EORTC consensus recommendations on the optimal management of colorectal cancer liver metastases

•The optimal management of colorectal cancer liver metastases is a matter of debate•The EORTC GITCG promoted the development of a European consensus on this subject•A multidisciplinary team of 43 international experts participated to a Delphi survey•34 practical recommendations and 2 consensus state...

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Published inCancer treatment reviews Vol. 136; p. 102926
Main Authors Bregni, Giacomo, Adams, Richard, Bale, Reto, Bali, Maria A, Bargellini, Irene, Blomqvist, Lennart, Brown, Gina, Cremolini, Chiara, Demetter, Pieter, Denecke, Timm, Dohan, Anthony, Dopazo, Cristina, Elez, Elena, Evrard, Serge, Feakins, Roger, Guckenberger, Matthias, Guren, Marianne Gronlie, Hawkins, Maria, Hoorens, Anne, Huguet, Emmanuel, Intven, Martijn, Koessler, Thibaud, Kunz, Wolfgang G, Lordick, Florian, Lucidi, Valerio, Mahnken, Andreas H, Malik, Hassan, Martinive, Philippe, Mauer, Murielle, Romero, Alejandra Méndez, Nagtegaal, Iris, Orsi, Franco, Oyen, Wim JG, Pellerin, Olivier, Rengo, Marco, Ricke, Jens, Ricoeur, Alexis, Riddell, Angela, Ronot, Maxime, Scorsetti, Marta, Seligmann, Jenny, Sempoux, Christine, Sheahan, Kieran, Stättner, Stefan, Svrcek, Magali, Taieb, Julien, West, Nick, Wyrwicz, Lucjan, Zech, Christoph J, Moehler, Markus, Sclafani, Francesco
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.05.2025
Subjects
Colorectal cancer
Colorectal Neoplasms - pathology
Colorectal Neoplasms - therapy
Consensus
Delphi survey
Delphi Technique
EORTC
Europe
European consensus
Expert consensus
Humans
Liver metastases
Liver Neoplasms - secondary
Liver Neoplasms - therapy
Practice Guidelines as Topic
Europe
Delphi survey
European consensus
Liver metastases
EORTC
Colorectal cancer
Expert consensus
Online AccessGet full text
ISSN0305-7372
1532-1967
1532-1967
DOI10.1016/j.ctrv.2025.102926

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Abstract •The optimal management of colorectal cancer liver metastases is a matter of debate•The EORTC GITCG promoted the development of a European consensus on this subject•A multidisciplinary team of 43 international experts participated to a Delphi survey•34 practical recommendations and 2 consensus statements were proposed•This document provides clinical guidance and highlights grey areas and unmet needs Patients with colorectal cancer liver metastases have long represented a unique and thoroughly investigated population. Nevertheless, the optimal management of these is still controversial with a number of open questions which are only partially addressed by available studies and existing guidelines. The European Organisation for Research and Treatment of Cancer (EORTC) Gastrointestinal Tract Cancer Group (GITCG) sought to fill this knowledge gap and promoted the development of a European consensus on this subject. By using the Delphi methodology and leveraging a multidisciplinary team of 43 international experts, including gastrointestinal oncologists, hepatobiliary surgeons, interventional radiologists, radiation oncologists, radiologists, nuclear medicine physicians and pathologists from 12 European countries, 34 practical recommendations and two consensus statements were proposed. These cover varying aspects of the optimal management of colorectal cancer liver metastases such as baseline imaging, selection criteria for liver-directed therapies, treatment strategies, assessment of treatment response, follow-up, care delivery, clinical research and future perspectives. This roadmap document is intended to complement national and international guidelines, and to provide practical guidance for clinicians and multidisciplinary teams, ultimately promoting practice standardisation, optimal management and better patient outcomes across Europe. Also, it provides a unique opportunity to highlight grey areas and unmet needs, and to give a strategic direction to future research in the field by identifying topics where there is no consensus among experts.
