ROS-induced biodegradable polythioketal nanoparticles for intracellular delivery of anti-cancer therapeutics
This study introduces biodegradable poly(1,4-phenyleneacetone dimethylene thioketal) (PPADT) nanoparticles as an intracellular delivery carrier for anti-cancer therapeutic applications. PPADT is synthesized through condensation polymerization of 2,2-dimethoxypropane and 1,4-benzenedimethanethiol. Th...
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| Published in | Journal of industrial and engineering chemistry (Seoul, Korea) Vol. 21; pp. 1137 - 1142 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier B.V
25.01.2015
한국공업화학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1226-086X 1876-794X |
| DOI | 10.1016/j.jiec.2014.05.026 |
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| Abstract | This study introduces biodegradable poly(1,4-phenyleneacetone dimethylene thioketal) (PPADT) nanoparticles as an intracellular delivery carrier for anti-cancer therapeutic applications. PPADT is synthesized through condensation polymerization of 2,2-dimethoxypropane and 1,4-benzenedimethanethiol. The synthesized PPADT is used to prepare polymeric nanoparticles encapsulated with Nile red or paclitaxel. The presence of reactive oxygen species (ROS) facilitates the polymer degradation via breakage of the thioketal bonds, resulting in disruption of the nanoparticle structure and release of the encapsulated molecules. Therapeutic effects of the paclitaxel-loaded PPADT nanoparticles are demonstrated using PC-3 prostate cancer cells, while no significant cytotoxic effects of placebo PPADT nanoparticles are observed. Our study suggests that ROS-sensitive biodegradable PPADT nanoparticles can be a new promising material for intracellular drug delivery of insoluble drugs. |
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| AbstractList | This study introduces biodegradable poly(1,4-phenyleneacetone dimethylene thioketal) (PPADT) nanoparticles as an intracellular delivery carrier for anti-cancer therapeutic applications. PPADT is synthesized through condensation polymerization of 2,2-dimethoxypropane and 1,4-benzenedimethanethiol. The synthesized PPADT is used to prepare polymeric nanoparticles encapsulated with Nile red or paclitaxel. The presence of reactive oxygen species (ROS) facilitates the polymer degradation via breakage of the thioketal bonds, resulting in disruption of the nanoparticle structure and release of the encapsulated molecules. Therapeutic effects of the paclitaxel-loaded PPADT nanoparticles are demonstrated using PC-3 prostate cancer cells, while no significant cytotoxic effects of placebo PPADT nanoparticles are observed. Our study suggests that ROS-sensitive biodegradable PPADT nanoparticles can be a new promising material for intracellular drug delivery of insoluble drugs. This study introduces biodegradable poly(1,4-phenyleneacetone dimethylene thioketal) (PPADT)nanoparticles as an intracellular delivery carrier for anti-cancer therapeutic applications. PPADT issynthesized through condensation polymerization of 2,2-dimethoxypropane and 1,4-benzenedimethanethiol. The synthesized PPADT is used to prepare polymeric nanoparticles encapsulated with Nile red orpaclitaxel. The presence of reactive oxygen species (ROS) facilitates the polymer degradation viabreakage of the thioketal bonds, resulting in disruption of the nanoparticle structure and release of theencapsulated molecules. Therapeutic effects of the paclitaxel-loaded PPADT nanoparticles aredemonstrated using PC-3 prostate cancer cells, while no significant cytotoxic effects of placebo PPADTnanoparticles are observed. Our study suggests that ROS-sensitive biodegradable PPADT nanoparticlescan be a new promising material for intracellular drug delivery of insoluble drugs. KCI Citation Count: 37 |
| Author | Kim, Insu Nam, Yoon Sung Jo, Sung Duk Kim, Jee Seon Seah, Geok Leng |
| Author_xml | – sequence: 1 givenname: Jee Seon surname: Kim fullname: Kim, Jee Seon organization: Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea – sequence: 2 givenname: Sung Duk orcidid: 0000-0001-7651-1067 surname: Jo fullname: Jo, Sung Duk organization: Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea – sequence: 3 givenname: Geok Leng orcidid: 0000-0002-5115-0434 surname: Seah fullname: Seah, Geok Leng organization: Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea – sequence: 4 givenname: Insu surname: Kim fullname: Kim, Insu organization: Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea – sequence: 5 givenname: Yoon Sung surname: Nam fullname: Nam, Yoon Sung email: yoonsung@kaist.ac.kr, yensonn.nam@gmail.com organization: Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea |
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| Cites_doi | 10.1021/ma061357b 10.1016/j.progpolymsci.2011.06.004 10.1002/anie.201209633 10.1016/S0168-3659(98)00050-9 10.1038/nmat2859 10.1163/156856299X00801 10.1016/j.tet.2005.09.154 10.1158/0008-5472.CAN-07-5259 10.1038/nrc2067 10.1002/(SICI)1097-4636(199910)47:1<8::AID-JBM2>3.0.CO;2-L 10.1038/nrc1046 10.1016/0891-5849(89)90066-X 10.1039/c3ra40883c 10.1016/j.progpolymsci.2011.01.001 10.1016/0168-3659(95)00070-O 10.1016/S0168-3659(98)00123-0 10.1016/j.biomaterials.2011.07.063 10.1002/adhm.201200338 10.1016/0142-9612(96)85755-3 10.1016/S0168-3659(01)00442-4 10.1002/adfm.200801838 10.1021/bc200449k 10.1016/S0891-5849(99)00051-9 10.1021/bc8000485 10.1002/1097-0290(20001105)70:3<270::AID-BIT4>3.0.CO;2-8 |
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| Snippet | This study introduces biodegradable poly(1,4-phenyleneacetone dimethylene thioketal) (PPADT) nanoparticles as an intracellular delivery carrier for anti-cancer... This study introduces biodegradable poly(1,4-phenyleneacetone dimethylene thioketal) (PPADT)nanoparticles as an intracellular delivery carrier for anti-cancer... |
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| SubjectTerms | Biodegradable Cancer Nanoparticles Paclitaxel Poly(thioketal) 화학공학 |
| Title | ROS-induced biodegradable polythioketal nanoparticles for intracellular delivery of anti-cancer therapeutics |
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