Curcumin stably interacts with DNA hairpin through minor groove binding and demonstrates enhanced cytotoxicity in combination with FdU nucleotides - Ghosh, Supratim; Mallick, Sumana; Das, Upasana; Verma, Ajay; Pal, Uttam; Chatterjee, Sabyasachi; Nandy, Abhishek; Saha, Krishna D.; Maiti, Nakul Chandra; Baishya, Bikash; Suresh Kumar, G.; Gmeiner, William H. (Biochimica et biophysica acta, 2018)
Keywords: acridine orange; apoptosis; Cancer therapy; circular dichroism spectroscopy; Curcumin; cytotoxicity; DNA; DNA-curcumin complex; fluorescence; fluorescence emission spectroscopy; hydrogen bonding; hydrophobic bonding; molecular dynamics; mouth neoplasms; neoplasm cells; nuclear magnetic resonance spectroscopy; nucleic acid conformation; nucleotides; Poly-FdUMP; staining; therapeutics; thymidine; ultraviolet-visible spectroscopy; Curcumin; Poly-FdUMP; Cancer therapy; DNA-curcumin complex