Multidrug resistance protein-6 (MRP6) in human dermal fibroblasts. Comparison between cells from normal subjects and from Pseudoxanthoma elasticum patients - Boraldi, F.; Quaglino, D.; Croce, M.A.; Garcia Fernandez, M.I.; Tiozzo, R.; Gheduzzi, D.; Bacchelli, B.; Pasquali Ronchetti, I. (Matrix biology, 2003)
Keywords: ABCC6; Adult; Benzbromarone - pharmacology; Cell Count; Cell Division; Chlorambucil - pharmacology; Female; Fibroblast; Fibroblasts - cytology; Fibroblasts - drug effects; Fibroblasts - metabolism; Fluoresceins - pharmacokinetics; Fluoresceins - pharmacology; Fluorescent Dyes - pharmacokinetics; Fluorescent Dyes - pharmacology; Humans; Indomethacin - pharmacology; Lysosomes - chemistry; Male; Membrane Transport Proteins - physiology; Membrane transporter; Microscopy, Fluorescence; Middle Aged; MRP6; Multidrug Resistance-Associated Proteins - antagonists & inhibitors; Multidrug Resistance-Associated Proteins - physiology; Propionates - pharmacology; Pseudoxanthoma elasticum; Pseudoxanthoma Elasticum - metabolism; Pseudoxanthoma Elasticum - physiopathology; Quinolines - pharmacology; Skin - metabolism; Skin - physiopathology; Verapamil - pharmacology; Vinblastine - pharmacology; CHB, chlorambucil; NEM-GS, N-ethyl-maleimide- S-glutathione; PXE, Pseudoxanthoma elasticum (on-line Mendelian inheritance in man 264800, MIM 177850); DMEM, Dulbecco modified eagle medium; ABCC6; BNZ, benzbromarone; FBS, fetal bovine serum; PBS, phosphate buffered saline; MK571, 3-(3-(2-(7-choro-2 quinolinyl) ethenyl)phenyl ((3-dimethyl amino-3-oxo-propyl)thio) methyl) propanoic acid; MRP6; VPL, verapamil; Calcein-AM, calcein acetoxy-methyl-ester; IDM, indomethacin; VBL, vinblastine; ABCC, ATP-binding cassette C; Pseudoxanthoma elasticum; MRP, multidrug resistance protein; Fibroblast; Membrane transporter; DMSO, dimethyl-sulphoxide