Chitosan nanocarriers for non-coding RNA therapeutics: A review

Non-coding RNA (ncRNA)-based therapies entail delivering ncRNAs to cells to regulate gene expression and produce proteins that combat infections, cancer, neurological diseases, and bone abnormalities. Nevertheless, the therapeutic potential of these ncRNAs has been limited due to the difficulties in...

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Published inInternational journal of biological macromolecules Vol. 263; no. Pt 1; p. 130361
Main Authors Karthik, S., Mohan, Sahithya, Magesh, Induja, Bharathy, Ashok, Kolipaka, Rushil, Ganesamoorthi, Srinidhi, Sathiya, K., Shanmugavadivu, Abinaya, Gurunathan, Raghav, Selvamurugan, N.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.04.2024
Subjects
biocompatible materials
Chitosan
Drug delivery
gene expression
Nanocarriers
non-coding RNA
Non-coding RNAs
polymers
Therapeutics
Tissue engineering
DD
lncRNAs
circRNAs
BBB
miRNAs
Drug delivery
CNV
GDH
HIF-1α
Mw
ncRNAs
N/P
TMCS
siRNAs
MSCs
UTR
ChT-TAT-H
TPP
CMC
PD-L1
AKT1
Nanocarriers
SPION
Cy5
dsRNA
FC-g-PEI
PBS
Non-coding RNAs
RNAi
DsiRNA
Tissue engineering
MS
STAT3
HTTR
NEAT1
BACE1
CS
CVD
PEG
Therapeutics
GTANP
HA
Chitosan
shRNAs
Online AccessGet full text
ISSN0141-8130
1879-0003
1879-0003
DOI10.1016/j.ijbiomac.2024.130361

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Abstract Non-coding RNA (ncRNA)-based therapies entail delivering ncRNAs to cells to regulate gene expression and produce proteins that combat infections, cancer, neurological diseases, and bone abnormalities. Nevertheless, the therapeutic potential of these ncRNAs has been limited due to the difficulties in delivering them to specific cellular targets within the body. Chitosan (CS), a biocompatible cationic polymer, interacts with negatively charged RNA molecules to form stable complexes. It is a promising biomaterial to develop nanocarriers for ncRNA delivery, overcoming several disadvantages of traditional delivery systems. CS-based nanocarriers can protect ncRNAs from degradation and target-specific delivery by surface modifications and intracellular release profiles over an extended period. This review briefly summarizes the recent developments in CS nanocarriers' synthesis and design considerations and their applications in ncRNA therapeutics for treating various diseases. We also discuss the challenges and limitations of CS-based nanocarriers for ncRNA therapeutics and potential strategies for overcoming these challenges.
AbstractList Non-coding RNA (ncRNA)-based therapies entail delivering ncRNAs to cells to regulate gene expression and produce proteins that combat infections, cancer, neurological diseases, and bone abnormalities. Nevertheless, the therapeutic potential of these ncRNAs has been limited due to the difficulties in delivering them to specific cellular targets within the body. Chitosan (CS), a biocompatible cationic polymer, interacts with negatively charged RNA molecules to form stable complexes. It is a promising biomaterial to develop nanocarriers for ncRNA delivery, overcoming several disadvantages of traditional delivery systems. CS-based nanocarriers can protect ncRNAs from degradation and target-specific delivery by surface modifications and intracellular release profiles over an extended period. This review briefly summarizes the recent developments in CS nanocarriers' synthesis and design considerations and their applications in ncRNA therapeutics for treating various diseases. We also discuss the challenges and limitations of CS-based nanocarriers for ncRNA therapeutics and potential strategies for overcoming these challenges.
Non-coding RNA (ncRNA)-based therapies entail delivering ncRNAs to cells to regulate gene expression and produce proteins that combat infections, cancer, neurological diseases, and bone abnormalities. Nevertheless, the therapeutic potential of these ncRNAs has been limited due to the difficulties in delivering them to specific cellular targets within the body. Chitosan (CS), a biocompatible cationic polymer, interacts with negatively charged RNA molecules to form stable complexes. It is a promising biomaterial to develop nanocarriers for ncRNA delivery, overcoming several disadvantages of traditional delivery systems. CS-based nanocarriers can protect ncRNAs from degradation and target-specific delivery by surface modifications and intracellular release profiles over an extended period. This review briefly summarizes the recent developments in CS nanocarriers' synthesis and design considerations and their applications in ncRNA therapeutics for treating various diseases. We also discuss the challenges and limitations of CS-based nanocarriers for ncRNA therapeutics and potential strategies for overcoming these challenges.Non-coding RNA (ncRNA)-based therapies entail delivering ncRNAs to cells to regulate gene expression and produce proteins that combat infections, cancer, neurological diseases, and bone abnormalities. Nevertheless, the therapeutic potential of these ncRNAs has been limited due to the difficulties in delivering them to specific cellular targets within the body. Chitosan (CS), a biocompatible cationic polymer, interacts with negatively charged RNA molecules to form stable complexes. It is a promising biomaterial to develop nanocarriers for ncRNA delivery, overcoming several disadvantages of traditional delivery systems. CS-based nanocarriers can protect ncRNAs from degradation and target-specific delivery by surface modifications and intracellular release profiles over an extended period. This review briefly summarizes the recent developments in CS nanocarriers' synthesis and design considerations and their applications in ncRNA therapeutics for treating various diseases. We also discuss the challenges and limitations of CS-based nanocarriers for ncRNA therapeutics and potential strategies for overcoming these challenges.
ArticleNumber 130361
Author Karthik, S.
Ganesamoorthi, Srinidhi
Gurunathan, Raghav
Selvamurugan, N.
Kolipaka, Rushil
Mohan, Sahithya
Magesh, Induja
Sathiya, K.
Bharathy, Ashok
Shanmugavadivu, Abinaya
Author_xml – sequence: 1
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  surname: Ganesamoorthi
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  email: selvamun@srmist.edu.in
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Cites_doi 10.3109/21691401.2014.948548
10.3390/mps4010010
10.1016/j.ymthe.2006.04.010
10.1042/BSR20170122
10.1016/j.biopha.2023.114993
10.1038/s41392-021-00569-5
10.3390/molecules27186123
10.3390/molecules26020449
10.2147/IJN.S203113
10.1007/s00415-019-09421-x
10.1248/cpb.58.1423
10.1016/j.biomaterials.2015.08.024
10.3390/ijms21197111
10.1093/eurheartj/ehac463
10.1167/iovs.07-1077
10.1208/s12248-023-00860-z
10.1038/cddis.2016.438
10.1016/j.biomaterials.2019.119342
10.3390/ijms222111596
10.1016/j.tig.2022.02.006
10.1016/j.pdpdt.2021.102581
10.1039/C7TB00613F
10.1016/j.carbpol.2021.118791
10.1016/j.ijbiomac.2021.07.034
10.1016/j.jfda.2014.10.008
10.1007/978-1-4939-3112-5_12
10.2147/IJN.S132190
10.1016/j.carbpol.2015.11.044
10.1080/02652048.2017.1321047
10.1016/j.ijbiomac.2022.01.100
10.3762/bjnano.10.250
10.3390/md17060381
10.1056/NEJMoa1913147
10.1016/bs.acr.2017.11.003
10.3390/ijms17111790
10.3390/polym10030267
10.1056/NEJMoa1716153
10.1016/j.carbpol.2009.08.026
10.1093/nar/gkv1367
10.1016/j.matlet.2018.11.161
10.1101/gr.135350.111
10.1021/acs.jpcb.9b07031
10.1007/978-1-4939-7138-1_14
10.1016/j.ijbiomac.2018.06.018
10.3390/nano13081302
10.3390/polym13193256
10.1016/j.ijbiomac.2020.08.153
10.1016/j.jbiotec.2018.09.002
10.3389/fcimb.2021.643953
10.3390/molecules26020272
10.3390/molecules28041963
10.1016/j.addr.2016.06.011
10.1038/srep13567
10.1016/j.biomaterials.2021.121324
10.3390/ph15091036
10.1038/s41580-020-00315-9
10.1016/j.drudis.2019.11.006
10.3390/polym10030235
10.1016/j.biomaterials.2009.07.017
10.1016/j.nano.2017.01.015
10.3389/fonc.2022.951864
10.1007/978-1-4939-7046-9_4
10.1016/j.ijbiomac.2020.02.079
10.1016/j.lfs.2020.118423
10.3390/ijms24044233
10.1186/s40824-022-00292-4
10.1016/j.carbpol.2022.119489
10.2147/IJN.S200253
10.1038/s41392-020-0207-x
10.1016/j.actbio.2015.01.041
10.1016/j.xphs.2020.05.018
10.1021/acsnano.8b09679
10.1016/j.antiviral.2014.08.015
10.1016/j.ejphar.2020.173235
10.1007/s40265-020-01269-0
10.3390/ijms17101712
10.1016/j.carbpol.2019.03.098
10.1016/j.lfs.2020.118847
10.1016/j.ijbiomac.2020.06.246
10.1016/j.tranon.2023.101634
10.3390/pharmaceutics9040053
10.3390/nano6070131
10.3390/ncrna5010017
10.1016/j.carbpol.2021.117706
10.3390/ma4081399
10.1007/s11033-021-06680-8
10.3390/biomedicines9040433
10.1016/j.msec.2020.111036
10.1007/s40259-022-00549-3
10.1186/s43042-020-00074-4
10.1016/j.omtn.2017.08.013
10.3390/ijms21020487
10.1002/adhm.201801389
10.1515/gps-2016-0126
10.1002/jcp.25854
10.1016/j.carres.2021.108357
10.3390/diseases6030057
10.1016/j.ijbiomac.2016.07.061
10.4172/2332-0877.1000291
10.1093/ecco-jcc/jjy181
10.1007/s11802-021-4669-y
10.1016/j.molcel.2016.09.004
10.1101/gr.214205.116
10.1016/j.omtn.2021.12.039
10.1038/s41576-019-0158-7
10.1158/0008-5472.CAN-21-3432
10.1021/acsami.9b22440
10.1016/j.omtm.2019.09.010
10.1073/pnas.1016758108
10.1016/j.msec.2021.112258
10.3390/molecules24163009
10.1063/5.0007925
10.1007/s00109-023-02305-8
10.34172/bi.2021.22119
10.3109/1061186X.2011.654121
10.1186/s12951-020-00674-7
10.1016/j.carbpol.2018.08.060
10.1016/B978-0-08-100230-8.00008-X
10.3390/nu13113822
10.1111/cbdd.12993
10.1016/j.cell.2020.03.006
10.1016/j.carbpol.2020.117008
10.1073/pnas.75.1.285
10.1007/s40265-021-01473-6
10.1016/j.jconrel.2022.09.040
10.1159/000276996
10.1038/nrm3838
10.1021/acs.chemmater.9b00507
10.1038/s41573-021-00219-z
10.1158/1078-0432.CCR-20-3260
10.3390/app9112193
10.3390/polym10040444
10.1038/s41419-020-02820-3
10.1038/s41416-020-0802-1
10.3390/ph13100314
10.1016/j.carbpol.2019.115256
10.1007/s40265-020-01463-0
10.1615/CritRevTherDrugCarrierSyst.2016014850
10.1016/j.biomaterials.2022.121562
10.1016/j.lfs.2022.120375
10.3390/polym13111717
10.1007/s13105-018-00660-6
10.1056/NEJMoa1710504
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Keywords DD
lncRNAs
circRNAs
BBB
miRNAs
Drug delivery
CNV
GDH
HIF-1α
Mw
ncRNAs
N/P
TMCS
siRNAs
MSCs
UTR
ChT-TAT-H
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CMC
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AKT1
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PBS
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BACE1
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PEG
Therapeutics
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HA
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shRNAs
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References Lee, Choi, Choi, Kim, Yang, Kim, Yoon, Kwon (bb0495) 2022; 351
Jayasuriya (bb0340) 2017; 1
Scott, Keam (bb0800) 2021; 81
Sharma, Jha, Dahiya, Singh, Chaurasiya, Jha, Jha, Mishra, Dholpuria, Astya, Nand, Kumar, Ruokolainen, Kesari (bb0580) 2020; 3
Saikia, Gogoi, Maji (bb0310) 2015
Desai (bb0355) 2016; 33
G. Mahmoodi Chalbatani, H. Dana, E. Gharagouzloo, S. Grijalvo, R. Eritja, C.D. Logsdon, F. Memari, S.R. Miri, M.R. Rad, V. Marmari, Small interfering RNAs (siRNAs) in cancer therapy: a nano-based approach , Int. J. Nanomedicine 14 (2019) 3111–3128.
Nagpal, Singh, Mishra (bb0330) 2010; 58
Ito, Miyata, Okada (bb0805) 2023; 31
Lu, Pang, Yin, Cui, Fang, Xue, Luo (bb0025) 2020; 109
Song, Zhang, Wen, Li, Zhou, Liu, Wu, Lv, Wu (bb0500) 2022; 16
Adams, Gonzalez-Duarte, O’Riordan, Yang, Ueda, Kristen, Tournev, Schmidt, Coelho, Berk, Lin, Vita, Attarian, Planté-Bordeneuve, Mezei, Campistol, Buades, Brannagan, Kim, Oh, Parman, Sekijima, Hawkins, Solomon, Polydefkis, Dyck, Gandhi, Goyal, Chen, Strahs, Nochur, Sweetser, Garg, Vaishnaw, Gollob, Suhr (bb0770) 2018; 379
Jiang, Xu, Zhao, Kong, Lu, Tang, Yin (bb0760) 2022; 280
Howard, Rahbek, Liu, Damgaard, Glud, Andersen, Hovgaard, Schmitz, Nyengaard, Besenbacher, Kjems (bb0235) 2006; 14
Salehi Khesht, Karpisheh, Sahami Gilan, Melnikova, Olegovna Zekiy, Mohammadi, Hojjat-Farsangi, Majidi Zolbanin, Mahmoodpoor, Hassannia, Aghebati-Maleki, Jafari, Jadidi-Niaragh (bb0520) 2021; 186
Wei, Tan, Wang, Li, Dong, Guo (bb0215) 2019; 226
M. Gagliardi, A.T. Ashizawa, The Challenges and strategies of antisense oligonucleotide drug delivery, Biomedicines 2021, Vol. 9, Page 433 9 (2021) 433.
M. Winkle, S.M. El-Daly, M. Fabbri, G.A. Calin, Noncoding RNA therapeutics — challenges and potential solutions, Nature Reviews Drug Discovery 2021 20:8 20 (2021) 629–651.
Melé, Mattioli, Mallard, Shechner, Gerhardinger, Rinn (bb0095) 2017; 27
Boros, Dascalu, Ostafe, Isvoran (bb0870) 2022; 27
A Study Using Intravitreal Injections of a Small Interfering RNA in Patients With Age-Related Macular Degeneration - Full Text View -
MesomiR 1: A Phase I Study of TargomiRs as 2nd or 3rd Line Treatment for Patients With Recurrent MPM and NSCLC - Full Text View -
Gaspar, Silva-Marrero, Fàbregas, Miñarro, Ticó, Baanante, Metón (bb0605) 2018; 286
L.S. Kristensen, M.S. Andersen, L.V.W. Stagsted, K.K. Ebbesen, T.B. Hansen, J. Kjems, The biogenesis, biology and characterization of circular RNAs, Nature Reviews Genetics 2019 20:11 20 (2019) 675–691.
