Contribution of MINCLE–SYK Signaling to Activation of Primary Human APCs by Mycobacterial Cord Factor and the Novel Adjuvant TDB - Ostrop, Jenny; Jozefowski, Katrin; Zimmermann, Stephanie; Hofmann, Katharina; Strasser, Erwin; Lepenies, Bernd; Lang, Roland (The Journal of immunology (1950), 2015)
Keywords: Adjuvants, Immunologic - chemistry; Adjuvants, Immunologic - metabolism; Animals; Blotting, Western; CARD Signaling Adaptor Proteins - genetics; CARD Signaling Adaptor Proteins - metabolism; Cells, Cultured; Chemokines - immunology; Chemokines - metabolism; Cord Factors - chemistry; Cord Factors - immunology; Cord Factors - metabolism; Cytokines - immunology; Cytokines - metabolism; Dendritic Cells - immunology; Dendritic Cells - metabolism; Flow Cytometry; Gene Expression - immunology; HEK293 Cells; Humans; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - immunology; Intracellular Signaling Peptides and Proteins - metabolism; Lectins, C-Type - genetics; Lectins, C-Type - immunology; Lectins, C-Type - metabolism; Macrophages - immunology; Macrophages - metabolism; Mice, Knockout; Monocytes - immunology; Monocytes - metabolism; Mycobacterium tuberculosis; Mycobacterium tuberculosis - chemistry; Mycobacterium tuberculosis - immunology; Protein Binding - immunology; Protein-Tyrosine Kinases - genetics; Protein-Tyrosine Kinases - immunology; Protein-Tyrosine Kinases - metabolism; Receptors, Immunologic - genetics; Receptors, Immunologic - immunology; Receptors, Immunologic - metabolism; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction - immunology; Syk Kinase