Time‐Varying Spatial Propagation of Brain Networks in fMRI Data

• Published in: Human brain mapping Vol. 46; no. 2; pp. e70131 - n/a
• Main Authors: Bostami, Biozid, Lewis, Noah, Agcaoglu, Oktay, Turner, Jessica A., Erp, Theo, Ford, Judith M., Fouladivanda, Mahshid, Calhoun, Vince, Iraji, Armin
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.02.2025
• Subjects: Adult; Algorithms; Blood levels; Brain; Brain - diagnostic imaging; Brain - physiopathology; Brain mapping; Brain research; Connectome - methods; Datasets; Default Mode Network - diagnostic imaging; Default Mode Network - physiology; dynamic states; Female; Females; Functional magnetic resonance imaging; Humans; Information flow; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Males; Mental disorders; Nerve Net - diagnostic imaging; Nerve Net - physiology; network propagation; Networks; Neuroimaging; Oxygenation; Propagation; Propagation modes; Quality control; resting‐state fMRI; Schizophrenia; Schizophrenia - diagnostic imaging; Schizophrenia - physiopathology; sliding window; Spatial data; spatial dynamic propagation; Temporal lobe; Time Factors; Visual observation; spatial dynamic propagation; network propagation; sliding window; dynamic states; resting‐state fMRI
• ISSN: 1065-9471; 1097-0193; 1097-0193
• DOI: 10.1002/hbm.70131

ABSTRACT Spontaneous neural activity coherently relays information across the brain. Several efforts have been made to understand how spontaneous neural activity evolves at the macro‐scale level as measured by resting‐state functional magnetic resonance imaging (rsfMRI). Previous studies observe the global patterns and flow of information in rsfMRI using methods such as sliding window or temporal lags. However, to our knowledge, no studies have examined spatial propagation patterns evolving with time across multiple overlapping 4D networks. Here, we propose a novel approach to study how dynamic states of the brain networks spatially propagate and evaluate whether these propagating states contain information relevant to mental illness. We implement a lagged windowed correlation approach to capture voxel‐wise network‐specific spatial propagation patterns in dynamic states. Results show systematic spatial state changes over time, which we confirmed are replicable across multiple scan sessions using human connectome project data. We observe networks varying in propagation speed; for example, the default mode network (DMN) propagates slowly and remains positively correlated with blood oxygenation level‐dependent (BOLD) signal for 6–8 s, whereas the visual network propagates much quicker. We also show that summaries of network‐specific propagative patterns are linked to schizophrenia. More specifically, we find significant group differences in multiple dynamic parameters between patients with schizophrenia and controls within four large‐scale networks: default mode, temporal lobe, subcortical, and visual network. Individuals with schizophrenia spend more time in certain propagating states. In summary, this study introduces a promising general approach to exploring the spatial propagation in dynamic states of brain networks and their associated complexity and reveals novel insights into the neurobiology of schizophrenia. In this work, we proposed a novel methodology for tracking propagation of a specific brain network utilizing lagged, sliding window Pearson correlation to capture voxel‐level network propagation that evolves with time.