S.M. Lemma, F. Bossard, M. Rinaudo, Preparation of pure and stable chitosan nanofibers by electrospinning in the presence of poly(ethylene oxide), International Journal of Molecular Sciences 2016, Vol. 17, Page 1790 17 (2016) 1790.
.
(accessed March 24, 2023).
C. Hidai, H. Kitano, Nonviral gene therapy for cancer: a review, Diseases 2018, Vol. 6, Page 57 6 (2018) 57.
X. Ao, W. Ding, X. Li, Q. Xu, X. Chen, X. Zhou, J. Wang, Y. Liu, Non-coding RNAs regulating mitochondrial function in cardiovascular diseases, Journal of Molecular Medicine 2023 101:5 101 (2023) 501–526.
Zhao, Xu, Cao, Yu, Zhou, Liu (bb0085) 2017; 5
Acosta, Johansson, Drake (bb0755) 2021; 13
Song, Li, Li, Che, Li, Zhao, Chen, Zheng, Yuan (bb0465) 2017; 12
Baghaei, Tekie, Khoshayand, Varshochian, Hajiramezanali, Kachousangi, Dinarvand, Atyabi (bb0660) 2021; 118
D.P. Facchi, S.P. Facchi, Aless, ro F. Martins, N,N,N-trimethyl chitosan and its potential bactericidal activity: current aspects and technological applications, Journal of Infectious Diseases & Therapy 2016 4:4 4 (2016) 1–4.
Grenha (bb0350) 2012; 20
:
Sargazi, Siddiqui, Qindeel, Rahdar, Bilal, Behzadmehr, Mirinejad, Pandey (bb0685) 2022; 290
A. Bozkir, G. Hayta, O.M. Saka, Comparison of biodegradable nanoparticles and multiple emulsions (water-in-oil-in-water) containing influenza virus antigen on the in vivo immune response in rats, (n.d.).
Eskildsen, Taipaleenmäki, Stenvang, Abdallah, Ditzel, Nossent, Bak, Kauppinen, Kassem (bb0475) 2011; 108
Mercuri, Darras, Chiriboga, Day, Campbell, Connolly, Iannaccone, Kirschner, Kuntz, Saito, Shieh, Tulinius, Mazzone, Montes, Bishop, Yang, Foster, Gheuens, Bennett, Farwell, Schneider, De Vivo, Finkel (bb0780) 2018; 378
Efficacy, Safety, and Tolerability of Remlarsen (MRG-201) Following Intradermal Injection in Subjects With a History of Keloids - Full Text View -
Sukumar, Bose, Malhotra, Babikir, Afjei, Robinson, Zeng, Chang, Habte, Sinclair, Gambhir, Massoud, Paulmurugan (bb0460) 2019; 218
F.S. El-banna, M.E. Mahfouz, S. Leporatti, M. El-Kemary, N.A.N. Hanafy, Chitosan as a natural copolymer with unique properties for the development of hydrogels, Applied Sciences 2019, Vol. 9, Page 2193 9 (2019) 2193.
Astuti, Yulizar, Saefumillah, Apriandanu (bb0890) 2020; 2242
Ragelle, Vanvarenberg, Vandermeulen, Préat (bb0245) 2016; 1364
Lamb (bb0795) 2021; 81
Selvam, Mutisya, Prakash, Ranganna, Thilagavathi (bb0080) 2017; 90
Keskin, Brouwers, Sogorb-Gonzalez, Martier, Depla, Vallès, van Deventer, Konstantinova, Evers (bb0410) 2019; 15
M. Li, X. Ding, Y. Zhang, X. Li, H. Zhou, L. Yang, Y. Li, P. Yang, X. Zhang, J. Hu, E. Nice, H. Wu, H. Xu, Antisense oligonucleotides targeting lncRNA AC104041.1 induces antitumor activity through Wnt2B/β-catenin pathway in head and neck squamous cell carcinomas, Cell Death & Disease 2020 11:8 11 (2020) 1–12.
Byun, Wu, Park, Kim, Li, Choi, Shin, Lan, Cai, Lee, Oh, Nanomedicine (bb0880) 2023; 25
Sharma, Arora, Banerjee, Singh (bb0595) 2021; 33
Motiei, Aboutalebi, Forouzanfar, Dormiani, Nasr-Esfahani, Mirahmadi-Zare (bb0445) 2021; 128
Zhang, Liu, Shao, Qiu, Yao, Ji, Wang, Lu, Chen, Zhang (bb0575) 2017; 13
Yan, Gao, Shui, Liu, Qu, Liu, Zheng (bb0250) 2020; 162
B. Fathi Dizaji, Strategies to target long non-coding RNAs in cancer treatment: progress and challenges, Egyptian Journal of Medical Human Genetics 2020 21:1 21 (2020) 1–15.
Zhang, Zhang, Jiang, Sun, Wang, Gu, Li, Guo, Chen, Zhang, Han, Chang (bb0640) 2021; 20
Abdelgawad, El-Naggar, Hudson, Rojas (bb0185) 2017; 94
Abd-Rabou, Abdelaziz, Shaker, Ayeldeen (bb0275) 2021; 48
Sheikholeslami, Salimi-Kenari, Imani, Atai, Nodehi (bb0345) 2017; 34
Jayakumar, Chennazhi, Muzzarelli, Tamura, Nair, Selvamurugan (bb0365) 2010; 79
Tang, Panja, Jogdeo, Tang, Ding, Yu, Foster, Dsouza, Chhonker, Jensen-Smith, Jang, Boesen, Murry, Padanilam, Oupický (bb0900) 2022; 285
Y. Ysrafil, I. Astuti, Chitosan nanoparticle-mediated effect of antimiRNA-324-5p on decreasing the ovarian cancer cell proliferation by regulation of GLI1 expression., Bioimpacts 12 (2022) 195–202.
J. Zhang, W. Tan, G. Wang, X. Yin, Q. Li, F. Dong, Z. Guo, Synthesis, characterization, and the antioxidant activity of N,N,N-trimethyl chitosan salts, Int. J. Biol. Macromol. 118 (2018) 9–14.
Yu, Wen, Wang, Zha, Qiu, Li, Xue, Ma (bb0590) 2019; 31
Mai, Shen, Liu, Tang, Yin (bb0615) 2019; 238
Han, Scherer, Gethers, Salvador, Salah, Mancusi, Sagar, Hu, DeRogatis, Kuo, Marcucci, Das, Rossi, Goddard (bb0485) 2022; 27
Wu, Feng, Hui, Wang, Tan, Luo, Xue, Wang, Chen (bb0730) 2016; 138
Chen, Deng, Zhang (bb0015) 2021; 258
K.C. Hembram, S. Prabha, R. Chandra, B. Ahmed, S. Nimesh, Advances in preparation and characterization of chitosan nanoparticles for therapeutics
A.M. Omer, Z.M. Ziora, T.M. Tamer, R.E. Khalifa, M.A. Hassan, M.S. Mohy-Eldin, M.A.T. Blaskovich, Formulation of quaternized aminated chitosan nanoparticles for efficient encapsulation and slow release of curcumin, Molecules 2021, Vol. 26, Page 449 26 (2021) 449.
H.H. Genedy, T. Delair, A. Montembault, Chitosan based microRNA nanocarriers, Pharmaceuticals 2022, Vol. 15, Page 1036 15 (2022) 1036.
T.M.M. Ways, W.M. Lau, V. V. Khutoryanskiy, Chitosan and its derivatives for application in mucoadhesive drug delivery systems, Polymers 2018, Vol. 10, Page 267 10 (2018) 267.
Wiegand, Winter, Hipler (bb0875) 2010; 23
J.P. Quiñones, H. Peniche, C. Peniche, Chitosan based self-assembled nanoparticles in drug delivery, Polymers 2018, Vol. 10, Page 235 10 (2018) 235.
Hajizadeh, Moghadaszadeh Ardebili, Baghi Moornani, Masjedi, Atyabi, Kiani, Namdar, Karpisheh, Izadi, Baradaran, Azizi, Ghalamfarsa, Sabz, Yousefi, Jadidi-Niaragh (bb0560) 2020; 882
44 (2014) 305–314.
M. Friedrich, A. Aigner, Therapeutic siRNA: state-of-the-art and future perspectives, BioDrugs 2022 36:5 36 (2022) 549–571.
I. Aranaz, A.R. Alcántara, M.C. Civera, C. Arias, B. Elorza, A.H. Caballero, N. Acosta, H. Velasco, D. Mecerreyes, R. Antonio, B. Gimeno, A. María Díez-Pascual, V.C. Moreno, A. Serra, Chitosan: an overview of its properties and applications, Polymers 2021, Vol. 13, Page 3256 13 (2021) 3256.
De La Fuente, Seijo, Alonso (bb0230) 2008; 49
Jia, Li, Zheng, Li, Zhao (bb0620) 2021; 251
F. Peng, T.T. Li, K.L. Wang, G.Q. Xiao, J.H. Wang, H.D. Zhao, Z.J. Kang, W.J. Fan, L.L. Zhu, M. Li, B. Cui, F.M. Zheng, H.J. Wang, E.W.F. Lam, B. Wang, J. Xu, Q. Liu, H19/let-7/LIN28 reciprocal negative regulatory circuit promotes breast cancer stem cell maintenance, Cell Death & Disease 2017 8:1 8 (2017) e2569–e2569.
Stephenson, Zamecnik (bb0765) 1978; 75
Amreddy, Babu, Muralidharan, Panneerselvam, Srivastava, Ahmed, Mehta, Munshi, Ramesh (bb0570) 2018; 137
M. Abdelrahim, S. Safe, C. Baker, A. Abudayyeh, RNAi and cancer: implications and applications, J RNAi Gene Silencing 2 (2006) 136. /pmc/articles/PMC2737210/ (accessed March 26, 2023).
Alzhrani, Alsaab, Petrovici, Bhise, Vanamala, Sau, Krinock, Iyer (bb0915) 2020; 25
Chen, Fan, Zhao, Zhi, Cui, Zhang, Lan, Du, Zhang, Zhang, Zhen (bb0385) 2020; 12
Mohammed, Syeda, Wasan, Wasan (bb0325) 2017; 9
Elgadir, Uddin, Ferdosh, Adam, Chowdhury, Sarker (bb0315) 2015; 23
He, Yin, Song, Tang, Yin (bb0545) 2015; 17
Broughton, Lovci, Huang, Yeo, Pasquinelli (bb0040) 2016; 64
Thipe, Karikachery, Çakılkaya, Farooq, Genedy, Kaeokhamloed, Phan, Rezwan, Tezcan, Roger, Katti (bb0300) 2022; 70
K. Jafernik, A. Ładniak, E. Blicharska, K. Czarnek, H. Ekiert, A.E. Wiącek, A. Szopa, Chitosan-based nanoparticles as effective drug delivery systems—a review, Molecules 2023, Vol. 28, Page 1963 28 (2023) 1963.
