Serum adiponectin in breast cancer: A meta-analysis
Accumulating data have found that adiponectin is involved in development of breast cancer (BC). However, these results were inconsistent. A systematic search in PubMed, Embase, ISI Web of Science, and Chinese National Knowledge Infrastructure databases were conducted up to October 1, 2017. The stand...
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| Published in | Medicine (Baltimore) Vol. 97; no. 29; p. e11433 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved
01.07.2018
Wolters Kluwer Health |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0025-7974 1536-5964 1536-5964 |
| DOI | 10.1097/MD.0000000000011433 |
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| Abstract | Accumulating data have found that adiponectin is involved in development of breast cancer (BC). However, these results were inconsistent.
A systematic search in PubMed, Embase, ISI Web of Science, and Chinese National Knowledge Infrastructure databases were conducted up to October 1, 2017. The standardized mean difference (SMD) with 95% confidence interval was applied to pool the effect size.
Finally, 31 eligible studies were included in this meta-analysis. The overall results indicated that serum adiponectin levels in BC cases were significantly lower than the controls (SMD = -0.33, P < 0.0001). As for the subgroup analysis of menstrual status, serum adiponectin levels were significantly lower in pre- and postmenopausal BC cases. Moreover, the subgroup analysis by ethnicity in pre- and postmenopausal group indicated an inverse association between adiponectin levels and BC risk in Asian population, but not in Caucasian population.
The present meta-analysis suggests that low serum adiponectin concentration may be associated with an increased BC risk in premenopausal and postmenopausal women, especially among Asians. Adiponectin may serve as a biomarker of BC risk and help to identify subjects at high risk for BC development. |
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| AbstractList | Accumulating data have found that adiponectin is involved in development of breast cancer (BC). However, these results were inconsistent.
A systematic search in PubMed, Embase, ISI Web of Science, and Chinese National Knowledge Infrastructure databases were conducted up to October 1, 2017. The standardized mean difference (SMD) with 95% confidence interval was applied to pool the effect size.
Finally, 31 eligible studies were included in this meta-analysis. The overall results indicated that serum adiponectin levels in BC cases were significantly lower than the controls (SMD = -0.33, P < 0.0001). As for the subgroup analysis of menstrual status, serum adiponectin levels were significantly lower in pre- and postmenopausal BC cases. Moreover, the subgroup analysis by ethnicity in pre- and postmenopausal group indicated an inverse association between adiponectin levels and BC risk in Asian population, but not in Caucasian population.
The present meta-analysis suggests that low serum adiponectin concentration may be associated with an increased BC risk in premenopausal and postmenopausal women, especially among Asians. Adiponectin may serve as a biomarker of BC risk and help to identify subjects at high risk for BC development. Accumulating data have found that adiponectin is involved in development of breast cancer (BC). However, these results were inconsistent.BACKGROUNDAccumulating data have found that adiponectin is involved in development of breast cancer (BC). However, these results were inconsistent.A systematic search in PubMed, Embase, ISI Web of Science, and Chinese National Knowledge Infrastructure databases were conducted up to October 1, 2017. The standardized mean difference (SMD) with 95% confidence interval was applied to pool the