Predictive Value of the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society Classification of Lung Adenocarcinoma in Tumor Recurrence and Patient Survival

• Published in: Journal of clinical oncology Vol. 32; no. 22; pp. 2357 - 2364
• Main Authors: Hung, Jung-Jyh, Yeh, Yi-Chen, Jeng, Wen-Juei, Wu, Kou-Juey, Huang, Biing-Shiun, Wu, Yu-Chung, Chou, Teh-Ying, Hsu, Wen-Hu
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Society of Clinical Oncology 01.08.2014
• Subjects: Adenocarcinoma - classification; Adenocarcinoma - mortality; Adenocarcinoma - pathology; Adenocarcinoma of Lung; Biological and medical sciences; Female; Humans; Lung Neoplasms - classification; Lung Neoplasms - mortality; Lung Neoplasms - pathology; Male; Medical sciences; Middle Aged; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Neoplasm Recurrence, Local - pathology; Neoplasm Staging; Pneumology; Prognosis; Survival Analysis; Tumors; Tumors of the respiratory system and mediastinum; United States - epidemiology; United States; North America; Europe; America; Human; Lung disease; Relapse; Respiratory disease; Lung cancer; Thorax; Malignant tumor; Bronchopulmonary adenocarcinoma; Respiratory system; Survival; Association; Cancerology; Classification; Predictive value; Bronchus disease; Cancer; International
• ISSN: 0732-183X; 1527-7755; 1527-7755
• DOI: 10.1200/JCO.2013.50.1049

This study investigated the pattern of recurrence of lung adenocarcinoma and the predictive value of histologic classification in resected lung adenocarcinoma using the new International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS) classification system. Histologic classification of 573 patients undergoing resection for lung adenocarcinoma was determined according to the IASLC/ATS/ERS classification system, and the percentage of each histologic component (lepidic, acinar, papillary, micropapillary, and solid) was recorded. The pattern of recurrence of those components and their predictive value were investigated. The predominant histologic pattern was significantly associated with sex (P < .01), invasive tumor size (P < .01), T status (P < .01), N status (P < .01), TNM stage (P < .01), and visceral pleural invasion (P < .01). The percentage of recurrence was significantly higher in micropapillary- and solid-predominant adenocarcinomas (P < .01). Micropapillary- and solid-predominant adenocarcinomas had a significantly higher possibility of developing initial extrathoracic-only recurrence than other types (P < .01). The predominant pattern group (micropapillary or solid v lepidic, acinar, or papillary) was a significant prognostic factor in overall survival (OS; P < .01), probability of freedom from recurrence (P < .01), and disease-specific survival (P < .01) in multivariable analysis. For patients receiving adjuvant chemotherapy, solid-predominant adenocarcinoma was a significant predictor for poor OS (P = .04). In lung adenocarcinoma, the IASLC/ATS/ERS classification system has significant prognostic and predictive value regarding death and recurrence. Solid-predominant adenocarcinoma was also a significant predictor in patients undergoing adjuvant chemotherapy. Prognostic and predictive information is important for stratifying patients for aggressive adjuvant chemoradiotherapy.