M. Bronstein, R. Jha, R.A. Mayanovic, A review of the preparation, char
Wu (10.1016/j.ijbiomac.2024.130361_bb0430) 2020; 18
Eskildsen (10.1016/j.ijbiomac.2024.130361_bb0475) 2011; 108
Wu (10.1016/j.ijbiomac.2024.130361_bb0730) 2016; 138
Song (10.1016/j.ijbiomac.2024.130361_bb0465) 2017; 12
Adams (10.1016/j.ijbiomac.2024.130361_bb0770) 2018; 379
10.1016/j.ijbiomac.2024.130361_bb0075
Jayasuriya (10.1016/j.ijbiomac.2024.130361_bb0340) 2017; 1
Van Der Ree (10.1016/j.ijbiomac.2024.130361_bb0810) 2014; 111
Bastaki (10.1016/j.ijbiomac.2024.130361_bb0510) 2021; 266
Zhao (10.1016/j.ijbiomac.2024.130361_bb0085) 2017; 5
10.1016/j.ijbiomac.2024.130361_bb0070
Liang (10.1016/j.ijbiomac.2024.130361_bb0535) 2021; 27
Guo (10.1016/j.ijbiomac.2024.130361_bb0100) 2020; 181
10.1016/j.ijbiomac.2024.130361_bb0115
Roehr (10.1016/j.ijbiomac.2024.130361_bb0785) 1998; 4
Mai (10.1016/j.ijbiomac.2024.130361_bb0615) 2019; 238
10.1016/j.ijbiomac.2024.130361_bb0910
Broughton (10.1016/j.ijbiomac.2024.130361_bb0040) 2016; 64
Sharma (10.1016/j.ijbiomac.2024.130361_bb0580) 2020; 3
Scott (10.1016/j.ijbiomac.2024.130361_bb0800) 2021; 81
10.1016/j.ijbiomac.2024.130361_bb0630
Chaharband (10.1016/j.ijbiomac.2024.130361_bb0525) 2020; 26
Jiang (10.1016/j.ijbiomac.2024.130361_bb0760) 2022; 280
Stephenson (10.1016/j.ijbiomac.2024.130361_bb0765) 1978; 75
Youssef (10.1016/j.ijbiomac.2024.130361_bb0740) 2019; 75
Lu (10.1016/j.ijbiomac.2024.130361_bb0025) 2020; 109
Baghaei (10.1016/j.ijbiomac.2024.130361_bb0660) 2021; 118
Denizli (10.1016/j.ijbiomac.2024.130361_bb0905) 2017; 1632
Harrow (10.1016/j.ijbiomac.2024.130361_bb0005) 2012; 22
Mercuri (10.1016/j.ijbiomac.2024.130361_bb0780) 2018; 378
Zheng (10.1016/j.ijbiomac.2024.130361_bb0610) 2015; 70
10.1016/j.ijbiomac.2024.130361_bb0240
Zhang (10.1016/j.ijbiomac.2024.130361_bb0715) 2019; 14
Salehi Khesht (10.1016/j.ijbiomac.2024.130361_bb0520) 2021; 186
Aguilar (10.1016/j.ijbiomac.2024.130361_bb0720) 2019; 24
Mohammed (10.1016/j.ijbiomac.2024.130361_bb0325) 2017; 9
10.1016/j.ijbiomac.2024.130361_bb0885
10.1016/j.ijbiomac.2024.130361_bb0645
Abdelgawad (10.1016/j.ijbiomac.2024.130361_bb0185) 2017; 94
10.1016/j.ijbiomac.2024.130361_bb0125
10.1016/j.ijbiomac.2024.130361_bb0400
Paul (10.1016/j.ijbiomac.2024.130361_bb0055) 2018; 233
Selvam (10.1016/j.ijbiomac.2024.130361_bb0080) 2017; 90
Gaspar (10.1016/j.ijbiomac.2024.130361_bb0605) 2018; 286
Duan (10.1016/j.ijbiomac.2024.130361_bb0665) 2019; 8
Chen (10.1016/j.ijbiomac.2024.130361_bb0015) 2021; 258
Sargazi (10.1016/j.ijbiomac.2024.130361_bb0685) 2022; 290
Astuti (10.1016/j.ijbiomac.2024.130361_bb0890) 2020; 2242
Diener (10.1016/j.ijbiomac.2024.130361_bb0405) 2022; 38
10.1016/j.ijbiomac.2024.130361_bb0090
Ragelle (10.1016/j.ijbiomac.2024.130361_bb0245) 2016; 1364
Acosta (10.1016/j.ijbiomac.2024.130361_bb0755) 2021; 13
10.1016/j.ijbiomac.2024.130361_bb0010
Jayakumar (10.1016/j.ijbiomac.2024.130361_bb0365) 2010; 79
Raja (10.1016/j.ijbiomac.2024.130361_bb0265) 2013; 2013
Wiegand (10.1016/j.ijbiomac.2024.130361_bb0875) 2010; 23
Zhang (10.1016/j.ijbiomac.2024.130361_bb0640) 2021; 20
10.1016/j.ijbiomac.2024.130361_bb0655
Cunniffe (10.1016/j.ijbiomac.2024.130361_bb0735) 2021; 268
Abd El-Hack (10.1016/j.ijbiomac.2024.130361_bb0205) 2020; 164
10.1016/j.ijbiomac.2024.130361_bb0255
10.1016/j.ijbiomac.2024.130361_bb0650
10.1016/j.ijbiomac.2024.130361_bb0895
10.1016/j.ijbiomac.2024.130361_bb0135
Lamb (10.1016/j.ijbiomac.2024.130361_bb0795) 2021; 81
Sharma (10.1016/j.ijbiomac.2024.130361_bb0595) 2021; 33
Yan (10.1016/j.ijbiomac.2024.130361_bb0250) 2020; 162
Mahajan (10.1016/j.ijbiomac.2024.130361_bb0270) 2019; 123
Lee (10.1016/j.ijbiomac.2024.130361_bb0495) 2022; 351
Motiei (10.1016/j.ijbiomac.2024.130361_bb0445) 2021; 128
10.1016/j.ijbiomac.2024.130361_bb0815
Elgadir (10.1016/j.ijbiomac.2024.130361_bb0315) 2015; 23
De La Fuente (10.1016/j.ijbiomac.2024.130361_bb0230) 2008; 49
10.1016/j.ijbiomac.2024.130361_bb0140
Keskin (10.1016/j.ijbiomac.2024.130361_bb0410) 2019; 15
Boros (10.1016/j.ijbiomac.2024.130361_bb0870) 2022; 27
Huang (10.1016/j.ijbiomac.2024.130361_bb0060) 2017; 1617
Nguyen (10.1016/j.ijbiomac.2024.130361_bb0210) 2017; 6
10.1016/j.ijbiomac.2024.130361_bb0260
10.1016/j.ijbiomac.2024.130361_bb0380
10.1016/j.ijbiomac.2024.130361_bb0820
10.1016/j.ijbiomac.2024.130361_bb0305
10.1016/j.ijbiomac.2024.130361_bb0700
10.1016/j.ijbiomac.2024.130361_bb0145
Abd-Rabou (10.1016/j.ijbiomac.2024.130361_bb0275) 2021; 48
Tang (10.1016/j.ijbiomac.2024.130361_bb0900) 2022; 285
Melé (10.1016/j.ijbiomac.2024.130361_bb0095) 2017; 27
Balwani (10.1016/j.ijbiomac.2024.130361_bb0775) 2020; 382
Ito (10.1016/j.ijbiomac.2024.130361_bb0805) 2023; 31
10.1016/j.ijbiomac.2024.130361_bb0825
Grenha (10.1016/j.ijbiomac.2024.130361_bb0350) 2012; 20
Deng (10.1016/j.ijbiomac.2024.130361_bb0435) 2019; 13
Hong (10.1016/j.ijbiomac.2024.130361_bb0415) 2020; 122
Salimifard (10.1016/j.ijbiomac.2024.130361_bb0550) 2020; 260
Huang (10.1016/j.ijbiomac.2024.130361_bb0110) 2021; 12
10.1016/j.ijbiomac.2024.130361_bb0030
Byun (10.1016/j.ijbiomac.2024.130361_bb0880) 2023; 25
10.1016/j.ijbiomac.2024.130361_bb0395
10.1016/j.ijbiomac.2024.130361_bb0390
10.1016/j.ijbiomac.2024.130361_bb0150
Nandgude (10.1016/j.ijbiomac.2024.130361_bb0455) 2021; 506
Wang (10.1016/j.ijbiomac.2024.130361_bb0625) 2021; 36
10.1016/j.ijbiomac.2024.130361_bb0830
Scott (10.1016/j.ijbiomac.2024.130361_bb0790) 2020; 80
10.1016/j.ijbiomac.2024.130361_bb0035
10.1016/j.ijbiomac.2024.130361_bb0155
10.1016/j.ijbiomac.2024.130361_bb0675
10.1016/j.ijbiomac.2024.130361_bb0835
Li (10.1016/j.ijbiomac.2024.130361_bb0705) 2021; 2021
Alzhrani (10.1016/j.ijbiomac.2024.130361_bb0915) 2020; 25
Budi (10.1016/j.ijbiomac.2024.130361_bb0515) 2021; 34
Nagpal (10.1016/j.ijbiomac.2024.130361_bb0330) 2010; 58
10.1016/j.ijbiomac.2024.130361_bb0165
10.1016/j.ijbiomac.2024.130361_bb0440
10.1016/j.ijbiomac.2024.130361_bb0285
10.1016/j.ijbiomac.2024.130361_bb0280
Jia (10.1016/j.ijbiomac.2024.130361_bb0620) 2021; 251
Sayed (10.1016/j.ijbiomac.2024.130361_bb0370) 2022; 294
10.1016/j.ijbiomac.2024.130361_bb0160
Kim (10.1016/j.ijbiomac.2024.130361_bb0020) 2016; 104
Wei (10.1016/j.ijbiomac.2024.130361_bb0215) 2019; 226
10.1016/j.ijbiomac.2024.130361_bb0200
10.1016/j.ijbiomac.2024.130361_bb0045
Pan (10.1016/j.ijbiomac.2024.130361_bb0670) 2023; 83
Li (10.1016/j.ijbiomac.2024.130361_bb0425) 2022; 277
Hajizadeh (10.1016/j.ijbiomac.2024.130361_bb0560) 2020; 882
Liu (10.1016/j.ijbiomac.2024.130361_bb0120) 2023; 164
Howard (10.1016/j.ijbiomac.2024.130361_bb0235) 2006; 14
Tekie (10.1016/j.ijbiomac.2024.130361_bb0710) 2018; 201
Hueso (10.1016/j.ijbiomac.2024.130361_bb0680) 2021; 22
Enuka (10.1016/j.ijbiomac.2024.130361_bb0130) 2016; 44
10.1016/j.ijbiomac.2024.130361_bb0295
Martins (10.1016/j.ijbiomac.2024.130361_bb0505) 2019; 216
Desai (10.1016/j.ijbiomac.2024.130361_bb0355) 2016; 33
He (10.1016/j.ijbiomac.2024.130361_bb0545) 2015; 17
10.1016/j.ijbiomac.2024.130361_bb0690
10.1016/j.ijbiomac.2024.130361_bb0175
Amreddy (10.1016/j.ijbiomac.2024.130361_bb0570) 2018; 137
10.1016/j.ijbiomac.2024.130361_bb0170
10.1016/j.ijbiomac.2024.130361_bb0290
10.1016/j.ijbiomac.2024.130361_bb0050
Song (10.1016/j.ijbiomac.2024.130361_bb0500) 2022; 16
10.1016/j.ijbiomac.2024.130361_bb0335
Boroumand (10.1016/j.ijbiomac.2024.130361_bb0375) 2021; 11
Sheikholeslami (10.1016/j.ijbiomac.2024.130361_bb0345) 2017; 34
Thipe (10.1016/j.ijbiomac.2024.130361_bb0300) 2022; 70
Jiang (10.1016/j.ijbiomac.2024.130361_bb0585) 2009; 30
Saikia (10.1016/j.ijbiomac.2024.130361_bb0310) 2015
Zhang (10.1016/j.ijbiomac.2024.130361_bb0575) 2017; 13
Helmschrodt (10.1016/j.ijbiomac.2024.130361_bb0840) 2017; 9
Han (10.1016/j.ijbiomac.2024.130361_bb0485) 2022; 27
Chen (10.1016/j.ijbiomac.2024.130361_bb0385) 2020; 12
Yu (10.1016/j.ijbiomac.2024.130361_bb0590) 2019; 31
10.1016/j.ijbiomac.2024.130361_bb0065
Li (10.1016/j.ijbiomac.2024.130361_bb0450) 2022; 39
10.1016/j.ijbiomac.2024.130361_bb0180
10.1016/j.ijbiomac.2024.130361_bb0105
Sukumar (10.1016/j.ijbiomac.2024.130361_bb0460) 2019; 218
10.1016/j.ijbiomac.2024.130361_bb0225
Shamaeizadeh (10.1016/j.ijbiomac.2024.130361_bb0745) 2022; 200
10.1016/j.ijbiomac.2024.130361_bb0865
Sudhakar (10.1016/j.ijbiomac.2024.130361_bb0190) 2020; 150
Nguyen (10.1016/j.ijbiomac.2024.130361_bb0220) 2019; 13
10.1016/j.ijbiomac.2024.130361_bb0860
Jiang (10.1016/j.ijbiomac.2024.130361_bb0420) 2020; 24
Yu (10.1016/j.ijbiomac.2024.130361_bb0565) 2017; 37
Shah (10.1016/j.ijbiomac.2024.130361_bb0750) 2022; 43
References_xml – volume: 268
  start-page: 30
  year: 2021
  end-page: 44
  ident: bb0735
  article-title: Promoting remyelination in multiple sclerosis
  publication-title: J. Neurol.
– volume: 382
  start-page: 2289
  year: 2020
  end-page: 2301
  ident: bb0775
  article-title: Phase 3 trial of RNAi therapeutic Givosiran for acute intermittent porphyria
  publication-title: N. Engl. J. Med.
– reference: K.C. Hembram, S. Prabha, R. Chandra, B. Ahmed, S. Nimesh, Advances in preparation and characterization of chitosan nanoparticles for therapeutics,
– volume: 118
  year: 2021
  ident: bb0660
  article-title: Optimization of chitosan-based polyelectrolyte nanoparticles for gene delivery, using design of experiment: in vitro and in vivo study
  publication-title: Mater. Sci. Eng. C
– volume: 27
  start-page: 2340
  year: 2021
  end-page: 2351
  ident: bb0535
  article-title: Emergence of enzalutamide resistance in prostate cancer is associated with BCL-2 and IKKB dependencies
  publication-title: Clin. Cancer Res.
– reference: 44 (2014) 305–314.
– reference: M. Abdelrahim, S. Safe, C. Baker, A. Abudayyeh, RNAi and cancer: implications and applications, J RNAi Gene Silencing 2 (2006) 136. /pmc/articles/PMC2737210/ (accessed March 26, 2023).
– volume: 238
  start-page: 143
  year: 2019
  end-page: 146
  ident: bb0615
  article-title: PEG modified trimethyl chitosan based nanoparticles for the codelivery of doxorubicin and iSur-pDNA
  publication-title: Mater. Lett.
– reference: C. Hidai, H. Kitano, Nonviral gene therapy for cancer: a review, Diseases 2018, Vol. 6, Page 57 6 (2018) 57.
– reference: J. Zhang, W. Tan, G. Wang, X. Yin, Q. Li, F. Dong, Z. Guo, Synthesis, characterization, and the antioxidant activity of N,N,N-trimethyl chitosan salts, Int. J. Biol. Macromol. 118 (2018) 9–14.
– volume: 22
  start-page: 1760
  year: 2012
  end-page: 1774
  ident: bb0005
  article-title: GENCODE: the reference human genome annotation for the ENCODE project
  publication-title: Genome Res.
– volume: 233
  start-page: 2007
  year: 2018
  end-page: 2018
  ident: bb0055
  article-title: Interplay between miRNAs and human diseases
  publication-title: J. Cell. Physiol.
– volume: 27
  start-page: 27
  year: 2017
  end-page: 37
  ident: bb0095
  article-title: Chromatin environment, transcriptional regulation, and splicing distinguish lincRNAs and mRNAs
  publication-title: Genome Res.
– reference: Phase I, Multicenter, Dose Escalation Study of DCR-MYC in Patients With Solid Tumors, Multiple Myeloma, or Lymphoma - Full Text View -
– reference: S.M. Lemma, F. Bossard, M. Rinaudo, Preparation of pure and stable chitosan nanofibers by electrospinning in the presence of poly(ethylene oxide), International Journal of Molecular Sciences 2016, Vol. 17, Page 1790 17 (2016) 1790.
– reference: V. Campani, G. Salzano, S. Lusa, G. de Rosa, Lipid nanovectors to deliver RNA oligonucleotides in cancer, Nanomaterials 2016, Vol. 6, Page 131 6 (2016) 131.
– volume: 123
  start-page: 9629
  year: 2019
  end-page: 9640
  ident: bb0270
  article-title: Polyethylenimine-DNA ratio strongly affects their nanoparticle formation: a large-scale coarse-grained molecular dynamics study
  publication-title: J. Phys. Chem. B
– volume: 216
  start-page: 332
  year: 2019
  end-page: 342
  ident: bb0505
  article-title: Amphipathic chitosans improve the physicochemical properties of siRNA-chitosan nanoparticles at physiological conditions
  publication-title: Carbohydr. Polym.
– volume: 79
  start-page: 1
  year: 2010
  end-page: 8
  ident: bb0365
  article-title: Chitosan conjugated DNA nanoparticles in gene therapy
  publication-title: Carbohydr. Polym.
– volume: 81
  start-page: 389
  year: 2021
  end-page: 395
  ident: bb0795
  article-title: Inclisiran: first approval
  publication-title: Drugs
– volume: 2013
  year: 2013
  ident: bb0265
  article-title: Physicochemical properties and in vitro cytotoxicity studies of chitosan as a potential carrier for dicer-substrate siRNA
  publication-title: J. Nanomater.
– volume: 201
  start-page: 131
  year: 2018
  end-page: 140
  ident: bb0710
  article-title: Glutathione responsive chitosan-thiolated dextran conjugated miR-145 nanoparticles targeted with AS1411 aptamer for cancer treatment
  publication-title: Carbohydr. Polym.
– volume: 83
  start-page: 103
  year: 2023
  end-page: 116
  ident: bb0670
  article-title: Extracellular vesicle-mediated transfer of LncRNA IGFL2-AS1 confers sunitinib resistance in renal cell carcinoma
  publication-title: Cancer Res.
