Extraction, characterization of xylan from Azadirachta indica (neem) sawdust and production of antiproliferative xylooligosaccharides

Xylan extracted from neem sawdust gave 22.5%, (w/w) yield. The extracted xylan was composed of xylose and glucuronic acid at a molar ratio of 8:1 and with a molecular mass, ~66 kDa. FTIR and NMR analyses indicated a backbone of xylan substituted with 4-O-methyl glucuronic acid at the O-2 position. F...

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Published inInternational journal of biological macromolecules Vol. 163; pp. 1897 - 1907
Main Authors Sharma, Kedar, Morla, Sudhir, Khaire, Kaustubh Chandrakant, Thakur, Abhijeet, Moholkar, Vijayanand Suryakant, Kumar, Sachin, Goyal, Arun
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 15.11.2020
Subjects
apoptosis
Azadirachta - chemistry
Azadirachta indica
biocompatibility
cell growth
Cell Proliferation - drug effects
colorectal neoplasms
Colorectal Neoplasms - drug therapy
denaturation
DNA
DSC
fibroblasts
flow cytometry
glucuronic acid
Glucuronoxylan
HT29 Cells
Human colorectal cancer (HT-29) cells
Humans
Hydrolysis
membrane potential
mice
mitochondrial membrane
molecular weight
MTT
Neem
NMR
Oligosaccharides - chemistry
Oligosaccharides - isolation & purification
Oligosaccharides - pharmacology
polymerization
sawdust
thermogravimetry
Wood - chemistry
xylan
Xylans - chemistry
Xylans - isolation & purification
Xylans - pharmacology
xylooligosaccharides
xylose
Xylose - chemistry
NMR
Glucuronoxylan
Neem
MTT
DSC
Human colorectal cancer (HT-29) cells
Online AccessGet full text
ISSN0141-8130
1879-0003
1879-0003
DOI10.1016/j.ijbiomac.2020.09.086

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Abstract Xylan extracted from neem sawdust gave 22.5%, (w/w) yield. The extracted xylan was composed of xylose and glucuronic acid at a molar ratio of 8:1 and with a molecular mass, ~66 kDa. FTIR and NMR analyses indicated a backbone of xylan substituted with 4-O-methyl glucuronic acid at the O-2 position. FESEM analysis showed a highly porous and granular surface structure of xylan. A thermogravimetric study of xylan showed thermal denaturation at 271 °C. The hydrolysis of xylan by recombinant endo-β-1,4-xylanase produced a mixture of xylooligosaccharides ranging from degree of polymerization 2–7. Xylooligosaccharides inhibited cell growth of human colorectal cancer (HT-29) cells but did not affect the mouse fibroblast cells confirming its biocompatibility. Western blotting, DNA laddering and flow cytometric analysis displayed inhibition of HT-29 cells by xylooligosaccharides. FLICA staining and mitochondrial membrane potential analyses confirmed the activation of the intrinsic pathway of apoptosis. The study amply indicated that the xylooligosaccharides produced from neem xylan could be potentially used as an antiproliferative agent.
AbstractList Xylan extracted from neem sawdust gave 22.5%, (w/w) yield. The extracted xylan was composed of xylose and glucuronic acid at a molar ratio of 8:1 and with a molecular mass, ~66 kDa. FTIR and NMR analyses indicated a backbone of xylan substituted with 4-O-methyl glucuronic acid at the O-2 position. FESEM analysis showed a highly porous and granular surface structure of xylan. A thermogravimetric study of xylan showed thermal denaturation at 271 °C. The hydrolysis of xylan by recombinant endo-β-1,4-xylanase produced a mixture of xylooligosaccharides ranging from degree of polymerization 2-7. Xylooligosaccharides inhibited cell growth of human colorectal cancer (HT-29) cells but did not affect the mouse fibroblast cells confirming its biocompatibility. Western blotting, DNA laddering and flow cytometric analysis displayed inhibition of HT-29 cells by xylooligosaccharides. FLICA staining and mitochondrial membrane potential analyses confirmed the activation of the intrinsic pathway of apoptosis. The study amply indicated that the xylooligosaccharides produced from neem xylan could be potentially used as an antiproliferative agent.
Xylan extracted from neem sawdust gave 22.5%, (w/w) yield. The extracted xylan was composed of xylose and glucuronic acid at a molar ratio of 8:1 and with a molecular mass, ~66 kDa. FTIR and NMR analyses indicated a backbone of xylan substituted with 4-O-methyl glucuronic acid at the O-2 position. FESEM analysis showed a highly porous and granular surface structure of xylan. A thermogravimetric study of xylan showed thermal denaturation at 271 °C. The hydrolysis of xylan by recombinant endo-β-1,4-xylanase produced a mixture of xylooligosaccharides ranging from degree of polymerization 2-7. Xylooligosaccharides inhibited cell growth of human colorectal cancer (HT-29) cells but did not affect the mouse fibroblast cells confirming its biocompatibility. Western blotting, DNA laddering and flow cytometric analysis displayed inhibition of HT-29 cells by xylooligosaccharides. FLICA staining and mitochondrial membrane potential analyses confirmed the activation of the intrinsic pathway of apoptosis. The study amply indicated that the xylooligosaccharides produced from neem xylan could be potentially used as an antiproliferative agent.Xylan extracted from neem sawdust gave 22.5%, (w/w) yield. The extracted xylan was composed of xylose and glucuronic acid at a molar ratio of 8:1 and with a molecular mass, ~66 kDa. FTIR and NMR analyses indicated a backbone of xylan substituted with 4-O-methyl glucuronic acid at the O-2 position. FESEM analysis showed a highly porous and granular surface structure of xylan. A thermogravimetric study of xylan showed thermal denaturation at 271 °C. The hydrolysis of xylan by recombinant endo-β-1,4-xylanase produced a mixture of xylooligosaccharides ranging from degree of polymerization 2-7. Xylooligosaccharides inhibited cell growth of human colorectal cancer (HT-29) cells but did not affect the mouse fibroblast cells confirming its biocompatibility. Western blotting, DNA laddering and flow cytometric analysis displayed inhibition of HT-29 cells by xylooligosaccharides. FLICA staining and mitochondrial membrane potential analyses confirmed the activation of the intrinsic pathway of apoptosis. The study amply indicated that the xylooligosaccharides produced from neem xylan could be potentially used as an antiproliferative agent.
