripheral Blood Mononuclear Cells of Patients with Takayasu’s Arteritis publication-title: Cell J. – volume: 279 start-page: 23536 year: 2004 ident: ref_74 article-title: Heparanase induces endothelial cell migration via protein kinase B/Akt activation publication-title: J. Biol. Chem. doi: 10.1074/jbc.M400554200 – ident: ref_8 doi: 10.1371/journal.pone.0156006 – ident: ref_3 doi: 10.3390/cancers12040806 – volume: 12 start-page: 963617 year: 2022 ident: ref_86 article-title: The Functions of Long Noncoding RNAs on Regulation of F-Box Proteins in Tumorigenesis and Progression publication-title: Front. Oncol. doi: 10.3389/fonc.2022.963617 – volume: 12 start-page: 19279 year: 2023 ident: ref_37 article-title: Revealing metastatic castration-resistant prostate cancer master regulator through lncRNAs-centered regulatory network publication-title: Cancer Med. doi: 10.1002/cam4.6481 – volume: 5 start-page: 1408 year: 2016 ident: ref_41 article-title: RNA-seq analysis is easy as 1-2-3 with limma, Glimma and edgeR publication-title: F1000Research doi: 10.12688/f1000research.9005.1 – volume: 9 start-page: 372 year: 2018 ident: ref_81 article-title: LncRNA HCP5 promotes the progression of follicular thyroid carcinoma through miRNA sponging publication-title: Cell Death Dis. doi: 10.1038/s41419-018-0382-7 – volume: 82 start-page: 1088 year: 2022 ident: ref_2 article-title: Current and projected number of years of life lost due to prostate cancer: A global study publication-title: Prostate doi: 10.1002/pros.24360 – volume: 17 start-page: 261 year: 2020 ident: ref_45 article-title: SciPy 1.0: Fundamental algorithms for scientific computing in Python publication-title: Nat. Methods doi: 10.1038/s41592-019-0686-2 – volume: 13 start-page: 13 year: 2014 ident: ref_49 article-title: Beyond modules and hubs: The potential of gene coexpression networks for investigating molecular mechanisms of complex brain disorders publication-title: Genes Brain Behav. doi: 10.1111/gbb.12106 – volume: 29 start-page: 22056 year: 2022 ident: ref_92 article-title: Identification of epigenetic modifications mediating the antagonistic effect of selenium against cadmium-induced breast carcinogenesis publication-title: Environ. Sci. Pollut. Res. Int. doi: 10.1007/s11356-021-17355-z – ident: ref_38 doi: 10.3390/e21121139 – volume: 20 start-page: 148 year: 2007 ident: ref_80 article-title: Spindle cell lesions of the adult prostate publication-title: Mod. Pathol. doi: 10.1038/modpathol.3800676 – volume: 2007 start-page: 1 year: 2007 ident: ref_36 article-title: Information-theoretic inference of large transcriptional regulatory networks publication-title: EURASIP J. Bioinform. Syst. Biol. doi: 10.1155/2007/79879 – volume: 32 start-page: 303 year: 2013 ident: ref_5 article-title: Stromal cells in tumor microenvironment and breast cancer publication-title: Cancer Metastasis Rev. doi: 10.1007/s10555-012-9415-3 – ident: ref_39 doi: 10.1371/journal.pone.0018640 – volume: 13 start-page: 100781 year: 2020 ident: ref_30 article-title: Adrenergic blockade promotes maintenance of dormancy in prostate cancer through upregulation of GAS6 publication-title: Transl. Oncol. doi: 10.1016/j.tranon.2020.100781 – volume: 8 start-page: 374 year: 2018 ident: ref_19 article-title: Prognostic genes of breast cancer identified by gene co-expression network analysis publication-title: Front. Oncol. doi: 10.3389/fonc.2018.00374 – volume: 33 start-page: 1791 year: 2017 ident: ref_58 article-title: Weighted gene co-expression network analysis in biomedicine research publication-title: Chin. J. Biotechnol. – volume: 14 start-page: 233 year: 2014 ident: ref_85 article-title: Roles of F-box proteins in cancer publication-title: Nat. Rev. Cancer doi: 10.1038/nrc3700 – ident: ref_17 doi: 10.3390/genes10120962 – volume: 348 start-page: 74 year: 2015 ident: ref_73 article-title: T cell exclusion, immune privilege, and the tumor microenvironment publication-title: Science doi: 10.1126/science.aaa6204 – volume: 112 start-page: 135 year: 2020 ident: ref_21 