Poly(ADP-ribosyl)ation enhances nucleosome dynamics and organizes DNA damage repair components within biomolecular condensates
Nucleosomes, the basic structural units of chromatin, hinder recruitment and activity of various DNA repair proteins, necessitating modifications that enhance DNA accessibility. Poly(ADP-ribosyl)ation (PARylation) of proteins near damage sites is an essential initiation step in several DNA-repair pa...
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| Published in | Molecular cell Vol. 84; no. 3; pp. 429 - 446.e17 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.02.2024
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1097-2765 1097-4164 1097-4164 |
| DOI | 10.1016/j.molcel.2023.12.019 |
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| Abstract | Nucleosomes, the basic structural units of chromatin, hinder recruitment and activity of various DNA repair proteins, necessitating modifications that enhance DNA accessibility. Poly(ADP-ribosyl)ation (PARylation) of proteins near damage sites is an essential initiation step in several DNA-repair pathways; however, its effects on nucleosome structural dynamics and organization are unclear. Using NMR, cryoelectron microscopy (cryo-EM), and biochemical assays, we show that PARylation enhances motions of the histone H3 tail and DNA, leaving the configuration of the core intact while also stimulating nuclease digestion and ligation of nicked nucleosomal DNA by LIG3. PARylation disrupted interactions between nucleosomes, preventing self-association. Addition of LIG3 and XRCC1 to PARylated nucleosomes generated condensates that selectively partition DNA repair-associated proteins in a PAR- and phosphorylation-dependent manner in vitro. Our results establish that PARylation influences nucleosomes across different length scales, extending from the atom-level motions of histone tails to the mesoscale formation of condensates with selective compositions.
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•Nucleosome PARylation enhances H3 tail dynamics without perturbing the histone core•PARylation dramatically enhances ligation of single-strand nicks in nucleosomes•Stacking and self-association of mononucleosomes is inhibited by PARylation•PARylation reorganizes condensates containing nucleosomes and DNA repair factors
Nosella et al. establish that poly(ADP-ribosyl)ation of nucleosomes dramatically increases histone H3 tail dynamics and DNA conformational variability while leaving the core structure intact. These changes correlated with enhanced ligation of nucleosome single-strand nicks, disruption of nucleosome oligomers, and colocalization of nucleosomes with DNA repair factors inside biomolecular condensates. |
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| AbstractList | Nucleosomes, the basic structural units of chromatin, hinder recruitment and activity of various DNA repair proteins, necessitating modifications that enhance DNA accessibility. Poly(ADP-ribosyl)ation (PARylation) of proteins near damage sites is an essential initiation step in several DNA-repair pathways; however, its effects on nucleosome structural dynamics and organization are unclear. Using NMR, cryoelectron microscopy (cryo-EM), and biochemical assays, we show that PARylation enhances motions of the histone H3 tail and DNA, leaving the configuration of the core intact while also stimulating nuclease digestion and ligation of nicked nucleosomal DNA by LIG3. PARylation disrupted interactions between nucleosomes, preventing self-association. Addition of LIG3 and XRCC1 to PARylated nucleosomes generated condensates that selectively partition DNA repair-associated proteins in a PAR- and phosphorylation-dependent manner in vitro. Our results establish that PARylation influences nucleosomes across different length scales, extending from the atom-level motions of histone tails to the mesoscale formation of condensates with selective compositions.
