Selection, tuning, and adaptation in mouse NK cell education
Summary Natural killer (NK) cells recognize transformed cells with an array of germline‐encoded inhibitory and activating receptors. Inhibitory Ly49 receptors bind major histocompatibility complex class I (MHC‐I) molecules, providing a mechanism by which NK cells maintain self‐tolerance yet eliminat...
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| Published in | Immunological reviews Vol. 267; no. 1; pp. 167 - 177 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Blackwell Publishing Ltd
01.09.2015
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0105-2896 1600-065X |
| DOI | 10.1111/imr.12330 |
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| Abstract | Summary
Natural killer (NK) cells recognize transformed cells with an array of germline‐encoded inhibitory and activating receptors. Inhibitory Ly49 receptors bind major histocompatibility complex class I (MHC‐I) molecules, providing a mechanism by which NK cells maintain self‐tolerance yet eliminate cells expressing reduced levels of MHC‐I. Additionally, MHC‐I molecules are required for NK cell education, a process in which NK cells acquire responsiveness. In this review, we discuss three facets of MHC class I‐dependent education of mouse NK cells: skewing of the inhibitory receptor repertoire, induction of functional responsiveness, and tuning in response to changes in MHC‐I expression. We discuss prevailing models for education such as licensing and disarming and propose a model for positive selection of ‘useful’ NK cell subsets. Furthermore, we argue that both repertoire skewing and functional NK cell education may be altered in mature NK cells subject to changes in MHC‐I input and suggest that this process may provide increased dynamics to the NK cell system. |
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| AbstractList | Natural killer (
NK
) cells recognize transformed cells with an array of germline‐encoded inhibitory and activating receptors. Inhibitory Ly49 receptors bind major histocompatibility complex class I (
MHC
‐I) molecules, providing a mechanism by which
NK
cells maintain self‐tolerance yet eliminate cells expressing reduced levels of
MHC
‐I. Additionally,
MHC
‐I molecules are required for
NK
cell education, a process in which
NK
cells acquire responsiveness. In this review, we discuss three facets of
MHC
class I‐dependent education of mouse
NK
cells: skewing of the inhibitory receptor repertoire, induction of functional responsiveness, and tuning in response to changes in
MHC
‐I expression. We discuss prevailing models for education such as licensing and disarming and propose a model for positive selection of ‘useful’
NK
cell subsets. Furthermore, we argue that both repertoire skewing and functional
NK
cell education may be altered in mature
NK
cells subject to changes in
MHC
‐I input and suggest that this process may provide increased dynamics to the
NK
cell system. Natural killer (NK) cells recognize transformed cells with an array of germline-encoded inhibitory and activating receptors. Inhibitory Ly49 receptors bind major histocompatibility complex class I (MHC-I) molecules, providing a mechanism by which NK cells maintain self-tolerance yet eliminate cells expressing reduced levels of MHC-I. Additionally, MHC-I molecules are required for NK cell education, a process in which NK cells acquire responsiveness. In this review, we discuss three facets of MHC class I-dependent education of mouse NK cells: skewing of the inhibitory receptor repertoire, induction of functional responsiveness, and tuning in response to changes in MHC-I expression. We discuss prevailing models for education such as licensing and disarming and propose a model for positive selection of 'useful' NK cell subsets. Furthermore, we argue that both repertoire skewing and functional NK cell education may be altered in mature NK cells subject to changes in MHC-I input and suggest that this process may provide increased dynamics to the NK cell system. Summary Natural killer (NK) cells recognize transformed cells with an array of germline‐encoded inhibitory and activating receptors. Inhibitory Ly49 receptors bind major histocompatibility complex class I (MHC‐I) molecules, providing a mechanism by which NK cells maintain self‐tolerance yet eliminate cells expressing reduced levels of MHC‐I. Additionally, MHC‐I molecules are required for NK cell education, a process in which NK cells acquire responsiveness. In this review, we discuss three facets of MHC class I‐dependent education of mouse NK cells: skewing of the inhibitory receptor repertoire, induction of functional responsiveness, and tuning in response to changes in MHC‐I expression. We discuss prevailing models for education such as licensing and disarming and propose a model for positive selection of ‘useful’ NK cell subsets. Furthermore, we argue that both repertoire skewing and functional NK cell education may be altered in mature NK cells subject to changes in MHC‐I input and suggest that this process may provide increased dynamics to the NK cell system. |
| Author | Luu Thanh, Thuy Höglund, Petter Kadri, Nadir |
| Author_xml | – sequence: 1 givenname: Nadir surname: Kadri fullname: Kadri, Nadir organization: Center for Hematology and Regenerative Medicine (HERM), Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden – sequence: 2 givenname: Thuy surname: Luu Thanh fullname: Luu Thanh, Thuy organization: Center for Hematology and Regenerative Medicine (HERM), Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden – sequence: 3 givenname: Petter surname: Höglund fullname: Höglund, Petter email: petter.hoglund@ki.se organization: Center for Hematology and Regenerative Medicine (HERM), Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26284477$$D View this record in MEDLINE/PubMed http://kipublications.ki.se/Default.aspx?queryparsed=id:131840477$$DView record from Swedish Publication Index |
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| SecondaryResourceType | review_article |
| Snippet | Summary
Natural killer (NK) cells recognize transformed cells with an array of germline‐encoded inhibitory and activating receptors. Inhibitory Ly49 receptors... Natural killer ( NK ) cells recognize transformed cells with an array of germline‐encoded inhibitory and activating receptors. Inhibitory Ly49 receptors bind... Natural killer (NK) cells recognize transformed cells with an array of germline-encoded inhibitory and activating receptors. Inhibitory Ly49 receptors bind... |
| SourceID | swepub proquest pubmed crossref wiley istex |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 167 |
| SubjectTerms | Animals education Histocompatibility Antigens Class I - immunology Histocompatibility Antigens Class I - metabolism Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Ly49 Mice Models, Immunological NK cell NK Cell Lectin-Like Receptor Subfamily A - immunology NK Cell Lectin-Like Receptor Subfamily A - metabolism Protein Binding - immunology rheostat selection Self Tolerance - immunology Signal Transduction - immunology |
| Title | Selection, tuning, and adaptation in mouse NK cell education |
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