effect size.METHODA systematic search in PubMed, Embase, ISI Web of Science, and Chinese National Knowledge Infrastructure databases were conducted up to October 1, 2017. The standardized mean difference (SMD) with 95% confidence interval was applied to pool the effect size.Finally, 31 eligible studies were included in this meta-analysis. The overall results indicated that serum adiponectin levels in BC cases were significantly lower than the controls (SMD = -0.33, P < 0.0001). As for the subgroup analysis of menstrual status, serum adiponectin levels were significantly lower in pre- and postmenopausal BC cases. Moreover, the subgroup analysis by ethnicity in pre- and postmenopausal group indicated an inverse association between adiponectin levels and BC risk in Asian population, but not in Caucasian population.RESULTSFinally, 31 eligible studies were included in this meta-analysis. The overall results indicated that serum adiponectin levels in BC cases were significantly lower than the controls (SMD = -0.33, P < 0.0001). As for the subgroup analysis of menstrual status, serum adiponectin levels were significantly lower in pre- and postmenopausal BC cases. Moreover, the subgroup analysis by ethnicity in pre- and postmenopausal group indicated an inverse association between adiponectin levels and BC risk in Asian population, but not in Caucasian population.The present meta-analysis suggests that low serum adiponectin concentration may be associated with an increased BC risk in premenopausal and postmenopausal women, especially among Asians. Adiponectin may serve as a biomarker of BC risk and help to identify subjects at high risk for BC development.CONCLUSIONThe present meta-analysis suggests that low serum adiponectin concentration may be associated with an increased BC risk in premenopausal and postmenopausal women, especially among Asians. Adiponectin may serve as a biomarker of BC risk and help to identify subjects at high risk for BC development. |
| Author | Li, Qian Li, De-Hua Gu, Li Chen, Ming-Yao Fu, Jing Cao, Chang |
| AuthorAffiliation | Department of Obstetrics, West China Women's and Children's Hospital Key Laboratory of Birth and Related Diseases of Women and Children, Sichuan University Department of Cosmetic Plastic and Burns surgery, West China Hospital, Sichuan University, Chengdu International Education School, Southwest Medical University, Luzhou Department of Operations Management, West China Hospital, Sichuan University Department of West China Second University Hospital Quality improvement, West China Women's and Children's Hospital, Chengdu Dazhou vocational and technical college, Dazhou, PR China |
| AuthorAffiliation_xml | – name: Department of Obstetrics, West China Women's and Children's Hospital Key Laboratory of Birth and Related Diseases of Women and Children, Sichuan University Department of Cosmetic Plastic and Burns surgery, West China Hospital, Sichuan University, Chengdu International Education School, Southwest Medical University, Luzhou Department of Operations Management, West China Hospital, Sichuan University Department of West China Second University Hospital Quality improvement, West China Women's and Children's Hospital, Chengdu Dazhou vocational and technical college, Dazhou, PR China – name: b Key Laboratory of Birth and Related Diseases of Women and Children, Sichuan University – name: e Department of Operations Management, West China Hospital, Sichuan University – name: g Dazhou vocational and technical college, Dazhou, PR China – name: a Department of Obstetrics, West China Women's and Children's Hospital – name: f Department of West China Second University Hospital Quality improvement, West China Women's and Children's Hospital, Chengdu – name: d International Education School, Southwest Medical University, Luzhou – name: c Department of Cosmetic Plastic and Burns surgery, West China Hospital, Sichuan University, Chengdu |
