Exosomal microRNA in Pancreatic Cancer Diagnosis, Prognosis, and Treatment: From Bench to Bedside

Pancreatic cancer is the fourth leading cause of cancer death among men and women in the United States, and pancreatic ductal adenocarcinoma (PDAC) accounts for more than 90% of pancreatic cancer cases. PDAC is one of the most lethal gastrointestinal malignancies with an overall five-year survival r...

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Published inCancers Vol. 13; no. 11; p. 2777
Main Authors Uddin, Md. Hafiz, Al-Hallak, Mohammed Najeeb, Philip, Philip A., Mohammad, Ramzi M., Viola, Nerissa, Wagner, Kay-Uwe, Azmi, Asfar S.
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 03.06.2021
MDPI
Subjects
Adenocarcinoma
Antigens
Biomarkers
Body fluids
Communication
Exosomes
Medical prognosis
Membrane vesicles
Metastases
Metastasis
MicroRNAs
miRNA
Mutation
Pancreatic cancer
Proteins
Review
Survival
Tumors
Online AccessGet full text
ISSN2072-6694
2072-6694
DOI10.3390/cancers13112777

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Abstract Pancreatic cancer is the fourth leading cause of cancer death among men and women in the United States, and pancreatic ductal adenocarcinoma (PDAC) accounts for more than 90% of pancreatic cancer cases. PDAC is one of the most lethal gastrointestinal malignancies with an overall five-year survival rate of ~10%. Developing effective therapeutic strategies against pancreatic cancer is a great challenge. Novel diagnostic, prognostic, and therapeutic strategies are an immediate necessity to increase the survival of pancreatic cancer patients. So far, studies have demonstrated microRNAs (miRNAs) as sensitive biomarkers because of their significant correlation with disease development and metastasis. The miRNAs have been shown to be more stable inside membrane-bound vesicles in the extracellular environment called exosomes. Varieties of miRNAs are released into the body fluids via exosomes depending on the normal physiological or pathological conditions of the body. In this review, we discuss the recent findings on the diagnostic, prognostic, and therapeutic roles of exosomal miRNAs in pancreatic cancer.
AbstractList Pancreatic cancer is the fourth leading cause of cancer death among men and women in the United States, and pancreatic ductal adenocarcinoma (PDAC) accounts for more than 90% of pancreatic cancer cases. PDAC is one of the most lethal gastrointestinal malignancies with an overall five-year survival rate of ~10%. Developing effective therapeutic strategies against pancreatic cancer is a great challenge. Novel diagnostic, prognostic, and therapeutic strategies are an immediate necessity to increase the survival of pancreatic cancer patients. So far, studies have demonstrated microRNAs (miRNAs) as sensitive biomarkers because of their significant correlation with disease development and metastasis. The miRNAs have been shown to be more stable inside membrane-bound vesicles in the extracellular environment called exosomes. Varieties of miRNAs are released into the body fluids via exosomes depending on the normal physiological or pathological conditions of the body. In this review, we discuss the recent findings on the diagnostic, prognostic, and therapeutic roles of exosomal miRNAs in pancreatic cancer.
Simple SummaryPancreatic cancer is the fourth leading cause of cancer death in the United States and over 90% of the patients suffer from pancreatic ductal adenocarcinoma (PDAC). PDAC is the most lethal gastrointestinal malignancies and only 10% of the people survive more than 5 years, therefore, novel diagnostic, prognostic, and therapeutic strategies are an immediate necessity. Studies have demonstrated microRNAs in bodily fluids that are bound with membranes (exosomes) can act as stable biomarkers both for disease development and metastasis. The diagnostic, prognostic, as well as therapeutic roles of exosomal microRNAs in pancreatic cancer have been discussed in this review.AbstractPancreatic cancer is the fourth leading cause of cancer death among men and women in the United States, and pancreatic ductal adenocarcinoma (PDAC) accounts for more than 90% of pancreatic cancer cases. PDAC is one of the most lethal gastrointestinal malignancies with an overall five-year survival rate of ~10%. Developing effective therapeutic strategies against pancreatic cancer is a great challenge. Novel diagnostic, prognostic, and therapeutic strategies are an immediate necessity to increase the survival of pancreatic cancer patients. So far, studies have demonstrated microRNAs (miRNAs) as sensitive biomarkers because of their significant correlation with disease development and metastasis. The miRNAs have been shown to be more stable inside membrane-bound vesicles in the extracellular environment called exosomes. Varieties of miRNAs are released into the body fluids via exosomes depending on the normal physiological or pathological conditions of the body. In this review, we discuss the recent findings on the diagnostic, prognostic, and therapeutic roles of exosomal miRNAs in pancreatic cancer.