Xylan extracted from neem sawdust gave 22.5%, (w/w) yield. The extracted xylan was composed of xylose and glucuronic acid at a molar ratio of 8:1 and with a molecular mass, ~66 kDa. FTIR and NMR analyses indicated a backbone of xylan substituted with 4-O-methyl glucuronic acid at the O-2 position. FESEM analysis showed a highly porous and granular surface structure of xylan. A thermogravimetric study of xylan showed thermal denaturation at 271 °C. The hydrolysis of xylan by recombinant endo-β-1,4-xylanase produced a mixture of xylooligosaccharides ranging from degree of polymerization 2–7. Xylooligosaccharides inhibited cell growth of human colorectal cancer (HT-29) cells but did not affect the mouse fibroblast cells confirming its biocompatibility. Western blotting, DNA laddering and flow cytometric analysis displayed inhibition of HT-29 cells by xylooligosaccharides. FLICA staining and mitochondrial membrane potential analyses confirmed the activation of the intrinsic pathway of apoptosis. The study amply indicated that the xylooligosaccharides produced from neem xylan could be potentially used as an antiproliferative agent.
Author Goyal, Arun
Kumar, Sachin
Morla, Sudhir
Sharma, Kedar
Thakur, Abhijeet
Moholkar, Vijayanand Suryakant
Khaire, Kaustubh Chandrakant
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– sequence: 2
  givenname: Sudhir
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  givenname: Kaustubh Chandrakant
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  fullname: Goyal, Arun
  email: arungoyl@iitg.ac.in
  organization: Carbohydrate Enzyme Biotechnology Laboratory, Indian Institute of Technology Guwahati, Guwahati, 781039, Assam, India
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32946939$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1021/np800207g
10.1038/nprot.2006.238
10.1016/j.carbpol.2012.11.052
10.1016/j.ijbiomac.2017.10.014
10.1155/2016/7382506
10.1007/s13197-014-1664-4
10.1371/journal.pone.0122374
10.1016/j.biortech.2010.01.137
10.1016/j.carbpol.2016.09.041
10.1016/0022-1759(83)90303-4
10.1016/j.foodchem.2013.11.091
10.1021/np060354p
10.1016/j.carbpol.2012.01.010
10.1016/j.jcs.2017.03.032
10.1016/j.carres.2010.01.014
10.1021/ac60111a017
10.1016/j.ijbiomac.2013.09.043
10.1016/j.carres.2005.01.039
10.1016/S0144-8617(03)00144-9
10.1016/j.carbpol.2012.12.013
10.1016/j.carbpol.2016.12.046
10.1016/S0141-0229(97)00105-1
10.7314/APJCP.2015.16.13.5265
10.1016/j.procbio.2018.03.025
10.1002/polc.5070110120
10.1016/0922-3371(90)90133-H
10.1016/j.indcrop.2017.03.017
10.1016/j.carbpol.2006.10.016
10.3923/jbs.2014.110.123
10.1038/s41598-019-47244-y
10.1016/j.carbpol.2018.05.088
10.1021/jf050755v
10.1016/j.carbpol.2016.01.022
10.1016/S0144-8617(00)00151-X
10.1016/S0141-8130(01)00186-6
10.2174/1568011053174828
10.1016/j.carbpol.2014.12.066
10.1016/j.carbpol.2016.03.036
10.1016/j.ijbiomac.2013.10.037
10.1016/j.carbpol.2014.02.039
10.1016/j.carbpol.2019.01.073
10.3389/fimmu.2018.01504
10.1016/j.bbagen.2015.07.003
10.1016/j.freeradbiomed.2003.08.022
10.1016/j.lfs.2010.09.026
10.1007/s13205-013-0159-8
10.1016/j.biortech.2011.03.012
10.1021/acsomega.0c00896
10.1016/j.carbpol.2012.10.052
10.1016/j.fbp.2019.06.012
10.1248/bpb1978.6.668
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Keywords NMR
Glucuronoxylan
Neem
MTT
DSC
Human colorectal cancer (HT-29) cells
Language English
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References Bendahou, Dufresne, Kaddami, Habibi (bb0060) 2007; 68
Dubois, Gilles, Hamilton, Rebers, Smith (bb0135) 1956; 28
Ordaz-Ortiz, Devaux, Saulnier (bb0070) 2005; 53
Zhang, Yu, Li, Mu, Peng, Wang (bb0160) 2016; 141
Prashanth, Shruthi, Muralikrishna (bb0090) 2015; 52
Alzohairy (bb0100) 2016; 2016
Melo-Silveira, Viana, Sabry, da Silva, Machado, Nascimento, Scortecci, Ferreira-Halder, Sassaki, Rocha (bb0030) 2019; 210
Cesaretti, Luppi, Maccari, Volpi (bb0125) 2003; 54
Theerakittayakorn, Bunprasert (bb0255) 2011; 50
Habibi, Vignon (bb0230) 2005; 340
Biely, Malovíková, Hirsch, Krogh, Ebringerová (bb0210) 2015; 1850
Delphi, Sepehri, Khorramizadeh, Mansoori (bb0275) 2015; 16
Palaniappan, Yuvaraj, Sonaimuthu, Antony (bb0240) 2017; 75
Konduri, Fatehi (bb0180) 2016; 146
Gutmann, Timell (bb0185) 1965
Banerjee, Patti, Ranganathan, Arora (bb0200) 2019; 117
Sharma, Rajulapati, Goyal (bb0120) 2019; 11