| Author_xml | – sequence: 1 givenname: Li surname: Gu fullname: Gu, Li organization: Department of Obstetrics, West China Women's and Children's Hospital Key Laboratory of Birth and Related Diseases of Women and Children, Sichuan University Department of Cosmetic Plastic and Burns surgery, West China Hospital, Sichuan University, Chengdu International Education School, Southwest Medical University, Luzhou Department of Operations Management, West China Hospital, Sichuan University Department of West China Second University Hospital Quality improvement, West China Women's and Children's Hospital, Chengdu Dazhou vocational and technical college, Dazhou, PR China – sequence: 2 givenname: Chang surname: Cao fullname: Cao, Chang – sequence: 3 givenname: Jing surname: Fu fullname: Fu, Jing – sequence: 4 givenname: Qian surname: Li fullname: Li, Qian – sequence: 5 givenname: De-Hua surname: Li fullname: Li, De-Hua – sequence: 6 givenname: Ming-Yao surname: Chen fullname: Chen, Ming-Yao |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30024516$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1371/journal.pone.0129246 10.1007/s12282-013-0502-2 10.7314/APJCP.2014.15.3.1387 10.1093/jnci/djv169 10.1016/j.cytogfr.2016.03.014 10.18632/oncotarget.17853 10.1097/GME.0b013e31827f06dc 10.7314/APJCP.2012.13.1.395 10.1093/aje/kws359 10.3346/jkms.2007.22.1.117 10.1038/srep30220 10.1002/ijc.29210 10.1186/1475-2840-10-13 10.1016/j.canlet.2005.05.047 10.4143/crt.2013.45.3.210 10.1158/1940-6207.CAPR-12-0374 10.1038/oby.2008.480 10.1210/jc.2006-1858 10.1007/s10549-009-0577-9 10.1016/j.breast.2016.07.025 10.1016/B978-0-12-398313-8.00010-5 10.1093/ije/dyu088 10.7314/APJCP.2015.16.12.4945 10.1002/jcla.21555 10.1016/j.beem.2013.08.006 10.1074/jbc.M117.792838 10.1158/1055-9965.EPI-14-0173 10.1530/ERC-12-0229 10.1016/j.mce.2013.09.030 10.1677/erc.1.00729 10.1515/med-2017-0028 10.1210/jc.2006-1371 10.1097/00029330-200709020-00009 10.1002/ijc.20315 10.1371/journal.pone.0073183 10.1002/mc.20764 10.1158/1055-9965.EPI-12-1444 10.1097/CEJ.0b013e328364f293 10.1186/1471-2407-13-54 10.1007/s12020-016-0893-x 10.1155/2015/253519 10.1016/j.currproblcancer.2018.01.004 10.1007/s10552-017-0917-8 10.1007/s10549-008-9958-8 10.1155/2011/832165 10.1023/A:1020239211145 10.1210/jc.2006-1975 10.1111/j.1753-4887.2011.00414.x 10.1111/j.1467-789X.2004.00142.x 10.1210/jc.2003-031804 10.1200/JCO.2010.29.7614 |
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| References | Korner (R46-23-20210309) 2007; 92 Al Khaldi (R42-23-20210309) 2011; 30 Cubukcu (R5-23-20210309) 2014; 18 Hancke (R13-23-20210309) 2010; 119 Maruthur (R58-23-20210309) 2009; 17 Wang (R35-23-20210309) 2016; 6 Zhang (R39-23-20210309) 2012; 50 Ye (R19-23-20210309) 2014; 23 Ozmen (R27-23-20210309) 2017; 12 Dalamaga (R37-23-20210309) 2013; 20 Gulcelik (R40-23-20210309) 2012; 13 Hou (R48-23-20210309) 2007; 120 Santillan-Benitez (R34-23-20210309) 2013; 27 Assiri (R16-23-20210309) 2015; 2015 Lyons (R11-23-20210309) 2017; 292 Liu (R21-23-20210309) 2013; 8 Palin (R57-23-20210309) 2012; 90 Ahmed (R17-23-20210309) 2015; 16 Mantzoros (R50-23-20210309) 2004; 89 Ollberding (R22-23-20210309) 2013; 6 Gross (R23-23-20210309) 2013; 22 Dossus (R7-23-20210309) 2017; 28 Westerink (R56-23-20210309) 2011; 10 Nagaraju (R8-23-20210309) 2016; 31 Li (R24-23-20210309) 2018; 42 Cust (R59-23-20210309) 2007; 92 Kishida (R60-23-20210309) 2014; 28 Lorincz (R4-23-20210309) 2006; 13 Cust (R45-23-20210309) 2009; 113 Miyoshi (R51-23-20210309) 2003; 9 Ewertz (R3-23-20210309) 2011; 29 Panis (R52-23-20210309) 2014; 382 Gunter (R31-23-20210309) 2015; 107 Dallal (R6-23-20210309) 2013; 20 Chen (R49-23-20210309) 2006; 237 Wang (R32-23-20210309) 2013; 17 Touvier (R33-23-20210309) 2013; 177 Morimoto (R15-23-20210309) 2002; 13 Alokail (R38-23-20210309) 2013; 13 Kang (R47-23-20210309) 2007; 22 Nalabolu (R9-23-20210309) 2014; 8 Keramatinia (R1-23-20210309) 2014; 15 Tworoger (R36-23-20210309) 2007; 92 Silva (R26-23-20210309) 2011; 69 Shahar (R43-23-20210309) 2010; 11 Bachelder (R10-23-20210309) 2002; 62 Crisostomo (R28-23-20210309) 2016; 53 Al Awadhi (R41-23-20210309) 2012; 135 Fan (R44-23-20210309) 2010; 25 Macis (R20-23-20210309) 2014; 43 Llanos (R53-23-20210309) 2014; 23 Carroll (R55-23-20210309) 2011; 50 Ferlay (R2-23-20210309) 2015; 136 Lahmann (R14-23-20210309) 2004; 111 Cho (R54-23-20210309) 2013; 45 Georgiou (R12-23-20210309) 2016; 29 Guo (R30-23-20210309) 2015; 10 Rose (R25-23-20210309) 2004; 5 Gui (R18-23-20210309) 2017; 8 Minatoya (R29-23-20210309) 2015; 22 |
| References_xml | – volume: 10 start-page: e0129246 year: 2015 ident: R30-23-20210309 article-title: Circulating high-molecular-weight (HMW) adiponectin level is related with breast cancer risk better than total adiponectin: a case–control study publication-title: PLoS One doi: 10.1371/journal.pone.0129246 – volume: 22 start-page: 452 year: 2015 ident: R29-23-20210309 article-title: Relationship of serum isoflavone, insulin and adiponectin levels with breast cancer risk publication-title: Breast Cancer doi: 10.1007/s12282-013-0502-2 – volume: 15 start-page: 1387 year: 2014 ident: R1-23-20210309 article-title: Trends in incidence of breast cancer among women under 40 in Asia publication-title: Asian Pac J Cancer Prev doi: 10.7314/APJCP.2014.15.3.1387 – volume: 107 start-page: 221 year: 2015 ident: R31-23-20210309 article-title: Circulating adipokines and inflammatory markers and postmenopausal breast cancer risk publication-title: J Natl Cancer Inst doi: 10.1093/jnci/djv169 – volume: 31 start-page: 37 year: 2016 ident: R8-23-20210309 article-title: The role of adiponectin in obesity-associated female-specific carcinogenesis publication-title: Cytokine Growth Factor Rev doi: 10.1016/j.cytogfr.2016.03.014 – volume: 8 start-page: 75389 year: 2017 ident: R18-23-20210309 article-title: The association between obesity related adipokines and risk of breast cancer: a meta-analysis publication-title: Oncotarget doi: 10.18632/oncotarget.17853 – volume: 20 start-page: 845 year: 2013 ident: R37-23-20210309 article-title: Hyperresistinemia is associated with postmenopausal breast cancer publication-title: Menopause doi: 10.1097/GME.0b013e31827f06dc – volume: 13 start-page: 395 year: 2012 ident: R40-23-20210309 article-title: Associations between adiponectin and two different cancers: breast and colon publication-title: Asian Pac J Cancer Prev doi: 10.7314/APJCP.2012.13.1.395 – volume: 177 start-page: 3 year: 2013 ident: R33-23-20210309 article-title: Association between prediagnostic biomarkers of inflammation and endothelial function and cancer risk: a nested case–control study publication-title: Am J Epidemiol doi: 10.1093/aje/kws359 – volume: 22 start-page: 117 year: 2007 ident: R47-23-20210309 article-title: Relationship of serum adiponectin and resistin levels with breast cancer risk publication-title: J Korean Med Sci doi: 10.3346/jkms.2007.22.1.117 – volume: 18 start-page: 34 year: 2014 ident: R5-23-20210309 article-title: Lack of prognostic significance of adiponectin immunohistochemical expression in patients with triple-negative breast cancer publication-title: Contemp Oncol (Pozn – volume: 6 start-page: 30220 year: 2016 ident: R35-23-20210309 article-title: Genetic association between NFKB1-94 ins/del ATTG promoter polymorphism and cancer risk: a meta-analysis of 42 case–control studies publication-title: Sci Rep doi: 10.1038/srep30220 – volume: 62 start-page: 7203 year: 2002 ident: R10-23-20210309 article-title: Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4 publication-title: Cancer Res – volume: 136 start-page: