Juvenile xanthogranuloma manifesting with LCH‐associated neurodegenerative disease‐like radiological findings
Here, we describe two patients with juvenile xanthogranuloma (JXG) manifesting with Langerhans cell histiocytosis (LCH)‐associated neurodegenerative disease (ND)‐like radiological findings. One patient showed typical radiological abnormalities at onset, which worsened with progressing central nervou...
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| Published in | Pediatric blood & cancer Vol. 71; no. 7; pp. e31043 - n/a |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Wiley Subscription Services, Inc
01.07.2024
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| ISSN | 1545-5009 1545-5017 1545-5017 |
| DOI | 10.1002/pbc.31043 |
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| Abstract | Here, we describe two patients with juvenile xanthogranuloma (JXG) manifesting with Langerhans cell histiocytosis (LCH)‐associated neurodegenerative disease (ND)‐like radiological findings. One patient showed typical radiological abnormalities at onset, which worsened with progressing central nervous system symptoms 7 years after LCH‐oriented chemotherapy. Another showed spontaneous regression of clinical symptoms, with a transient radiological change 1 year after salvage chemotherapy for recurrence of JXG. These data regarding JXG‐associated ND will facilitate future investigation of the disease, as well as development of therapeutic interventions. |
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| AbstractList | Here, we describe two patients with juvenile xanthogranuloma (JXG) manifesting with Langerhans cell histiocytosis (LCH)-associated neurodegenerative disease (ND)-like radiological findings. One patient showed typical radiological abnormalities at onset, which worsened with progressing central nervous system symptoms 7 years after LCH-oriented chemotherapy. Another showed spontaneous regression of clinical symptoms, with a transient radiological change 1 year after salvage chemotherapy for recurrence of JXG. These data regarding JXG-associated ND will facilitate future investigation of the disease, as well as development of therapeutic interventions.Here, we describe two patients with juvenile xanthogranuloma (JXG) manifesting with Langerhans cell histiocytosis (LCH)-associated neurodegenerative disease (ND)-like radiological findings. One patient showed typical radiological abnormalities at onset, which worsened with progressing central nervous system symptoms 7 years after LCH-oriented chemotherapy. Another showed spontaneous regression of clinical symptoms, with a transient radiological change 1 year after salvage chemotherapy for recurrence of JXG. These data regarding JXG-associated ND will facilitate future investigation of the disease, as well as development of therapeutic interventions. Here, we describe two patients with juvenile xanthogranuloma (JXG) manifesting with Langerhans cell histiocytosis (LCH)‐associated neurodegenerative disease (ND)‐like radiological findings. One patient showed typical radiological abnormalities at onset, which worsened with progressing central nervous system symptoms 7 years after LCH‐oriented chemotherapy. Another showed spontaneous regression of clinical symptoms, with a transient radiological change 1 year after salvage chemotherapy for recurrence of JXG. These data regarding JXG‐associated ND will facilitate future investigation of the disease, as well as development of therapeutic interventions. Here, we describe two patients with juvenile xanthogranuloma (JXG) manifesting with Langerhans cell histiocytosis (LCH)‐associated neurodegenerative disease (ND)‐like radiological findings. One patient showed typical radiological abnormalities at onset, which worsened with progressing central nervous system symptoms 7 years after LCH‐oriented chemotherapy. Another showed spontaneous regression of clinical symptoms, with a transient radiological change 1 year after salvage chemotherapy for recurrence of JXG. These data regarding JXG‐associated ND will facilitate future investigation of the disease, as well as development of therapeutic interventions. |
| Author | Saida, Satoshi Umeda, Katsutsugu Hiramatsu, Hidefumi Takita, Junko Kato, Itaru Daifu, Tomoo Yoshida, Takeshi Higuchi, Yoshihisa Kudo, Ko Yokoyama, Atsushi |
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| Snippet | Here, we describe two patients with juvenile xanthogranuloma (JXG) manifesting with Langerhans cell histiocytosis (LCH)‐associated neurodegenerative disease... Here, we describe two patients with juvenile xanthogranuloma (JXG) manifesting with Langerhans cell histiocytosis (LCH)-associated neurodegenerative disease... |
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| SubjectTerms | Central nervous system Chemotherapy Child Child, Preschool Female histiocytic disorders Histiocytosis Histiocytosis, Langerhans-Cell - complications Histiocytosis, Langerhans-Cell - diagnostic imaging Histiocytosis, Langerhans-Cell - drug therapy Histiocytosis, Langerhans-Cell - pathology Humans Infant juvenile xanthogranuloma Magnetic Resonance Imaging Male Neurodegenerative diseases Neurodegenerative Diseases - complications Neurodegenerative Diseases - diagnostic imaging Neurodegenerative Diseases - pathology Therapeutic applications Xanthogranuloma, Juvenile - diagnostic imaging Xanthogranuloma, Juvenile - pathology |
| Title | Juvenile xanthogranuloma manifesting with LCH‐associated neurodegenerative disease‐like radiological findings |
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