Deumaga, Jacquet, Vanderghem, Aguedo, Thomas, Gerin, Deleu, Richel (bb0250) 2018
Shukla, Goyal (bb0020) 2013; 62
Tiwari, Verma, Chakraborty, Dhama, Singh (bb0105) 2014; 14
Sun, Wen, Xu, Sun (bb0155) 2011; 102
Das, Maiti, Maiti, Islam (bb0085) 2013; 92
Kacurakova, Capek, Sasinkova, Wellner, Ebringerova (bb0225) 2000; 43
Bian, Peng, Peng, Xu, Sun (bb0205) 2010; 345
Zhao, Tong, Li, Lu, Ren, Zhang, Deng, Chen, Wu (bb0170) 2017; 156
Singh, Bhuyan, Banerjee, Muir, Arora (bb0195) 2017; 102
Ebringerova, Kardošová, Hromadkova, Malovı́ková, Hříbalová (bb0035) 2002; 30
Rowley, Decker, Michener, Black (bb0115) 2013; 3
Lin, Xia, Yang, Gao, Huo, Lou (bb0050) 2013; 92
Zilliox, Debeire (bb0110) 1998; 22
Shi, Dong, Ding (bb0190) 2014; 152
Mosmann (bb0140) 1983; 65
Kapoor, Dharmesh (bb0045) 2017; 160
Corradini, Baldez, Milessi, Tardioli, Ferreira, de Campos Giordano, de LC Giordano (bb0215) 2018; 197
Sharma, Thakur, Goyal (bb0005) 2019
Subapriya, Nagini (bb0095) 2005; 5
Zhang, Wang, Liu, Zhang, Ren (bb0245) 2017; 7
Hekmati, Ben-Shaul, Polak-Charcon (bb0260) 1990; 31
Gil, Almeida, Oliveira, Rego (bb0265) 2003; 35
Thangam, Sathuvan, Poongodi, Suresh, Pazhanichamy, Sivasubramanian, Kanipandian, Ganesan, Rengasamy, Thirumurugan (bb0270) 2014; 107
Sharma, Khaire, Thakur, Moholkar, Goyal (bb2005) 2020; 5
Sharma, Antunes, Rajulapati, Goyal (bb0130) 2018; 70
Riccardi, Nicoletti (bb0145) 2006; 1
Zhang, Tang, Zhou, Jia, Da Silva, Nguyen, Reutter, Fan (bb0025) 2010; 87
Zhao, Mao, Zhang, Zou, Feng, Gu, Zhu, Mao, Yang, Wu (bb0015) 2014; 63
Li, Sun, Zhou, Peng, Sun (bb0165) 2015; 123
Chang, Lai, Chyan, Yin, Chen, Wei, Yang (bb0055) 2015; 10
Petzold-Welcke, Schwikal, Daus, Heinze (bb0065) 2014; 100
Barbat, Gloaguen, Moine, Sainte-Catherine, Kraemer, Rogniaeux, Ropartz, Krausz (bb0080) 2008; 71
Feng, Yin, Nie, Wan, Xie (bb0175) 2018; 107
Moine, Krausz, Chaleix, Sainte-Catherine, Kraemer, Gloaguen (bb0075) 2007; 70
Morla, Kumar, Kumar (bb0150) 2019; 9
Tan, Chen, Liu, Yang, Li (bb0010) 2018; 9
Oliveira, Silva, Júnior, Gomes, Aguiar, Marcelino, Araújo, Bayer, Ricardo, Oliveira (bb0235) 2010; 101
Hashimoto, Okawa, Suzuki, Okura, Suzuki, Suzuki (bb0040) 1983; 6
Bian, Peng, Peng, Xu, Sun, Kennedy (bb0220) 2012; 88
Bian (10.1016/j.ijbiomac.2020.09.086_bb0220) 2012; 88
Biely (10.1016/j.ijbiomac.2020.09.086_bb0210) 2015; 1850
Habibi (10.1016/j.ijbiomac.2020.09.086_bb0230) 2005; 340
Oliveira (10.1016/j.ijbiomac.2020.09.086_bb0235) 2010; 101
Chang (10.1016/j.ijbiomac.2020.09.086_bb0055) 2015; 10
Kacurakova (10.1016/j.ijbiomac.2020.09.086_bb0225) 2000; 43
Feng (10.1016/j.ijbiomac.2020.09.086_bb0175) 2018; 107
Melo-Silveira (10.1016/j.ijbiomac.2020.09.086_bb0030) 2019; 210
Subapriya (10.1016/j.ijbiomac.2020.09.086_bb0095) 2005; 5
Shi (10.1016/j.ijbiomac.2020.09.086_bb0190) 2014; 152
Lin (10.1016/j.ijbiomac.2020.09.086_bb0050) 2013; 92
Theerakittayakorn (10.1016/j.ijbiomac.2020.09.086_bb0255) 2011; 50
Ebringerova (10.1016/j.ijbiomac.2020.09.086_bb0035) 2002; 30
Zhang (10.1016/j.ijbiomac.2020.09.086_bb0245) 2017; 7
Sun (10.1016/j.ijbiomac.2020.09.086_bb0155) 2011; 102
Deumaga (10.1016/j.ijbiomac.2020.09.086_bb0250) 2018
Konduri (10.1016/j.ijbiomac.2020.09.086_bb0180) 2016; 146
Kapoor (10.1016/j.ijbiomac.2020.09.086_bb0045) 2017; 160
Moine (10.1016/j.ijbiomac.2020.09.086_bb0075) 2007; 70
Das (10.1016/j.ijbiomac.2020.09.086_bb0085) 2013; 92
Tan (10.1016/j.ijbiomac.2020.09.086_bb0010) 2018; 9
Alzohairy (10.1016/j.ijbiomac.2020.09.086_bb0100) 2016; 2016
Dubois (10.1016/j.ijbiomac.2020.09.086_bb0135) 1956; 28
Zhang (10.1016/j.ijbiomac.2020.09.086_bb0025) 2010; 87
Hekmati (10.1016/j.ijbiomac.2020.09.086_bb0260) 1990; 31
Gil (10.1016/j.ijbiomac.2020.09.086_bb0265) 2003; 35
Zhao (10.1016/j.ijbiomac.2020.09.086_bb0015) 2014; 63
Ordaz-Ortiz (10.1016/j.ijbiomac.2020.09.086_bb0070) 2005; 53
Petzold-Welcke (10.1016/j.ijbiomac.2020.09.086_bb0065) 2014; 100
Corradini (10.1016/j.ijbiomac.2020.09.086_bb0215) 2018; 197
Thangam (10.1016/j.ijbiomac.2020.09.086_bb0270) 2014; 107
Sharma (10.1016/j.ijbiomac.2020.09.086_bb0120) 2019; 11
Palaniappan (10.1016/j.ijbiomac.2020.09.086_bb0240) 2017; 75
Tiwari (10.1016/j.ijbiomac.2020.09.086_bb0105) 2014; 14
Rowley (10.1016/j.ijbiomac.2020.09.086_bb0115) 2013; 3
Riccardi (10.1016/j.ijbiomac.2020.09.086_bb0145) 2006; 1
Singh (10.1016/j.ijbiomac.2020.09.086_bb0195) 2017; 102
Shukla (10.1016/j.ijbiomac.2020.09.086_bb0020) 2013; 62
