Pharmacokinetic interactions of almorexant with midazolam and simvastatin, two CYP3A4 model substrates, in healthy male subjects - Hoch, Matthias; Hoever, Petra; Alessi, Federica; Theodor, Rudolf; Dingemanse, Jasper (European journal of clinical pharmacology, 2013)
Keywords: Acetamides - administration & dosage; Acetamides - adverse effects; Acetamides - blood; Acetamides - pharmacokinetics; Administration, Oral; Adult; Analysis of Variance; Area Under Curve; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Biotransformation; Cross-Over Studies; Cytochrome P-450 CYP3A - metabolism; Cytochrome P-450 CYP3A Inhibitors; Drug Administration Schedule; Drug Interactions; Drug therapy; Enzyme Inhibitors - administration & dosage; Enzyme Inhibitors - adverse effects; Enzyme Inhibitors - blood; Enzyme Inhibitors - pharmacokinetics; Germany; Half-Life; Health; Humans; Hydrocortisone - analogs & derivatives; Hydrocortisone - urine; Hydroxylation; Isoquinolines - administration & dosage; Isoquinolines - adverse effects; Isoquinolines - blood; Isoquinolines - pharmacokinetics; Kinetics; Male; Males; Medical sciences; Metabolic Clearance Rate; Midazolam - administration & dosage; Midazolam - adverse effects; Midazolam - blood; Midazolam - pharmacokinetics; Middle Aged; Pharmacokinetics and Disposition; Pharmacology; Pharmacology. Drug treatments; Pharmacology/Toxicology; Simvastatin - administration & dosage; Simvastatin - adverse effects; Simvastatin - blood; Simvastatin - pharmacokinetics; Substrate Specificity; Substrates; Young Adult; Orexin receptor antagonist; Midazolam; CYP3A4; Simvastatin; Orexin; Almorexant; Cytochrome CYP3A4; Isozyme; Psychotropic; Orexin receptor; Hypocholesterolemic agent; Neuropeptide; HMG-CoA reductase inhibitor; Benzodiazepine derivatives; Antagonist; Sedative; Human; Isoquinoline derivatives; Healthy subject; Enzyme; Cytochrome P450; Interaction; Enzyme inhibitor; Hypnotic; Statin derivative; Substrate; Hydroxymethylglutaryl-CoA reductase; Models; Oxidoreductases; Pharmacokinetics; Antilipemic agent