AbstractList Patients with colorectal cancer liver metastases have long represented a unique and thoroughly investigated population. Nevertheless, the optimal management of these is still controversial with a number of open questions which are only partially addressed by available studies and existing guidelines. The European Organisation for Research and Treatment of Cancer (EORTC) Gastrointestinal Tract Cancer Group (GITCG) sought to fill this knowledge gap and promoted the development of a European consensus on this subject. By using the Delphi methodology and leveraging a multidisciplinary team of 43 international experts, including gastrointestinal oncologists, hepatobiliary surgeons, interventional radiologists, radiation oncologists, radiologists, nuclear medicine physicians and pathologists from 12 European countries, 34 practical recommendations and two consensus statements were proposed. These cover varying aspects of the optimal management of colorectal cancer liver metastases such as baseline imaging, selection criteria for liver-directed therapies, treatment strategies, assessment of treatment response, follow-up, care delivery, clinical research and future perspectives. This roadmap document is intended to complement national and international guidelines, and to provide practical guidance for clinicians and multidisciplinary teams, ultimately promoting practice standardisation, optimal management and better patient outcomes across Europe. Also, it provides a unique opportunity to highlight grey areas and unmet needs, and to give a strategic direction to future research in the field by identifying topics where there is no consensus among experts.Patients with colorectal cancer liver metastases have long represented a unique and thoroughly investigated population. Nevertheless, the optimal management of these is still controversial with a number of open questions which are only partially addressed by available studies and existing guidelines. The European Organisation for Research and Treatment of Cancer (EORTC) Gastrointestinal Tract Cancer Group (GITCG) sought to fill this knowledge gap and promoted the development of a European consensus on this subject. By using the Delphi methodology and leveraging a multidisciplinary team of 43 international experts, including gastrointestinal oncologists, hepatobiliary surgeons, interventional radiologists, radiation oncologists, radiologists, nuclear medicine physicians and pathologists from 12 European countries, 34 practical recommendations and two consensus statements were proposed. These cover varying aspects of the optimal management of colorectal cancer liver metastases such as baseline imaging, selection criteria for liver-directed therapies, treatment strategies, assessment of treatment response, follow-up, care delivery, clinical research and future perspectives. This roadmap document is intended to complement national and international guidelines, and to provide practical guidance for clinicians and multidisciplinary teams, ultimately promoting practice standardisation, optimal management and better patient outcomes across Europe. Also, it provides a unique opportunity to highlight grey areas and unmet needs, and to give a strategic direction to future research in the field by identifying topics where there is no consensus among experts.
•The optimal management of colorectal cancer liver metastases is a matter of debate•The EORTC GITCG promoted the development of a European consensus on this subject•A multidisciplinary team of 43 international experts participated to a Delphi survey•34 practical recommendations and 2 consensus statements were proposed•This document provides clinical guidance and highlights grey areas and unmet needs Patients with colorectal cancer liver metastases have long represented a unique and thoroughly investigated population. Nevertheless, the optimal management of these is still controversial with a number of open questions which are only partially addressed by available studies and existing guidelines. The European Organisation for Research and Treatment of Cancer (EORTC) Gastrointestinal Tract Cancer Group (GITCG) sought to fill this knowledge gap and promoted the development of a European consensus on this subject. By using the Delphi methodology and leveraging a multidisciplinary team of 43 international experts, including gastrointestinal oncologists, hepatobiliary surgeons, interventional radiologists, radiation oncologists, radiologists, nuclear medicine physicians and pathologists from 12 European countries, 34 practical recommendations and two consensus statements were proposed. These cover varying aspects of the optimal management of colorectal cancer liver metastases such as baseline imaging, selection criteria for liver-directed therapies, treatment strategies, assessment of treatment response, follow-up, care delivery, clinical research and future perspectives. This roadmap document is intended to complement national and international guidelines, and to provide practical guidance for clinicians and multidisciplinary teams, ultimately promoting practice standardisation, optimal management and better patient outcomes across Europe. Also, it provides a unique opportunity to highlight grey areas and unmet needs, and to give a strategic direction to future research in the field by identifying topics where there is no consensus among experts.