article-title: Gene co-expression network approach for predicting prognostic microRNA biomarkers in different subtypes of breast cancer publication-title: Genomics doi: 10.1016/j.ygeno.2019.01.010 – volume: 13 start-page: 9741 year: 2020 ident: ref_87 article-title: Long Non-Coding RNA GATA6-AS1 Sponges miR-324-5p to Inhibit Lung Cancer Cell Proliferation and Invasion publication-title: OncoTargets Ther. doi: 10.2147/OTT.S256336 – ident: ref_33 doi: 10.1186/1752-0509-6-145 – ident: ref_59 doi: 10.3390/genes11070831 – volume: 4 start-page: 202 year: 2010 ident: ref_54 article-title: An introduction to effective use of enrichment analysis software publication-title: Hum. Genom. doi: 10.1186/1479-7364-4-3-202 – volume: 7 start-page: 12823 year: 2016 ident: ref_72 article-title: G protein-coupled receptor GPR160 is associated with apoptosis and cell cycle arrest of prostate cancer cells publication-title: Oncotarget doi: 10.18632/oncotarget.7313 – volume: 28 start-page: e935055 year: 2022 ident: ref_82 article-title: Downregulated Expression of RIPOR3 Correlated with Immune Infiltrates Predicts Poor Prognosis in Oral Tongue Cancer publication-title: Med. Sci. Monit. – volume: 25 start-page: 25 year: 2000 ident: ref_53 article-title: Gene ontology: Tool for the unification of biology publication-title: Nat. Genet. doi: 10.1038/75556 – volume: 25 start-page: 101634 year: 2024 ident: ref_60 article-title: CyEnGNet—App: A new Cytoscape app for the reconstruction of large co-expression networks using an ensemble approach publication-title: SoftwareX doi: 10.1016/j.softx.2024.101634 – volume: 5 start-page: 40 year: 2014 ident: ref_64 article-title: Aspirin, cyclooxygenase inhibition and colorectal cancer publication-title: World J. Gastrointest. Pharmacol. Ther. doi: 10.4292/wjgpt.v5.i1.40 – ident: ref_42 doi: 10.2202/1544-6115.1027 – volume: 11 start-page: 634075 year: 2021 ident: ref_24 article-title: Development and validation of novel biomarkers related to M2 macrophages infiltration by weighted gene co-expression network analysis in prostate cancer publication-title: Front. Oncol. doi: 10.3389/fonc.2021.634075 – volume: 11 start-page: 2359 year: 2012 ident: ref_62 article-title: Human Fidgetin is a microtubule severing enzyme and minus-end depolymerase that regulates mitosis publication-title: Cell Cycle doi: 10.4161/cc.20849 – volume: 6 start-page: e27356 year: 2017 ident: ref_65 article-title: A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis publication-title: eLife doi: 10.7554/eLife.27356 – volume: 166 start-page: 61 year: 2018 ident: ref_46 article-title: GNC–app: A new Cytoscape app to rate gene networks biological coherence using gene–gene indirect relationships publication-title: Biosystems doi: 10.1016/j.biosystems.2018.01.007 – volume: 56 start-page: 142 year: 2015 ident: ref_48 article-title: Gene network coherence based on prior knowledge using direct and indirect relationships publication-title: Comput. Biol. Chem. doi: 10.1016/j.compbiolchem.2015.03.002 – volume: 12 start-page: 695399 year: 2021 ident: ref_18 article-title: Comparative analyses of gene co-expression networks: Implementations and applications in the study of evolution publication-title: Front. Genet. doi: 10.3389/fgene.2021.695399 – volume: 15 start-page: 906 year: 2014 ident: ref_44 article-title: A Comparative Study of Statistical Methods Used to Identify Dependencies Between Gene Expression Signals publication-title: Brief. Bioinform. doi: 10.1093/bib/bbt051 – volume: 33 start-page: 1121 year: 2017 ident: ref_27 article-title: MetaDCN: Meta-analysis framework for differential co-expression network detection with an application in breast cancer publication-title: Bioinformatics doi: 10.1093/bioinformatics/btw788 – volume: 293 start-page: 1579 year: 2018 ident: ref_66 article-title: Prodomain-growth factor swapping in the structure of pro-TGF-β1 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M117.809657 – volume: 120 start-page: 2331 year: 2007 ident: ref_69 article-title: Galectin-1 expression