Turn Up the Heat: Circulating Serotonin Tunes Our Internal Heating System

Serotonin acts as neurotransmitter in the brain and as a multifaceted signaling molecule coordinating many physiological processes in the periphery. In a recent issue of Nature Medicine, Crane et al. (2014) find that peripheral serotonin controls thermogenesis in adipose tissue by modulating β-adren...

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Bibliographic Details
Published inCell metabolism Vol. 21; no. 2; pp. 156 - 158
Main Authors Schneider, Jochen G., Nadeau, Joseph H.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 03.02.2015
Subjects
Adipose Tissue, Brown - metabolism
Animals
Insulin Resistance - genetics
Ion Channels - metabolism
Mitochondrial Proteins - metabolism
Non-alcoholic Fatty Liver Disease - genetics
Obesity - genetics
Serotonin - biosynthesis
Thermogenesis - genetics
Tryptophan Hydroxylase - genetics
Online AccessGet full text
ISSN1550-4131
1932-7420
1932-7420
DOI10.1016/j.cmet.2015.01.011

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Summary:Serotonin acts as neurotransmitter in the brain and as a multifaceted signaling molecule coordinating many physiological processes in the periphery. In a recent issue of Nature Medicine, Crane et al. (2014) find that peripheral serotonin controls thermogenesis in adipose tissue by modulating β-adrenergic stimulation of UCP-1, thereby affecting glucose homeostasis and weight gain.
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ISSN:1550-4131
1932-7420
1932-7420
DOI:10.1016/j.cmet.2015.01.011