Immune Microenvironment Features and Dynamics in Hodgkin Lymphoma

Classical Hodgkin’s lymphoma (cHL) accounts for 10% of all lymphoma diagnosis. The peculiar feature of the disease is the presence of large multinucleated Reed–Sternberg and mononuclear Hodgkin cells interspersed with a reactive microenvironment (ME). Due to the production of a large number of cytok...

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Published inCancers Vol. 13; no. 14; p. 3634
Main Authors Bertuzzi, Clara, Sabattini, Elena, Agostinelli, Claudio
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 20.07.2021
MDPI
Subjects
Cytokines
Cytotoxicity
Hodgkin's lymphoma
Immune response
Kinases
Ligands
Lymphocytes
Lymphoma
Malignancy
Medical prognosis
Microenvironments
Mutation
Neoplasia
Recruitment
Reed-Sternberg cells
Review
Spatial distribution
Tumor necrosis factor-TNF
Online AccessGet full text
ISSN2072-6694
2072-6694
DOI10.3390/cancers13143634

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Summary:Classical Hodgkin’s lymphoma (cHL) accounts for 10% of all lymphoma diagnosis. The peculiar feature of the disease is the presence of large multinucleated Reed–Sternberg and mononuclear Hodgkin cells interspersed with a reactive microenvironment (ME). Due to the production of a large number of cytokines, Hodgkin cells (HCs) and Hodgkin Reed–Sternberg cells (HRSCs) attract and favour the expansion of different immune cell populations, modifying their functional status in order to receive prosurvival stimuli and to turn off the antitumour immune response. To this purpose HRSCs shape a biological niche by organizing the spatial distribution of cells in the ME. This review will highlight the contribution of the ME in the pathogenesis and prognosis of cHL and its role as a possible therapeutic target.
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ISSN:2072-6694
2072-6694
DOI:10.3390/cancers13143634