Correlation of apparent diffusion coefficient and intravoxel incoherent motion imaging parameters with Ki-67 expression in extrahepatic cholangiocarcinoma

• Published in: Magnetic resonance imaging Vol. 63; pp. 80 - 84
• Main Authors: Cui, Xingyu, Chen, Hongwei, Cai, Song, Tang, Qunfeng, Fang, Xiangming
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.11.2019
• Subjects: Adult; Aged; Aged, 80 and over; Algorithms; Bile Duct Neoplasms - diagnostic imaging; Cholangiocarcinoma - diagnostic imaging; Diffusion Magnetic Resonance Imaging; Diffusion-weighted imaging; Extrahepatic cholangiocarcinoma; Female; Humans; Image Processing, Computer-Assisted - methods; Ki-67 antigen; Ki-67 Antigen - metabolism; Male; Middle Aged; Motion; Perfusion; Retrospective Studies; ROC Curve; Diffusion-weighted imaging; Ki-67 antigen; Extrahepatic cholangiocarcinoma
• ISSN: 0730-725X; 1873-5894; 1873-5894
• DOI: 10.1016/j.mri.2019.08.018

To investigate the correlation of magnetic resonance imaging (MRI), apparent diffusion coefficient (ADC) and intravoxel incoherent motion imaging parameters with Ki-67 expression in cholangiocarcinoma. A total of 42 extrahepatic cholangiocarcinoma (EHCC) cases confirmed by surgical pathology were analyzed retrospectively. Subjects underwent MRI at 3.0 T and intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) sequential scanning prior to surgery, and postoperative Ki-67 expression was recorded by immunohistochemistry (IHC). The patients were divided into 4 groups (I–IV) based on increasing Ki-67 expression from − to +++. ADC values and IVIM-DWI parameters were calculated, including true diffusion coefficient (D), perfusion fraction (f), and pseudo-diffusion coefficient (D*). The comparison among groups was analyzed by univariate ANOVA (normal distribution) or Kruskal-Wallis H (non-normal distribution). Spearman correlation analysis was used to analyze the correlation of each parameter with Ki-67 expression. The diagnostic efficiency of each parameter was compared using the area under the curve (AUC) of the receiver operating characteristic (ROC) curve. Except for D*, other values had statistically significant differences between groups (P < 0.05). ADC, D and f values had negative correlations with Ki-67 expression (r values were −0.607, −0.795, −0.531, respectively, P < 0.05). The AUCs were 0.701, 0.880, 0.623, respectively (P < 0.0001). IVIM-DWI technology can reflect the proliferative activity of EHCC cells to a certain extent, and has clinical value for predicting the degree of malignancy of a tumor.