– volume: 13
  start-page: 482
  year: 2019
  end-page: 494
  ident: bb0435
  article-title: A molecular targeted immunotherapeutic strategy for ulcerative colitis via dual-targeting nanoparticles delivering miR-146b to intestinal macrophages
  publication-title: J. Crohns Colitis
– volume: 16
  year: 2022
  ident: bb0500
  article-title: Improved anti-hepatocellular carcinoma effect by enhanced co-delivery of Tim-3 siRNA and sorafenib via multiple pH triggered drug-eluting nanoparticles
  publication-title: Mater Today Bio
– volume: 290
  year: 2022
  ident: bb0685
  article-title: Chitosan nanocarriers for microRNA delivery and detection: a preliminary review with emphasis on cancer
  publication-title: Carbohydr. Polym.
– reference: B. Fathi Dizaji, Strategies to target long non-coding RNAs in cancer treatment: progress and challenges, Egyptian Journal of Medical Human Genetics 2020 21:1 21 (2020) 1–15.
– volume: 8
  year: 2019
  ident: bb0665
  article-title: Orally delivered antisense oligodeoxyribonucleotides of TNF-α via polysaccharide-based nanocomposites targeting intestinal inflammation
  publication-title: Adv. Healthc. Mater.
– volume: 12
  start-page: 2013
  year: 2021
  ident: bb0110
  article-title: LncRNAs as therapeutic targets and potential biomarkers for lipid-related diseases
  publication-title: Front. Pharmacol.
– volume: 39
  start-page: 178
  year: 2022
  end-page: 186
  ident: bb0450
  article-title: Biomimetic nanosystems for the synergistic delivery of miR-144/451a for oral squamous cell carcinoma
  publication-title: Balkan Med J. Balkan Med J
– volume: 20
  start-page: 291
  year: 2012
  end-page: 300
  ident: bb0350
  article-title: Chitosan nanoparticles: a survey of preparation methods
  publication-title: J. Drug Target.
– volume: 1632
  start-page: 219
  year: 2017
  end-page: 230
  ident: bb0905
  article-title: Chitosan nanoparticles for miRNA delivery
  publication-title: Methods Mol. Biol.
– reference: Efficacy, Safety, and Tolerability of Remlarsen (MRG-201) Following Intradermal Injection in Subjects With a History of Keloids - Full Text View -
– volume: 882
  year: 2020
  ident: bb0560
  article-title: Silencing of HIF-1α/CD73 axis by siRNA-loaded TAT-chitosan-spion nanoparticles robustly blocks cancer cell progression
  publication-title: Eur. J. Pharmacol.
– reference: A. Gennari, J.M.R. de la Rosa, E. Hohn, M. Pelliccia, E. Lallana, R. Donno, A. Tirella, N. Tirelli, The different ways to chitosan/hyaluronic acid nanoparticles: templated vs direct complexation. Influence of particle preparation on morphology, cell uptake and silencing efficiency, Beilstein Journal of Nanotechnology 10:250 10 (2019) 2594–2608.
– volume: 24
  year: 2019
  ident: bb0720
  article-title: Application of chitosan in bone and dental engineering
  publication-title: Molecules
– volume: 70
  start-page: 126
  year: 2015
  end-page: 137
  ident: bb0610
  article-title: Oral delivery of shRNA based on amino acid modified chitosan for improved antitumor efficacy
  publication-title: Biomaterials
– reference: C. Catalanotto, C. Cogoni, G. Zardo, MicroRNA in control of gene expression: an overview of nuclear functions, International Journal of Molecular Sciences 2016, Vol. 17, Page 1712 17 (2016) 1712.
– volume: 164
  year: 2023
  ident: bb0120
  article-title: Non-coding RNA-mediated modulation of ferroptosis in cardiovascular diseases
  publication-title: Biomed. Pharmacother.
– volume: 49
  start-page: 2016
  year: 2008
  end-page: 2024
  ident: bb0230
  article-title: Novel hyaluronic acid-chitosan nanoparticles for ocular gene therapy
  publication-title: Invest. Ophthalmol. Vis. Sci.
– volume: 12
  start-page: 22074
  year: 2020
  end-page: 22087
  ident: bb0385
  article-title: Stimuli-responsive polysaccharide enveloped liposome for targeting and penetrating delivery of survivin-shRNA into breast tumor
  publication-title: ACS Appl. Mater. Interfaces
– volume: 30
  start-page: 5844
  year: 2009
  end-page: 5852
  ident: bb0585
  article-title: The suppression of lung tumorigenesis by aerosol-delivered folate–chitosan-graft-polyethylenimine/Akt1 shRNA complexes through the Akt signaling pathway
  publication-title: Biomaterials
– reference: Multiple Ascending Dose Study of Miravirsen in Treatment-Naïve Chronic Hepatitis C Subjects - Full Text View -
– reference: J. Jhaveri, Z. Raichura, T. Khan, M. Momin, A. Omri, R. Stancanelli, S. Tommasini, C. Anna Ventura, V. Crupi, D. Majolino, Chitosan nanoparticles-insight into properties, functionalization and applications in drug delivery and theranostics, Molecules 2021, Vol. 26, Page 272 26 (2021) 272.
– reference: B. Santos-Carballal, L.J. Aaldering, M. Ritzefeld, S. Pereira, N. Sewald, B.M. Moerschbacher, M. Götte, F.M. Goycoolea, Physicochemical and biological characterization of chitosan-microRNA nanocomplexes for gene delivery to MCF-7 breast cancer cells, Scientific Reports 2015 5:1 5 (2015) 1–15.
– volume: 23
  start-page: 164
  year: 2010
  end-page: 170
  ident: bb0875
  article-title: Molecular-weight-dependent toxic effects of chitosans on the human keratinocyte cell line HaCaT
  publication-title: Skin Pharmacol. Physiol.
– volume: 9
  year: 2017
  ident: bb0325
  article-title: An overview of chitosan nanoparticles and its application in non-parenteral drug delivery
  publication-title: Pharmaceutics
– volume: 38
  start-page: 613
  year: 2022
  end-page: 626
  ident: bb0405
  article-title: Emerging concepts of miRNA therapeutics: from cells to clinic
  publication-title: Trends Genet.
– reference: A Study Using Intravitreal Injections of a Small Interfering RNA in Patients With Age-Related Macular Degeneration - Full Text View -
– volume: 286
  start-page: 5
  year: 2018
  end-page: 13
  ident: bb0605
  article-title: Administration of chitosan-tripolyphosphate-DNA nanoparticles to knockdown glutamate dehydrogenase expression impairs transdeamination and gluconeogenesis in the liver
  publication-title: J. Biotechnol.
– reference: J. Li, Y. Han, S. Wang, X. Wu, J. Cao, T. Sun, Circular RNAs: biogenesis, biological functions, and roles in myocardial infarction, International Journal of Molecular Sciences 2023, Vol. 24, Page 4233 24 (2023) 4233.
– reference: I. Dasgupta, A. Chatterjee, Recent Advances in miRNA Delivery Systems, Methods and Protocols 2021, Vol. 4, Page 10 4 (2021) 10.
– volume: 1364
  start-page: 143
  year: 2016
  end-page: 150
  ident: bb0245
  article-title: Chitosan nanoparticles for siRNA delivery in vitro
  publication-title: Methods Mol. Biol.
– volume: 122
  start-page: 1630
  year: 2020
  end-page: 1637
  ident: bb0415
  article-title: Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours
  publication-title: Br. J. Cancer
– reference: MesomiR 1: A Phase I Study of TargomiRs as 2nd or 3rd Line Treatment for Patients With Recurrent MPM and NSCLC - Full Text View -
– reference: Y. Yuan, B.M. Chesnutt, W.O. Haggard, J.D. Bumgardner, Deacetylation of chitosan: material characterization and in vitro evaluation via albumin adsorption and pre-osteoblastic cell cultures, Materials 2011, Vol. 4, Pages 1399-1416 4 (2011) 1399–1416.
– reference: A Study of DCR-PH1 in Patients With Primary Hyperoxaluria Type 1 (PH1) - Full Text View -
– reference: K. Jafernik, A. Ładniak, E. Blicharska, K. Czarnek, H. Ekiert, A.E. Wiącek, A. Szopa, Chitosan-based nanoparticles as effective drug delivery systems—a review, Molecules 2023, Vol. 28, Page 1963 28 (2023) 1963.
– reference: F.S. El-banna, M.E. Mahfouz, S. Leporatti, M. El-Kemary, N.A.N. Hanafy, Chitosan as a natural copolymer with unique properties for the development of hydrogels, Applied Sciences 2019, Vol. 9, Page 2193 9 (2019) 2193.
– volume: 1617
  start-page: 57
  year: 2017
  end-page: 67
  ident: bb0060
  article-title: MicroRNAs: biomarkers, diagnostics, and therapeutics
  publication-title: Methods Mol. Biol.
– volume: 506
  year: 2021
  ident: bb0455
  article-title: Plausible role of chitosan in drug and gene delivery against resistant breast cancer cells
  publication-title: Carbohydr. Res.
– volume: 81
  start-page: 277
  year: 2021
  end-page: 282
  ident: bb0800
  article-title: Lumasiran: first approval
  publication-title: Drugs
– reference: F. Peng, T.T. Li, K.L. Wang, G.Q. Xiao, J.H. Wang, H.D. Zhao, Z.J. Kang, W.J. Fan, L.L. Zhu, M. Li, B. Cui, F.M. Zheng, H.J. Wang, E.W.F. Lam, B. Wang, J. Xu, Q. Liu, H19/let-7/LIN28 reciprocal negative regulatory circuit promotes breast cancer stem cell maintenance, Cell Death & Disease 2017 8:1 8 (2017) e2569–e2569.
– reference: A Study to Assess the Safety and Tolerability of Single Doses of AZD4076 in Healthy Male Subjects - Full Text View -
– volume: 94
  start-page: 96
  year: 2017
  end-page: 105
  ident: bb0185
  article-title: Fabrication and characterization of bactericidal thiol-chitosan and chitosan iodoacetamide nanofibres
  publication-title: Int. J. Biol. Macromol.
– volume: 25
  start-page: 1
  year: 2023
  end-page: 19
  ident: bb0880
  article-title: Delivery strategies and applications
  publication-title: AAPS Journal
– volume: 351
  start-page: 713
  year: 2022
  end-page: 726
  ident: bb0495
  article-title: Molecularly engineered siRNA conjugates for tumor-targeted RNAi therapy
  publication-title: J. Control. Release
– reference: A. Bozkir, G. Hayta, O.M. Saka, Comparison of biodegradable nanoparticles and multiple emulsions (water-in-oil-in-water) containing influenza virus antigen on the in vivo immune response in rats, (n.d.).
– volume: 36
  year: 2021
  ident: bb0625
  article-title: Chitosan-tripolyphosphate nanoparticles-mediated co-delivery of MTHFD1L shRNA and 5-aminolevulinic acid for combination photodynamic-gene therapy in oral cancer
  publication-title: Photodiagn. Photodyn. Ther.
– volume: 20
  start-page: 1097
  year: 2021
  end-page: 1108
  ident: bb0640
  article-title: Effects on the STAT3-shRNA in non-small-cell lung cancer therapy: design, induction of apoptosis, and conjugation with chitosan-based gene vectors
  publication-title: J. Ocean Univ. China
– volume: 14
  start-page: 5287
  year: 2019
  end-page: 5301
  ident: bb0715
  article-title: <p>Antitumor effect of hyaluronic-acid-modified chitosan nanoparticles loaded with siRNA for targeted therapy for non-small cell lung cancer</p>
  publication-title: Int. J. Nanomedicine
– reference: A.T. He, J. Liu, F. Li, B.B. Yang, Targeting circular RNAs as a therapeutic approach: current strategies and challenges, Signal Transduction and Targeted Therapy 2021 6:1 6 (2021) 1–14.
– reference: X. Zhou, X. Ao, Z. Jia, Y. Li, S. Kuang, C. Du, J. Zhang, J. Wang, Y. Liu, Non-coding RNA in cancer drug resistance: underlying mechanisms and clinical applications Front. Oncol. (2022) 12:951864.
– volume: 18
  start-page: 1
  year: 2020
  end-page: 18
  ident: bb0430
  article-title: Chitosan-miRNA functionalized microporous titanium oxide surfaces via a layer-by-layer approach with a sustained release profile for enhanced osteogenic activity
  publication-title: J Nanobiotechnology
– volume: 378
  start-page: 625
  year: 2018
  end-page: 635
  ident: bb0780
  article-title: Nusinersen versus sham control in later-onset spinal muscular atrophy
  publication-title: N. Engl. J. Med.
– volume: 5
  start-page: 6908
  year: 2017
  end-page: 6919
  ident: bb0085
  article-title: A redox-responsive strategy using mesoporous silica nanoparticles for co-delivery of siRNA and doxorubicin
  publication-title: J. Mater. Chem. B
– volume: 90
  start-page: 665
  year: 2017
  end-page: 678
  ident: bb0080
  article-title: Therapeutic potential of chemically modified siRNA: recent trends
  publication-title: Chem. Biol. Drug Des.
– reference: D.P. Facchi, S.P. Facchi, Aless, ro F. Martins, N,N,N-trimethyl chitosan and its potential bactericidal activity: current aspects and technological applications, Journal of Infectious Diseases & Therapy 2016 4:4 4 (2016) 1–4.
– volume: 70
  year: 2022
  ident: bb0300
  article-title: Green nanotechnology—an innovative pathway towards biocompatible and medically relevant gold nanoparticles
  publication-title: J Drug Deliv Sci Technol
– reference: (accessed March 24, 2023).
– reference: M. Friedrich, A. Aigner, Therapeutic siRNA: state-of-the-art and future perspectives, BioDrugs 2022 36:5 36 (2022) 549–571.
– volume: 181
  start-page: 621
  year: 2020
  end-page: 636.e22
  ident: bb0100
  article-title: Distinct processing of lncRNAs contributes to non-conserved functions in stem cells
  publication-title: Cell
– reference: M. Bronstein, R. Jha, R.A. Mayanovic, A review of the preparation, characterization, and applications of chitosan nanoparticles in nanomedicine, Nanomaterials 2023, Vol. 13, Page 1302 13 (2023) 1302.
– volume: 13
  year: 2021
  ident: bb0755
  article-title: Diet and lifestyle factors and risk of atherosclerotic cardiovascular disease—a prospective cohort study
  publication-title: Nutrients
– reference: SOLAR: Efficacy and Safety of Cobomarsen (MRG-106) Vs. Active Comparator in Subjects With Mycosis Fungoides - Full Text View - ClinicalTrials.gov, (n.d.).
– volume: 25
  start-page: 718
  year: 2020
  ident: bb0915
  article-title: Improving the therapeutic efficiency of noncoding RNAs in cancers using targeted drug delivery systems
  publication-title: Drug Discov. Today
– volume: 164
  start-page: 2726
  year: 2020
  end-page: 2744
  ident: bb0205
  article-title: Antimicrobial and antioxidant properties of chitosan and its derivatives and their applications: a review
  publication-title: Int. J. Biol. Macromol.
– volume: 27
  start-page: 797
  year: 2022
  end-page: 809
  ident: bb0485
  article-title: Programmable siRNA pro-drugs that activate RNAi activity in response to specific cellular RNA biomarkers
  publication-title: Mol Ther Nucleic Acids
– reference: , (n.d.).
