The Translation of Scale in Fermentation Processes: The Impact of Computer Process Control

Many of the physical and chemical parameters which influence the behavior of a microorganism are changed as the scale of operation is changed. A description is given of how the most important of these effect process performance. As well as opening up new doors for novel process control techniques, t...

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Bibliographic Details
Published inBio/Technology Vol. 2; no. 10; pp. 875 - 883
Main Author Buckland, B. C.
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.10.1984
Subjects
Agriculture
Bioinformatics
Biomedical and Life Sciences
Biomedical Engineering/Biotechnology
Biomedicine
Biotechnology
Life Sciences
review-article
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ISSN0733-222X
1087-0156
1546-1696
DOI10.1038/nbt1084-875

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Summary:Many of the physical and chemical parameters which influence the behavior of a microorganism are changed as the scale of operation is changed. A description is given of how the most important of these effect process performance. As well as opening up new doors for novel process control techniques, the introduction of computer process control and data acquisition have had a positive impact on all process development activities. Experimental batches in a pilot plant can now be run with greater precision than previously possible and a complete record is available of every event, both planned and unplanned, which occurs during the fermentation cycle.
ISSN:0733-222X
1087-0156
1546-1696
DOI:10.1038/nbt1084-875