E359 year: 2015 ident: R2-23-20210309 article-title: Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012 publication-title: Int J Cancer doi: 10.1002/ijc.29210 – volume: 8 start-page: 31 year: 2014 ident: R9-23-20210309 article-title: Adiponectin and leptin molecular actions and clinical significance in breast cancer publication-title: Int J Hematol Oncol Stem Cell Res – volume: 17 start-page: 210 year: 2013 ident: R32-23-20210309 article-title: Correlation of serum adiponectin, body mass index and lipid metabolic disorder and breast cancer publication-title: Chin J Lab Diagn – volume: 10 start-page: 13 year: 2011 ident: R56-23-20210309 article-title: Pharmacological and non-pharmacological interventions to influence adipose tissue function publication-title: Cardiovasc Diabetol doi: 10.1186/1475-2840-10-13 – volume: 237 start-page: 109 year: 2006 ident: R49-23-20210309 article-title: Serum adiponectin and leptin levels in Taiwanese breast cancer patients publication-title: Cancer Lett doi: 10.1016/j.canlet.2005.05.047 – volume: 45 start-page: 210 year: 2013 ident: R54-23-20210309 article-title: Prognostic role of interleukin-6, interleukin-8, and leptin levels according to breast cancer subtype publication-title: Cancer Res Treat doi: 10.4143/crt.2013.45.3.210 – volume: 6 start-page: 188 year: 2013 ident: R22-23-20210309 article-title: Prediagnostic leptin, adiponectin, C-reactive protein, and the risk of postmenopausal breast cancer publication-title: Cancer Prev Res doi: 10.1158/1940-6207.CAPR-12-0374 – volume: 17 start-page: 375 year: 2009 ident: R58-23-20210309 article-title: The association of obesity and cervical cancer screening: a systematic review and meta-analysis publication-title: Obesity doi: 10.1038/oby.2008.480 – volume: 92 start-page: 1041 year: 2007 ident: R46-23-20210309 article-title: Total and high-molecular-weight adiponectin in breast cancer: in vitro and in vivo studies publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2006-1858 – volume: 119 start-page: 367 year: 2010 ident: R13-23-20210309 article-title: Adipocyte fatty acid-binding protein as a novel prognostic factor in obese breast cancer patients publication-title: Breast Cancer Res Treat doi: 10.1007/s10549-009-0577-9 – volume: 29 start-page: 163 year: 2016 ident: R12-23-20210309 article-title: Serum resistin is inversely related to breast cancer risk in premenopausal women publication-title: Breast doi: 10.1016/j.breast.2016.07.025 – volume: 25 start-page: 192 year: 2010 ident: R44-23-20210309 article-title: Postoperative radiotherapy combined with temozolomidein treatment of malignantgliomas publication-title: J Pract Oncol – volume: 90 start-page: 239 year: 2012 ident: R57-23-20210309 article-title: Adiponectin and the control of female reproductive functions publication-title: Vitam Horm doi: 10.1016/B978-0-12-398313-8.00010-5 – volume: 43 start-page: 1226 year: 2014 ident: R20-23-20210309 article-title: Circulating adiponectin and breast cancer risk: a systematic review and meta-analysis publication-title: Int J Epidemiol doi: 10.1093/ije/dyu088 – volume: 16 start-page: 4945 year: 2015 ident: R17-23-20210309 article-title: Serum adiponectin level association with breast cancer risk: evidence from a case–control study publication-title: Asian Pac J Cancer Prev doi: 10.7314/APJCP.2015.16.12.4945 – volume: 27 start-page: 12 year: 2013 ident: R34-23-20210309 article-title: The tetrad BMI, leptin, leptin/adiponectin (L/A) ratio and CA 15-3 are reliable biomarkers of breast cancer publication-title: J Clin Lab Anal doi: 10.1002/jcla.21555 – volume: 28 start-page: 119 year: 2014 ident: R60-23-20210309 article-title: Adiponectin as a routine clinical biomarker publication-title: Best Pract Res Clin Endocrinol Metab doi: 10.1016/j.beem.2013.08.006 – volume: 292 start-page: 16983 year: 