– volume: 150
  start-page: 281
  year: 2020
  end-page: 288
  ident: bb0190
  article-title: Biodistribution and pharmacokinetics of thiolated chitosan nanoparticles for oral delivery of insulin in vivo
  publication-title: Int. J. Biol. Macromol.
– volume: 75
  start-page: 285
  year: 1978
  end-page: 288
  ident: bb0765
  article-title: Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide
  publication-title: Proc. Natl. Acad. Sci.
– reference: Y.J. Lu, Y.H. Lan, C.C. Chuang, W.T. Lu, L.Y. Chan, P.W. Hsu, J.P. Chen, Injectable thermo-sensitive chitosan hydrogel containing CPT-11-loaded EGFR-targeted graphene oxide and SLP2 shRNA for localized drug/gene delivery in glioblastoma therapy, International Journal of Molecular Sciences 2020, Vol. 21, Page 7111 21 (2020) 7111.
– volume: 108
  start-page: 6139
  year: 2011
  end-page: 6144
  ident: bb0475
  article-title: MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo
  publication-title: Proc. Natl. Acad. Sci. USA
– reference: Y. Cao, Y.F. Tan, Y.S. Wong, M.W.J. Liew, S. Venkatraman, Recent advances in chitosan-based carriers for gene delivery, Marine Drugs 2019, Vol. 17, Page 381 17 (2019) 381.
– reference: B. Hu, L. Zhong, Y. Weng, L. Peng, Y. Huang, Y. Zhao, X.J. Liang, Therapeutic siRNA: state of the art, Signal Transduction and Targeted Therapy 2020 5:1 5 (2020) 1–25.
– reference: (accessed March 27, 2023).
– volume: 379
  start-page: 11
  year: 2018
  end-page: 21
  ident: bb0770
  article-title: Patisiran, an RNAi therapeutic, for hereditary transthyretin amyloidosis
  publication-title: N. Engl. J. Med.
– reference: X. Ao, W. Ding, X. Li, Q. Xu, X. Chen, X. Zhou, J. Wang, Y. Liu, Non-coding RNAs regulating mitochondrial function in cardiovascular diseases, Journal of Molecular Medicine 2023 101:5 101 (2023) 501–526.
– volume: 285
  year: 2022
  ident: bb0900
  article-title: Modified chitosan for effective renal delivery of siRNA to treat acute kidney injury
  publication-title: Biomaterials
– volume: 6
  start-page: 461
  year: 2017
  end-page: 468
  ident: bb0210
  article-title: Preparation, characterization, and antioxidant activity of water-soluble oligochitosan
  publication-title: Green Processes Synth.
– volume: 294
  year: 2022
  ident: bb0370
  article-title: Gene therapy: comprehensive overview and therapeutic applications
  publication-title: Life Sci.
– volume: 280
  year: 2022
  ident: bb0760
  article-title: Dual targeted delivery of statins and nucleic acids by chitosan-based nanoparticles for enhanced antiatherosclerotic efficacy
  publication-title: Biomaterials
– volume: 200
  start-page: 543
  year: 2022
  end-page: 556
  ident: bb0745
  article-title: Glutathione targeted tragacanthic acid-chitosan as a non-viral vector for brain delivery of miRNA-219a-5P: an in vitro/in vivo study
  publication-title: Int. J. Biol. Macromol.
– volume: 226
  year: 2019
  ident: bb0215
  article-title: The antioxidant and antifungal activity of chitosan derivatives bearing Schiff bases and quaternary ammonium salts
  publication-title: Carbohydr. Polym.
– reference: H.H. Genedy, T. Delair, A. Montembault, Chitosan based microRNA nanocarriers, Pharmaceuticals 2022, Vol. 15, Page 1036 15 (2022) 1036.
– reference: S. Huang, X.Y. Hao, Y.J. Li, J.Y. Wu, D.X. Xiang, S. Luo, Nonviral delivery systems for antisense oligonucleotide therapeutics, Biomaterials Research 2022 26:1 26 (2022) 1–23.
– reference: I. Aranaz, A.R. Alcántara, M.C. Civera, C. Arias, B. Elorza, A.H. Caballero, N. Acosta, H. Velasco, D. Mecerreyes, R. Antonio, B. Gimeno, A. María Díez-Pascual, V.C. Moreno, A. Serra, Chitosan: an overview of its properties and applications, Polymers 2021, Vol. 13, Page 3256 13 (2021) 3256.
– volume: 27
  start-page: 6123
  year: 2022
  ident: bb0870
  article-title: Assessment of the effects of chitosan, chitooligosaccharides and their derivatives on Lemna minor
  publication-title: Molecules
– volume: 37
  year: 2017
  ident: bb0565
  article-title: Chitosan nanoparticle-delivered siRNA reduces CXCR4 expression and sensitizes breast cancer cells to cisplatin
  publication-title: Biosci. Rep.
– volume: 4
  start-page: 14
  year: 1998
  end-page: 16
  ident: bb0785
  article-title: Fomivirsen approved for CMV retinitis
  publication-title: J. Int. Assoc. Phys. AIDS Care
– volume: 138
  start-page: 49
  year: 2016
  end-page: 58
  ident: bb0730
  article-title: Improving the osteogenesis of rat mesenchymal stem cells by chitosan-based-microRNA nanoparticles
  publication-title: Carbohydr. Polym.
– volume: 80
  start-page: 335
  year: 2020
  end-page: 339
  ident: bb0790
  article-title: Givosiran: first approval
  publication-title: Drugs
– reference: Y. Herdiana, N. Wathoni, S. Shamsuddin, I.M. Joni, M. Muchtaridi, Chitosan-based nanoparticles of targeted drug delivery system in breast cancer treatment, Polymers 2021, Vol. 13, Page 1717 13 (2021) 1717.
– reference: :
– volume: 24
  year: 2020
  ident: bb0420
  article-title: The promotion of bone regeneration through CS/GP-CTH/antagomir-133a/b sustained release system
  publication-title: Nanomedicine
– volume: 9
  start-page: 57
  year: 2017
  end-page: 68
  ident: bb0840
  article-title: Polyethylenimine nanoparticle-mediated siRNA delivery to reduce α-synuclein expression in a model of Parkinson’s disease
  publication-title: Mol Ther Nucleic Acids
– reference: G. Mahmoodi Chalbatani, H. Dana, E. Gharagouzloo, S. Grijalvo, R. Eritja, C.D. Logsdon, F. Memari, S.R. Miri, M.R. Rad, V. Marmari, <p>Small interfering RNAs (siRNAs) in cancer therapy: a nano-based approach</p>, Int. J. Nanomedicine 14 (2019) 3111–3128.
– reference: L. Statello, C.J. Guo, L.L. Chen, M. Huarte, Gene regulation by long non-coding RNAs and its biological functions, Nature Reviews Molecular Cell Biology 2020 22:2 22 (2020) 96–118.
– volume: 162
  start-page: 1303
  year: 2020
  end-page: 1310
  ident: bb0250
  article-title: Small interfering RNA-loaded chitosan hydrochloride/carboxymethyl chitosan nanoparticles for ultrasound-triggered release to hamper colorectal cancer growth in vitro
  publication-title: Int. J. Biol. Macromol.
– volume: 34
  start-page: 270
  year: 2017
  end-page: 279
  ident: bb0345
  article-title: Exploring the effect of formulation parameters on the particle size of carboxymethyl chitosan nanoparticles prepared via reverse micellar crosslinking
  publication-title: J. Microencapsul.
– volume: 44
  start-page: 1370
  year: 2016
  end-page: 1383
  ident: bb0130
  article-title: Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor
  publication-title: Nucleic Acids Res.
– volume: 1
  start-page: 185
  year: 2017
  end-page: 209
  ident: bb0340
  article-title: Production of micro- and nanoscale chitosan particles for biomedical applications
  publication-title: Chitosan Based Biomaterials
– volume: 13
  start-page: 1309
  year: 2017
  end-page: 1321
  ident: bb0575
  article-title: Folate-targeted nanoparticle delivery of androgen receptor shRNA enhances the sensitivity of hormone-independent prostate cancer to radiotherapy
  publication-title: Nanomedicine
– volume: 111
  start-page: 53
  year: 2014
  end-page: 59
  ident: bb0810
  article-title: Long-term safety and efficacy of microRNA-targeted therapy in chronic hepatitis C patients
  publication-title: Antivir. Res.
– volume: 12
  start-page: 4195
  year: 2017
  ident: bb0465
  article-title: Biodegradable and biocompatible cationic polymer delivering microRNA-221/222 promotes nerve regeneration after sciatic nerve crush
  publication-title: Int. J. Nanomedicine
– reference: B. Santos-Carballal, E.F. Fernández, F.M. Goycoolea, Chitosan in non-viral gene delivery: role of structure, characterization methods, and insights in cancer and rare diseases therapies, Polymers 2018, Vol. 10, Page 444 10 (2018) 444.
– reference: M. Ha, V.N. Kim, Regulation of microRNA biogenesis, Nature Reviews Molecular Cell Biology 2014 15:8 15 (2014) 509–524.
– reference: W. Wang, Q. Meng, Q. Li, J. Liu, M. Zhou, Z. Jin, K. Zhao, Chitosan derivatives and their application in biomedicine, International Journal of Molecular Sciences 2020, Vol. 21, Page 487 21 (2020) 487.
– volume: 2021
  year: 2021
  ident: bb0705
  article-title: NEAT1 siRNA packed with chitosan nanoparticles regulates the development of colon cancer cells via lncRNA NEAT1/miR-377-3p axis
  publication-title: Biomed. Res. Int.
– volume: 3
  year: 2020
  ident: bb0580
  article-title: Nanoparticulate RNA delivery systems in cancer
  publication-title: Cancer Rep
– year: 2015
  ident: bb0310
  publication-title: Chitosan: a promising biopolymer in drug delivery applications removal of contaminants from water by polymer nanocomposites view project Chitosan: A Promising Biopolymer in Drug Delivery Applications
– volume: 260
  year: 2020
  ident: bb0550
  article-title: Codelivery of BV6 and anti-IL6 siRNA by hyaluronate-conjugated PEG-chitosan-lactate nanoparticles inhibits tumor progression
  publication-title: Life Sci.
– reference: A.M. Omer, Z.M. Ziora, T.M. Tamer, R.E. Khalifa, M.A. Hassan, M.S. Mohy-Eldin, M.A.T. Blaskovich, Formulation of quaternized aminated chitosan nanoparticles for efficient encapsulation and slow release of curcumin, Molecules 2021, Vol. 26, Page 449 26 (2021) 449.
– reference: J.P. Quiñones, H. Peniche, C. Peniche, Chitosan based self-assembled nanoparticles in drug delivery, Polymers 2018, Vol. 10, Page 235 10 (2018) 235.
– volume: 128
  year: 2021
  ident: bb0445
  article-title: Smart co-delivery of miR-34a and cytotoxic peptides (LTX-315 and melittin) by chitosan based polyelectrolyte nanocarriers for specific cancer cell death induction
  publication-title: Mater. Sci. Eng. C
– volume: 64
  start-page: 320
  year: 2016
  end-page: 333
  ident: bb0040
  article-title: Pairing beyond the seed supports MicroRNA targeting specificity
  publication-title: Mol. Cell
– reference: T.M.M. Ways, W.M. Lau, V. V. Khutoryanskiy, Chitosan and its derivatives for application in mucoadhesive drug delivery systems, Polymers 2018, Vol. 10, Page 267 10 (2018) 267.
– reference: M. Li, X. Ding, Y. Zhang, X. Li, H. Zhou, L. Yang, Y. Li, P. Yang, X. Zhang, J. Hu, E. Nice, H. Wu, H. Xu, Antisense oligonucleotides targeting lncRNA AC104041.1 induces antitumor activity through Wnt2B/β-catenin pathway in head and neck squamous cell carcinomas, Cell Death & Disease 2020 11:8 11 (2020) 1–12.
– volume: 17
  start-page: 98
  year: 2015
  end-page: 106
  ident: bb0545
  article-title: Optimization of multifunctional chitosan–siRNA nanoparticles for oral delivery applications, targeting TNF-α silencing in rats
  publication-title: Acta Biomater.
– volume: 186
  start-page: 849
  year: 2021
  end-page: 863
  ident: bb0520
  article-title: Blockade of CD73 using siRNA loaded chitosan lactate nanoparticles functionalized with TAT-hyaluronate enhances doxorubicin mediated cytotoxicity in cancer cells both in vitro and in vivo
  publication-title: Int. J. Biol. Macromol.
– reference: (accessed January 13, 2024).
– volume: 33
  start-page: 107
  year: 2016
  end-page: 158
  ident: bb0355
  article-title: Chitosan nanoparticles prepared by ionotropic gelation: an overview of recent advances
  publication-title: Crit. Rev. Ther. Drug Carrier Syst.
– volume: 277
  year: 2022
  ident: bb0425
  article-title: Silk fibroin nanofibrous scaffolds incorporated with microRNA-222 loaded chitosan nanoparticles for enhanced neuronal differentiation of neural stem cells
  publication-title: Carbohydr. Polym.
– volume: 266
  year: 2021
  ident: bb0510
  article-title: Codelivery of STAT3 and PD-L1 siRNA by hyaluronate-TAT trimethyl/thiolated chitosan nanoparticles suppresses cancer progression in tumor-bearing mice
  publication-title: Life Sci.
– volume: 33
  year: 2021
  ident: bb0595
  article-title: Improved insulin sensitivity in obese-diabetic mice via chitosan nanomicelles mediated silencing of pro-inflammatory adipocytokines
  publication-title: Nanomedicine
– volume: 251
  year: 2021
  ident: bb0620
  article-title: A targeted and redox/pH-responsive chitosan oligosaccharide derivatives based nanohybrids for overcoming multidrug resistance of breast cancer cells
  publication-title: Carbohydr. Polym.
– volume: 58
  start-page: 1423
  year: 2010
  end-page: 1430
  ident: bb0330
  article-title: Chitosan nanoparticles: a promising system in novel drug delivery
  publication-title: Chem Pharm Bull (Tokyo)
– reference: Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Liposomal siRNA in Subjects With High Cholesterol - Full Text View -
– volume: 13
  start-page: 6491
  year: 2019
  end-page: 6505
  ident: bb0220
  article-title: Delivery of MicroRNAs by chitosan nanoparticles to functionally alter macrophage cholesterol efflux in vitro and in Vivo
  publication-title: ACS Nano
– volume: 258
  year: 2021
  ident: bb0015
  article-title: Cationic nanoparticles self-assembled from amphiphilic chitosan derivatives containing poly(amidoamine) dendrons and deoxycholic acid as a vector for co-delivery of doxorubicin and gene
  publication-title: Carbohydr. Polym.
– volume: 137
  start-page: 115
  year: 2018
  end-page: 170
  ident: bb0570
  article-title: Recent advances in nanoparticle-based cancer drug and gene delivery
  publication-title: Adv. Cancer Res.