Delphi (10.1016/j.ijbiomac.2020.09.086_bb0275) 2015; 16
Sharma (10.1016/j.ijbiomac.2020.09.086_bb0005) 2019
Zilliox (10.1016/j.ijbiomac.2020.09.086_bb0110) 1998; 22
Sharma (10.1016/j.ijbiomac.2020.09.086_bb0130) 2018; 70
Barbat (10.1016/j.ijbiomac.2020.09.086_bb0080) 2008; 71
Banerjee (10.1016/j.ijbiomac.2020.09.086_bb0200) 2019; 117
Bian (10.1016/j.ijbiomac.2020.09.086_bb0205) 2010; 345
Morla (10.1016/j.ijbiomac.2020.09.086_bb0150) 2019; 9
Zhao (10.1016/j.ijbiomac.2020.09.086_bb0170) 2017; 156
Sharma (10.1016/j.ijbiomac.2020.09.086_bb2005) 2020; 5
Zhang (10.1016/j.ijbiomac.2020.09.086_bb0160) 2016; 141
Prashanth (10.1016/j.ijbiomac.2020.09.086_bb0090) 2015; 52
Cesaretti (10.1016/j.ijbiomac.2020.09.086_bb0125) 2003; 54
Hashimoto (10.1016/j.ijbiomac.2020.09.086_bb0040) 1983; 6
Li (10.1016/j.ijbiomac.2020.09.086_bb0165) 2015; 123
Bendahou (10.1016/j.ijbiomac.2020.09.086_bb0060) 2007; 68
Mosmann (10.1016/j.ijbiomac.2020.09.086_bb0140) 1983; 65
Gutmann (10.1016/j.ijbiomac.2020.09.086_bb0185) 1965
References_xml – start-page: 281
  year: 1965
  end-page: 292
  ident: bb0185
  article-title: The optical rotation of wood xylans
  publication-title: Journal of Polymer Science Part C: Polymer Symposia
– volume: 68
  start-page: 601
  year: 2007
  end-page: 608
  ident: bb0060
  article-title: Isolation and structural characterization of hemicelluloses from palm of
  publication-title: Carbohydr. Polym.
– volume: 71
  start-page: 1404
  year: 2008
  end-page: 1409
  ident: bb0080
  article-title: Structural characterization and cytotoxic properties of a 4-O-methylglucuronoxylan from
  publication-title: J. Nat. Prod.
– volume: 53
  start-page: 8349
  year: 2005
  end-page: 8356
  ident: bb0070
  article-title: Classification of wheat varieties based on structural features of arabinoxylans as revealed by endoxylanase treatment of flour and grain
  publication-title: J. Agric. Food Chem.
– volume: 70
  start-page: 79
  year: 2018
  end-page: 89
  ident: bb0130
  article-title: Molecular characterization of a first endo-acting β-1, 4-xylanase of family 10 glycoside hydrolase (
  publication-title: Process Biochem.
– volume: 107
  start-page: 138
  year: 2014
  end-page: 150
  ident: bb0270
  article-title: Activation of intrinsic apoptotic signaling pathway in cancer cells by
  publication-title: Carbohydr. Polym.
– volume: 146
  start-page: 26
  year: 2016
  end-page: 35
  ident: bb0180
  article-title: Synthesis and characterization of carboxymethylated xylan and its application as a dispersant
  publication-title: Carbohydr. Polym.
– volume: 1850
  start-page: 2246
  year: 2015
  end-page: 2255
  ident: bb0210
  article-title: The role of the glucuronoxylan carboxyl groups in the action of endoxylanases of three glycoside hydrolase families: a study with two substrate mutants
  publication-title: Biochimica et Biophysica Acta (BBA)-General Subjects
– volume: 1
  start-page: 1458
  year: 2006
  ident: bb0145
  article-title: Analysis of apoptosis by propidium iodide staining and flow cytometry
  publication-title: Nat. Protoc.
– volume: 345
  start-page: 802
  year: 2010
  end-page: 809
  ident: bb0205
  article-title: Isolation and fractionation of hemicelluloses by graded ethanol precipitation from
  publication-title: Carbohydr. Res.
– volume: 340
  start-page: 1431
  year: 2005
  end-page: 1436
  ident: bb0230
  article-title: Isolation and characterization of xylans from seed pericarp of Argania spinosa fruit
  publication-title: Carbohydr. Res.
– volume: 35
  start-page: 1500
  year: 2003
  end-page: 1514
  ident: bb0265
  article-title: Cytosolic and mitochondrial ROS in staurosporine-induced retinal cell apoptosis
  publication-title: Free Radic. Biol. Med.
– volume: 92
  start-page: 1243
  year: 2013
  end-page: 1248
  ident: bb0085
  article-title: A new arabinoxylan from green leaves of
  publication-title: Carbohydr. Polym.
– volume: 7
  start-page: 1
  year: 2017
  end-page: 10
  ident: bb0245
  article-title: Synthesis of thermoplastic xylan-lactide copolymer with amidine-mediated organocatalyst in ionic liquid
  publication-title: Sci. Rep.
– volume: 63
  start-page: 114
  year: 2014
  end-page: 118
  ident: bb0015
  article-title: Enhanced antitumor and reduced toxicity effect of Schisanreae polysaccharide in 5-Fu treated Heps-bearing mice
  publication-title: Int. J. Biol. Macromol.
