Turn Up the Heat: Circulating Serotonin Tunes Our Internal Heating System

Serotonin acts as neurotransmitter in the brain and as a multifaceted signaling molecule coordinating many physiological processes in the periphery. In a recent issue of Nature Medicine, Crane et al. (2014) find that peripheral serotonin controls thermogenesis in adipose tissue by modulating β-adren...

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Published inCell metabolism Vol. 21; no. 2; pp. 156 - 158
Main Authors Schneider, Jochen G., Nadeau, Joseph H.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 03.02.2015
Subjects
Adipose Tissue, Brown - metabolism
Animals
Insulin Resistance - genetics
Ion Channels - metabolism
Mitochondrial Proteins - metabolism
Non-alcoholic Fatty Liver Disease - genetics
Obesity - genetics
Serotonin - biosynthesis
Thermogenesis - genetics
Tryptophan Hydroxylase - genetics
Online AccessGet full text
ISSN1550-4131
1932-7420
1932-7420
DOI10.1016/j.cmet.2015.01.011

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Abstract Serotonin acts as neurotransmitter in the brain and as a multifaceted signaling molecule coordinating many physiological processes in the periphery. In a recent issue of Nature Medicine, Crane et al. (2014) find that peripheral serotonin controls thermogenesis in adipose tissue by modulating β-adrenergic stimulation of UCP-1, thereby affecting glucose homeostasis and weight gain.
AbstractList Serotonin acts as neurotransmitter in the brain and as a multifaceted signaling molecule coordinating many physiological processes in the periphery. In a recent issue of Nature Medicine, Crane et al. (2014) find that peripheral serotonin controls thermogenesis in adipose tissue by modulating β-adrenergic stimulation of UCP-1, thereby affecting glucose homeostasis and weight gain.Serotonin acts as neurotransmitter in the brain and as a multifaceted signaling molecule coordinating many physiological processes in the periphery. In a recent issue of Nature Medicine, Crane et al. (2014) find that peripheral serotonin controls thermogenesis in adipose tissue by modulating β-adrenergic stimulation of UCP-1, thereby affecting glucose homeostasis and weight gain.
Serotonin acts as neurotransmitter in the brain and as a multifaceted signaling molecule coordinating many physiological processes in the periphery. In a recent issue of Nature Medicine, Crane et al. (2014) find that peripheral serotonin controls thermogenesis in adipose tissue by modulating β-adrenergic stimulation of UCP-1, thereby affecting glucose homeostasis and weight gain.
Serotonin acts as neurotransmitter in the brain and as a multifaceted signaling molecule coordinating many physiological processes in the periphery. In a recent issue of Nature Medicine, Crane et al. (2014) find that peripheral serotonin controls thermogenesis in adipose tissue by modulating β-adrenergic stimulation of UCP-1, thereby affecting glucose homeostasis and weight gain.
Author Schneider, Jochen G.
Nadeau, Joseph H.
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Cites_doi 10.1146/annurev.med.60.042307.110802
10.1097/MOL.0b013e3283462273
10.1126/science.1097540
10.1371/journal.pbio.1000229
10.1016/j.cmet.2012.09.014
10.1172/JCI62308
10.1021/cn300154j
10.1056/NEJMoa0810780
10.1021/pr100892r
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References Crane, Palanivel, Mottillo, Bujak, Wang, Ford, Collins, Blümer, Fullerton, Yabut (bib3) 2014
Cypess, Lehman, Williams, Tal, Rodman, Goldfine, Kuo, Palmer, Tseng, Doria (bib4) 2009; 360
Kim, Kim, Noh, Hur, Sung, Hwang, Park, Yang, Kim, Kwon, Yoon (bib5) 2011; 10
Paulmann, Grohmann, Voigt, Bert, Vowinckel, Bader, Skelin, Jevsek, Fink, Rupnik, Walther (bib6) 2009; 7
Berger, Gray, Roth (bib2) 2009; 60
Stanford, Middelbeek, Townsend, An, Nygaard, Hitchcox, Markan, Nakano, Hirshman, Tseng, Goodyear (bib7) 2013; 123
Amireault, Sibon, Côté (bib1) 2013; 4
Sumara, Sumara, Kim, Karsenty (bib8) 2012; 16
