SGLT2 Inhibitor: Not a Traditional Diuretic for Heart Failure
Recent studies have shown impressive cardiovascular health benefits in individuals treated with SGLT2 inhibitors (SGLT2i) regardless of diabetic status. The underlying mechanisms driving these benefits are not well understood. Recently in Circulation, Griffin et al. (2020) reported the first human s...
Saved in:
| Published in | Cell metabolism Vol. 32; no. 1; pp. 13 - 14 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
07.07.2020
|
| Online Access | Get full text |
| ISSN | 1550-4131 1932-7420 1932-7420 |
| DOI | 10.1016/j.cmet.2020.06.014 |
Cover
| Abstract | Recent studies have shown impressive cardiovascular health benefits in individuals treated with SGLT2 inhibitors (SGLT2i) regardless of diabetic status. The underlying mechanisms driving these benefits are not well understood. Recently in Circulation, Griffin et al. (2020) reported the first human study investigating the diuretic effect of empagliflozin.
Recent studies have shown impressive cardiovascular health benefits in individuals treated with SGLT2 inhibitors (SGLT2i) regardless of diabetic status. The underlying mechanisms driving these benefits are not well understood. Recently in Circulation, Griffin et al. reported the first human study investigating the diuretic effect of empagliflozin. |
|---|---|
| AbstractList | Recent studies have shown impressive cardiovascular health benefits in individuals treated with SGLT2 inhibitors (SGLT2i) regardless of diabetic status. The underlying mechanisms driving these benefits are not well understood. Recently in Circulation, Griffin et al. (2020) reported the first human study investigating the diuretic effect of empagliflozin.
Recent studies have shown impressive cardiovascular health benefits in individuals treated with SGLT2 inhibitors (SGLT2i) regardless of diabetic status. The underlying mechanisms driving these benefits are not well understood. Recently in Circulation, Griffin et al. reported the first human study investigating the diuretic effect of empagliflozin. Recent studies have shown impressive cardiovascular health benefits in individuals treated with SGLT2 inhibitors (SGLT2i) regardless of diabetic status. The underlying mechanisms driving these benefits are not well understood. Recently in Circulation, Griffin et al. (2020) reported the first human study investigating the diuretic effect of empagliflozin.Recent studies have shown impressive cardiovascular health benefits in individuals treated with SGLT2 inhibitors (SGLT2i) regardless of diabetic status. The underlying mechanisms driving these benefits are not well understood. Recently in Circulation, Griffin et al. (2020) reported the first human study investigating the diuretic effect of empagliflozin. Recent studies have shown impressive cardiovascular health benefits in individuals treated with SGLT2 inhibitors (SGLT2i) regardless of diabetic status. The underlying mechanisms driving these benefits are not well understood. Recently in Circulation, Griffin et al. (2020) reported the first human study investigating the diuretic effect of empagliflozin. |
| Author | Patel, Ankit B. Waikar, Sushrut S. Verma, Ashish |