– volume: 75
  start-page: 296
  year: 2017
  end-page: 305
  ident: bb0240
  article-title: Characterization of xylan from rice bran and finger millet seed coat for functional food applications
  publication-title: J. Cereal Sci.
– volume: 102
  start-page: 65
  year: 2017
  end-page: 74
  ident: bb0195
  article-title: Hydrothermal and microwave assisted alkali pretreatment for fractionation of arecanut husk
  publication-title: Ind. Crop. Prod.
– volume: 3
  start-page: 433
  year: 2013
  end-page: 438
  ident: bb0115
  article-title: Efficient extraction of xylan from delignified corn stover using dimethyl sulfoxide
  publication-title: 3 Biotech
– volume: 28
  start-page: 350
  year: 1956
  end-page: 356
  ident: bb0135
  article-title: Colorimetric method for determination of sugars and related substances
  publication-title: Anal. Chem.
– volume: 123
  start-page: 17
  year: 2015
  end-page: 26
  ident: bb0165
  article-title: Structural characterization of hemicelluloses and topochemical changes in Eucalyptus cell wall during alkali ethanol treatment
  publication-title: Carbohydr. Polym.
– volume: 31
  start-page: 207
  year: 1990
  end-page: 218
  ident: bb0260
  article-title: A morphological study of a human adenocarcinoma cell line (HT29) differentiating in culture. Similarities to intestinal embryonic development
  publication-title: Cell Differentiation and Development
– volume: 117
  start-page: 38
  year: 2019
  end-page: 50
  ident: bb0200
  article-title: Hemicellulose based biorefinery from pineapple peel waste: xylan extraction and its conversion into xylooligosaccharides
  publication-title: Food Bioprod. Process.
– volume: 156
  start-page: 333
  year: 2017
  end-page: 339
  ident: bb0170
  article-title: Characterization of hemicelluloses from
  publication-title: Carbohydr. Polym.
– volume: 152
  start-page: 291
  year: 2014
  end-page: 296
  ident: bb0190
  article-title: Structure elucidation and immunomodulatory activity in vitro of a xylan from roots of
  publication-title: Food Chem.
– volume: 5
  start-page: 13729
  year: 2020
  end-page: 13738
  ident: bb2005
  article-title: Acacia xylan as a substitute for commercially available xylan and its application in the production of xylooligosaccharides
  publication-title: ACS Omega
– volume: 2016
  year: 2016
  ident: bb0100
  article-title: Therapeutics role of
  publication-title: Evid. Based Complement. Alternat. Med.
– volume: 141
  start-page: 238
  year: 2016
  end-page: 243
  ident: bb0160
  article-title: Hemicellulose isolation, characterization, and the production of xylo-oligosaccharides from the wastewater of a viscose fiber mill
  publication-title: Carbohydr. Polym.
– volume: 54
  start-page: 59
  year: 2003
  end-page: 61
  ident: bb0125
  article-title: A 96-well assay for uronic acid carbazole reaction
  publication-title: Carbohydr. Polym.
– volume: 10
  year: 2015
  ident: bb0055
  article-title: Specific medicinal plant polysaccharides effectively enhance the potency of a DC-based vaccine against mouse mammary tumor metastasis
  publication-title: PLoS One
– volume: 100
  start-page: 80
  year: 2014
  end-page: 88
  ident: bb0065
  article-title: Xylan derivatives and their application potential–mini-review of own results
  publication-title: Carbohydr. Polym.
– volume: 88
  start-page: 638
  year: 2012
  end-page: 645
  ident: bb0220
  article-title: Isolation of hemicelluloses from sugarcane bagasse at different temperatures: structure and properties
  publication-title: Carbohydr. Polym.
– volume: 6
  start-page: 668
  year: 1983
  end-page: 676
  ident: bb0040
  article-title: Antitumor activity of acidic mannan fraction from bakers'yeast
  publication-title: Journal of Pharmacobio-dynamics
– volume: 197
  start-page: 167
  year: 2018
  end-page: 173
  ident: bb0215
  article-title: Eucalyptus xylan: an in-house-produced substrate for xylanase evaluation to substitute birchwood xylan
  publication-title: Carbohydr. Polym.
– volume: 65
  start-page: 55
  year: 1983
  end-page: 63
  ident: bb0140
  article-title: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
  publication-title: J. Immunol. Methods
– volume: 107
  start-page: 1438
  year: 2018
  end-page: 1446
  ident: bb0175
  article-title: Enzymatic purification and structure characterization of glucuronoxylan from water extract of
  publication-title: Int. J. Biol. Macromol.
– volume: 11
  year: 2019
  ident: bb0120
  article-title: Green synthesis of arabinoxyloglucan coated antimicrobial copper nanoparticles
  publication-title: Trends in Carbohydrate Research
– volume: 101
  start-page: 5402
  year: 2010
  end-page: 5406
  ident: bb0235
  article-title: Xylan from corn cobs, a promising polymer for drug delivery: production and characterization
  publication-title: Bioresour. Technol.
– start-page: 1
  year: 2018
  end-page: 10
  ident: bb0250
  article-title: Fractionation and structural characterization of hemicellulose from steam-exploded banana rachis
  publication-title: Waste and Biomass Valorization
– volume: 9
  start-page: 1504
  year: 2018
  ident: bb0010
  article-title: Pectin oligosaccharides ameliorate colon cancer by regulating oxidative stress-and inflammation-activated signaling pathways
  publication-title: Front. Immunol.
– volume: 52
  start-page: 6049
  year: 2015
  end-page: 6054
  ident: bb0090
  article-title: Immunomodulatory activity of purified arabinoxylans from finger millet (
  publication-title: J. Food Sci. Technol.
– volume: 160
  start-page: 52
  year: 2017
  end-page: 61
  ident: bb0045
  article-title: Pectic oligosaccharide from tomato exhibiting anticancer potential on a gastric cancer cell line: structure-function relationship
  publication-title: Carbohydr. Polym.
– volume: 9
  start-page: 1
  year: 2019
  end-page: 9
  ident: bb0150
  article-title: Newcastle disease virus mediated apoptosis and migration inhibition of human oral cancer cells: a probable role of β-catenin and matrix metalloproteinase-7
  publication-title: Sci. Rep.
