Statins are associated with reduced risk of gastric cancer: A meta-analysis

Background Statins are widely prescribed to reduce cholesterol levels in the prevention of atherosclerotic cardiovascular disease. However, the debate about the effect of statins on cancer risk remains unsettled. The aim of this study was to investigate the association of utilization of statins with...

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Published inEuropean journal of clinical pharmacology Vol. 69; no. 10; pp. 1855 - 1860
Main Authors Wu, Xiao-Dan, Zeng, Kai, Xue, Fang-Qin, Chen, Jin-Hua, Chen, Yan-Qing
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2013
Springer
Springer Nature B.V
Subjects
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Drug Utilization - statistics & numerical data
Drug Utilization - trends
Gastric cancer
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Medical sciences
Meta-analysis
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Observational Studies as Topic
Pharmacoepidemiology and Prescription
Pharmacology
Pharmacology. Drug treatments
Pharmacology/Toxicology
Randomized Controlled Trials as Topic
Risk
Statins
Stomach Neoplasms - epidemiology
Stomach Neoplasms - prevention & control
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
Gastric cancer
Statin
Meta-analysis
Human
Statin derivative
Malignant tumor
Stomach cancer
Metaanalysis
Risk factor
Digestive diseases
Cancer
Gastric disease
Antilipemic agent
Online AccessGet full text
ISSN0031-6970
1432-1041
1432-1041
DOI10.1007/s00228-013-1547-z

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Abstract Background Statins are widely prescribed to reduce cholesterol levels in the prevention of atherosclerotic cardiovascular disease. However, the debate about the effect of statins on cancer risk remains unsettled. The aim of this study was to investigate the association of utilization of statins with the risk of gastric cancer by carrying out a meta-analysis. Methods A literature search was performed on PubMed and EMBASE up to March 2013 to identify the cohort or case–control studies or randomized controlled trials (RCTs) that examined the relationship between statins use and the risk of gastric cancer. The bibliographies of the retrieved articles were also reviewed to identify additional studies. A random-effects model was used to calculate the summary relative risks (RRs) with 95 % confidence intervals (CIs). Results Three post-hoc analyses of 26 RCTs involving 290 gastric cancers and eight observational studies totaling 7,321 gastric cancers were included. Statins use was shown to be significantly associated with a 27 % reduction in the risk of gastric cancer (RR = 0.73, 95 % CI = 0.58–0.93), with considerable heterogeneity among studies ( I 2  = 88.9 %). Excluding one study in which all subjects are diabetic patients obtained an attenuated, but homogeneous result (RR = 0.85, 95 % CI = 0.80–0.91, I 2  = 0.0 %). These findings were consistent in the subgroup analysis. Conclusion A meta-analysis of existing evidence, primarily from observational studies, indicates that use of statins reduces the risk of gastric cancer.
AbstractList Statins are widely prescribed to reduce cholesterol levels in the prevention of atherosclerotic cardiovascular disease. However, the debate about the effect of statins on cancer risk remains unsettled. The aim of this study was to investigate the association of utilization of statins with the risk of gastric cancer by carrying out a meta-analysis. A literature search was performed on PubMed and EMBASE up to March 2013 to identify the cohort or case-control studies or randomized controlled trials (RCTs) that examined the relationship between statins use and the risk of gastric cancer. The bibliographies of the retrieved articles were also reviewed to identify additional studies. A random-effects model was used to calculate the summary relative risks (RRs) with 95 % confidence intervals (CIs). Three post-hoc analyses of 26 RCTs involving 290 gastric cancers and eight observational studies totaling 7,321 gastric cancers were included. Statins use was shown to be significantly associated with a 27 % reduction in the risk of gastric cancer (RR=0.73, 95 % CI=0.58-0.93), with considerable heterogeneity among studies (I ^sup 2^=88.9 %). Excluding one study in which all subjects are diabetic patients obtained an attenuated, but homogeneous result (RR=0.85, 95 % CI=0.80-0.91, I ^sup 2^=0.0 %). These findings were consistent in the subgroup analysis. A meta-analysis of existing evidence, primarily from observational studies, indicates that use of statins reduces the risk of gastric cancer.[PUBLICATION ABSTRACT]