[Display omitted]
•Nucleosome PARylation enhances H3 tail dynamics without perturbing the histone core•PARylation dramatically enhances ligation of single-strand nicks in nucleosomes•Stacking and self-association of mononucleosomes is inhibited by PARylation•PARylation reorganizes condensates containing nucleosomes and DNA repair factors
Nosella et al. establish that poly(ADP-ribosyl)ation of nucleosomes dramatically increases histone H3 tail dynamics and DNA conformational variability while leaving the core structure intact. These changes correlated with enhanced ligation of nucleosome single-strand nicks, disruption of nucleosome oligomers, and colocalization of nucleosomes with DNA repair factors inside biomolecular condensates. Nucleosomes, the basic structural units of chromatin, hinder recruitment and activity of various DNA repair proteins, necessitating modifications that enhance DNA accessibility. Poly(ADP-ribosyl)ation (PARylation) of proteins near damage sites is an essential initiation step in several DNA-repair pathways; however, its effects on nucleosome structural dynamics and organization are unclear. Using NMR, cryoelectron microscopy (cryo-EM), and biochemical assays, we show that PARylation enhances motions of the histone H3 tail and DNA, leaving the configuration of the core intact while also stimulating nuclease digestion and ligation of nicked nucleosomal DNA by LIG3. PARylation disrupted interactions between nucleosomes, preventing self-association. Addition of LIG3 and XRCC1 to PARylated nucleosomes generated condensates that selectively partition DNA repair-associated proteins in a PAR- and phosphorylation-dependent manner in vitro. Our results establish that PARylation influences nucleosomes across different length scales, extending from the atom-level motions of histone tails to the mesoscale formation of condensates with selective compositions. Nucleosomes, the basic structural units of chromatin, hinder recruitment and activity of various DNA repair proteins, necessitating modifications that enhance DNA accessibility. Poly(ADP-ribosyl)ation (PARylation) of proteins near damage sites is an essential initiation step in several DNA-repair pathways; however, its effects on nucleosome structural dynamics and organization are unclear. Using NMR, cryoelectron microscopy (cryo-EM), and biochemical assays, we show that PARylation enhances motions of the histone H3 tail and DNA, leaving the configuration of the core intact while also stimulating nuclease digestion and ligation of nicked nucleosomal DNA by LIG3. PARylation disrupted interactions between nucleosomes, preventing self-association. Addition of LIG3 and XRCC1 to PARylated nucleosomes generated condensates that selectively partition DNA repair-associated proteins in a PAR- and phosphorylation-dependent manner in vitro. Our results establish that PARylation influences nucleosomes across different length scales, extending from the atom-level motions of histone tails to the mesoscale formation of condensates with selective compositions.Nucleosomes, the basic structural units of chromatin, hinder recruitment and activity of various DNA repair proteins, necessitating modifications that enhance DNA accessibility. Poly(ADP-ribosyl)ation (PARylation) of proteins near damage sites is an essential initiation step in several DNA-repair pathways; however, its effects on nucleosome structural dynamics and organization are unclear. Using NMR, cryoelectron microscopy (cryo-EM), and biochemical assays, we show that PARylation enhances motions of