Myocardial Strain by Doppler Echocardiography Validation of a New Method to Quantify Regional Myocardial Function

• Published in: Circulation (New York, N.Y.) Vol. 102; no. 10; pp. 1158 - 1164
• Main Authors: Urheim, Stig, Edvardsen, Thor, Torp, Hans, Angelsen, Bjørn, Smiseth, Otto A.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 05.09.2000; American Heart Association, Inc
• Subjects: Algorithms; Animals; Biological and medical sciences; Cardiology. Vascular system; Computer Simulation; Coronary heart disease; Dogs; Echocardiography, Doppler - methods; Female; Heart; Heart - physiology; Hemodynamics; Male; Medical sciences; Myocardial Contraction - physiology; Myocardial Ischemia - physiopathology; Reproducibility of Results; Stress, Mechanical; Systole - physiology; Ventricular Function, Left - physiology; Sonography; Fissipedia; Carnivora; Cardiac performance; Cardiovascular disease; Duplex ultrasonography; Coronary heart disease; Myocardial disease; Vascular disease; Deformation measurement; Vertebrata; Mammalia; Ischemia; Animal; Myocardium; Medical imagery; Diagnosis; Technique; Dog
• ISSN: 0009-7322; 1524-4539; 1524-4539
• DOI: 10.1161/01.CIR.102.10.1158

Background —Myocardial strain is a measure of regional deformation, and by definition, negative strain means shortening and positive strain, elongation. This study investigates whether myocardial strain can be measured by Doppler echocardiography as the time integral of regional velocity gradients, using sonomicrometry as reference method. Methods and Results —In 13 anesthetized dogs, myocardial longitudinal strain was measured on apical images as the time integral of regional Doppler velocity gradients. Ultrasonic segment-length crystals were placed near the left ventricular (LV) apex and near the base. Apical ischemia was induced by occluding the left anterior descending coronary artery (LAD), and preload was increased by saline. Percentage systolic strain by Doppler correlated well with strain by sonomicrometry ( y =0.82 x −1.79, r =0.92, P <0.01). During LAD occlusion, apical myocardium became dyskinetic, as indicated by positive strain values and negative Doppler velocities. At the LV base, myocardial strain by Doppler, strain by sonomicrometry, and velocity of shortening by sonomicrometry (dL/dt) were unchanged during apical ischemia. However, myocardial Doppler velocities at the base decreased from 4.2±0.7 (±SEM) to 2.7±0.4 cm/s ( P <0.05), probably reflecting loss of motion caused by tethering to apical segments. Volume loading increased myocardial Doppler velocities from 2.2±0.3 to 4.1±0.8 cm/s ( P <0.05) and Doppler-derived strain from −12±1% to −22±2% ( P <0.05), whereas peak LV elastance remained unchanged. Conclusions —Myocardial strain by Doppler echocardiography may represent a new, powerful method for quantifying regional myocardial function and is less influenced by tethering effects than Doppler tissue imaging. Like myocardial Doppler velocities, strain is markedly load-dependent.