Statins are widely prescribed to reduce cholesterol levels in the prevention of atherosclerotic cardiovascular disease. However, the debate about the effect of statins on cancer risk remains unsettled. The aim of this study was to investigate the association of utilization of statins with the risk of gastric cancer by carrying out a meta-analysis. A literature search was performed on PubMed and EMBASE up to March 2013 to identify the cohort or case-control studies or randomized controlled trials (RCTs) that examined the relationship between statins use and the risk of gastric cancer. The bibliographies of the retrieved articles were also reviewed to identify additional studies. A random-effects model was used to calculate the summary relative risks (RRs) with 95 % confidence intervals (CIs). Three post-hoc analyses of 26 RCTs involving 290 gastric cancers and eight observational studies totaling 7,321 gastric cancers were included. Statins use was shown to be significantly associated with a 27 % reduction in the risk of gastric cancer (RR = 0.73, 95 % CI = 0.58-0.93), with considerable heterogeneity among studies (I (2) = 88.9 %). Excluding one study in which all subjects are diabetic patients obtained an attenuated, but homogeneous result (RR = 0.85, 95 % CI = 0.80-0.91, I (2) = 0.0 %). These findings were consistent in the subgroup analysis. A meta-analysis of existing evidence, primarily from observational studies, indicates that use of statins reduces the risk of gastric cancer.
Background Statins are widely prescribed to reduce cholesterol levels in the prevention of atherosclerotic cardiovascular disease. However, the debate about the effect of statins on cancer risk remains unsettled. The aim of this study was to investigate the association of utilization of statins with the risk of gastric cancer by carrying out a meta-analysis. Methods A literature search was performed on PubMed and EMBASE up to March 2013 to identify the cohort or case–control studies or randomized controlled trials (RCTs) that examined the relationship between statins use and the risk of gastric cancer. The bibliographies of the retrieved articles were also reviewed to identify additional studies. A random-effects model was used to calculate the summary relative risks (RRs) with 95 % confidence intervals (CIs). Results Three post-hoc analyses of 26 RCTs involving 290 gastric cancers and eight observational studies totaling 7,321 gastric cancers were included. Statins use was shown to be significantly associated with a 27 % reduction in the risk of gastric cancer (RR = 0.73, 95 % CI = 0.58–0.93), with considerable heterogeneity among studies ( I 2  = 88.9 %). Excluding one study in which all subjects are diabetic patients obtained an attenuated, but homogeneous result (RR = 0.85, 95 % CI = 0.80–0.91, I 2  = 0.0 %). These findings were consistent in the subgroup analysis. Conclusion A meta-analysis of existing evidence, primarily from observational studies, indicates that use of statins reduces the risk of gastric cancer.
Statins are widely prescribed to reduce cholesterol levels in the prevention of atherosclerotic cardiovascular disease. However, the debate about the effect of statins on cancer risk remains unsettled. The aim of this study was to investigate the association of utilization of statins with the risk of gastric cancer by carrying out a meta-analysis.BACKGROUNDStatins are widely prescribed to reduce cholesterol levels in the prevention of atherosclerotic cardiovascular disease. However, the debate about the effect of statins on cancer risk remains unsettled. The aim of this study was to investigate the association of utilization of statins with the risk of gastric cancer by carrying out a meta-analysis.A literature search was performed on PubMed and EMBASE up to March 2013 to identify the cohort or case-control studies or randomized controlled trials (RCTs) that examined the relationship between statins use and the risk of gastric cancer. The bibliographies of the retrieved articles were also reviewed to identify additional studies. A random-effects model was used to calculate the summary relative risks (RRs) with 95 % confidence intervals (CIs).METHODSA literature search was performed on PubMed and EMBASE up to March 2013 to identify the cohort or case-control studies or randomized controlled trials (RCTs) that examined the relationship between statins use and the risk of gastric cancer. The bibliographies of the retrieved articles were also reviewed to identify additional studies. A random-effects model was used to calculate the summary relative risks (RRs) with 95 % confidence intervals (CIs).Three post-hoc analyses of 26 RCTs involving 290 gastric cancers and eight observational studies totaling 7,321 gastric cancers were included. Statins use was shown to be significantly associated with a 27 % reduction in the risk of gastric cancer (RR = 0.73, 95 % CI = 0.58-0.93), with considerable heterogeneity among studies (I (2) = 88.9 %). Excluding one study in which all subjects are diabetic patients obtained an attenuated, but homogeneous result (RR = 0.85, 95 % CI = 0.80-0.91, I (2) = 0.0 %). These findings were consistent in the subgroup analysis.RESULTSThree post-hoc analyses of 26 RCTs involving 290 gastric cancers and eight observational studies totaling 7,321 gastric cancers were included. Statins use was shown to be significantly associated with a 27 % reduction in the risk of gastric cancer (RR = 0.73, 95 % CI = 0.58-0.93), with considerable heterogeneity among studies (I (2) = 88.9 %). Excluding one study in which all subjects are diabetic patients obtained an attenuated, but homogeneous result (RR = 0.85, 95 % CI = 0.80-0.91, I (2) = 0.0 %). These findings were consistent in the subgroup analysis.A meta-analysis of existing evidence, primarily from observational studies, indicates that use of statins reduces the risk of gastric cancer.CONCLUSIONA meta-analysis of existing evidence, primarily from observational studies, indicates that use of statins reduces the risk of gastric cancer.