the histone H3 tail and DNA, leaving the configuration of the core intact while also stimulating nuclease digestion and ligation of nicked nucleosomal DNA by LIG3. PARylation disrupted interactions between nucleosomes, preventing self-association. Addition of LIG3 and XRCC1 to PARylated nucleosomes generated condensates that selectively partition DNA repair-associated proteins in a PAR- and phosphorylation-dependent manner in vitro. Our results establish that PARylation influences nucleosomes across different length scales, extending from the atom-level motions of histone tails to the mesoscale formation of condensates with selective compositions. Nucleosomes, the basic structural units of chromatin, hinder recruitment and activity of various DNA repair proteins, necessitating modifications that enhance DNA accessibility. Poly(ADP-ribosyl)ation (PARylation) of proteins near damage sites is an essential initiation step in several DNA-repair pathways; however, its effects on nucleosome structural dynamics and organization are unclear. Using NMR, cryoelectron microscopy (cryo-EM), and biochemical assays, we show that PARylation enhances motions of the histone H3 tail and DNA, leaving the configuration of the core intact while also stimulating nuclease digestion and ligation of nicked nucleosomal DNA by LIG3. PARylation disrupted interactions between nucleosomes, preventing self-association. Addition of LIG3 and XRCC1 to PARylated nucleosomes generated condensates that selectively partition DNA repair-associated proteins in a PAR- and phosphorylation-dependent manner in vitro. Our results establish that PARylation influences nucleosomes across different length scales, extending from the atom-level motions of histone tails to the mesoscale formation of condensates with selective compositions. |
| Author | Tereshchenko, Maria Kim, Tae Hun Pan, Alisia Vahidi, Siavash Nosella, Michael L. Forman-Kay, Julie D. Harkness, Robert W. Goncalves, Monica Huang, Shuya Kate Kay, Lewis E. Lee, Hyun O. Rubinstein, John L. |
| Author_xml | – sequence: 1 givenname: Michael L. surname: Nosella fullname: Nosella, Michael L. organization: Molecular Medicine Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada – sequence: 2 givenname: Tae Hun surname: Kim fullname: Kim, Tae Hun organization: Molecular Medicine Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada – sequence: 3 givenname: Shuya Kate surname: Huang fullname: Huang, Shuya Kate organization: Molecular Medicine Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada – sequence: 4 givenname: Robert W. surname: Harkness fullname: Harkness, Robert W. organization: Molecular Medicine Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada – sequence: 5 givenname: Monica surname: Goncalves fullname: Goncalves, Monica organization: Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1G 2W1, Canada – sequence: 6 givenname: Alisia surname: Pan fullname: Pan, Alisia organization: Molecular Medicine Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada – sequence: 7 givenname: Maria surname: Tereshchenko fullname: Tereshchenko, Maria organization: Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada – sequence: 8 givenname: Siavash surname: Vahidi fullname: Vahidi, Siavash organization: Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1G 2W1, Canada – sequence: 9 givenname: John L. surname: Rubinstein fullname: Rubinstein, John L. organization: Molecular Medicine Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada – sequence: 10 givenname: Hyun O. surname: Lee fullname: Lee, Hyun O. organization: Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada – sequence: 11 givenname: Julie D. surname: Forman-Kay fullname: Forman-Kay, Julie D. email: forman@sickkids.ca