Pancreatic cancer is the fourth leading cause of cancer death among men and women in the United States, and pancreatic ductal adenocarcinoma (PDAC) accounts for more than 90% of pancreatic cancer cases. PDAC is one of the most lethal gastrointestinal malignancies with an overall five-year survival rate of ~10%. Developing effective therapeutic strategies against pancreatic cancer is a great challenge. Novel diagnostic, prognostic, and therapeutic strategies are an immediate necessity to increase the survival of pancreatic cancer patients. So far, studies have demonstrated microRNAs (miRNAs) as sensitive biomarkers because of their significant correlation with disease development and metastasis. The miRNAs have been shown to be more stable inside membrane-bound vesicles in the extracellular environment called exosomes. Varieties of miRNAs are released into the body fluids via exosomes depending on the normal physiological or pathological conditions of the body. In this review, we discuss the recent findings on the diagnostic, prognostic, and therapeutic roles of exosomal miRNAs in pancreatic cancer.Pancreatic cancer is the fourth leading cause of cancer death among men and women in the United States, and pancreatic ductal adenocarcinoma (PDAC) accounts for more than 90% of pancreatic cancer cases. PDAC is one of the most lethal gastrointestinal malignancies with an overall five-year survival rate of ~10%. Developing effective therapeutic strategies against pancreatic cancer is a great challenge. Novel diagnostic, prognostic, and therapeutic strategies are an immediate necessity to increase the survival of pancreatic cancer patients. So far, studies have demonstrated microRNAs (miRNAs) as sensitive biomarkers because of their significant correlation with disease development and metastasis. The miRNAs have been shown to be more stable inside membrane-bound vesicles in the extracellular environment called exosomes. Varieties of miRNAs are released into the body fluids via exosomes depending on the normal physiological or pathological conditions of the body. In this review, we discuss the recent findings on the diagnostic, prognostic, and therapeutic roles of exosomal miRNAs in pancreatic cancer.
Author Wagner, Kay-Uwe
Uddin, Md. Hafiz
Al-Hallak, Mohammed Najeeb
Mohammad, Ramzi M.
Viola, Nerissa
Philip, Philip A.
Azmi, Asfar S.
AuthorAffiliation Departments of Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA; uddinh@wayne.edu (M.H.U.); alhallakm@karmanos.org (M.N.A.-H.); philipp@karmanos.org (P.A.P.); mohammad@karmanos.org (R.M.M.); violan@karmanos.org (N.V.); wagnerk@karmanos.org (K.-U.W.)
AuthorAffiliation_xml – name: Departments of Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA; uddinh@wayne.edu (M.H.U.); alhallakm@karmanos.org (M.N.A.-H.); philipp@karmanos.org (P.A.P.); mohammad@karmanos.org (R.M.M.); violan@karmanos.org (N.V.); wagnerk@karmanos.org (K.-U.W.)
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  givenname: Md. Hafiz
  orcidid: 0000-0002-0188-6857
  surname: Uddin
  fullname: Uddin, Md. Hafiz
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  givenname: Philip A.
  orcidid: 0000-0002-6513-3491
  surname: Philip
  fullname: Philip, Philip A.
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  givenname: Ramzi M.
  orcidid: 0000-0001-8332-5246
  surname: Mohammad
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  fullname: Viola, Nerissa
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  orcidid: 0000-0002-5081-0226
  surname: Wagner
  fullname: Wagner, Kay-Uwe
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  orcidid: 0000-0003-1178-9505
  surname: Azmi
  fullname: Azmi, Asfar S.
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Snippet Pancreatic cancer is the fourth leading cause of cancer death among men and women in the United States, and pancreatic ductal adenocarcinoma (PDAC) accounts...
Simple SummaryPancreatic cancer is the fourth leading cause of cancer death in the United States and over 90% of the patients suffer from pancreatic ductal...
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SubjectTerms Adenocarcinoma
Antigens
Biomarkers
Body fluids
Communication
Exosomes
Medical prognosis
Membrane vesicles
Metastases
Metastasis
MicroRNAs
miRNA
Mutation
Pancreatic cancer
Proteins
Review
Survival
Tumors
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Title Exosomal microRNA in Pancreatic Cancer Diagnosis, Prognosis, and Treatment: From Bench to Bedside
URI https://www.proquest.com/docview/2539606334
https://www.proquest.com/docview/2548396533
https://pubmed.ncbi.nlm.nih.gov/PMC8199777
Volume 13
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