Neural network algorithms predict new diffusion MRI data for multi-compartmental analysis of brain microstructure in a clinical setting

• Published in: Magnetic resonance imaging Vol. 102; pp. 9 - 19
• Main Authors: Murray, Cayden, Oladosu, Olayinka, Joshi, Manish, Kolind, Shannon, Oh, Jiwon, Zhang, Yunyan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.10.2023
• Subjects: Brain microstructure; Convolutional neural network; High angular resolution diffusion imaging; Multilayer perceptron; Neurite orientation dispersion and density imaging; Multilayer perceptron; Brain microstructure; Neurite orientation dispersion and density imaging; High angular resolution diffusion imaging; Convolutional neural network
• ISSN: 0730-725X; 1873-5894; 1873-5894
• DOI: 10.1016/j.mri.2023.03.023

High angular resolution diffusion imaging (HARDI) is a promising method for advanced analysis of brain microstructure. However, comprehensive HARDI analysis requires multiple acquisitions of diffusion images (multi-shell HARDI), which is time consuming and often impractical in clinical settings. This study aimed to establish neural network models that can predict new diffusion datasets from clinically feasible brain diffusion MRI for multi-shell HARDI. The development included 2 algorithms: multi-layer perceptron (MLP) and convolutional neural network (CNN). Both followed a voxel-based approach for model training (70%), validation (15%), and testing (15%). The investigations involved 2 multi-shell HARDI datasets: 1) 11 healthy subjects from the Human Connectome Project (HCP); and 2) 10 local subjects with multiple sclerosis (MS). To assess outcomes, we conducted neurite orientation dispersion and density imaging using both predicted and original data and compared their orientation dispersion index (ODI) and neurite density index (NDI) in different brain tissues with 2 measures: peak signal-to-noise ratio (PSNR) and structural similarity index measure (SSIM). Results showed that both models achieved robust predictions, which provided competitive ODI and NDI, especially in brain white matter. The CNN outperformed MLP with the HCP data on both PSNR (p < 0.001) and SSIM (p < 0.01). With the MS data, the models performed similarly. Overall, the optimized neural networks can help generate non-acquired brain diffusion MRI, which will make advanced HARDI analysis possible in clinical practice following further validation. Enabling detailed characterization of brain microstructure will allow enhanced understanding of brain function in both health and disease.