organization: Molecular Medicine Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada – sequence: 12 givenname: Lewis E. surname: Kay fullname: Kay, Lewis E. email: lewiskay@utoronto.ca organization: Molecular Medicine Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38215753$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1021/bi00385a042 10.1038/s41594-023-00977-x 10.7554/eLife.65773 10.1126/science.1177321 10.1007/s13361-018-2056-1 10.1002/j.1460-2075.1983.tb01643.x 10.1016/S0021-9258(19)62715-8 10.1038/38444 10.1007/s13361-015-1330-8 10.1016/j.celrep.2019.04.031 10.1021/acschembio.1c00954 10.1016/j.str.2018.08.006 10.1002/pro.3943 10.1093/nar/gkab618 10.1002/anie.202012046 10.1021/acs.analchem.5b00831 10.1146/annurev-anchem-062011-143113 10.1126/science.1216338 10.1080/073911010010524945 10.1016/j.molcel.2017.10.017 10.1038/s41467-020-14546-z 10.1021/ja00052a088 10.1038/nmeth.2019 10.1016/S0092-8674(04)00206-5 10.1074/jbc.M115.694992 10.1007/s13361-017-1860-3 10.1073/pnas.1520464113 10.1038/nsmb.1664 10.1126/science.1078764 10.1016/S0022-2836(03)00025-1 10.1093/nar/gkq900 10.1016/S0021-9258(18)69007-6 10.1074/jbc.M116.736728 10.3390/ijms21197020 10.1093/nar/gkz820 10.1016/j.dnarep.2020.102908 10.1074/jbc.M705989200 10.1073/pnas.79.11.3423 10.1006/jmra.1995.1047 10.1021/ja906842s 10.1016/j.cell.2015.07.047 10.1093/nar/gkv623 10.1093/nar/gkr304 10.1038/s41392-020-00311-7 10.1146/annurev-biochem-060713-035829 10.1006/jmra.1993.1093 10.1016/j.cell.2004.11.002 10.1021/ja072717t 10.1016/j.tcb.2020.02.002 10.1002/jps.22432 10.1074/jbc.M110.175190 10.1007/BF01122502 10.1021/j100830a521 10.1021/j100834a026 10.1021/ja00133a039 10.1016/j.ab.2012.06.015 10.1038/s42003-020-01369-3 10.1007/s13361-012-0485-9 10.1016/S0022-2836(02)00386-8 10.1038/nrg2380 10.1038/srep31437 10.1006/bbrc.1996.5903 10.1016/j.molcel.2016.03.008 10.1006/jmbi.2000.3644 10.1093/nar/24.22.4387 10.2741/3329 10.1021/jacs.0c12246 10.1038/nsmb869 10.1016/j.molcel.2022.01.018 10.1016/j.str.2022.08.008 10.1006/jmbi.2001.5328 10.1016/0022-2836(89)90493-2 10.1038/s41589-021-00801-x 10.1128/MCB.02248-06 10.1016/j.jmb.2004.02.003 10.1016/j.cell.2018.10.057 10.1038/s41467-020-15858-w 10.1021/cr040498d 10.1038/nature22822 10.1073/pnas.76.2.595 10.1038/s41589-018-0097-1 10.1021/cr500373h 10.1016/j.molcel.2019.08.019 10.1016/j.jmb.2004.11.056 10.1016/j.dnarep.2019.102664 10.1128/MCB.23.16.5919-5927.2003 10.1016/j.pnmrs.2019.09.004 10.1038/ncomms10806 10.1128/MCB.01343-08 10.1016/0022-2836(89)90302-1 10.1038/s41467-021-22636-9 10.1016/0006-291X(83)91803-X 10.1016/j.molcel.2015.12.015 10.1093/nar/gkz120 10.15252/embj.2018101379 10.1093/emboj/19.20.5492 10.1016/j.jsb.2013.11.002 10.1021/cr500350x 10.1038/nrm.2017.53 10.1074/jbc.274.25.17860 10.1529/biophysj.106.093815 10.3390/cancers9010003 10.1038/ncomms9088 10.3389/fgene.2022.870640 10.1128/MCB.02229-06 10.1038/nrg.2016.59 10.1021/bi970801n 10.1128/MCB.01314-07 10.1093/nar/gkaa022 10.1093/nar/gkl492 10.1038/s41556-019-0392-4 10.1093/nar/28.10.2049 10.7554/eLife.31481 10.1038/s41467-022-30303-w 10.1371/journal.pcbi.1004788 10.1016/j.cell.2019.08.037 10.1016/j.molcel.2013.08.026 10.1021/jacs.8b00931 10.1146/annurev-biochem-032620-104508 10.1038/s41580-020-00303-z 10.1016/j.tibs.2020.12.012 10.1093/nar/gkg761 10.7554/eLife.34334 10.1038/s41586-022-05386-6 10.1128/MCB.06667-11 10.1021/ja030153x 10.1016/j.bpj.2013.01.019 10.1038/nchembio.2180 10.1038/nmeth.4169 10.1093/jb/mvx081 10.1093/nar/gkz593 10.1073/pnas.2010506117 10.1073/pnas.1105848108 10.1016/j.molcel.2018.07.002 10.1006/jmra.1993.1098 10.7554/eLife.71420 10.1016/j.molcel.2017.01.003 10.1038/s41589-021-00774-x 10.1038/nrm3382 10.1016/j.bpc.2022.106767 10.1038/nrm.2017.7 10.1038/s41586-019-1669-2 10.1006/jmbi.1997.1494 10.1016/j.dnarep.2004.06.002 10.1023/B:JNMR.0000013824.93994.1f 10.1074/jbc.M507048200 10.1038/nmeth.1524 10.1128/MCB.05715-11 10.1016/j.celrep.2018.12.082 10.1073/pnas.2004317117 10.1038/nmeth.2089 |