Patients with colorectal cancer liver metastases have long represented a unique and thoroughly investigated population. Nevertheless, the optimal management of these is still controversial with a number of open questions which are only partially addressed by available studies and existing guidelines. The European Organisation for Research and Treatment of Cancer (EORTC) Gastrointestinal Tract Cancer Group (GITCG) sought to fill this knowledge gap and promoted the development of a European consensus on this subject. By using the Delphi methodology and leveraging a multidisciplinary team of 43 international experts, including gastrointestinal oncologists, hepatobiliary surgeons, interventional radiologists, radiation oncologists, radiologists, nuclear medicine physicians and pathologists from 12 European countries, 34 practical recommendations and two consensus statements were proposed. These cover varying aspects of the optimal management of colorectal cancer liver metastases such as baseline imaging, selection criteria for liver-directed therapies, treatment strategies, assessment of treatment response, follow-up, care delivery, clinical research and future perspectives. This roadmap document is intended to complement national and international guidelines, and to provide practical guidance for clinicians and multidisciplinary teams, ultimately promoting practice standardisation, optimal management and better patient outcomes across Europe. Also, it provides a unique opportunity to highlight grey areas and unmet needs, and to give a strategic direction to future research in the field by identifying topics where there is no consensus among experts.
ArticleNumber 102926
Author Denecke, Timm
Ricoeur, Alexis
Wyrwicz, Lucjan
Guckenberger, Matthias
Dopazo, Cristina
Elez, Elena
Adams, Richard
Pellerin, Olivier
Mahnken, Andreas H
Blomqvist, Lennart
Koessler, Thibaud
Malik, Hassan
Bale, Reto
Nagtegaal, Iris
Seligmann, Jenny
Moehler, Markus
Demetter, Pieter
Romero, Alejandra Méndez
Scorsetti, Marta
Bali, Maria A
Kunz, Wolfgang G
Intven, Martijn
Lordick, Florian
Rengo, Marco
Cremolini, Chiara
Evrard, Serge
Bargellini, Irene
Orsi, Franco
Ronot, Maxime
Svrcek, Magali
Riddell, Angela
Guren, Marianne Gronlie
Bregni, Giacomo
Brown, Gina
Hawkins, Maria
Sclafani, Francesco
Zech, Christoph J
Dohan, Anthony
Huguet, Emmanuel
Ricke, Jens
Oyen, Wim JG
Sheahan, Kieran
Martinive, Philippe
Sempoux, Christine
Lucidi, Valerio
West, Nick
Feakins, Roger
Taieb, Julien
Stättner, Stefan
Mauer, Murielle
Hoorens, Anne
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Fri Sep 05 17:45:00 EDT 2025
Mon Jul 21 05:30:32 EDT 2025
Tue Aug 05 12:01:13 EDT 2025
Sat May 24 17:07:14 EDT 2025
Tue Aug 26 17:04:23 EDT 2025
IsPeerReviewed true
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Keywords Delphi survey
European consensus
Liver metastases
EORTC
Colorectal cancer
Expert consensus
Language English
License Copyright © 2025 Elsevier Ltd. All rights reserved.
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Snippet •The optimal management of colorectal cancer liver metastases is a matter of debate•The EORTC GITCG promoted the development of a European consensus on this...
Patients with colorectal cancer liver metastases have long represented a unique and thoroughly investigated population. Nevertheless, the optimal management of...
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SubjectTerms Colorectal cancer
Colorectal Neoplasms - pathology
Colorectal Neoplasms - therapy
Consensus
Delphi survey
Delphi Technique
EORTC
Europe
European consensus
Expert consensus
Humans
Liver metastases
Liver Neoplasms - secondary
Liver Neoplasms - therapy
Practice Guidelines as Topic
Title EORTC consensus recommendations on the optimal management of colorectal cancer liver metastases
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https://dx.doi.org/10.1016/j.ctrv.2025.102926
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