| Author_xml | – sequence: 1 givenname: Ashish surname: Verma fullname: Verma, Ashish email: averma8@bwh.harvard.edu organization: Renal Division, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA – sequence: 2 givenname: Ankit B. surname: Patel fullname: Patel, Ankit B. organization: Renal Division, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA – sequence: 3 givenname: Sushrut S. surname: Waikar fullname: Waikar, Sushrut S. organization: Section of Nephrology, Department of Medicine, Boston University School of Medicine and Boston Medical Center, Boston, MA, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32640243$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kD1PwzAQhi0Eonz9AQaUkSXh_BGTIhhQoQWpgoEyW45zEa7SuNgOEv8eV4WFodOdTu9z0vsck_3e9UjIOYWCApVXy8KsMBYMGBQgC6BijxzRMWf5tWCwn_ayhFxQTkfkOIQlAJd8zA_JiDMpgAl-RO7eZvMFy577D1vb6PxN9uJiprOF142N1vW6yx7s4DFak7XOZ0-ofcym2nbpeEoOWt0FPPudJ-R9-riYPOXz19nz5H6eGwEQ8xJYfV1rMW7acaOl4SWWrBTppEHWSLGhFTeVqbGqa4ai5Vy0LWOStwIkan5CLrd_1959DhiiWtlgsOt0j24IignGAASvyhS9-I0O9QobtfZ2pf23-qucAtU2YLwLwWOrjI16UzX61EpRUBu7aqk2dtXGrgKpkt2Esn_o3_ed0O0WwiToy6JXwVjsDTbWo4mqcXYX_gNsZpFz |
| CitedBy_id | crossref_primary_10_1038_s41440_022_01085_x crossref_primary_10_1016_j_jacc_2020_11_029 crossref_primary_10_1080_17446651_2022_2014322 crossref_primary_10_3390_antiox12091772 crossref_primary_10_1016_j_bbrc_2025_151364 crossref_primary_10_1186_s13098_023_01116_8 crossref_primary_10_1016_j_jacc_2024_02_020 crossref_primary_10_2174_1871525719666210809121016 crossref_primary_10_1001_jamacardio_2023_1090 crossref_primary_10_1002_ehf2_13905 crossref_primary_10_5009_gnl240038 crossref_primary_10_33393_gcnd_2023_2620 crossref_primary_10_1016_j_biopha_2022_113606 crossref_primary_10_31083_j_rcm2401001 crossref_primary_10_3390_biom14080919 crossref_primary_10_1016_j_ekir_2022_04_094 crossref_primary_10_3389_fendo_2021_749010 crossref_primary_10_1016_j_jdiacomp_2023_108409 crossref_primary_10_1177_20420188221090001 crossref_primary_10_1016_j_diabet_2021_101285 crossref_primary_10_1016_j_amjcard_2023_12_056 crossref_primary_10_1093_eurheartj_ehad389 crossref_primary_10_1093_eurheartj_ehad522 crossref_primary_10_1093_cvr_cvab075 crossref_primary_10_3389_fcvm_2022_869272 crossref_primary_10_2337_db20_1045 crossref_primary_10_4239_wjd_v16_i2_97287 crossref_primary_10_31083_j_rcm2512455 crossref_primary_10_1016_j_arr_2020_101250 |
| Cites_doi | 10.1096/fasebj.2018.32.1_supplement.lb355 10.1161/CIRCULATIONAHA.120.045691 10.1053/j.ajkd.2016.08.027 10.1371/journal.pone.0079327 10.1161/JAHA.117.007046 10.1016/j.cmet.2019.10.008 10.1681/ASN.2005070732 10.1016/j.jacc.2019.12.059 10.1007/s40261-017-0577-1 10.1038/s41581-020-0256-y |
| ContentType | Journal Article |
| Copyright | 2020 Copyright © 2020. Published by Elsevier Inc. |
| Copyright_xml | – notice: 2020 – notice: Copyright © 2020. Published by Elsevier Inc. |
| DBID | AAYXX CITATION NPM 7X8 |
| DOI | 10.1016/j.cmet.2020.06.014 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1932-7420 |
| EndPage | 14 |
| ExternalDocumentID | 32640243 10_1016_j_cmet_2020_06_014 S1550413120303156 |
| Genre | Comment Journal Article |