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| Keywords | PARP1 poly(ADP-ribosyl)ation NMR spectroscopy nucleosome interactions nucleosome structural dynamics DNA repair biomolecular condensates |
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| References | Rhine, Dasovich, Yoniles, Badiee, Skanchy, Ganser, Ge, Fare, Shorter, Leung (bib121) 2022; 82 Karch, Coradin, Zandarashvili, Kan, Gerace, Englander, Black, Garcia (bib95) 2018; 26 Min, Wang (bib80) 2009; 14 Furukawa, Wakamori, Arimura, Ohtomo, Tsunaka, Kurumizaka, Umehara, Nishimura (bib119) 2020; 117 Hammonds, Harwig, Paintsil, Tillison, Hill, Morrison (bib24) 2022; 283 Hayashi, Tanaka, Shimada, Miwa, Sugimura (bib113) 1983; 112 Ray Chaudhuri, Nussenzweig (bib37) 2017; 18 Nurse, Jimenez-Useche, Smith, Yuan (bib120) 2013; 104 Ménissier-de Murcia, Molinete, Gradwohl, Simonin, de Murcia (bib69) 1989; 210 Rudolph, Roberts, Muthurajan, Luger (bib73) 2021; 10 Allis, Jenuwein (bib27) 2016; 17 Guttman, Wales, Whittington, Engen, Brown, Lee (bib149) 2016; 27 Rabdano, Shannon, Izmailov, Gonzalez Salguero, Zandian, Purusottam, Poirier, Skrynnikov, Jaroniec (bib16) 2021; 60 Tan, Krukenberg, Mitchison (bib72) 2012; 428 Moore, Ausió (bib97) 1997; 230 Larson, Elnatan, Keenen, Trnka, Johnston, Burlingame, Agard, Redding, Narlikar (bib125) 2017; 547 Alemasova, Lavrik (bib34) 2019; 47 Kato, van Ingen, Zhou, Feng, Bustin, Kay, Bai (bib133) 2011; 108 Musselman, Kutateladze (bib7) 2022; 17 Ikebe, Sakuraba, Kono (bib116) 2016; 12 Banani, Lee, Hyman, Rosen (bib109) 2017; 18 Schmitz (bib96) 1990 Lehmann, Hewitt, Aibara, Leitner, Marklund, Maslen, Maturi, Chen, van der Spoel, Skehel (bib39) 2017; 68 Lowary, Widom (bib65) 1998; 276 Caldecott, McKeown, Tucker, Ljungquist, Thompson (bib78) 1994; 14 Caldecott (bib110) 2019; 81 Chang, Chau, Landas, Pang (bib135) 2017; 1 Mikkelsen, Nielsen (bib143) 1960; 64 Valieva, Gerasimova, Kudryashova, Kozlova, Kirpichnikov, Hu, Botuyan, Mer, Feofanov, Studitsky (bib17) 2017; 9 Wacker, Ruhl, Balagamwala, Hope, Zhang, Kraus (bib45) 2007; 27 Cannan, Rashid, Tomkinson, Wallace, Pederson (bib76) 2017; 292 Marintchev, Robertson, Dimitriadis, Prasad, Wilson, Mullen (bib112) 2000; 28 Choy, Mulder, Crowhurst, Muhandiram, Millett, Doniach, Forman-Kay, Kay (bib140) 2002; 316 Sanulli, Trnka, Dharmarajan, Tibble, Pascal, Burlingame, Griffin, Gross, Narlikar (bib94) 2019; 575 Dorigo, Schalch, Bystricky, Richmond (bib100) 2003; 327 Hansen, Feng, Zhou, Bai, Kay (bib138) 2009; 131 Poirier, de Murcia, Jongstra-Bilen, Niedergang, Mandel (bib40) 1982; 79 Kim, Nosella, Bolik-Coulon, Harkness, Huang, Kay (bib9) 2023; 120 Kennedy, Hughes, Peteya, Schwartz, Ehlers, Tucker (bib129) 2010; 7 Stützer, Liokatis, Kiesel, Schwarzer, Sprangers, Söding, Selenko, Fischle (bib117) 2016; 61 Breslin, Hornyak, Ridley, Rulten, Hanzlikova, Oliver, Caldecott (bib102) 2015; 43 Allahverdi, Yang, Korolev, Fan, Davey, Liu, Nordenskiöld (bib19) 2011; 39 Amé, Rolli, Schreiber, Niedergang, Apiou, Decker, Muller, Höger, Ménissier-de Murcia, de Murcia (bib32) 1999; 274 Krüger, Bürkle, Hauser, Mangerich (bib84) 2020; 11 Brower-Toland, Wacker, Fulbright, Lis, Kraus, Wang (bib14) 2005; 346 Altmeyer, Neelsen, Teloni, Pozdnyakova, Pellegrino, Grøfte, Rask, Streicher, Jungmichel, Nielsen (bib46) 2015; 6 Jungmichel, Rosenthal, Altmeyer, Lukas, Hottiger, Nielsen (bib36) 2013; 52 Shi, Zhai, Chen, Li, Nordenskiöld (bib6) 2022; 13 Singatulina, Hamon, Sukhanova, Desforges, Joshi, Bouhss, Lavrik, Pastré (bib49) 2019; 27 Wang, Gao, Zheng, Liu, Dong, Li, Zhang, Wei, Qu, Li (bib126) 2019; 76 Ahmad, Henikoff, Ramachandran (bib5) 2022; 91 Schneider, Rasband, Eliceiri (bib155) 2012; 9 Mortusewicz, Rothbauer, Cardoso, Leonhardt (bib123) 2006; 34 Li, Kono (bib13) 2016; 6 Ghoneim, Fuchs, Musselman (bib83) 2021; 46 Loizou, El-Khamisy, Zlatanou, Moore, Chan, Qin, Sarno, Meggio, Pinna, Caldecott (bib111) 2004; 117 Dasovich, Beckett, Bailey, Ong, Greenberg, Leung (bib107) 2021; 143 Yang, Hoeppner, Rey, Kadek, Man, Schriemer (bib145) 2015; 87 Smith, Lebeaupin, Juhász, Chapuis, D'Augustin, Dutertre, Burkovics, Biertümpfel, Timinszky, Huet (bib61) 2019; 47 Kay, Keifer, Saarinen (bib136) 1992; 114 Polo, Xu, Hornyak, Garces, Zeng, Hailstone, Matthews, Caldecott, Oliver, Pearl (bib105) 2019; 26 Hwang, Shaka (bib141) 1995; 112 Kilic, Lezaja, Gatti, Bianco, Michelena, Imhof, Altmeyer (bib56) 2019; 38 Huber, Bai, de Murcia, de Murcia (bib67) 2004; 3 El-Khamisy, Masutani, Suzuki, Caldecott (bib103) 2003; 31 Altieri, Hinton, Byrd (bib101) 1995; 117 Johnson (bib154) 1993; 102 Glasoe, Long (bib142) 1960; 64 Buttress, He, Wang, Zhou, Saalbach, Vickers, Li, Li, Feng (bib25) 2022; 611 Leung (bib57) 2020; 30 Tibble, Depaix, Kowalska, Jemielity, Gross (bib51) 2021; 17 Oshidari, Huang, Medghalchi, Tse, Ashgriz, Lee, Wyatt, Mekhail (bib54) 2020; 11 Peeples, Rosen (bib52) 2021; 17 Zhu, Samuelson, Zhou, Dore, Xu (bib70) 2004; 337 Armeev, Kniazeva, Komarova, Kirpichnikov, Shaytan (bib11) 2021; 12 Shi, Prasanna, Soman, Pervushin, Nordenskiöld (bib12) 2020; 3 Tse, Hansen (bib22) 1997; 36 Morrison, Bowerman, Sylvers, Wereszczynski, Musselman (bib134) 2018; 7 Pessina, Giavazzi, Yin, Gioia, Vitelli, Galbiati, Barozzi, Garre, Oldani, Flaus (bib53) 2019; 21 Vahidi, Bi, Dunn, Konermann (bib147) 2016; 113 Ausio, Dong, van Holde (bib18) 1989; 206 Alvarez-Gonzalez, Jacobson (bib114) 1987; 26 Timinszky, Till, Hassa, Hothorn, Kustatscher, Nijmeijer, Colombelli, Altmeyer, Stelzer, Scheffzek (bib62) 2009; 16 Sukhanova, Singatulina, Pastré, Lavrik (bib122) 2020; 21 Gibson, Doolittle, Schneider, Jensen, Gamarra, Henry, Gerlich, Redding, Rosen (bib23) 2019; 179 Bacic, Gaullier, Sabantsev, Lehmann, Brackmann, Dimakou, Halic, Hewitt, Boulton, Deindl (bib38) 2021; 10 Hansen, Yang, Feng, Zhou, Wiesner, Bai, Kay (bib139) 2007; 129 Sallmyr, Rashid, Bhandari, Naila, Tomkinson (bib75) 2020; 93 Xie, Zhang, Gao, Huang, Huber, Zhou, Li, Shen, Zou (bib30) 2020; 5 Gordon, Luger, Hansen (bib21) 2005; 280 Rosenzweig, Kay (bib88) 2014; 83 Sklenar, Piotto, Leppik, Saudek (bib137) 1993; 102 Tomkinson, Vijayakumar, Pascal, Ellenberger (bib74) 2006; 106 Bertin, Renouard, Pedersen, Livolant, Durand (bib98) 2007; 92 Huambachano, Herrera, Rancourt, Satoh (bib68) 2011; 286 Koyama, Kurumizaka (bib4) 2018; 163 Gibbs-Seymour, Fontana, Rack, Ahel (bib71) 2016; 62 Odell, Barbour, Murphy, Della-Maria, Sweasy, Tomkinson, Wallace, Pederson (bib79) 2011; 31 Miwa, Saikawa, Yamaizumi, Nishimura, Sugimura (bib115) 1979; 76 Pinnola, Naumova, Shah, Tulin (bib44) 2007; 282 Langelier, Planck, Roy, Pascal (bib106) 2012; 336 Luger, Mäder, Richmond, Sargent, Richmond (bib2) 1997; 389 Clark (bib82) 2010; 27 Leidecker, Bonfiglio, Colby, Zhang, Atanassov, Zaja, Palazzo, Stockum, Ahel, Matic (bib85) 2016; 12 Otterstrom, Castells-Garcia, Vicario, Gomez-Garcia, Cosma, Lakadamyali (bib20) 2019; 47 Reber, Mangerich (bib33) 2021; 49 Liszczak, Diehl, Dann, Muir (bib127) 2018; 14 de Murcia, Huletsky, Lamarre, Gaudreau, Pouyet, Daune, Poirier (bib60) 1986; 261 North, Javaid, Ferdinand, Chatterjee, Picking, Shoffner, Nakkula, Bartholomew, Ottesen, Fishel (bib118) 2011; 39 Wang, Zhao, Bai, Feng, Bie, Gong, Wang, Wei, Feng, Pang (bib55) 2022; 13 Kim, Mauro, Gévry, Lis, Kraus (bib43) 2004; 119 Aubin, Fréchette, de Murcia, Mandel, Lord, Grondin, Poirier (bib59) 1983; 2 Tugarinov, Kay (bib90) 2004; 28 Houde, Berkowitz, Engen (bib150) 