– volume: 50
  start-page: 373
  year: 2011
  end-page: 376
  ident: bb0255
  article-title: Differentiation capacity of mouse L929 fibroblastic cell line compare with human dermal fibroblast
  publication-title: World Acad. Sci. Eng. Technol.
– volume: 14
  start-page: 110
  year: 2014
  end-page: 123
  ident: bb0105
  article-title: Neem (
  publication-title: J. Biol. Sci.
– volume: 43
  start-page: 195
  year: 2000
  end-page: 203
  ident: bb0225
  article-title: FT-IR study of plant cell wall model compounds: pectic polysaccharides and hemicelluloses
  publication-title: Carbohydr. Polym.
– volume: 5
  start-page: 149
  year: 2005
  end-page: 156
  ident: bb0095
  article-title: Medicinal properties of neem leaves: a review
  publication-title: Current Medicinal Chemistry-Anti-Cancer Agents
– volume: 62
  start-page: 352
  year: 2013
  end-page: 357
  ident: bb0020
  article-title: Novel dextran from
  publication-title: Int. J. Biol. Macromol.
– volume: 210
  start-page: 245
  year: 2019
  end-page: 253
  ident: bb0030
  article-title: Antiproliferative xylan from corn cobs induces apoptosis in tumor cells
  publication-title: Carbohydr. Polym.
– start-page: 99
  year: 2019
  end-page: 118
  ident: bb0005
  article-title: Xylanases for Food Applications, Green Bio-processes
– volume: 30
  start-page: 1
  year: 2002
  end-page: 6
  ident: bb0035
  article-title: Immunomodulatory activity of acidic xylans in relation to their structural and molecular properties
  publication-title: Int. J. Biol. Macromol.
– volume: 16
  start-page: 5265
  year: 2015
  end-page: 5271
  ident: bb0275
  article-title: Pectic-oligoshaccharides from apples induce apoptosis and cell cycle arrest in MDA-MB-231 cells, a model of human breast cancer
  publication-title: Asian Pac. J. Cancer Prev.
– volume: 87
  start-page: 628
  year: 2010
  end-page: 637
  ident: bb0025
  article-title: GLIS, a bioactive proteoglycan fraction from
  publication-title: Life Sci.
– volume: 92
  start-page: 2212
  year: 2013
  end-page: 2217
  ident: bb0050
  article-title: Anti-ovarian cancer potential of two acidic polysaccharides from the rhizoma of
  publication-title: Carbohydr. Polym.
– volume: 22
  start-page: 58
  year: 1998
  end-page: 63
  ident: bb0110
  article-title: Hydrolysis of wheat straw by a thermostable endoxylanase: adsorption and kinetic studies
  publication-title: Enzym. Microb. Technol.
– volume: 102
  start-page: 5947
  year: 2011
  end-page: 5951
  ident: bb0155
  article-title: Structural and thermal characterization of hemicelluloses isolated by organic solvents and alkaline solutions from
  publication-title: Bioresour. Technol.
– volume: 70
  start-page: 60
  year: 2007
  end-page: 66
  ident: bb0075
  article-title: Structural characterization and cytotoxic properties of a 4-O-methylglucuronoxylan from
  publication-title: J. Nat. Prod.
– volume: 71
  start-page: 1404
  issue: 8
  year: 2008
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0080
  article-title: Structural characterization and cytotoxic properties of a 4-O-methylglucuronoxylan from Castanea sativa. 2. Evidence of a structure-activity relationship
  publication-title: J. Nat. Prod.
  doi: 10.1021/np800207g
– volume: 1
  start-page: 1458
  issue: 3
  year: 2006
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0145
  article-title: Analysis of apoptosis by propidium iodide staining and flow cytometry
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2006.238
– volume: 100
  start-page: 80
  year: 2014
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0065
  article-title: Xylan derivatives and their application potential–mini-review of own results
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2012.11.052
– volume: 107
  start-page: 1438
  year: 2018
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0175
  article-title: Enzymatic purification and structure characterization of glucuronoxylan from water extract of Cassia obtusifolia seeds
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2017.10.014
– volume: 2016
  year: 2016
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0100
  article-title: Therapeutics role of Azadirachta indica (neem) and their active constituents in diseases prevention and treatment
  publication-title: Evid. Based Complement. Alternat. Med.
  doi: 10.1155/2016/7382506
– volume: 52
  start-page: 6049
  issue: 9
  year: 2015
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0090
  article-title: Immunomodulatory activity of purified arabinoxylans from finger millet (Eleusine coracana, v. Indaf 15) bran
  publication-title: J. Food Sci. Technol.
  doi: 10.1007/s13197-014-1664-4
– volume: 10
  issue: 3
  year: 2015
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0055
  article-title: Specific medicinal plant polysaccharides effectively enhance the potency of a DC-based vaccine against mouse mammary tumor metastasis
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0122374
– volume: 101
  start-page: 5402
  issue: 14
  year: 2010
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0235
  article-title: Xylan from corn cobs, a promising polymer for drug delivery: production and characterization
  publication-title: Bioresour. Technol.
  doi: 10.1016/j.biortech.2010.01.137
– volume: 50
  start-page: 373
  year: 2011
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0255
  article-title: Differentiation capacity of mouse L929 fibroblastic cell line compare with human dermal fibroblast
  publication-title: World Acad. Sci. Eng. Technol.
