Substrate stiffness modulates the viscoelastic properties of MCF-7 cells
Cells sense stiffness of surrounding tissues and adapt their activity, proliferation, motility and mechanical properties based on such interactions. Cells probe the stiffness of the substrate by anchoring and pulling to their surroundings, transmitting force to the extracellular matrix and other cel...
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| Published in | Journal of the mechanical behavior of biomedical materials Vol. 125; p. 104979 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Ltd
01.01.2022
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1751-6161 1878-0180 1878-0180 |
| DOI | 10.1016/j.jmbbm.2021.104979 |
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| Abstract | Cells sense stiffness of surrounding tissues and adapt their activity, proliferation, motility and mechanical properties based on such interactions. Cells probe the stiffness of the substrate by anchoring and pulling to their surroundings, transmitting force to the extracellular matrix and other cells, and respond to the resistance they sense, mainly through changes in their cytoskeleton. Cancer and other diseases alter stiffness of tissues, and the response of cancer cells to this stiffness can also be affected. In the present study we show that MCF-7 breast cancer cells seeded on polyacrylamide gels have the ability to detect the stiffness of the substrate and alter their mechanical properties in response. MCF-7 cells plated on soft substrates display lower stiffness and viscosity when compared to those seeded on stiffer gels or glass. These differences can be associated with differences in the morphology and cytoskeleton organisation, since cells seeded on soft substrates have a round morphology, while cells seeded on stiffer substrates acquire a flat and spread morphology with formation of actin filaments, similar to that observed when seeded on glass. These findings show that MCF-7 cells can detect the stiffness of the surrounding microenvironment and thus, modify their mechanical properties. |
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| AbstractList | Cells sense stiffness of surrounding tissues and adapt their activity, proliferation, motility and mechanical properties based on such interactions. Cells probe the stiffness of the substrate by anchoring and pulling to their surroundings, transmitting force to the extracellular matrix and other cells, and respond to the resistance they sense, mainly through changes in their cytoskeleton. Cancer and other diseases alter stiffness of tissues, and the response of cancer cells to this stiffness can also be affected. In the present study we show that MCF-7 breast cancer cells seeded on polyacrylamide gels have the ability to detect the stiffness of the substrate and alter their mechanical properties in response. MCF-7 cells plated on soft substrates display lower stiffness and viscosity when compared to those seeded on stiffer gels or glass. These differences can be associated with differences in the morphology and cytoskeleton organisation, since cells seeded on soft substrates have a round morphology, while cells seeded on stiffer substrates acquire a flat and spread morphology with formation of actin filaments, similar to that observed when seeded on glass. These findings show that MCF-7 cells can detect the stiffness of the surrounding microenvironment and thus, modify their mechanical properties.Cells sense stiffness of surrounding tissues and adapt their activity, proliferation, motility and mechanical properties based on such interactions. Cells probe the stiffness of the substrate by anchoring and pulling to their surroundings, transmitting force to the extracellular matrix and other cells, and respond to the resistance they sense, mainly through changes in their cytoskeleton. Cancer and other diseases alter stiffness of tissues, and the response of cancer cells to this stiffness can also be affected. In the present study we show that MCF-7 breast cancer cells seeded on polyacrylamide gels have the ability to detect the stiffness of the substrate and alter their mechanical properties in response. MCF-7 cells plated on soft substrates display lower stiffness and viscosity when compared to those seeded on stiffer gels or glass. These differences can be associated with differences in the morphology and cytoskeleton organisation, since cells seeded on soft substrates have a round morphology, while cells seeded on stiffer substrates acquire a flat and spread morphology with formation of actin filaments, similar to that observed when seeded on glass. These findings show that MCF-7 cells can detect the stiffness of the surrounding microenvironment and thus, modify their mechanical properties. Cells sense stiffness of surrounding tissues and adapt their activity, proliferation, motility and mechanical properties based on such interactions. Cells probe the stiffness of the substrate by anchoring and pulling to their surroundings, transmitting force to the extracellular matrix and other cells, and respond to the resistance they sense, mainly through changes in their cytoskeleton. Cancer and other diseases alter stiffness of tissues, and the response of cancer cells to this stiffness can also be affected. In the present study we show that MCF-7 breast cancer cells seeded on polyacrylamide gels have the ability to detect the stiffness of the substrate and alter their mechanical properties in response. MCF-7 cells plated on soft substrates display lower stiffness and viscosity when compared to those seeded on stiffer gels or glass. These differences can be associated with differences in the morphology and cytoskeleton organisation, since cells seeded on soft substrates have a round morphology, while cells seeded on stiffer substrates acquire a flat and spread morphology with formation of actin filaments, similar to that observed when seeded on glass. These findings show that MCF-7 cells can detect the stiffness of the surrounding microenvironment and thus, modify their mechanical properties. |
| ArticleNumber | 104979 |
| Author | Vivanco, Maria dM Gil-Redondo, Juan Carlos Zbiral, Barbara Weber, Andreas Toca-Herrera, José L. |
| Author_xml | – sequence: 1 givenname: Juan Carlos orcidid: 0000-0002-4797-7033 surname: Gil-Redondo fullname: Gil-Redondo, Juan Carlos email: juan.gil-redondo@boku.ac.at organization: Institute of Biophysics, Department of Nanobiotechnology, University of Natural Resources and Life Sciences Vienna, Muthgasse 11, 1190, Vienna, Austria – sequence: 2 givenname: Andreas surname: Weber fullname: Weber, Andreas email: andreas.weber@boku.ac.at organization: Institute of Biophysics, Department of Nanobiotechnology, University of Natural Resources and Life Sciences Vienna, Muthgasse 11, 1190, Vienna, Austria – sequence: 3 givenname: Barbara orcidid: 0000-0003-3277-082X surname: Zbiral fullname: Zbiral, Barbara email: barbara.zbiral@boku.ac.at organization: Institute of Biophysics, Department of Nanobiotechnology, University of Natural Resources and Life Sciences Vienna, Muthgasse 11, 1190, Vienna, Austria – sequence: 4 givenname: Maria dM orcidid: 0000-0002-9540-247X surname: Vivanco fullname: Vivanco, Maria dM email: mdmvivanco@cicbiogune.es organization: Cancer Heterogeneity Lab, CIC BioGUNE, Basque Research and Technology Alliance, BRTA, Bizkaia Technology Park, 48160, Derio, Spain – sequence: 5 givenname: José L. orcidid: 0000-0001-8951-2616 surname: Toca-Herrera fullname: Toca-Herrera, José L. email: jose.toca-herrera@boku.ac.at organization: Institute of Biophysics, Department of Nanobiotechnology, University of Natural Resources and Life Sciences Vienna, Muthgasse 11, 1190, Vienna, Austria |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34826769$$D View this record in MEDLINE/PubMed |
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| Keywords | Atomic force microscopy Rheology MCF-7 Substrate stiffness Breast cancer Zener and power law models Stress-relaxation |
| Language | English |
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| SubjectTerms | Atomic force microscopy Breast cancer Humans MCF-7 MCF-7 Cells Rheology Stress-relaxation Substrate stiffness Zener and power law models |
| Title | Substrate stiffness modulates the viscoelastic properties of MCF-7 cells |
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