Extracellular matrix degrading enzyme with stroma-targeting peptides enhance the penetration of liposomes into tumors - Ikeda-Imafuku, Mayumi; Gao, Yongsheng; Shaha, Suyog; Wang, Lily Li-Wen; Park, Kyung Soo; Nakajima, Mayuka; Adebowale, Omokolade; Mitragotri, Samir (Journal of controlled release, 2022)
Keywords: Animals; breast neoplasms; Bromelain; bromelains; Bromelains - therapeutic use; Cancer stroma; Cell Line, Tumor; collagen; Collagen type IV; collagenase; doxorubicin; Doxorubicin - therapeutic use; EPR effect; Extracellular Matrix; hyaluronic acid; Hyaluronic Acid - therapeutic use; hyaluronoglucosaminidase; intravenous injection; Liposomes - therapeutic use; Mice; nanomedicine; nanoparticles; Nanoparticles - therapeutic use; Neoplasms - drug therapy; Neoplasms - pathology; peptides; Peptides - therapeutic use; permeability; Triple-negative breast cancer; Bromelain; Extracellular matrix; Cancer stroma; EPR effect; Collagen type IV; Triple-negative breast cancer