Zhang, Beaulieu, Sotnikova, Gainetdinov, Caron (bib10) 2004; 305
Watanabe, Rose, Aso (bib9) 2011; 22
Watanabe (10.1016/j.cmet.2015.01.011_bib9) 2011; 22
Paulmann (10.1016/j.cmet.2015.01.011_bib6) 2009; 7
Zhang (10.1016/j.cmet.2015.01.011_bib10) 2004; 305
Crane (10.1016/j.cmet.2015.01.011_bib3) 2014
Cypess (10.1016/j.cmet.2015.01.011_bib4) 2009; 360
Berger (10.1016/j.cmet.2015.01.011_bib2) 2009; 60
Stanford (10.1016/j.cmet.2015.01.011_bib7) 2013; 123
Kim (10.1016/j.cmet.2015.01.011_bib5) 2011; 10
Amireault (10.1016/j.cmet.2015.01.011_bib1) 2013; 4
Sumara (10.1016/j.cmet.2015.01.011_bib8) 2012; 16
25485911 - Nat Med. 2015 Feb;21(2):166-72
References_xml – volume: 16
  start-page: 588
  year: 2012
  end-page: 600
  ident: bib8
  publication-title: Cell Metab.
– volume: 360
  start-page: 1509
  year: 2009
  end-page: 1517
  ident: bib4
  publication-title: N. Engl. J. Med.
– volume: 123
  start-page: 215
  year: 2013
  end-page: 223
  ident: bib7
  publication-title: J. Clin. Invest.
– volume: 60
  start-page: 355
  year: 2009
  end-page: 366
  ident: bib2
  publication-title: Annu. Rev. Med.
– volume: 10
  start-page: 722
  year: 2011
  end-page: 731
  ident: bib5
  publication-title: J. Proteome Res.
– volume: 22
  start-page: 186
  year: 2011
  end-page: 191
  ident: bib9
  publication-title: Curr. Opin. Lipidol.
– volume: 7
  start-page: e1000229
  year: 2009
  ident: bib6
  publication-title: PLoS Biol.
– volume: 305
  start-page: 217
  year: 2004
  ident: bib10
  publication-title: Science
– year: 2014
  ident: bib3
  publication-title: Nat. Med.
– volume: 4
  start-page: 64
  year: 2013
  end-page: 71
  ident: bib1
  publication-title: ACS Chem. Neurosci.
– volume: 60
  start-page: 355
  year: 2009
  ident: 10.1016/j.cmet.2015.01.011_bib2
  publication-title: Annu. Rev. Med.
  doi: 10.1146/annurev.med.60.042307.110802
– volume: 22
  start-page: 186
  year: 2011
  ident: 10.1016/j.cmet.2015.01.011_bib9
  publication-title: Curr. Opin. Lipidol.
  doi: 10.1097/MOL.0b013e3283462273
– year: 2014
  ident: 10.1016/j.cmet.2015.01.011_bib3
  publication-title: Nat. Med.
– volume: 305
  start-page: 217
  year: 2004
  ident: 10.1016/j.cmet.2015.01.011_bib10
  publication-title: Science
  doi: 10.1126/science.1097540
– volume: 7
  start-page: e1000229
  year: 2009
  ident: 10.1016/j.cmet.2015.01.011_bib6
  publication-title: PLoS Biol.
  doi: 10.1371/journal.pbio.1000229
– volume: 16
  start-page: 588
  year: 2012
  ident: 10.1016/j.cmet.2015.01.011_bib8
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2012.09.014
– volume: 123
  start-page: 215
  year: 2013
  ident: 10.1016/j.cmet.2015.01.011_bib7
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI62308
– volume: 4
  start-page: 64
  year: 2013
  ident: 10.1016/j.cmet.2015.01.011_bib1
  publication-title: ACS Chem. Neurosci.
  doi: 10.1021/cn300154j
– volume: 360
  start-page: 1509
  year: 2009
  ident: 10.1016/j.cmet.2015.01.011_bib4
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa0810780
– volume: 10
  start-page: 722
  year: 2011
  ident: 10.1016/j.cmet.2015.01.011_bib5
  publication-title: J. Proteome Res.
  doi: 10.1021/pr100892r
– reference: 25485911 - Nat Med. 2015 Feb;21(2):166-72
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Snippet Serotonin acts as neurotransmitter in the brain and as a multifaceted signaling molecule coordinating many physiological processes in the periphery. In a...
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SubjectTerms Adipose Tissue, Brown - metabolism
Animals
Insulin Resistance - genetics
Ion Channels - metabolism
Mitochondrial Proteins - metabolism
Non-alcoholic Fatty Liver Disease - genetics
Obesity - genetics
Serotonin - biosynthesis
Thermogenesis - genetics
Tryptophan Hydroxylase - genetics
Title Turn Up the Heat: Circulating Serotonin Tunes Our Internal Heating System
URI https://dx.doi.org/10.1016/j.cmet.2015.01.011
https://www.ncbi.nlm.nih.gov/pubmed/25651169
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