Natural polymers-based surface engineering of bone scaffolds – A review

• Published in: International journal of biological macromolecules Vol. 282; no. Pt 2; p. 136840
• Main Authors: Sathiya, K., Ganesamoorthi, Srinidhi, Mohan, Sahithya, Shanmugavadivu, Abinaya, Selvamurugan, Nagarajan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2024
• Subjects: adhesion; adsorption; alginates; Animals; Biocompatible Materials - chemistry; Bone and Bones; bone formation; Bone Regeneration; bones; BTE; ceramics; Chitosan; Chitosan - chemistry; Collagen; gelatin; health services; Humans; hyaluronic acid; Natural polymers; Osteogenesis - drug effects; polymers; Polymers - chemistry; Surface modification; Surface Properties; Tissue Engineering - methods; Tissue Scaffolds - chemistry; ALP; EDC; RAS; mMSCs; MSCs; TiGC; EDX; DOPA; Natural polymers; Bgh; PKB; AgNPs; BTE; RSV; PCL; Mg; SEM; Chitosan; P13K; BMSCs; ERK; TiO2; TCP; PLA; BG; NT; MC3T3-E1; PDA; FDM; TTO; SD; MgO; PLLA; BMD; TGF-β; XPS; COL; Surface modification; TAmc; VEGF; GP; PHBV; B2O3; TA; ECM; CS; SCPP; Collagen; MgCaS; EPD; HA; OGP; MgHApCh; PVA; LAS
• ISSN: 0141-8130; 1879-0003; 1879-0003
• DOI: 10.1016/j.ijbiomac.2024.136840

Critical-sized bone defects present a major challenge in healthcare, necessitating innovative solutions like bone tissue engineering (BTE) to address these issues. Surface engineering of bone scaffolds plays a crucial role in BTE by integrating natural polymers with advanced techniques to closely replicate the bone microenvironment, enhancing cellular responses such as adhesion, proliferation, and osteogenic differentiation. Natural polymers like collagen, chitosan, gelatin, hyaluronic acid, and alginate are used in various surface modification methods, including physical adsorption, covalent immobilization, electrospinning, and layer-by-layer assembly. This review provides a thorough analysis of these surface modification strategies across metallic, ceramic, and polymeric scaffolds, along with characterization methodologies, preclinical studies, and future prospects. By analysing recent research, the review offers valuable insights for advancing natural polymer-based surface engineering and developing next-generation scaffolds with improved bone regenerative capabilities.