| GroupedDBID | --- --K 0R~ 1~5 29B 2WC 4.4 457 4G. 53G 5GY 62- 6J9 7-5 AACTN AAEDW AAFTH AAIAV AAKRW AAKUH AALRI AAUCE AAVLU AAXUO ABJNI ABMAC ABMWF ABVKL ACGFO ACGFS ADBBV ADEZE ADJPV AEFWE AENEX AEXQZ AFTJW AGKMS AITUG ALKID ALMA_UNASSIGNED_HOLDINGS AMRAJ ASPBG AVWKF AZFZN BAWUL CS3 DIK DU5 E3Z EBS F5P FCP FDB FEDTE FIRID HVGLF IHE IXB J1W JIG M3Z M41 O-L O9- OK1 P2P RCE ROL RPZ SES SSZ TR2 UNMZH WQ6 ZA5 AAEDT AAIKJ AAMRU AAYWO AAYXX ABDGV ACVFH ADCNI ADVLN AEUPX AFPUW AGCQF AGHFR AIGII AKAPO AKBMS AKRWK AKYEP APXCP CITATION EJD HZ~ OZT RIG EFKBS NPM 7X8 |
| ID | FETCH-LOGICAL-c400t-502b7ba49df9da6c35e52547baa06be1ed183c8cbe8bb2e4f334ff2263f406ea3 |
| IEDL.DBID | IXB |
| ISSN | 1550-4131 1932-7420 |
| IngestDate | Thu Sep 04 17:27:11 EDT 2025 Mon Jul 21 06:02:45 EDT 2025 Thu Apr 24 23:06:34 EDT 2025 Tue Jul 01 03:58:19 EDT 2025 Fri Feb 23 02:47:26 EST 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | Copyright © 2020. Published by Elsevier Inc. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c400t-502b7ba49df9da6c35e52547baa06be1ed183c8cbe8bb2e4f334ff2263f406ea3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Commentary-3 content type line 23 |
| OpenAccessLink | http://www.cell.com/article/S1550413120303156/pdf |
| PMID | 32640243 |
| PQID | 2422004385 |
| PQPubID | 23479 |
| PageCount | 2 |
| ParticipantIDs | proquest_miscellaneous_2422004385 pubmed_primary_32640243 crossref_citationtrail_10_1016_j_cmet_2020_06_014 crossref_primary_10_1016_j_cmet_2020_06_014 elsevier_sciencedirect_doi_10_1016_j_cmet_2020_06_014 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2020-07-07 |
| PublicationDateYYYYMMDD | 2020-07-07 |
| PublicationDate_xml | – month: 07 year: 2020 text: 2020-07-07 day: 07 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Cell metabolism |
| PublicationTitleAlternate | Cell Metab |
| PublicationYear | 2020 |
| Publisher | Elsevier Inc |
| Publisher_xml | – name: Elsevier Inc |
| References | Griffin, Rao, Ivey-Miranda, Fleming, Mahoney, Maulion, Suda, Siwakoti, Ahmad, Jacoby (bib4) 2020 Borges, Silva, Crajoinas, Castelo-Branco, Luchi, Girardi (bib2) 2018; 32 Bhatt, Verma, Braunwald (bib1) 2019; 30 Imiela, Budaj (bib6) 2017; 37 Vallon, Thomson (bib8) 2020; 16 Felker, Ellison, Mullens, Cox, Testani (bib3) 2020; 75 Nijenhuis, Renkema, Hoenderop, Bindels (bib7) 2006; 17 Zahedi, Barone, Xu, Soleimani (bib10) 2013; 8 Wilcox, Shen, Boulton, Leslie, Griffen (bib9) 2018; 7 Hoorn, Ellison (bib5) 2017; 69 Vallon (10.1016/j.cmet.2020.06.014_bib8) 2020; 16 Felker (10.1016/j.cmet.2020.06.014_bib3) 2020; 75 Imiela (10.1016/j.cmet.2020.06.014_bib6) 2017; 37 Wilcox (10.1016/j.cmet.2020.06.014_bib9) 2018; 7 Hoorn (10.1016/j.cmet.2020.06.014_bib5) 2017; 69 Borges (10.1016/j.cmet.2020.06.014_bib2) 2018; 32 Zahedi (10.1016/j.cmet.2020.06.014_bib10) 2013; 8 Griffin (10.1016/j.cmet.2020.06.014_bib4) 2020 Nijenhuis (10.1016/j.cmet.2020.06.014_bib7) 2006; 17 Bhatt (10.1016/j.cmet.2020.06.014_bib1) 2019; 30 32410463 - Circulation. 2020 Sep 15;142(11):1028-1039 |