2017 ident: R11-23-20210309 article-title: Insulin-like growth factor 1 signaling is essential for mitochondrial biogenesis and mitophagy in cancer cells publication-title: J Biol Chem doi: 10.1074/jbc.M117.792838 – volume: 23 start-page: 1559 year: 2014 ident: R53-23-20210309 article-title: Genetic variation in adipokine genes and associations with adiponectin and leptin concentrations in plasma and breast tissue publication-title: Cancer Epidemiol Biomarkers Prev doi: 10.1158/1055-9965.EPI-14-0173 – volume: 20 start-page: 151 year: 2013 ident: R6-23-20210309 article-title: Obesity-related hormones and endometrial cancer among postmenopausal women: a nested case–control study within the B∼FIT cohort publication-title: Endocr Relat Cancer doi: 10.1530/ERC-12-0229 – volume: 50 start-page: 132 year: 2012 ident: R39-23-20210309 article-title: Associations between breast cancer and serum levels of adiponectin and leptin publication-title: J Shandong Univ – volume: 382 start-page: 190 year: 2014 ident: R52-23-20210309 article-title: Clinical insights from adiponectin analysis in breast cancer patients reveal its anti-inflammatory properties in non-obese women publication-title: Mol Cell Endocrinol doi: 10.1016/j.mce.2013.09.030 – volume: 13 start-page: 279 year: 2006 ident: R4-23-20210309 article-title: Molecular links between obesity and breast cancer publication-title: Endocr Relat Cancer doi: 10.1677/erc.1.00729 – volume: 12 start-page: 189 year: 2017 ident: R27-23-20210309 article-title: Carnitine and adiponectin levels in breast cancer after radiotherapy publication-title: Open Med (Wars doi: 10.1515/med-2017-0028 – volume: 92 start-page: 255 year: 2007 ident: R59-23-20210309 article-title: Plasma adiponectin levels and endometrial cancer risk in pre- and postmenopausal women publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2006-1371 – volume: 120 start-page: 1592 year: 2007 ident: R48-23-20210309 article-title: Adipocytokines and breast cancer risk publication-title: Chin Med J (Engl doi: 10.1097/00029330-200709020-00009 – volume: 111 start-page: 762 year: 2004 ident: R14-23-20210309 article-title: Body size and breast cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC) publication-title: Int J Cancer doi: 10.1002/ijc.20315 – volume: 8 start-page: e73183 year: 2013 ident: R21-23-20210309 article-title: The role of adiponectin in breast cancer: a meta-analysis publication-title: PLoS One doi: 10.1371/journal.pone.0073183 – volume: 50 start-page: 643 year: 2011 ident: R55-23-20210309 article-title: Influence of the metabolic syndrome on leptin and leptin receptor in breast cancer publication-title: Mol Carcinog doi: 10.1002/mc.20764 – volume: 22 start-page: 1319 year: 2013 ident: R23-23-20210309 article-title: Adipocytokines, inflammation, and breast cancer risk in postmenopausal women: a prospective study publication-title: Cancer Epidemiol Biomarkers Prev doi: 10.1158/1055-9965.EPI-12-1444 – volume: 11 start-page: 61 year: 2010 ident: R43-23-20210309 article-title: Roles of adiposity, lifetime physical activity and serum adiponectin in occurrence of breast cancer among Malaysian women in Klang Valley publication-title: Asian Pac J Cancer Prev – volume: 23 start-page: 158 year: 2014 ident: R19-23-20210309 article-title: Circulating adiponectin levels and the risk of breast cancer: a meta-analysis publication-title: Eur J Cancer Prev doi: 10.1097/CEJ.0b013e328364f293 – volume: 135 start-page: 500 year: 2012 ident: R41-23-20210309 article-title: Associations of adipokines & insulin resistance with sex steroids in patients with breast cancer publication-title: Indian J Med Res – volume: 13 start-page: 54 year: 2013 ident: R38-23-20210309 article-title: Metabolic syndrome biomarkers and early breast cancer in Saudi women: evidence for the presence of a systemic stress