A Single Nucleotide Polymorphism in GAS5 lncRNA is Associated with Risk of Bladder Cancer in Iranian Population

Down-regulation of the long non-coding RNA (lncRNA) growth arrest-specific 5 ( GAS5 ) has a pathogenic role in bladder cancer. Moreover, genomic variants of this lncRNA have been associated with risk of diverse cancers. In the present project, we genotyped two putative functional SNPs (rs2067079 and...

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Published inPathology oncology research Vol. 26; no. 2; pp. 1251 - 1254
Main Authors Rakhshan, Azadeh, Esmaeili, Mohammad Hossein, Kahaei, Mir Salar, Taheri, Mohammad, Omrani, Mir Davood, Noroozi, Rezvan, Ghafouri-Fard, Soudeh
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.04.2020
Springer Nature B.V
Subjects
Adult
Aged
Biomedical and Life Sciences
Biomedicine
Bladder cancer
Cancer
Cancer Research
Carcinoma, Transitional Cell - genetics
Case-Control Studies
Female
Genetic Predisposition to Disease - genetics
Genotype
Haplotypes
Health risk assessment
Heredity
Humans
Immunology
Iran
Male
Middle Aged
Non-coding RNA
Oncology
Original Article
Pathology
Polymorphism, Single Nucleotide
RNA, Long Noncoding - genetics
Single-nucleotide polymorphism
Urinary Bladder Neoplasms - genetics
Iran
Bladder cancer
lncRNA
GAS5
Online AccessGet full text
ISSN1219-4956
1532-2807
1532-2807
DOI10.1007/s12253-019-00693-2

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Abstract Down-regulation of the long non-coding RNA (lncRNA) growth arrest-specific 5 ( GAS5 ) has a pathogenic role in bladder cancer. Moreover, genomic variants of this lncRNA have been associated with risk of diverse cancers. In the present project, we genotyped two putative functional SNPs (rs2067079 and rs6790) in 122 bladder cancer patients and 150 age- and sex-matched healthy subjects. The rs2067079 was associated risk of bladder cancer in recessive inheritance model (TT vs.CC + CT: OR (95% Confidence interval (CI)) = 2.67 (1.27–5.62), adjusted P value = 0.02). The T G haplotype (rs2067079 and rs6790) increased the risk of bladder cancer in the assessed population (OR (95% CI) = 1.73 (1.18–2.56), adjusted P value = 0.02). Consequently, in the current project we introduced a novel risk locus for bladder cancer in Iranian population.
AbstractList Down-regulation of the long non-coding RNA (lncRNA) growth arrest-specific 5 (GAS5) has a pathogenic role in bladder cancer. Moreover, genomic variants of this lncRNA have been associated with risk of diverse cancers. In the present project, we genotyped two putative functional SNPs (rs2067079 and rs6790) in 122 bladder cancer patients and 150 age- and sex-matched healthy subjects. The rs2067079 was associated risk of bladder cancer in recessive inheritance model (TT vs.CC + CT: OR (95% Confidence interval (CI)) = 2.67 (1.27-5.62), adjusted P value = 0.02). The T G haplotype (rs2067079 and rs6790) increased the risk of bladder cancer in the assessed population (OR (95% CI) = 1.73 (1.18-2.56), adjusted P value = 0.02). Consequently, in the current project we introduced a novel risk locus for bladder cancer in Iranian population.Down-regulation of the long non-coding RNA (lncRNA) growth arrest-specific 5 (GAS5) has a pathogenic role in bladder cancer. Moreover, genomic variants of this lncRNA have been associated with risk of diverse cancers. In the present project, we genotyped two putative functional SNPs (rs2067079 and rs6790) in 122 bladder cancer patients and 150 age- and sex-matched healthy subjects. The rs2067079 was associated risk of bladder cancer in recessive inheritance model (TT vs.CC + CT: OR (95% Confidence interval (CI)) = 2.67 (1.27-5.62), adjusted P value = 0.02). The T G haplotype (rs2067079 and rs6790) increased the risk of bladder cancer in the assessed population (OR (95% CI) = 1.73 (1.18-2.56), adjusted P value = 0.02). Consequently, in the current project we introduced a novel risk locus for bladder cancer in Iranian population.
Down-regulation of the long non-coding RNA (lncRNA) growth arrest-specific 5 (GAS5) has a pathogenic role in bladder cancer. Moreover, genomic variants of this lncRNA have been associated with risk of diverse cancers. In the present project, we genotyped two putative functional SNPs (rs2067079 and rs6790) in 122 bladder cancer patients and 150 age- and sex-matched healthy subjects. The rs2067079 was associated risk of bladder cancer in recessive inheritance model (TT vs.CC + CT: OR (95% Confidence interval (CI)) = 2.67 (1.27–5.62), adjusted P value = 0.02). The T G haplotype (rs2067079 and rs6790) increased the risk of bladder cancer in the assessed population (OR (95% CI) = 1.73 (1.18–2.56), adjusted P value = 0.02). Consequently, in the current project we introduced a novel risk locus for bladder cancer in Iranian population.
Down-regulation of the long non-coding RNA (lncRNA) growth arrest-specific 5 ( GAS5 ) has a pathogenic role in bladder cancer. Moreover, genomic variants of this lncRNA have been associated with risk of diverse cancers. In the present project, we genotyped two putative functional SNPs (rs2067079 and rs6790) in 122 bladder cancer patients and 150 age- and sex-matched healthy subjects. The rs2067079 was associated risk of bladder cancer in recessive inheritance model (TT vs.CC + CT: OR (95% Confidence interval (CI)) = 2.67 (1.27–5.62), adjusted P value = 0.02). The T G haplotype (rs2067079 and rs6790) increased the risk of bladder cancer in the assessed population (OR (95% CI) = 1.73 (1.18–2.56), adjusted P value = 0.02). Consequently, in the current project we introduced a novel risk locus for bladder cancer in Iranian population.
Author Noroozi, Rezvan
Taheri, Mohammad
Ghafouri-Fard, Soudeh
Omrani, Mir Davood
Rakhshan, Azadeh
Esmaeili, Mohammad Hossein
Kahaei, Mir Salar
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  email: s.ghafourifard@sbmu.ac.ir
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Arányi Lajos Foundation 2019.
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Snippet Down-regulation of the long non-coding RNA (lncRNA) growth arrest-specific 5 ( GAS5 ) has a pathogenic role in bladder cancer. Moreover, genomic variants of...
Down-regulation of the long non-coding RNA (lncRNA) growth arrest-specific 5 (GAS5) has a pathogenic role in bladder cancer. Moreover, genomic variants of this...
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StartPage 1251
SubjectTerms Adult
Aged
Biomedical and Life Sciences
Biomedicine
Bladder cancer
Cancer
Cancer Research
Carcinoma, Transitional Cell - genetics
Case-Control Studies
Female
Genetic Predisposition to Disease - genetics
Genotype
Haplotypes
Health risk assessment
Heredity
Humans
Immunology
Iran
Male
Middle Aged
Non-coding RNA
Oncology
Original Article
Pathology
Polymorphism, Single Nucleotide
RNA, Long Noncoding - genetics
Single-nucleotide polymorphism
Urinary Bladder Neoplasms - genetics
Title A Single Nucleotide Polymorphism in GAS5 lncRNA is Associated with Risk of Bladder Cancer in Iranian Population
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https://www.ncbi.nlm.nih.gov/pubmed/31250374
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https://www.proquest.com/docview/2250638689
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