| References_xml | – volume: 75 start-page: 1178 year: 2020 end-page: 1195 ident: bib3 article-title: Diuretic therapy for patients with heart failure: JACC state-of-the-art review publication-title: J. Am. Coll. Cardiol. – volume: 32 start-page: lb355 year: 2018 ident: bib2 article-title: Empagliflozin inhibits NHE3 activity in the proximal tubule of normotensive and hypertensive rats publication-title: FASEB J. – volume: 16 start-page: 317 year: 2020 end-page: 336 ident: bib8 article-title: The tubular hypothesis of nephron filtration and diabetic kidney disease publication-title: Nat. Rev. Nephrol. – volume: 69 start-page: 136 year: 2017 end-page: 142 ident: bib5 article-title: Diuretic resistance publication-title: Am. J. Kidney Dis. – volume: 30 start-page: 847 year: 2019 end-page: 849 ident: bib1 article-title: The DAPA-HF trial: a momentous victory in the war against heart failure publication-title: Cell Metab. – volume: 8 start-page: e79327 year: 2013 ident: bib10 article-title: Potentiation of the effect of thiazide derivatives by carbonic anhydrase inhibitors: molecular mechanisms and potential clinical implications publication-title: PLoS One – year: 2020 ident: bib4 article-title: Empagliflozin in heart failure: diuretic and cardio-renal effects publication-title: Circulation – volume: 7 start-page: e007046 year: 2018 ident: bib9 article-title: Interaction between the sodium-glucose-linked transporter 2 inhibitor dapagliflozin and the loop diuretic bumetanide in normal human subjects publication-title: J. Am. Heart Assoc. – volume: 37 start-page: 1175 year: 2017 end-page: 1181 ident: bib6 article-title: Acetazolamide as add-on diuretic therapy in exacerbations of chronic heart failure: a pilot study publication-title: Clin. Drug Invest. – volume: 17 start-page: 617 year: 2006 end-page: 626 ident: bib7 article-title: Acid-base status determines the renal expression of Ca publication-title: J. Am. Soc. Nephrol. – volume: 32 start-page: lb355 year: 2018 ident: 10.1016/j.cmet.2020.06.014_bib2 article-title: Empagliflozin inhibits NHE3 activity in the proximal tubule of normotensive and hypertensive rats publication-title: FASEB J. doi: 10.1096/fasebj.2018.32.1_supplement.lb355 – year: 2020 ident: 10.1016/j.cmet.2020.06.014_bib4 article-title: Empagliflozin in heart failure: diuretic and cardio-renal effects publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.120.045691 – volume: 69 start-page: 136 year: 2017 ident: 10.1016/j.cmet.2020.06.014_bib5 article-title: Diuretic resistance publication-title: Am. J. Kidney Dis. doi: 10.1053/j.ajkd.2016.08.027 – volume: 8 start-page: e79327 year: 2013 ident: 10.1016/j.cmet.2020.06.014_bib10 article-title: Potentiation of the effect of thiazide derivatives by carbonic anhydrase inhibitors: molecular mechanisms and potential clinical implications publication-title: PLoS One doi: 10.1371/journal.pone.0079327 – volume: 7 start-page: e007046 year: 2018 ident: 10.1016/j.cmet.2020.06.014_bib9 article-title: Interaction between the sodium-glucose-linked transporter 2 inhibitor dapagliflozin and the loop diuretic bumetanide in normal human subjects publication-title: J. Am. Heart Assoc. doi: 10.1161/JAHA.117.007046 – volume: 30 start-page: 847 year: 2019 ident: 10.1016/j.cmet.2020.06.014_bib1 article-title: The DAPA-HF trial: a momentous victory in the war against heart failure publication-title: Cell Metab. doi: 10.1016/j.cmet.2019.10.008 – volume: 17 start-page: 617 year: 2006 ident: 10.1016/j.cmet.2020.06.014_bib7 article-title: Acid-base status determines the renal expression of Ca2+ and Mg2+ transport proteins publication-title: J. Am. Soc. Nephrol. doi: 10.1681/ASN.2005070732 – volume: 75 start-page: 1178 year: 2020 ident: 10.1016/j.cmet.2020.06.014_bib3 article-title: Diuretic therapy for patients with heart failure: JACC state-of-the-art review publication-title: J. Am. Coll. Cardiol. doi: 10.1016/j.jacc.2019.12.059 – volume: 37 start-page: 1175 year: 2017 ident: 10.1016/j.cmet.2020.06.014_bib6 article-title: Acetazolamide as add-on diuretic therapy in exacerbations of chronic heart failure: a pilot study publication-title: Clin. Drug Invest. doi: 10.1007/s40261-017-0577-1 – volume: 16 start-page: 317 year: 2020 ident: 10.1016/j.cmet.2020.06.014_bib8 article-title: The tubular hypothesis of nephron filtration and diabetic kidney disease publication-title: Nat. Rev. Nephrol. doi: 10.1038/s41581-020-0256-y – reference: 32410463 - Circulation. 2020 Sep 15;142(11):1028-1039 |
| SSID | ssj0036393 |
| Score | 2.4806347 |
| Snippet | Recent studies have shown impressive cardiovascular health benefits in individuals treated with SGLT2 inhibitors (SGLT2i) regardless of diabetic status. The... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 13 |
| Title | SGLT2 Inhibitor: Not a Traditional Diuretic for Heart Failure |
| URI | https://dx.doi.org/10.1016/j.cmet.2020.06.014 https://www.ncbi.nlm.nih.gov/pubmed/32640243 https://www.proquest.com/docview/2422004385 |
| Volume | 32 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1JSwMxFA6lIHgRd-tSIniToZ0ks1TwoNXauvTSFnoLySTBEZ2WOj34733JzBQ8tAePExImvLzlS_K9F4SuNEThSMBO1VYr9xgRsRfLTuyZkCWBcekz9hzybRj2J-x5GkxrqFvlwlhaZen7C5_uvHXZ0iql2ZqnaWtkwTW4YJ-AnlLYhoAftlmlNolvel95YwoR2JHsobNne5eJMwXHK_nSlk9J2q6Gp8_WBad14NMFod4u2inRI74rJriHajrbR1vFe5I_B-h29PQ6JniQvacSLHVxg4ezHAsMAUmlxaEffkiXLnERA1rFfdDzHPdEasnph2jSexx3-175PoKXgOXlXtAmMpKCdZTpKBEmNNAB7PegCYQvta8V2GsSJ1LHUhLNDKXMGMBb1EAY14IeoXo2y_QJwhFYujJGS6UgrDEdUwm4UBGhqB_CrqWB_EowPCmLh9s3LD55xRL74FaY3AqTW6qczxroejVmXpTO2Ng7qOTN_ygAB9--cdxltTgcLMNed4hMz5bfHMAHcRedQQMdF6u2mgeAVmZrMZ7-869naNt-Od5udI7q-WKpLwCd5LIJuHzw0nRK-AvxF9-I |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV07T8MwED6VIgQL4k15GokNRW1ip02RGKBQWihd2krdLDu2RRCkCNKBf8_ZSSoxwMDq2Ip1vsdn-7szwLnGKNwSuFO11co9FojIi2Q78kyTxaFx6TP2HPJp2OxN2MM0nFagU-bCWFpl4ftzn-68ddFSL6RZf0-S-siCa3TBfoB6SnEbsgTLiAYaVrX705vSHVMMwY5lj709273InMlJXvGbtoTKoOGKePrst-j0G_p0Uai7AesFfCTX-Qw3oaLTLVjJH5T82oar0f1gHJB--pxINNWPSzKcZUQQjEgqyU_9yG0yd5mLBOEq6aGiZ6QrEstO34FJ927c6XnFAwlejKaXeWEjkC0pWFuZthLNmIY6xA0fNqH0pfa1QoONo1jqSMpAM0MpMwYBFzUYx7Wgu1BNZ6neB9JCU1fGaKkUxjWmIyoRGKpAKOo3cdtSA78UDI-L6uH2EYtXXtLEXrgVJrfC5JYr57MaXCzGvOe1M_7sHZby5j80gKNz_3PcWbk4HE3D3neIVM_mnxzRR-BuOsMa7OWrtpgHolZmizEe_POvp7DaGz8N-KA_fDyENfvFkXhbR1DNPub6GKFKJk-cKn4D_KHhsg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=SGLT2+Inhibitor%3A+Not+a+Traditional+Diuretic+for+Heart+Failure&rft.jtitle=Cell+metabolism&rft.au=Verma%2C+Ashish&rft.au=Patel%2C+Ankit+B.&rft.au=Waikar%2C+Sushrut+S.&rft.date=2020-07-07&rft.pub=Elsevier+Inc&rft.issn=1550-4131&rft.eissn=1932-7420&rft.volume=32&rft.issue=1&rft.spage=13&rft.epage=14&rft_id=info:doi/10.1016%2Fj.cmet.2020.06.014&rft.externalDocID=S1550413120303156 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1550-4131&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1550-4131&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1550-4131&client=summon |