in cancer-associated stromal cells correlates tumor invasiveness and tumor progression in breast cancer publication-title: Int. J. Cancer doi: 10.1002/ijc.22434 – volume: 197 start-page: 153 year: 2019 ident: ref_61 article-title: Sculpting tumor microenvironment with immune system: From immunometabolism to immunoediting publication-title: Clin. Exp. Immunol. doi: 10.1111/cei.13293 – volume: 19 start-page: 64 year: 2021 ident: ref_70 article-title: Genome-wide 5-Hydroxymethylcytosine Profiling Analysis Identifies MAP7D1 as A Novel Regulator of Lymph Node Metastasis in Breast Cancer publication-title: Genom. Proteom. Bioinform. doi: 10.1016/j.gpb.2019.05.005 – volume: 26 start-page: 3135 year: 2010 ident: ref_51 article-title: GLay: Community structure analysis of biological networks publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq596 – ident: ref_10 doi: 10.1186/s12859-022-04732-9 – ident: ref_52 doi: 10.1186/1471-2105-12-436 – volume: 100 start-page: 1468 year: 2009 ident: ref_89 article-title: Activation of an estrogen/estrogen receptor signaling by BIG3 through its inhibitory effect on nuclear transport of PHB2/REA in breast cancer publication-title: Cancer Sci. doi: 10.1111/j.1349-7006.2009.01209.x – ident: ref_34 – ident: ref_25 doi: 10.1186/s12920-022-01410-w – ident: ref_13 doi: 10.1186/1471-2105-9-559 – ident: ref_83 doi: 10.3390/cancers14133244 – volume: 13 start-page: 944970 year: 2022 ident: ref_93 article-title: Pan-Cancer Analysis of Forkhead Box Q1 as a Potential Prognostic and Immunological Biomarker publication-title: Front. Genet. doi: 10.3389/fgene.2022.944970 – volume: 4 start-page: 1547 year: 2015 ident: ref_68 article-title: Pérdida global de un componente de lámina nuclear, lamina A/C y componentes complejos LINC SUN1, SUN2 y nesprin-2 en el cáncer de mama publication-title: Cancer Med. doi: 10.1002/cam4.495 – ident: ref_28 doi: 10.1186/1471-2105-7-S1-S7 – volume: 14 start-page: 7332 year: 2017 ident: ref_84 article-title: DEPDC7 inhibits cell proliferation, migration and invasion in hepatoma cells publication-title: Oncol. Lett. – volume: 35 start-page: 298 year: 2023 ident: ref_22 article-title: Identification of T cell-related biomarkers for breast cancer based on weighted gene co-expression network analysis publication-title: J. Chemother. doi: 10.1080/1120009X.2022.2097431 – volume: 51 start-page: 24 year: 2018 ident: ref_12 article-title: Network structure inference, a survey: Motivations, methods, and applications publication-title: ACM Comput. Surv. (CSUR) – volume: Volume 585 start-page: 135 year: 2017 ident: ref_57 article-title: WGCNA application to proteomic and metabolomic data analysis publication-title: Methods in Enzymology doi: 10.1016/bs.mie.2016.09.016 – volume: 30 start-page: 187 year: 2021 ident: ref_47 article-title: The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions publication-title: Protein Sci. doi: 10.1002/pro.3978 – volume: 40 start-page: 587 year: 2017 ident: ref_91 article-title: Molecular genetics and targeted therapy of WNT-related human diseases (Review) publication-title: Int. J. Mol. Med. – volume: 28 start-page: 27 year: 2000 ident: ref_55 article-title: KEGG: Kyoto encyclopedia of genes and genomes publication-title: Nucleic Acids Res. doi: 10.1093/nar/28.1.27 – volume: 100 start-page: 150 year: 2009 ident: ref_6 article-title: Phthoxazolin A inhibits prostate cancer growth by modulating tumor–stromal cell interactions publication-title: Cancer Sci. doi: 10.1111/j.1349-7006.2008.00996.x – ident: ref_35 doi: 10.1371/journal.pbio.0050008 – volume: 13 start-page: 166 year: 2020 ident: ref_7 article-title: RNA sequencing: New technologies and applications in cancer research publication-title: J. Hematol. Oncol. doi: 10.1186/s13045-020-01005-x – volume: 35 start-page: 22 year: 2023 ident: ref_9 article-title: Gene co-expression network construction and analysis for identification of genetic biomarkers associated with glioblastoma multiforme using topological findings publication-title: J. Egypt. Natl. Cancer