Author Chen, Jin-Hua
Zeng, Kai
Wu, Xiao-Dan
Chen, Yan-Qing
Xue, Fang-Qin
Author_xml – sequence: 1
  givenname: Xiao-Dan
  surname: Wu
  fullname: Wu, Xiao-Dan
  organization: Department of Anesthesiology, Fujian Provincial Hospital, Fujian Provincial Clinical Medical College, Fujian Medical University
– sequence: 2
  givenname: Kai
  surname: Zeng
  fullname: Zeng, Kai
  organization: Department of Anesthesiology, The First Affiliated Hospital, Fujian Medical University
– sequence: 3
  givenname: Fang-Qin
  surname: Xue
  fullname: Xue, Fang-Qin
  organization: Department of Oncology, Fujian Provincial Hospital, Fujian Provincial Clinical Medical College, Fujian Medical University
– sequence: 4
  givenname: Jin-Hua
  surname: Chen
  fullname: Chen, Jin-Hua
  organization: Department of Statistics, Fuzhou General Hospital of Nanjing Military Region
– sequence: 5
  givenname: Yan-Qing
  surname: Chen
  fullname: Chen, Yan-Qing
  email: chenyq_fj@126.com
  organization: Department of Anesthesiology, Fujian Provincial Hospital, Fujian Provincial Clinical Medical College, Fujian Medical University
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1432-1041
IngestDate Fri Sep 05 11:19:18 EDT 2025
Tue Oct 07 05:32:41 EDT 2025
Wed Feb 19 01:54:20 EST 2025
Wed Apr 02 07:25:23 EDT 2025
Wed Oct 01 02:24:51 EDT 2025
Thu Apr 24 23:03:29 EDT 2025
Fri Feb 21 02:34:24 EST 2025
IsPeerReviewed true
IsScholarly true
Issue 10
Keywords Gastric cancer
Statin
Meta-analysis
Human
Statin derivative
Malignant tumor
Stomach cancer
Metaanalysis
Risk factor
Digestive diseases
Cancer
Gastric disease
Antilipemic agent
Language English
License http://www.springer.com/tdm
CC BY 4.0
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Snippet Background Statins are widely prescribed to reduce cholesterol levels in the prevention of atherosclerotic cardiovascular disease. However, the debate about...
Statins are widely prescribed to reduce cholesterol levels in the prevention of atherosclerotic cardiovascular disease. However, the debate about the effect of...
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SubjectTerms Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Drug Utilization - statistics & numerical data
Drug Utilization - trends
Gastric cancer
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Medical sciences
Meta-analysis
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Observational Studies as Topic
Pharmacoepidemiology and Prescription
Pharmacology
Pharmacology. Drug treatments
Pharmacology/Toxicology
Randomized Controlled Trials as Topic
Risk
Statins
Stomach Neoplasms - epidemiology
Stomach Neoplasms - prevention & control
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Title Statins are associated with reduced risk of gastric cancer: A meta-analysis
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