– volume: 31
  year: 2023
  ident: bb0805
  article-title: Current clinical trials with non-coding RNA-based therapeutics in malignant diseases: a systematic review
  publication-title: Transl. Oncol.
– volume: 14
  start-page: 476
  year: 2006
  end-page: 484
  ident: bb0235
  article-title: RNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle system
  publication-title: Mol. Ther.
– volume: 11
  start-page: 175
  year: 2021
  ident: bb0375
  article-title: Chitosan-based nanoparticles against viral infections
  publication-title: Front. Cell. Infect. Microbiol.
– reference: J.C.R. Fernandes, S.M. Acuña, J.I. Aoki, L.M. Floeter-Winter, S.M. Muxel, Long non-coding RNAs in the regulation of gene expression: physiology and disease, Non-Coding RNA 2019, Vol. 5, Page 17 5 (2019) 17.
– reference: (accessed January 4, 2023).
– volume: 15
  start-page: 275
  year: 2019
  end-page: 284
  ident: bb0410
  article-title: AAV5-miHTT lowers huntingtin mRNA and protein without off-target effects in patient-derived neuronal cultures and astrocytes
  publication-title: Mol Ther Methods Clin Dev
– volume: 31
  start-page: 3992
  year: 2019
  end-page: 4007
  ident: bb0590
  article-title: Chitosan- graft-poly(l -lysine) dendron-assisted facile self-assembly of au nanoclusters for enhanced X-ray computer tomography imaging and precise MMP-9 plasmid shRNA delivery
  publication-title: Chem. Mater.
– volume: 2242
  year: 2020
  ident: bb0890
  article-title: Chitosan nanoparticles modified by polyethylene glycol as lamivudine drug delivery system
  publication-title: AIP Conf. Proc.
– reference: L.S. Kristensen, M.S. Andersen, L.V.W. Stagsted, K.K. Ebbesen, T.B. Hansen, J. Kjems, The biogenesis, biology and characterization of circular RNAs, Nature Reviews Genetics 2019 20:11 20 (2019) 675–691.
– reference: M. Gagliardi, A.T. Ashizawa, The Challenges and strategies of antisense oligonucleotide drug delivery, Biomedicines 2021, Vol. 9, Page 433 9 (2021) 433.
– reference: .
– volume: 218
  year: 2019
  ident: bb0460
  article-title: Intranasal delivery of targeted polyfunctional gold–iron oxide nanoparticles loaded with therapeutic microRNAs for combined theranostic multimodality imaging and presensitization of glioblastoma to temozolomide
  publication-title: Biomaterials
– volume: 75
  start-page: 89
  year: 2019
  end-page: 99
  ident: bb0740
  article-title: LINGO-1 siRNA nanoparticles promote central remyelination in ethidium bromide-induced demyelination in rats
  publication-title: J. Physiol. Biochem.
– reference: P. Pereira, M. Barreira, C. Cruz, J. Tomás, Â. Luís, A.Q. Pedro, J.A. Queiroz, F. Sousa, Brain-targeted delivery of pre-miR-29b using lactoferrin-stearic acid-modified-chitosan/polyethyleneimine polyplexes, Pharmaceuticals 2020, Vol. 13, Page 314 13 (2020) 314.
– volume: 22
  start-page: 11596
  year: 2021
  ident: bb0680
  article-title: Ncrnas in therapeutics: challenges and limitations in nucleic acid-based drug delivery
  publication-title: Int. J. Mol. Sci.
– volume: 26
  year: 2020
  ident: bb0525
  article-title: Trimethyl chitosan-hyaluronic acid nano-polyplexes for intravitreal VEGFR-2 siRNA delivery: formulation and in vivo efficacy evaluation
  publication-title: Nanomedicine
– volume: 48
  start-page: 6805
  year: 2021
  end-page: 6820
  ident: bb0275
  article-title: Metformin-loaded lecithin nanoparticles induce colorectal cancer cytotoxicity via epigenetic modulation of noncoding RNAs
  publication-title: Mol. Biol. Rep.
– volume: 109
  start-page: 2854
  year: 2020
  end-page: 2860
  ident: bb0025
  article-title: Delivery of TSPAN1 siRNA by novel Th17 targeted cationic liposomes for gastric cancer intervention
  publication-title: J. Pharm. Sci.
– reference: M. Winkle, S.M. El-Daly, M. Fabbri, G.A. Calin, Noncoding RNA therapeutics — challenges and potential solutions, Nature Reviews Drug Discovery 2021 20:8 20 (2021) 629–651.
– reference: Y. Ysrafil, I. Astuti, Chitosan nanoparticle-mediated effect of antimiRNA-324-5p on decreasing the ovarian cancer cell proliferation by regulation of GLI1 expression., Bioimpacts 12 (2022) 195–202.
– volume: 34
  year: 2021
  ident: bb0515
  article-title: Blockade of HIF-1α and STAT3 by hyaluronate-conjugated TAT-chitosan-SPION nanoparticles loaded with siRNA molecules prevents tumor growth
  publication-title: Nanomedicine
– volume: 43
  start-page: 4548
  year: 2022
  end-page: 4561
  ident: bb0750
  article-title: Small non-coding RNA therapeutics for cardiovascular disease
  publication-title: Eur. Heart J.
– volume: 23
  start-page: 619
  year: 2015
  end-page: 629
  ident: bb0315
  article-title: Impact of chitosan composites and chitosan nanoparticle composites on various drug delivery systems: a review
  publication-title: J. Food Drug Anal.
– volume: 104
  start-page: 61
  year: 2016
  end-page: 77
  ident: bb0020
  article-title: Recent progress in development of siRNA delivery vehicles for cancer therapy
  publication-title: Adv. Drug Deliv. Rev.
– ident: 10.1016/j.ijbiomac.2024.130361_bb0290
  doi: 10.3109/21691401.2014.948548
– ident: 10.1016/j.ijbiomac.2024.130361_bb0400
  doi: 10.3390/mps4010010
– volume: 14
  start-page: 476
  year: 2006
  ident: 10.1016/j.ijbiomac.2024.130361_bb0235
  article-title: RNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle system
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2006.04.010
– volume: 70
  year: 2022
  ident: 10.1016/j.ijbiomac.2024.130361_bb0300
  article-title: Green nanotechnology—an innovative pathway towards biocompatible and medically relevant gold nanoparticles
  publication-title: J Drug Deliv Sci Technol
– volume: 37
  year: 2017
  ident: 10.1016/j.ijbiomac.2024.130361_bb0565
  article-title: Chitosan nanoparticle-delivered siRNA reduces CXCR4 expression and sensitizes breast cancer cells to cisplatin
  publication-title: Biosci. Rep.
  doi: 10.1042/BSR20170122
– volume: 2013
  year: 2013
  ident: 10.1016/j.ijbiomac.2024.130361_bb0265
  article-title: Physicochemical properties and in vitro cytotoxicity studies of chitosan as a potential carrier for dicer-substrate siRNA
  publication-title: J. Nanomater.
– volume: 34
  year: 2021
  ident: 10.1016/j.ijbiomac.2024.130361_bb0515
  article-title: Blockade of HIF-1α and STAT3 by hyaluronate-conjugated TAT-chitosan-SPION nanoparticles loaded with siRNA molecules prevents tumor growth
  publication-title: Nanomedicine
– volume: 164
  year: 2023
  ident: 10.1016/j.ijbiomac.2024.130361_bb0120
  article-title: Non-coding RNA-mediated modulation of ferroptosis in cardiovascular diseases
  publication-title: Biomed. Pharmacother.
  doi: 10.1016/j.biopha.2023.114993
– ident: 10.1016/j.ijbiomac.2024.130361_bb0140
  doi: 10.1038/s41392-021-00569-5
– volume: 27
  start-page: 6123
  year: 2022
  ident: 10.1016/j.ijbiomac.2024.130361_bb0870
  article-title: Assessment of the effects of chitosan, chitooligosaccharides and their derivatives on Lemna minor
  publication-title: Molecules
  doi: 10.3390/molecules27186123
– ident: 10.1016/j.ijbiomac.2024.130361_bb0895
  doi: 10.3390/molecules26020449
– volume: 3
  year: 2020
  ident: 10.1016/j.ijbiomac.2024.130361_bb0580
  article-title: Nanoparticulate RNA delivery systems in cancer
  publication-title: Cancer Rep
– volume: 24
  year: 2020
  ident: 10.1016/j.ijbiomac.2024.130361_bb0420
  article-title: The promotion of bone regeneration through CS/GP-CTH/antagomir-133a/b sustained release system
  publication-title: Nanomedicine
– volume: 14
  start-page: 5287
  year: 2019
  ident: 10.1016/j.ijbiomac.2024.130361_bb0715
  article-title: Antitumor effect of hyaluronic-acid-modified chitosan nanoparticles loaded with siRNA for targeted therapy for non-small cell lung cancer
  publication-title: Int. J. Nanomedicine
  doi: 10.2147/IJN.S203113
– volume: 268
  start-page: 30
  year: 2021
  ident: 10.1016/j.ijbiomac.2024.130361_bb0735
  article-title: Promoting remyelination in multiple sclerosis
  publication-title: J. Neurol.
  doi: 10.1007/s00415-019-09421-x
– volume: 58
  start-page: 1423
  year: 2010
  ident: 10.1016/j.ijbiomac.2024.130361_bb0330
  article-title: Chitosan nanoparticles: a promising system in novel drug delivery
  publication-title: Chem Pharm Bull (Tokyo)
  doi: 10.1248/cpb.58.1423
– volume: 70
  start-page: 126
  year: 2015
  ident: 10.1016/j.ijbiomac.2024.130361_bb0610
  article-title: Oral delivery of shRNA based on amino acid modified chitosan for improved antitumor efficacy
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2015.08.024
– ident: 10.1016/j.ijbiomac.2024.130361_bb0630
  doi: 10.3390/ijms21197111
– volume: 43
  start-page: 4548
  year: 2022
  ident: 10.1016/j.ijbiomac.2024.130361_bb0750
  article-title: Small non-coding RNA therapeutics for cardiovascular disease
  publication-title: Eur. Heart J.
  doi: 10.1093/eurheartj/ehac463
– volume: 49
  start-page: 2016
  year: 2008
  ident: 10.1016/j.ijbiomac.2024.130361_bb0230
  article-title: Novel hyaluronic acid-chitosan nanoparticles for ocular gene therapy
  publication-title: Invest. Ophthalmol. Vis. Sci.
  doi: 10.1167/iovs.07-1077
– volume: 25
  start-page: 1
  year: 2023
  ident: 10.1016/j.ijbiomac.2024.130361_bb0880
  article-title: Delivery strategies and applications
  publication-title: AAPS Journal
  doi: 10.1208/s12248-023-00860-z
– ident: 10.1016/j.ijbiomac.2024.130361_bb0145
  doi: 10.1038/cddis.2016.438
– volume: 218
  year: 2019
  ident: 10.1016/j.ijbiomac.2024.130361_bb0460
  article-title: Intranasal delivery of targeted polyfunctional gold–iron oxide nanoparticles loaded with therapeutic microRNAs for combined theranostic multimodality imaging and presensitization of glioblastoma to temozolomide
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2019.119342
– volume: 22
  start-page: 11596
  year: 2021
  ident: 10.1016/j.ijbiomac.2024.130361_bb0680
  article-title: Ncrnas in therapeutics: challenges and limitations in nucleic acid-based drug delivery
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms222111596
– volume: 38
  start-page: 613
  year: 2022
  ident: 10.1016/j.ijbiomac.2024.130361_bb0405
  article-title: Emerging concepts of miRNA therapeutics: from cells to clinic
  publication-title: Trends Genet.
  doi: 10.1016/j.tig.2022.02.006
– volume: 36
  year: 2021
  ident: 10.1016/j.ijbiomac.2024.130361_bb0625
  article-title: Chitosan-tripolyphosphate nanoparticles-mediated co-delivery of MTHFD1L shRNA and 5-aminolevulinic acid for combination photodynamic-gene therapy in oral cancer
  publication-title: Photodiagn. Photodyn. Ther.
  doi: 10.1016/j.pdpdt.2021.102581
– volume: 5
  start-page: 6908
  year: 2017
  ident: 10.1016/j.ijbiomac.2024.130361_bb0085
  article-title: A redox-responsive strategy using mesoporous silica nanoparticles for co-delivery of siRNA and doxorubicin
  publication-title: J. Mater. Chem. B
  doi: 10.1039/C7TB00613F
– ident: 10.1016/j.ijbiomac.2024.130361_bb0305
– volume: 277
  year: 2022
  ident: 10.1016/j.ijbiomac.2024.130361_bb0425
  article-title: Silk fibroin nanofibrous scaffolds incorporated with microRNA-222 loaded chitosan nanoparticles for enhanced neuronal differentiation of neural stem cells
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2021.118791
– volume: 186
  start-page: 849
  year: 2021
  ident: 10.1016/j.ijbiomac.2024.130361_bb0520
  article-title: Blockade of CD73 using siRNA loaded chitosan lactate nanoparticles functionalized with TAT-hyaluronate enhances doxorubicin mediated cytotoxicity in cancer cells both in vitro and in vivo
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2021.07.034
– volume: 23
  start-page: 619
  year: 2015
  ident: 10.1016/j.ijbiomac.2024.130361_bb0315
  article-title: Impact of chitosan composites and chitosan nanoparticle composites on various drug delivery systems: a review
  publication-title: J. Food Drug Anal.
  doi: 10.1016/j.jfda.2014.10.008
– volume: 16
  year: 2022
  ident: 10.1016/j.ijbiomac.2024.130361_bb0500
  article-title: Improved anti-hepatocellular carcinoma effect by enhanced co-delivery of Tim-3 siRNA and sorafenib via multiple pH triggered drug-eluting nanoparticles
  publication-title: Mater Today Bio
– volume: 1364
  start-page: 143
  year: 2016
  ident: 10.1016/j.ijbiomac.2024.130361_bb0245
  article-title: Chitosan nanoparticles for siRNA delivery in vitro
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-4939-3112-5_12
– volume: 12
  start-page: 4195
  year: 2017
  ident: 10.1016/j.ijbiomac.2024.130361_bb0465
  article-title: Biodegradable and biocompatible cationic polymer delivering microRNA-221/222 promotes nerve regeneration after sciatic nerve crush
  publication-title: Int. J. Nanomedicine
  doi: 10.2147/IJN.S132190
– volume: 138
  start-page: 49
  year: 2016
  ident: 10.1016/j.ijbiomac.2024.130361_bb0730
  article-title: Improving the osteogenesis of rat mesenchymal stem cells by chitosan-based-microRNA nanoparticles
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2015.11.044
– volume: 34
  start-page: 270
  year: 2017
  ident: 10.1016/j.ijbiomac.2024.130361_bb0345
  article-title: Exploring the effect of formulation parameters on the particle size of carboxymethyl chitosan nanoparticles prepared via reverse micellar crosslinking
  publication-title: J. Microencapsul.