response and/or a pre-existing metabolic syndrome-related neoplasia risk? publication-title: BMC Cancer doi: 10.1186/1471-2407-13-54 – volume: 53 start-page: 433 year: 2016 ident: R28-23-20210309 article-title: Hyperresistinemia and metabolic dysregulation: a risky crosstalk in obese breast cancer publication-title: Endocrine doi: 10.1007/s12020-016-0893-x – volume: 2015 start-page: 253519 year: 2015 ident: R16-23-20210309 article-title: Resistin, visfatin, adiponectin, and leptin: risk of breast cancer in pre- and postmenopausal saudi females and their possible diagnostic and predictive implications as novel biomarkers publication-title: Dis Markers doi: 10.1155/2015/253519 – volume: 42 start-page: 208 year: 2018 ident: R24-23-20210309 article-title: Adipocytokines and breast cancer publication-title: Curr Probl Cancer doi: 10.1016/j.currproblcancer.2018.01.004 – volume: 28 start-page: 939 year: 2017 ident: R7-23-20210309 article-title: Circulating leptin and adiponectin, and breast density in premenopausal Mexican women: the Mexican Teachers’ Cohort publication-title: Cancer Causes Control doi: 10.1007/s10552-017-0917-8 – volume: 113 start-page: 567 year: 2009 ident: R45-23-20210309 article-title: The influence of overweight and insulin resistance on breast cancer risk and tumour stage at diagnosis: a prospective study publication-title: Breast Cancer Res Treat doi: 10.1007/s10549-008-9958-8 – volume: 30 start-page: 197 year: 2011 ident: R42-23-20210309 article-title: Associations of single nucleotide polymorphisms in the adiponectin gene with adiponectin levels and cardio-metabolic risk factors in patients with cancer publication-title: Dis Markers doi: 10.1155/2011/832165 – volume: 9 start-page: 5699 year: 2003 ident: R51-23-20210309 article-title: Association of serum adiponectin levels with breast cancer risk publication-title: Clin Cancer Res – volume: 13 start-page: 741 year: 2002 ident: R15-23-20210309 article-title: Obesity, body size, and risk of postmenopausal breast cancer: the Women's Health Initiative (United States) publication-title: Cancer Causes Control doi: 10.1023/A:1020239211145 – volume: 92 start-page: 1510 year: 2007 ident: R36-23-20210309 article-title: Plasma adiponectin concentrations and risk of incident breast cancer publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2006-1975 – volume: 69 start-page: 599 year: 2011 ident: R26-23-20210309 article-title: Effect of diet on adiponectin levels in blood publication-title: Nutr Rev doi: 10.1111/j.1753-4887.2011.00414.x – volume: 5 start-page: 153 year: 2004 ident: R25-23-20210309 article-title: Obesity, adipocytokines, and insulin resistance in breast cancer publication-title: Obes Rev doi: 10.1111/j.1467-789X.2004.00142.x – volume: 89 start-page: 1102 year: 2004 ident: R50-23-20210309 article-title: Adiponectin and breast cancer risk publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2003-031804 – volume: 29 start-page: 25 year: 2011 ident: R3-23-20210309 article-title: Effect of obesity on prognosis after early-stage breast cancer publication-title: J Clin Oncol doi: 10.1200/JCO.2010.29.7614 |
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| Snippet | Accumulating data have found that adiponectin is involved in development of breast cancer (BC). However, these results were inconsistent.
A systematic search... Accumulating data have found that adiponectin is involved in development of breast cancer (BC). However, these results were inconsistent.BACKGROUNDAccumulating... |
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| SubjectTerms | Adiponectin - blood Biomarkers - blood Breast Neoplasms - blood Female Humans Risk Factors Systematic Review and Meta-Analysis |
| Title | Serum adiponectin in breast cancer: A meta-analysis |
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