– volume: 156
  start-page: 333
  year: 2017
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0170
  article-title: Characterization of hemicelluloses from Neolamarckia cadamba (Rubiaceae) during xylogenesis
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2016.09.041
– volume: 65
  start-page: 55
  issue: 1–2
  year: 1983
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0140
  article-title: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
  publication-title: J. Immunol. Methods
  doi: 10.1016/0022-1759(83)90303-4
– volume: 152
  start-page: 291
  year: 2014
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0190
  article-title: Structure elucidation and immunomodulatory activity in vitro of a xylan from roots of Cudrania tricuspidata
  publication-title: Food Chem.
  doi: 10.1016/j.foodchem.2013.11.091
– volume: 70
  start-page: 60
  issue: 1
  year: 2007
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0075
  article-title: Structural characterization and cytotoxic properties of a 4-O-methylglucuronoxylan from Castanea sativa
  publication-title: J. Nat. Prod.
  doi: 10.1021/np060354p
– volume: 88
  start-page: 638
  issue: 2
  year: 2012
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0220
  article-title: Isolation of hemicelluloses from sugarcane bagasse at different temperatures: structure and properties
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2012.01.010
– volume: 75
  start-page: 296
  year: 2017
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0240
  article-title: Characterization of xylan from rice bran and finger millet seed coat for functional food applications
  publication-title: J. Cereal Sci.
  doi: 10.1016/j.jcs.2017.03.032
– volume: 345
  start-page: 802
  issue: 6
  year: 2010
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0205
  article-title: Isolation and fractionation of hemicelluloses by graded ethanol precipitation from Caragana korshinskii
  publication-title: Carbohydr. Res.
  doi: 10.1016/j.carres.2010.01.014
– volume: 28
  start-page: 350
  issue: 3
  year: 1956
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0135
  article-title: Colorimetric method for determination of sugars and related substances
  publication-title: Anal. Chem.
  doi: 10.1021/ac60111a017
– volume: 62
  start-page: 352
  year: 2013
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0020
  article-title: Novel dextran from Pediococcus pentosaceus CRAG3 isolated from fermented cucumber with anticancer properties
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2013.09.043
– volume: 340
  start-page: 1431
  issue: 7
  year: 2005
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0230
  article-title: Isolation and characterization of xylans from seed pericarp of Argania spinosa fruit
  publication-title: Carbohydr. Res.
  doi: 10.1016/j.carres.2005.01.039
– volume: 54
  start-page: 59
  issue: 1
  year: 2003
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0125
  article-title: A 96-well assay for uronic acid carbazole reaction
  publication-title: Carbohydr. Polym.
  doi: 10.1016/S0144-8617(03)00144-9
– volume: 92
  start-page: 2212
  issue: 2
  year: 2013
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0050
  article-title: Anti-ovarian cancer potential of two acidic polysaccharides from the rhizoma of Menispermum dauricum
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2012.12.013
– volume: 7
  start-page: 1
  issue: 1
  year: 2017
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0245
  article-title: Synthesis of thermoplastic xylan-lactide copolymer with amidine-mediated organocatalyst in ionic liquid
  publication-title: Sci. Rep.
– volume: 160
  start-page: 52
  year: 2017
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0045
  article-title: Pectic oligosaccharide from tomato exhibiting anticancer potential on a gastric cancer cell line: structure-function relationship
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2016.12.046
– volume: 22
  start-page: 58
  issue: 1
  year: 1998
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0110
  article-title: Hydrolysis of wheat straw by a thermostable endoxylanase: adsorption and kinetic studies
  publication-title: Enzym. Microb. Technol.
  doi: 10.1016/S0141-0229(97)00105-1
– volume: 16
  start-page: 5265
  issue: 13
  year: 2015
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0275
  article-title: Pectic-oligoshaccharides from apples induce apoptosis and cell cycle arrest in MDA-MB-231 cells, a model of human breast cancer
  publication-title: Asian Pac. J. Cancer Prev.
  doi: 10.7314/APJCP.2015.16.13.5265
– volume: 70
  start-page: 79
  year: 2018
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0130
  article-title: Molecular characterization of a first endo-acting β-1, 4-xylanase of family 10 glycoside hydrolase (PsGH10A) from Pseudopedobacter saltans comb. nov
  publication-title: Process Biochem.
  doi: 10.1016/j.procbio.2018.03.025
– start-page: 281
  year: 1965
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0185
  article-title: The optical rotation of wood xylans
  publication-title: Journal of Polymer Science Part C: Polymer Symposia
  doi: 10.1002/polc.5070110120
– volume: 31
  start-page: 207
  issue: 3
  year: 1990
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0260
  article-title: A morphological study of a human adenocarcinoma cell line (HT29) differentiating in culture. Similarities to intestinal embryonic development
  publication-title: Cell Differentiation and Development
  doi: 10.1016/0922-3371(90)90133-H
– start-page: 99
  year: 2019
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0005
– volume: 102
  start-page: 65
  year: 2017
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0195
  article-title: Hydrothermal and microwave assisted alkali pretreatment for fractionation of arecanut husk
  publication-title: Ind. Crop. Prod.
  doi: 10.1016/j.indcrop.2017.03.017
– volume: 68
  start-page: 601
  issue: 3
  year: 2007
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0060
  article-title: Isolation and structural characterization of hemicelluloses from palm of Phoenix dactylifera L
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2006.10.016
– volume: 14
  start-page: 110
  issue: 2
  year: 2014
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0105
  article-title: Neem (Azadirachta indica) and its potential for safeguarding health of animals and humans: a review
  publication-title: J. Biol. Sci.
  doi: 10.3923/jbs.2014.110.123
– start-page: 1
  year: 2018
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0250
  article-title: Fractionation and structural characterization of hemicellulose from steam-exploded banana rachis
  publication-title: Waste and Biomass Valorization
– volume: 9
  start-page: 1
  issue: 1
  year: 2019
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0150
  article-title: Newcastle disease virus mediated apoptosis and migration inhibition of human oral cancer cells: a probable role of β-catenin and matrix metalloproteinase-7
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-019-47244-y
– volume: 197
  start-page: 167
  year: 2018
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0215
  article-title: Eucalyptus xylan: an in-house-produced substrate for xylanase evaluation to substitute birchwood xylan
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2018.05.088
– volume: 53
  start-page: 8349
  issue: 21
  year: 2005
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0070
  article-title: Classification of wheat varieties based on structural features of arabinoxylans as revealed by endoxylanase treatment of flour and grain
  publication-title: J. Agric. Food Chem.
  doi: 10.1021/jf050755v
– volume: 141
  start-page: 238
  year: 2016
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0160
  article-title: Hemicellulose isolation, characterization, and the production of xylo-oligosaccharides from the wastewater of a viscose fiber mill
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2016.01.022
– volume: 43
  start-page: 195
  issue: 2
  year: 2000
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0225
  article-title: FT-IR study of plant cell wall model compounds: pectic polysaccharides and hemicelluloses
  publication-title: Carbohydr. Polym.