  doi: 10.1080/02652048.2017.1321047
– volume: 200
  start-page: 543
  year: 2022
  ident: 10.1016/j.ijbiomac.2024.130361_bb0745
  article-title: Glutathione targeted tragacanthic acid-chitosan as a non-viral vector for brain delivery of miRNA-219a-5P: an in vitro/in vivo study
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2022.01.100
– ident: 10.1016/j.ijbiomac.2024.130361_bb0240
  doi: 10.3762/bjnano.10.250
– ident: 10.1016/j.ijbiomac.2024.130361_bb0395
  doi: 10.3390/md17060381
– volume: 382
  start-page: 2289
  year: 2020
  ident: 10.1016/j.ijbiomac.2024.130361_bb0775
  article-title: Phase 3 trial of RNAi therapeutic Givosiran for acute intermittent porphyria
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1913147
– volume: 137
  start-page: 115
  year: 2018
  ident: 10.1016/j.ijbiomac.2024.130361_bb0570
  article-title: Recent advances in nanoparticle-based cancer drug and gene delivery
  publication-title: Adv. Cancer Res.
  doi: 10.1016/bs.acr.2017.11.003
– ident: 10.1016/j.ijbiomac.2024.130361_bb0865
  doi: 10.3390/ijms17111790
– ident: 10.1016/j.ijbiomac.2024.130361_bb0160
  doi: 10.3390/polym10030267
– volume: 379
  start-page: 11
  year: 2018
  ident: 10.1016/j.ijbiomac.2024.130361_bb0770
  article-title: Patisiran, an RNAi therapeutic, for hereditary transthyretin amyloidosis
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1716153
– volume: 79
  start-page: 1
  year: 2010
  ident: 10.1016/j.ijbiomac.2024.130361_bb0365
  article-title: Chitosan conjugated DNA nanoparticles in gene therapy
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2009.08.026
– ident: 10.1016/j.ijbiomac.2024.130361_bb0830
– volume: 44
  start-page: 1370
  year: 2016
  ident: 10.1016/j.ijbiomac.2024.130361_bb0130
  article-title: Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkv1367
– volume: 238
  start-page: 143
  year: 2019
  ident: 10.1016/j.ijbiomac.2024.130361_bb0615
  article-title: PEG modified trimethyl chitosan based nanoparticles for the codelivery of doxorubicin and iSur-pDNA
  publication-title: Mater. Lett.
  doi: 10.1016/j.matlet.2018.11.161
– volume: 22
  start-page: 1760
  year: 2012
  ident: 10.1016/j.ijbiomac.2024.130361_bb0005
  article-title: GENCODE: the reference human genome annotation for the ENCODE project
  publication-title: Genome Res.
  doi: 10.1101/gr.135350.111
– volume: 123
  start-page: 9629
  year: 2019
  ident: 10.1016/j.ijbiomac.2024.130361_bb0270
  article-title: Polyethylenimine-DNA ratio strongly affects their nanoparticle formation: a large-scale coarse-grained molecular dynamics study
  publication-title: J. Phys. Chem. B
  doi: 10.1021/acs.jpcb.9b07031
– volume: 1632
  start-page: 219
  year: 2017
  ident: 10.1016/j.ijbiomac.2024.130361_bb0905
  article-title: Chitosan nanoparticles for miRNA delivery
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-4939-7138-1_14
– ident: 10.1016/j.ijbiomac.2024.130361_bb0155
– ident: 10.1016/j.ijbiomac.2024.130361_bb0860
– ident: 10.1016/j.ijbiomac.2024.130361_bb0170
  doi: 10.1016/j.ijbiomac.2018.06.018
– ident: 10.1016/j.ijbiomac.2024.130361_bb0285
  doi: 10.3390/nano13081302
– ident: 10.1016/j.ijbiomac.2024.130361_bb0165
  doi: 10.3390/polym13193256
– volume: 164
  start-page: 2726
  year: 2020
  ident: 10.1016/j.ijbiomac.2024.130361_bb0205
  article-title: Antimicrobial and antioxidant properties of chitosan and its derivatives and their applications: a review
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2020.08.153
– volume: 286
  start-page: 5
  year: 2018
  ident: 10.1016/j.ijbiomac.2024.130361_bb0605
  article-title: Administration of chitosan-tripolyphosphate-DNA nanoparticles to knockdown glutamate dehydrogenase expression impairs transdeamination and gluconeogenesis in the liver
  publication-title: J. Biotechnol.
  doi: 10.1016/j.jbiotec.2018.09.002
– volume: 11
  start-page: 175
  year: 2021
  ident: 10.1016/j.ijbiomac.2024.130361_bb0375
  article-title: Chitosan-based nanoparticles against viral infections
  publication-title: Front. Cell. Infect. Microbiol.
  doi: 10.3389/fcimb.2021.643953
– ident: 10.1016/j.ijbiomac.2024.130361_bb0280
  doi: 10.3390/molecules26020272
– ident: 10.1016/j.ijbiomac.2024.130361_bb0335
  doi: 10.3390/molecules28041963
– volume: 104
  start-page: 61
  year: 2016
  ident: 10.1016/j.ijbiomac.2024.130361_bb0020
  article-title: Recent progress in development of siRNA delivery vehicles for cancer therapy
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2016.06.011
– ident: 10.1016/j.ijbiomac.2024.130361_bb0390
  doi: 10.1038/srep13567
– volume: 39
  start-page: 178
  year: 2022
  ident: 10.1016/j.ijbiomac.2024.130361_bb0450
  article-title: Biomimetic nanosystems for the synergistic delivery of miR-144/451a for oral squamous cell carcinoma
  publication-title: Balkan Med J. Balkan Med J
– volume: 280
  year: 2022
  ident: 10.1016/j.ijbiomac.2024.130361_bb0760
  article-title: Dual targeted delivery of statins and nucleic acids by chitosan-based nanoparticles for enhanced antiatherosclerotic efficacy
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2021.121324
– ident: 10.1016/j.ijbiomac.2024.130361_bb0835
– ident: 10.1016/j.ijbiomac.2024.130361_bb0675
  doi: 10.3390/ph15091036
– ident: 10.1016/j.ijbiomac.2024.130361_bb0105
  doi: 10.1038/s41580-020-00315-9
– year: 2015
  ident: 10.1016/j.ijbiomac.2024.130361_bb0310
  publication-title: Chitosan: a promising biopolymer in drug delivery applications removal of contaminants from water by polymer nanocomposites view project Chitosan: A Promising Biopolymer in Drug Delivery Applications
– volume: 25
  start-page: 718
  year: 2020
  ident: 10.1016/j.ijbiomac.2024.130361_bb0915
  article-title: Improving the therapeutic efficiency of noncoding RNAs in cancers using targeted drug delivery systems
  publication-title: Drug Discov. Today
  doi: 10.1016/j.drudis.2019.11.006
– ident: 10.1016/j.ijbiomac.2024.130361_bb0295
  doi: 10.3390/polym10030235
– volume: 30
  start-page: 5844
  year: 2009
  ident: 10.1016/j.ijbiomac.2024.130361_bb0585
  article-title: The suppression of lung tumorigenesis by aerosol-delivered folate–chitosan-graft-polyethylenimine/Akt1 shRNA complexes through the Akt signaling pathway
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2009.07.017
– volume: 13
  start-page: 1309
  year: 2017
  ident: 10.1016/j.ijbiomac.2024.130361_bb0575
  article-title: Folate-targeted nanoparticle delivery of androgen receptor shRNA enhances the sensitivity of hormone-independent prostate cancer to radiotherapy
  publication-title: Nanomedicine
  doi: 10.1016/j.nano.2017.01.015
– ident: 10.1016/j.ijbiomac.2024.130361_bb0050
  doi: 10.3389/fonc.2022.951864
– volume: 1617
  start-page: 57
  year: 2017
  ident: 10.1016/j.ijbiomac.2024.130361_bb0060
  article-title: MicroRNAs: biomarkers, diagnostics, and therapeutics
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-4939-7046-9_4
– volume: 26
  year: 2020
  ident: 10.1016/j.ijbiomac.2024.130361_bb0525
  article-title: Trimethyl chitosan-hyaluronic acid nano-polyplexes for intravitreal VEGFR-2 siRNA delivery: formulation and in vivo efficacy evaluation
  publication-title: Nanomedicine
– volume: 150
  start-page: 281
  year: 2020
  ident: 10.1016/j.ijbiomac.2024.130361_bb0190
  article-title: Biodistribution and pharmacokinetics of thiolated chitosan nanoparticles for oral delivery of insulin in vivo
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2020.02.079
– volume: 260
  year: 2020
  ident: 10.1016/j.ijbiomac.2024.130361_bb0550
  article-title: Codelivery of BV6 and anti-IL6 siRNA by hyaluronate-conjugated PEG-chitosan-lactate nanoparticles inhibits tumor progression
  publication-title: Life Sci.
  doi: 10.1016/j.lfs.2020.118423
– ident: 10.1016/j.ijbiomac.2024.130361_bb0125
  doi: 10.3390/ijms24044233
– ident: 10.1016/j.ijbiomac.2024.130361_bb0645
  doi: 10.1186/s40824-022-00292-4
– volume: 290
  year: 2022
  ident: 10.1016/j.ijbiomac.2024.130361_bb0685
  article-title: Chitosan nanocarriers for microRNA delivery and detection: a preliminary review with emphasis on cancer
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2022.119489
– ident: 10.1016/j.ijbiomac.2024.130361_bb0075
  doi: 10.2147/IJN.S200253
– ident: 10.1016/j.ijbiomac.2024.130361_bb0065
  doi: 10.1038/s41392-020-0207-x
– ident: 10.1016/j.ijbiomac.2024.130361_bb0815
– ident: 10.1016/j.ijbiomac.2024.130361_bb0820
– volume: 17
  start-page: 98
  year: 2015
  ident: 10.1016/j.ijbiomac.2024.130361_bb0545
  article-title: Optimization of multifunctional chitosan–siRNA nanoparticles for oral delivery applications, targeting TNF-α silencing in rats
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2015.01.041
– volume: 33
  year: 2021
  ident: 10.1016/j.ijbiomac.2024.130361_bb0595
  article-title: Improved insulin sensitivity in obese-diabetic mice via chitosan nanomicelles mediated silencing of pro-inflammatory adipocytokines
  publication-title: Nanomedicine
– volume: 109
  start-page: 2854
  year: 2020
  ident: 10.1016/j.ijbiomac.2024.130361_bb0025
  article-title: Delivery of TSPAN1 siRNA by novel Th17 targeted cationic liposomes for gastric cancer intervention
  publication-title: J. Pharm. Sci.
  doi: 10.1016/j.xphs.2020.05.018
– volume: 13
  start-page: 6491
  year: 2019
  ident: 10.1016/j.ijbiomac.2024.130361_bb0220
  article-title: Delivery of MicroRNAs by chitosan nanoparticles to functionally alter macrophage cholesterol efflux in vitro and in Vivo
  publication-title: ACS Nano
  doi: 10.1021/acsnano.8b09679
– volume: 111
  start-page: 53
  year: 2014
  ident: 10.1016/j.ijbiomac.2024.130361_bb0810
  article-title: Long-term safety and efficacy of microRNA-targeted therapy in chronic hepatitis C patients
  publication-title: Antivir. Res.
  doi: 10.1016/j.antiviral.2014.08.015
– ident: 10.1016/j.ijbiomac.2024.130361_bb0150
– volume: 882
  year: 2020
  ident: 10.1016/j.ijbiomac.2024.130361_bb0560
  article-title: Silencing of HIF-1α/CD73 axis by siRNA-loaded TAT-chitosan-spion nanoparticles robustly blocks cancer cell progression
  publication-title: Eur. J. Pharmacol.
  doi: 10.1016/j.ejphar.2020.173235
– volume: 80
  start-page: 335
  year: 2020
  ident: 10.1016/j.ijbiomac.2024.130361_bb0790
  article-title: Givosiran: first approval
  publication-title: Drugs
  doi: 10.1007/s40265-020-01269-0
– ident: 10.1016/j.ijbiomac.2024.130361_bb0045
  doi: 10.3390/ijms17101712
– volume: 216
  start-page: 332
  year: 2019
  ident: 10.1016/j.ijbiomac.2024.130361_bb0505
  article-title: Amphipathic chitosans improve the physicochemical properties of siRNA-chitosan nanoparticles at physiological conditions
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2019.03.098
– volume: 266
  year: 2021
  ident: 10.1016/j.ijbiomac.2024.130361_bb0510
  article-title: Codelivery of STAT3 and PD-L1 siRNA by hyaluronate-TAT trimethyl/thiolated chitosan nanoparticles suppresses cancer progression in tumor-bearing mice
  publication-title: Life Sci.
  doi: 10.1016/j.lfs.2020.118847
– volume: 162
  start-page: 1303
  year: 2020
  ident: 10.1016/j.ijbiomac.2024.130361_bb0250
  article-title: Small interfering RNA-loaded chitosan hydrochloride/carboxymethyl chitosan nanoparticles for ultrasound-triggered release to hamper colorectal cancer growth in vitro
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2020.06.246
– volume: 12
  start-page: 2013
  year: 2021
  ident: 10.1016/j.ijbiomac.2024.130361_bb0110
  article-title: LncRNAs as therapeutic targets and potential biomarkers for lipid-related diseases
  publication-title: Front. Pharmacol.