Inst. doi: 10.1186/s43046-023-00181-4 – volume: 10 start-page: 695 year: 2019 ident: ref_26 article-title: Identification of potential crucial genes and key pathways in breast cancer using bioinformatic analysis publication-title: Front. Genet. doi: 10.3389/fgene.2019.00695 – ident: ref_43 doi: 10.1371/journal.pone.0050411 – volume: 314 start-page: 1892 year: 2008 ident: ref_67 article-title: Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness publication-title: Exp. Cell Res. doi: 10.1016/j.yexcr.2008.02.022 – volume: 22 start-page: 718 year: 2021 ident: ref_88 article-title: GATA6-AS1 inhibits ovarian cancer cell proliferation and migratory and invasive abilities by sponging miR-19a-5p and upregulating TET2 publication-title: Oncol. Lett. doi: 10.3892/ol.2021.12979 – volume: 66 start-page: 15 year: 2022 ident: ref_1 article-title: Current and future burden of breast cancer: Global statistics for 2020 and 2040 publication-title: Breast doi: 10.1016/j.breast.2022.08.010 – volume: 43 start-page: e47 year: 2015 ident: ref_40 article-title: limma powers differential expression analyses for RNA-sequencing and microarray studies publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkv007 – volume: 90 start-page: 7181 year: 1993 ident: ref_78 article-title: Hepsin, a putative cell-surface serine protease, is required for mammalian cell growth publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.90.15.7181 – ident: ref_76 doi: 10.1186/1741-7007-9-54 – ident: ref_29 doi: 10.1101/2022.05.06.490968 – ident: ref_15 doi: 10.1371/journal.pone.0284284 – volume: 11 start-page: 4736 year: 2019 ident: ref_23 article-title: Identification of hub genes in prostate cancer using robust rank aggregation and weighted gene co-expression network analysis publication-title: Aging doi: 10.18632/aging.102087 – volume: 28 start-page: 177 year: 2009 ident: ref_4 article-title: Tumor stroma derived biomarkers in cancer publication-title: Cancer Metastasis Rev. doi: 10.1007/s10555-008-9175-2 – volume: 145 start-page: 2383 year: 2019 ident: ref_20 article-title: Co-expression network analysis identified candidate biomarkers in association with progression and prognosis of breast cancer publication-title: J. Cancer Res. Clin. Oncol. doi: 10.1007/s00432-019-02974-4 – volume: 53 start-page: 12 year: 2021 ident: ref_79 article-title: Prostatic stromal proliferations: A review publication-title: Pathology doi: 10.1016/j.pathol.2020.09.017 – volume: 475 start-page: 659 year: 2019 ident: ref_90 article-title: Identification of a novel PRR15L-RSPO2 fusion transcript in a sigmoid colon cancer derived from superficially serrated adenoma publication-title: Virchows Arch. doi: 10.1007/s00428-019-02604-x – volume: 17 start-page: 1015 year: 2003 ident: ref_75 article-title: Heparanase mediates cell adhesion independent of its enzymatic activity publication-title: FASEB J. doi: 10.1096/fj.02-0773com – ident: ref_71 doi: 10.1109/EMBC48229.2022.9871422 – volume: 76 start-page: 44 year: 2022 ident: ref_16 article-title: Myths about linear and monotonic associations: Pearson’sr, Spearman’s ρ, and Kendall’s τ publication-title: Am. Stat. doi: 10.1080/00031305.2021.2004922 – volume: 9 start-page: 4484 year: 2019 ident: ref_14 article-title: Six novel immunoglobulin genes as biomarkers for better prognosis in triple-negative breast cancer by gene co-expression network analysis publication-title: Sci. Rep. doi: 10.1038/s41598-019-40826-w – ident: ref_50 doi: 10.1186/1752-0509-8-S4-S11 – volume: 66 start-page: 5173 year: 2006 ident: ref_77 article-title: The S100A4 metastasis factor regulates cellular motility via a direct interaction with myosin-IIA publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-05-3087 – ident: ref_32 doi: 10.1371/journal.pone.0057180 – volume: 18 start-page: 1 year: 2007 ident: ref_31 article-title: The pls Package: Principal Component and Partial Least Squares Regression in R publication-title: J. Stat. Softw. doi: 10.18637/jss.v018.i02 |
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