  doi: 10.1016/S0144-8617(00)00151-X
– volume: 30
  start-page: 1
  issue: 1
  year: 2002
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0035
  article-title: Immunomodulatory activity of acidic xylans in relation to their structural and molecular properties
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/S0141-8130(01)00186-6
– volume: 5
  start-page: 149
  issue: 2
  year: 2005
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0095
  article-title: Medicinal properties of neem leaves: a review
  publication-title: Current Medicinal Chemistry-Anti-Cancer Agents
  doi: 10.2174/1568011053174828
– volume: 123
  start-page: 17
  year: 2015
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0165
  article-title: Structural characterization of hemicelluloses and topochemical changes in Eucalyptus cell wall during alkali ethanol treatment
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2014.12.066
– volume: 146
  start-page: 26
  year: 2016
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0180
  article-title: Synthesis and characterization of carboxymethylated xylan and its application as a dispersant
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2016.03.036
– volume: 63
  start-page: 114
  year: 2014
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0015
  article-title: Enhanced antitumor and reduced toxicity effect of Schisanreae polysaccharide in 5-Fu treated Heps-bearing mice
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2013.10.037
– volume: 107
  start-page: 138
  year: 2014
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0270
  article-title: Activation of intrinsic apoptotic signaling pathway in cancer cells by Cymbopogon citratus polysaccharide fractions
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2014.02.039
– volume: 210
  start-page: 245
  year: 2019
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0030
  article-title: Antiproliferative xylan from corn cobs induces apoptosis in tumor cells
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2019.01.073
– volume: 9
  start-page: 1504
  year: 2018
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0010
  article-title: Pectin oligosaccharides ameliorate colon cancer by regulating oxidative stress-and inflammation-activated signaling pathways
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.01504
– volume: 1850
  start-page: 2246
  issue: 11
  year: 2015
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0210
  article-title: The role of the glucuronoxylan carboxyl groups in the action of endoxylanases of three glycoside hydrolase families: a study with two substrate mutants
  publication-title: Biochimica et Biophysica Acta (BBA)-General Subjects
  doi: 10.1016/j.bbagen.2015.07.003
– volume: 35
  start-page: 1500
  issue: 11
  year: 2003
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0265
  article-title: Cytosolic and mitochondrial ROS in staurosporine-induced retinal cell apoptosis
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2003.08.022
– volume: 87
  start-page: 628
  issue: 19–22
  year: 2010
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0025
  article-title: GLIS, a bioactive proteoglycan fraction from Ganoderma lucidum, displays anti-tumour activity by increasing both humoral and cellular immune response
  publication-title: Life Sci.
  doi: 10.1016/j.lfs.2010.09.026
– volume: 3
  start-page: 433
  issue: 5
  year: 2013
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0115
  article-title: Efficient extraction of xylan from delignified corn stover using dimethyl sulfoxide
  publication-title: 3 Biotech
  doi: 10.1007/s13205-013-0159-8
– volume: 102
  start-page: 5947
  issue: 10
  year: 2011
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0155
  article-title: Structural and thermal characterization of hemicelluloses isolated by organic solvents and alkaline solutions from Tamarix austromongolica
  publication-title: Bioresour. Technol.
  doi: 10.1016/j.biortech.2011.03.012
– volume: 11
  issue: 1
  year: 2019
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0120
  article-title: Green synthesis of arabinoxyloglucan coated antimicrobial copper nanoparticles
  publication-title: Trends in Carbohydrate Research
– volume: 5
  start-page: 13729
  issue: 23
  year: 2020
  ident: 10.1016/j.ijbiomac.2020.09.086_bb2005
  article-title: Acacia xylan as a substitute for commercially available xylan and its application in the production of xylooligosaccharides
  publication-title: ACS Omega
  doi: 10.1021/acsomega.0c00896
– volume: 92
  start-page: 1243
  issue: 2
  year: 2013
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0085
  article-title: A new arabinoxylan from green leaves of Litsea glutinosa (Lauraeae): structural and biological studies
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2012.10.052
– volume: 117
  start-page: 38
  year: 2019
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0200
  article-title: Hemicellulose based biorefinery from pineapple peel waste: xylan extraction and its conversion into xylooligosaccharides
  publication-title: Food Bioprod. Process.
  doi: 10.1016/j.fbp.2019.06.012
– volume: 6
  start-page: 668
  issue: 9
  year: 1983
  ident: 10.1016/j.ijbiomac.2020.09.086_bb0040
  article-title: Antitumor activity of acidic mannan fraction from bakers'yeast
  publication-title: Journal of Pharmacobio-dynamics
  doi: 10.1248/bpb1978.6.668
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Snippet Xylan extracted from neem sawdust gave 22.5%, (w/w) yield. The extracted xylan was composed of xylose and glucuronic acid at a molar ratio of 8:1 and with a...
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StartPage 1897
SubjectTerms apoptosis
Azadirachta - chemistry
Azadirachta indica
biocompatibility
cell growth
Cell Proliferation - drug effects
colorectal neoplasms
Colorectal Neoplasms - drug therapy
denaturation
DNA
DSC
fibroblasts
flow cytometry
glucuronic acid
Glucuronoxylan
HT29 Cells
Human colorectal cancer (HT-29) cells
Humans
Hydrolysis
membrane potential
mice
mitochondrial membrane
molecular weight
MTT
Neem
NMR
Oligosaccharides - chemistry
Oligosaccharides - isolation & purification
Oligosaccharides - pharmacology
polymerization
sawdust
thermogravimetry
Wood - chemistry
xylan
Xylans - chemistry
Xylans - isolation & purification
Xylans - pharmacology
xylooligosaccharides
xylose
Xylose - chemistry
Title Extraction, characterization of xylan from Azadirachta indica (neem) sawdust and production of antiproliferative xylooligosaccharides
URI https://dx.doi.org/10.1016/j.ijbiomac.2020.09.086
https://www.ncbi.nlm.nih.gov/pubmed/32946939
https://www.proquest.com/docview/2444380128
https://www.proquest.com/docview/2552006774
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