Rule-based standardised switching of drugs at the interface between primary and tertiary care

• Published in: European journal of clinical pharmacology Vol. 64; no. 3; pp. 319 - 327
• Main Authors: Walk, Stefanie U., Bertsche, Thilo, Kaltschmidt, Jens, Pruszydlo, Markus G., Hoppe-Tichy, Torsten, Walter-Sack I, Ingeborg, Haefeli, Walter E.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.03.2008; Springer; Springer Nature B.V
• Subjects: Aged; Algorithms; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Continuity of Patient Care; Decision support systems; Decision Support Techniques; Drug therapy; Drugs, Generic - administration & dosage; Female; Formularies, Hospital; Germany; Hospitals; Humans; Male; Medical sciences; Middle Aged; Pharmaceutical Preparations - administration & dosage; Pharmacoepidemiology and Prescription; Pharmacology; Pharmacology. Drug treatments; Pharmacology/Toxicology; Primary Health Care; Retrospective Studies; Therapeutic Equivalency; Germany; Generic/therapeutic equivalent; Hospital drug formulary; Computerised decision support system; Drug switching; Health care interfaces; Interchange algorithm; Human; Decision support system; Health; Primary health care; Standardization; Generic drug; Algorithm; Drug conversion; Treatment; Hospital
• ISSN: 0031-6970; 1432-1041
• DOI: 10.1007/s00228-007-0402-5

Introduction Changes in drug treatment are frequently mandatory with hospital admission and discharge because hospital drug formularies are generally restricted to about 3000 drugs as compared to the many times this number – 62,000 in Germany – that are commercially available. Without computerised support, the process involved with switching drugs to a corresponding generic or a therapeutic equivalent is time-consuming and error-prone. Methods We have developed and tested a standardised interchange algorithm for subsequent implementation into a computerised decision support system that switches drugs to the corresponding generic or a therapeutic equivalent if they are not listed on the hospital drug formulary. Results The algorithm was retrospectively applied to the medication regimens of 120 patients (774 prescribed drugs containing 886 active ingredients) at their time of admission to surgical wards. Of the prescribed drugs, 52.8% (409/774) were part of the hospital drug formulary, thereby rendering a switch unnecessary. The 365 drugs not listed consisted of 392 active ingredients that were successfully switched to a corresponding generic (84.7%) or a therapeutic equivalent (10.2%). No specific switching procedures were defined for only 2.3% (20/886) of the active ingredients. In these cases, the drugs were either discontinued (4/20) or special drug classes, current diseases or co-medication required manual switching (8/20), or the drugs were continued unchanged and ordered from a wholesaler (8/20). Conclusion Using a standardised interchange algorithm, pre-admission drug regimens can successfully be switched to drugs on a hospital drug formulary. These findings suggest that a computerised decision support system will likely be useful to support this important practice.