– volume: 31
  year: 2023
  ident: 10.1016/j.ijbiomac.2024.130361_bb0805
  article-title: Current clinical trials with non-coding RNA-based therapeutics in malignant diseases: a systematic review
  publication-title: Transl. Oncol.
  doi: 10.1016/j.tranon.2023.101634
– volume: 9
  year: 2017
  ident: 10.1016/j.ijbiomac.2024.130361_bb0325
  article-title: An overview of chitosan nanoparticles and its application in non-parenteral drug delivery
  publication-title: Pharmaceutics
  doi: 10.3390/pharmaceutics9040053
– ident: 10.1016/j.ijbiomac.2024.130361_bb0030
  doi: 10.3390/nano6070131
– ident: 10.1016/j.ijbiomac.2024.130361_bb0090
  doi: 10.3390/ncrna5010017
– volume: 258
  year: 2021
  ident: 10.1016/j.ijbiomac.2024.130361_bb0015
  article-title: Cationic nanoparticles self-assembled from amphiphilic chitosan derivatives containing poly(amidoamine) dendrons and deoxycholic acid as a vector for co-delivery of doxorubicin and gene
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2021.117706
– ident: 10.1016/j.ijbiomac.2024.130361_bb0200
  doi: 10.3390/ma4081399
– volume: 48
  start-page: 6805
  year: 2021
  ident: 10.1016/j.ijbiomac.2024.130361_bb0275
  article-title: Metformin-loaded lecithin nanoparticles induce colorectal cancer cytotoxicity via epigenetic modulation of noncoding RNAs
  publication-title: Mol. Biol. Rep.
  doi: 10.1007/s11033-021-06680-8
– ident: 10.1016/j.ijbiomac.2024.130361_bb0655
  doi: 10.3390/biomedicines9040433
– volume: 118
  year: 2021
  ident: 10.1016/j.ijbiomac.2024.130361_bb0660
  article-title: Optimization of chitosan-based polyelectrolyte nanoparticles for gene delivery, using design of experiment: in vitro and in vivo study
  publication-title: Mater. Sci. Eng. C
  doi: 10.1016/j.msec.2020.111036
– ident: 10.1016/j.ijbiomac.2024.130361_bb0070
  doi: 10.1007/s40259-022-00549-3
– ident: 10.1016/j.ijbiomac.2024.130361_bb0690
  doi: 10.1186/s43042-020-00074-4
– volume: 9
  start-page: 57
  year: 2017
  ident: 10.1016/j.ijbiomac.2024.130361_bb0840
  article-title: Polyethylenimine nanoparticle-mediated siRNA delivery to reduce α-synuclein expression in a model of Parkinson’s disease
  publication-title: Mol Ther Nucleic Acids
  doi: 10.1016/j.omtn.2017.08.013
– ident: 10.1016/j.ijbiomac.2024.130361_bb0180
  doi: 10.3390/ijms21020487
– volume: 8
  year: 2019
  ident: 10.1016/j.ijbiomac.2024.130361_bb0665
  article-title: Orally delivered antisense oligodeoxyribonucleotides of TNF-α via polysaccharide-based nanocomposites targeting intestinal inflammation
  publication-title: Adv. Healthc. Mater.
  doi: 10.1002/adhm.201801389
– volume: 6
  start-page: 461
  year: 2017
  ident: 10.1016/j.ijbiomac.2024.130361_bb0210
  article-title: Preparation, characterization, and antioxidant activity of water-soluble oligochitosan
  publication-title: Green Processes Synth.
  doi: 10.1515/gps-2016-0126
– volume: 233
  start-page: 2007
  year: 2018
  ident: 10.1016/j.ijbiomac.2024.130361_bb0055
  article-title: Interplay between miRNAs and human diseases
  publication-title: J. Cell. Physiol.
  doi: 10.1002/jcp.25854
– volume: 506
  year: 2021
  ident: 10.1016/j.ijbiomac.2024.130361_bb0455
  article-title: Plausible role of chitosan in drug and gene delivery against resistant breast cancer cells
  publication-title: Carbohydr. Res.
  doi: 10.1016/j.carres.2021.108357
– ident: 10.1016/j.ijbiomac.2024.130361_bb0700
  doi: 10.3390/diseases6030057
– volume: 94
  start-page: 96
  year: 2017
  ident: 10.1016/j.ijbiomac.2024.130361_bb0185
  article-title: Fabrication and characterization of bactericidal thiol-chitosan and chitosan iodoacetamide nanofibres
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2016.07.061
– ident: 10.1016/j.ijbiomac.2024.130361_bb0175
  doi: 10.4172/2332-0877.1000291
– volume: 13
  start-page: 482
  year: 2019
  ident: 10.1016/j.ijbiomac.2024.130361_bb0435
  article-title: A molecular targeted immunotherapeutic strategy for ulcerative colitis via dual-targeting nanoparticles delivering miR-146b to intestinal macrophages
  publication-title: J. Crohns Colitis
  doi: 10.1093/ecco-jcc/jjy181
– volume: 20
  start-page: 1097
  year: 2021
  ident: 10.1016/j.ijbiomac.2024.130361_bb0640
  article-title: Effects on the STAT3-shRNA in non-small-cell lung cancer therapy: design, induction of apoptosis, and conjugation with chitosan-based gene vectors
  publication-title: J. Ocean Univ. China
  doi: 10.1007/s11802-021-4669-y
– volume: 64
  start-page: 320
  year: 2016
  ident: 10.1016/j.ijbiomac.2024.130361_bb0040
  article-title: Pairing beyond the seed supports MicroRNA targeting specificity
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2016.09.004
– volume: 27
  start-page: 27
  year: 2017
  ident: 10.1016/j.ijbiomac.2024.130361_bb0095
  article-title: Chromatin environment, transcriptional regulation, and splicing distinguish lincRNAs and mRNAs
  publication-title: Genome Res.
  doi: 10.1101/gr.214205.116
– volume: 27
  start-page: 797
  year: 2022
  ident: 10.1016/j.ijbiomac.2024.130361_bb0485
  article-title: Programmable siRNA pro-drugs that activate RNAi activity in response to specific cellular RNA biomarkers
  publication-title: Mol Ther Nucleic Acids
  doi: 10.1016/j.omtn.2021.12.039
– ident: 10.1016/j.ijbiomac.2024.130361_bb0135
  doi: 10.1038/s41576-019-0158-7
– volume: 83
  start-page: 103
  year: 2023
  ident: 10.1016/j.ijbiomac.2024.130361_bb0670
  article-title: Extracellular vesicle-mediated transfer of LncRNA IGFL2-AS1 confers sunitinib resistance in renal cell carcinoma
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-21-3432
– volume: 12
  start-page: 22074
  year: 2020
  ident: 10.1016/j.ijbiomac.2024.130361_bb0385
  article-title: Stimuli-responsive polysaccharide enveloped liposome for targeting and penetrating delivery of survivin-shRNA into breast tumor
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.9b22440
– volume: 15
  start-page: 275
  year: 2019
  ident: 10.1016/j.ijbiomac.2024.130361_bb0410
  article-title: AAV5-miHTT lowers huntingtin mRNA and protein without off-target effects in patient-derived neuronal cultures and astrocytes
  publication-title: Mol Ther Methods Clin Dev
  doi: 10.1016/j.omtm.2019.09.010
– volume: 108
  start-page: 6139
  year: 2011
  ident: 10.1016/j.ijbiomac.2024.130361_bb0475
  article-title: MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1016758108
– volume: 128
  year: 2021
  ident: 10.1016/j.ijbiomac.2024.130361_bb0445
  article-title: Smart co-delivery of miR-34a and cytotoxic peptides (LTX-315 and melittin) by chitosan based polyelectrolyte nanocarriers for specific cancer cell death induction
  publication-title: Mater. Sci. Eng. C
  doi: 10.1016/j.msec.2021.112258
– volume: 24
  year: 2019
  ident: 10.1016/j.ijbiomac.2024.130361_bb0720
  article-title: Application of chitosan in bone and dental engineering
  publication-title: Molecules
  doi: 10.3390/molecules24163009
– volume: 2242
  year: 2020
  ident: 10.1016/j.ijbiomac.2024.130361_bb0890
  article-title: Chitosan nanoparticles modified by polyethylene glycol as lamivudine drug delivery system
  publication-title: AIP Conf. Proc.
  doi: 10.1063/5.0007925
– ident: 10.1016/j.ijbiomac.2024.130361_bb0115
  doi: 10.1007/s00109-023-02305-8
– ident: 10.1016/j.ijbiomac.2024.130361_bb0255
  doi: 10.34172/bi.2021.22119
– volume: 20
  start-page: 291
  year: 2012
  ident: 10.1016/j.ijbiomac.2024.130361_bb0350
  article-title: Chitosan nanoparticles: a survey of preparation methods
  publication-title: J. Drug Target.
  doi: 10.3109/1061186X.2011.654121
– volume: 2021
  year: 2021
  ident: 10.1016/j.ijbiomac.2024.130361_bb0705
  article-title: NEAT1 siRNA packed with chitosan nanoparticles regulates the development of colon cancer cells via lncRNA NEAT1/miR-377-3p axis
  publication-title: Biomed. Res. Int.
– volume: 18
  start-page: 1
  year: 2020
  ident: 10.1016/j.ijbiomac.2024.130361_bb0430
  article-title: Chitosan-miRNA functionalized microporous titanium oxide surfaces via a layer-by-layer approach with a sustained release profile for enhanced osteogenic activity
  publication-title: J Nanobiotechnology
  doi: 10.1186/s12951-020-00674-7
– volume: 201
  start-page: 131
  year: 2018
  ident: 10.1016/j.ijbiomac.2024.130361_bb0710
  article-title: Glutathione responsive chitosan-thiolated dextran conjugated miR-145 nanoparticles targeted with AS1411 aptamer for cancer treatment
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2018.08.060
– volume: 1
  start-page: 185
  year: 2017
  ident: 10.1016/j.ijbiomac.2024.130361_bb0340
  article-title: Production of micro- and nanoscale chitosan particles for biomedical applications
  publication-title: Chitosan Based Biomaterials
  doi: 10.1016/B978-0-08-100230-8.00008-X
– volume: 13
  year: 2021
  ident: 10.1016/j.ijbiomac.2024.130361_bb0755
  article-title: Diet and lifestyle factors and risk of atherosclerotic cardiovascular disease—a prospective cohort study
  publication-title: Nutrients
  doi: 10.3390/nu13113822
– volume: 90
  start-page: 665
  year: 2017
  ident: 10.1016/j.ijbiomac.2024.130361_bb0080
  article-title: Therapeutic potential of chemically modified siRNA: recent trends
  publication-title: Chem. Biol. Drug Des.
  doi: 10.1111/cbdd.12993
– volume: 181
  start-page: 621
  year: 2020
  ident: 10.1016/j.ijbiomac.2024.130361_bb0100
  article-title: Distinct processing of lncRNAs contributes to non-conserved functions in stem cells
  publication-title: Cell
  doi: 10.1016/j.cell.2020.03.006
– volume: 251
  year: 2021
  ident: 10.1016/j.ijbiomac.2024.130361_bb0620
  article-title: A targeted and redox/pH-responsive chitosan oligosaccharide derivatives based nanohybrids for overcoming multidrug resistance of breast cancer cells
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2020.117008
– volume: 75
  start-page: 285
  year: 1978
  ident: 10.1016/j.ijbiomac.2024.130361_bb0765
  article-title: Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide
  publication-title: Proc. Natl. Acad. Sci.
  doi: 10.1073/pnas.75.1.285
– volume: 81
  start-page: 389
  year: 2021
  ident: 10.1016/j.ijbiomac.2024.130361_bb0795
  article-title: Inclisiran: first approval
  publication-title: Drugs
  doi: 10.1007/s40265-021-01473-6
– volume: 351
  start-page: 713
  year: 2022
  ident: 10.1016/j.ijbiomac.2024.130361_bb0495
  article-title: Molecularly engineered siRNA conjugates for tumor-targeted RNAi therapy
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2022.09.040
– volume: 23
  start-page: 164
  year: 2010
  ident: 10.1016/j.ijbiomac.2024.130361_bb0875
  article-title: Molecular-weight-dependent toxic effects of chitosans on the human keratinocyte cell line HaCaT
  publication-title: Skin Pharmacol. Physiol.
  doi: 10.1159/000276996
– ident: 10.1016/j.ijbiomac.2024.130361_bb0380
– volume: 4
  start-page: 14
  year: 1998
  ident: 10.1016/j.ijbiomac.2024.130361_bb0785
  article-title: Fomivirsen approved for CMV retinitis
  publication-title: J. Int. Assoc. Phys. AIDS Care
– ident: 10.1016/j.ijbiomac.2024.130361_bb0035
  doi: 10.1038/nrm3838
– volume: 31
  start-page: 3992
  year: 2019
  ident: 10.1016/j.ijbiomac.2024.130361_bb0590
  article-title: Chitosan- graft-poly(l -lysine) dendron-assisted facile self-assembly of au nanoclusters for enhanced X-ray computer tomography imaging and precise MMP-9 plasmid shRNA delivery
  publication-title: Chem. Mater.
  doi: 10.1021/acs.chemmater.9b00507
– ident: 10.1016/j.ijbiomac.2024.130361_bb0010
  doi: 10.1038/s41573-021-00219-z
– ident: 10.1016/j.ijbiomac.2024.130361_bb0825
– volume: 27
  start-page: 2340
  year: 2021
  ident: 10.1016/j.ijbiomac.2024.130361_bb0535
  article-title: Emergence of enzalutamide resistance in prostate cancer is associated with BCL-2 and IKKB dependencies
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-20-3260
– ident: 10.1016/j.ijbiomac.2024.130361_bb0885
  doi: 10.3390/app9112193
– ident: 10.1016/j.ijbiomac.2024.130361_bb0225
  doi: 10.3390/polym10040444
– ident: 10.1016/j.ijbiomac.2024.130361_bb0650
  doi: 10.1038/s41419-020-02820-3
– volume: 122
  start-page: 1630
  year: 2020
  ident: 10.1016/j.ijbiomac.2024.130361_bb0415
  article-title: Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours
  publication-title: Br. J. Cancer
  doi: 10.1038/s41416-020-0802-1
– ident: 10.1016/j.ijbiomac.2024.130361_bb0440
  doi: 10.3390/ph13100314
– volume: 226
  year: 2019
  ident: 10.1016/j.ijbiomac.2024.130361_bb0215
  article-title: The antioxidant and antifungal activity of chitosan derivatives bearing Schiff bases and quaternary ammonium salts
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2019.115256
– volume: 81
  start-page: 277
  year: 2021
  ident: 10.1016/j.ijbiomac.2024.130361_bb0800
  article-title: Lumasiran: first approval
  publication-title: Drugs
  doi: 10.1007/s40265-020-01463-0
– volume: 33
  start-page: 107
  year: 2016
  ident: 10.1016/j.ijbiomac.2024.130361_bb0355
  article-title: Chitosan nanoparticles prepared by ionotropic gelation: an overview of recent advances
  publication-title: Crit. Rev. Ther. Drug Carrier Syst.
  doi: 10.1615/CritRevTherDrugCarrierSyst.2016014850
– volume: 285
  year: 2022
  ident: 10.1016/j.ijbiomac.2024.130361_bb0900
  article-title: Modified chitosan for effective renal delivery of siRNA to treat acute kidney injury
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2022.121562
– ident: 10.1016/j.ijbiomac.2024.130361_bb0910
– volume: 294
  year: 2022
  ident: 10.1016/j.ijbiomac.2024.130361_bb0370
  article-title: Gene therapy: comprehensive overview and therapeutic applications
  publication-title: Life Sci.
  doi: 10.1016/j.lfs.2022.120375
– ident: 10.1016/j.ijbiomac.2024.130361_bb0260
  doi: 10.3390/polym13111717
– volume: 75
  start-page: 89
  year: 2019
  ident: 10.1016/j.ijbiomac.2024.130361_bb0740
  article-title: LINGO-1 siRNA nanoparticles promote central remyelination in ethidium bromide-induced demyelination in rats
  publication-title: J. Physiol. Biochem.
  doi: 10.1007/s13105-018-00660-6
– volume: 378
  start-page: 625
  year: 2018
  ident: 10.1016/j.ijbiomac.2024.130361_bb0780
  article-title: Nusinersen versus sham control in later-onset spinal muscular atrophy
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1710504
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Snippet Non-coding RNA (ncRNA)-based therapies entail delivering ncRNAs to cells to regulate gene expression and produce proteins that combat infections, cancer,...
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SubjectTerms biocompatible materials
Chitosan
Drug delivery
gene expression
Nanocarriers
non-coding RNA
Non-coding RNAs
polymers
Therapeutics
Tissue engineering
Title Chitosan nanocarriers for non-coding RNA therapeutics: A review
URI https://dx.doi.org/10.1016/j.ijbiomac.2024.130361
https://www.ncbi.nlm.nih.gov/pubmed/38395284
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