2011; 100 Davey, Sargent, Luger, Maeder, Richmond (bib91) 2002; 319 Luger, Dechassa, Tremethick (bib1) 2012; 13 Leppard, Dong, Mackey, Tomkinson (bib104) 2003; 23 Fisher, Hochegger, Takeda, Caldecott (bib31) 2007; 27 Schütz, Sprangers (bib89) 2020; 116 Abramov, Velyvis, Rennella, Wong, Kay (bib93) 2020; 117 Caldecott (bib29) 2008; 9 Marr, Benlekbir, Rubinstein (bib153) 2014; 185 Du, Alvarado, Wales, Moroco, Engen, Smithgall (bib152) 2022; 30 Kitevski-LeBlanc, Yuwen, Dyer, Rudolph, Luger, Kay (bib10) 2018; 140 Weber, Krawczyk, Robertson, Kuśnierczyk, Vågbø, Schuermann, Klungland, Schär (bib128) 2016; 7 McGinty, Tan (bib3) 2015; 115 Böhm, Crane-Robinson (bib92) 1984; 4 Bonfiglio, Fontana, Zhang, Colby, Gibbs-Seymour, Atanassov, Bartlett, Zaja, Ahel, Matic (bib35) 2017; 65 Tulin, Spradling (bib42) 2003; 299 Yamanaka, Penning, Willis, Wasson, Carson (bib66) 1988; 263 Majumdar, Manikwar, Hickey, Arora, Middaugh, Volkin, Weis (bib146) 2012; 23 Engen, Wales (bib151) 2015; 8 McGurk, Gomes, Guo, Mojsilovic-Petrovic, Tran, Kalb, Shorter, Bonini (bib48) 2018; 71 Schindelin, Arganda-Carreras, Frise, Kaynig, Longair, Pietzsch, Preibisch, Rueden, Saalfeld, Schmid (bib130) 2012; 9 Chafin, Vitolo, Henricksen, Bambara, Hayes (bib77) 2000; 19 Kan, Caterino, Hayes (bib99) 2009; 29 Punjani, Rubinstein, Fleet, Brubaker (bib132) 2017; 14 Polach, Lowary, Widom (bib26) 2000; 298 Palazzo, Leidecker, Prokhorova, Dauben, Matic, Ahel (bib86) 2018; 7 Smith, Zentout, Rother, Bigot, Chapuis, Mihuț, Zobel, Ahel, van Attikum, Timinszky (bib58) 2023; 30 Li, Levitus, Bustamante, Widom (bib8) 2005; 12 Strickfaden, McDonald, Kruhlak, Haince, Th’ng, Rouleau, Ishibashi, Corry, Ausio, Underhill (bib41) 2016; 291 Ferreira, Somers, Webster, Flaus, Owen-Hughes (bib15) 2007; 27 Bowman, Poirier (bib28) 2015; 115 Caldecott, Aoufouchi, Johnson, Shall (bib108) 1996; 24 Hamuro, Coales (bib144) 2018; 29 Pettersen, Goddard, Huang, Meng, Couch, Croll, Morris, Ferrin (bib131) 2021; 30 Tugarinov, Hwang, Ollerenshaw, Kay (bib87) 2003; 125 Yang, Chen, Wu, Chen, Liu, Singh, Yu (bib63) 2020; 48 Martinez-Zamudio, Ha (bib81) 2012; 32 Patel, Lee, Jawerth, Maharana, Jahnel, Hein, Stoynov, Mahamid, Saha, Franzmann (bib47) 2015; 162 Ahel, Horejsí, Wiechens, Polo, Garcia-Wilson, Ahel, Flynn, Skehel, West, Jackson (bib64) 2009; 325 Lyon, Peeples, Rosen (bib50) 2021; 22 Shin, Chang, Lee, Berry, Sanders, Ronceray, Wingreen, Haataja, Brangwynne (bib124) 2018; 175 Sørensen, Salbo (bib148) 2018; 29 Ghoneim (10.1016/j.molcel.2023.12.019_bib83) 2021; 46 Lehmann (10.1016/j.molcel.2023.12.019_bib39) 2017; 68 Yang (10.1016/j.molcel.2023.12.019_bib63) 2020; 48 Banani (10.1016/j.molcel.2023.12.019_bib109) 2017; 18 North (10.1016/j.molcel.2023.12.019_bib118) 2011; 39 Ausio (10.1016/j.molcel.2023.12.019_bib18) 1989; 206 Ahel (10.1016/j.molcel.2023.12.019_bib64) 2009; 325 Tse (10.1016/j.molcel.2023.12.019_bib22) 1997; 36 Li (10.1016/j.molcel.2023.12.019_bib13) 2016; 6 Ménissier-de Murcia (10.1016/j.molcel.2023.12.019_bib69) 1989; 210 Larson (10.1016/j.molcel.2023.12.019_bib125) 2017; 547 Stützer (10.1016/j.molcel.2023.12.019_bib117) 2016; 61 Mikkelsen (10.1016/j.molcel.2023.12.019_bib143) 1960; 64 Du (10.1016/j.molcel.2023.12.019_bib152) 2022; 30 Böhm (10.1016/j.molcel.2023.12.019_bib92) 1984; 4 Hamuro (10.1016/j.molcel.2023.12.019_bib144) 2018; 29 Sukhanova (10.1016/j.molcel.2023.12.019_bib122) 2020; 21 Kim (10.1016/j.molcel.2023.12.019_bib43) 2004; 119 Smith (10.1016/j.molcel.2023.12.019_bib61) 2019; 47 Martinez-Zamudio (10.1016/j.molcel.2023.12.019_bib81) 2012; 32 Pinnola (10.1016/j.molcel.2023.12.019_bib44) 2007; 282 Musselman (10.1016/j.molcel.2023.12.019_bib7) 2022; 17 Schmitz (10.1016/j.molcel.2023.12.019_bib96) 1990 Rudolph (10.1016/j.molcel.2023.12.019_bib73) 2021; 10 Sallmyr (10.1016/j.molcel.2023.12.019_bib75) 2020; 93 Ahmad (10.1016/j.molcel.2023.12.019_bib5) 2022; 91 Caldecott (10.1016/j.molcel.2023.12.019_bib108) 1996; 24 Nurse (10.1016/j.molcel.2023.12.019_bib120) 2013; 104 Aubin (10.1016/j.molcel.2023.12.019_bib59) 1983; 2 Guttman (10.1016/j.molcel.2023.12.019_bib149) 2016; 27 Valieva (10.1016/j.molcel.2023.12.019_bib17) 2017; 9 Ferreira (10.1016/j.molcel.2023.12.019_bib15) 2007; 27 Rabdano (10.1016/j.molcel.2023.12.019_bib16) 2021; 60 Patel (10.1016/j.molcel.2023.12.019_bib47) 2015; 162 Rhine (10.1016/j.molcel.2023.12.019_bib121) 2022; 82 Fisher (10.1016/j.molcel.2023.12.019_bib31) 2007; 27 Altieri (10.1016/j.molcel.2023.12.019_bib101) 1995; 117 Ray Chaudhuri (10.1016/j.molcel.2023.12.019_bib37) 2017; 18 Tulin (10.1016/j.molcel.2023.12.019_bib42) 2003; 299 Miwa (10.1016/j.molcel.2023.12.019_bib115) 1979; 76 Rosenzweig (10.1016/j.molcel.2023.12.019_bib88) 2014; 83 Punjani (10.1016/j.molcel.2023.12.019_bib132) 2017; 14 Kitevski-LeBlanc (10.1016/j.molcel.2023.12.019_bib10) 2018; 140 Caldecott (10.1016/j.molcel.2023.12.019_bib29) 2008; 9 Amé (10.1016/j.molcel.2023.12.019_bib32) 1999; 274 Caldecott (10.1016/j.molcel.2023.12.019_bib78) 1994; 14 Shi (10.1016/j.molcel.2023.12.019_bib12) 2020; 3 Tugarinov (10.1016/j.molcel.2023.12.019_bib90) 2004; 28 Strickfaden (10.1016/j.molcel.2023.12.019_bib41) 2016; 291 Dorigo (10.1016/j.molcel.2023.12.019_bib100) 2003; 327 Ikebe (10.1016/j.molcel.2023.12.019_bib116) 2016; 12 Yamanaka (10.1016/j.molcel.2023.12.019_bib66) 1988; 263 Dasovich (10.1016/j.molcel.2023.12.019_bib107) 2021; 143 Polo (10.1016/j.molcel.2023.12.019_bib105) 2019; 26 Caldecott (10.1016/j.molcel.2023.12.019_bib110) 2019; 81 Tomkinson (10.1016/j.molcel.2023.12.019_bib74) 2006; 106 Morrison (10.1016/j.molcel.2023.12.019_bib134) 2018; 7 Schneider (10.1016/j.molcel.2023.12.019_bib155) 2012; 9 Hansen (10.1016/j.molcel.2023.12.019_bib139) 2007; 129 Hammonds (10.1016/j.molcel.2023.12.019_bib24) 2022; 283 Tan (10.1016/j.molcel.2023.12.019_bib72) 2012; 428 Schütz (10.1016/j.molcel.2023.12.019_bib89) 2020; 116 Wang (10.1016/j.molcel.2023.12.019_bib55) 2022; 13 Vahidi (10.1016/j.molcel.2023.12.019_bib147) 2016; 113 Loizou (10.1016/j.molcel.2023.12.019_bib111) 2004; 117 Schindelin (10.1016/j.molcel.2023.12.019_bib130) 2012; 9 Shi (10.1016/j.molcel.2023.12.019_bib6) 2022; 13 Lowary (10.1016/j.molcel.2023.12.019_bib65) 1998; 276 Liszczak (10.1016/j.molcel.2023.12.019_bib127) 2018; 14 Timinszky (10.1016/j.molcel.2023.12.019_bib62) 2009; 16 Pessina (10.1016/j.molcel.2023.12.019_bib53) 2019; 21 Mortusewicz (10.1016/j.molcel.2023.12.019_bib123) 2006; 34 Jungmichel (10.1016/j.molcel.2023.12.019_bib36) 2013; 52 Polach (10.1016/j.molcel.2023.12.019_bib26) 2000; 298 Tugarinov (10.1016/j.molcel.2023.12.019_bib87) 2003; 125 Buttress (10.1016/j.molcel.2023.12.019_bib25) 2022; 611 Zhu (10.1016/j.molcel.2023.12.019_bib70) 2004; 337 Singatulina (10.1016/j.molcel.2023.12.019_bib49) 2019; 27 Min (10.1016/j.molcel.2023.12.019_bib80) 2009; 14 Armeev (10.1016/j.molcel.2023.12.019_bib11) 2021; 12 El-Khamisy (10.1016/j.molcel.2023.12.019_bib103) 2003; 31 Engen (10.1016/j.molcel.2023.12.019_bib151) 2015; 8 Kan (10.1016/j.molcel.2023.12.019_bib99) 2009; 29 Luger (10.1016/j.molcel.2023.12.019_bib1) 2012; 13 Odell (10.1016/j.molcel.2023.12.019_bib79) 2011; 31 Bertin (10.1016/j.molcel.2023.12.019_bib98) 2007; 92 Kennedy (10.1016/j.molcel.2023.12.019_bib129) 2010; 7 Li (10.1016/j.molcel.2023.12.019_bib8) 2005; 12 Hansen (10.1016/j.molcel.2023.12.019_bib138) 2009; 131 Karch (10.1016/j.molcel.2023.12.019_bib95) 2018; 26 Shin (10.1016/j.molcel.2023.12.019_bib124) 2018; 175 McGinty (10.1016/j.molcel.2023.12.019_bib3) 2015; 115 Kim (10.1016/j.molcel.2023.12.019_bib9) 2023; 120 Leppard (10.1016/j.molcel.2023.12.019_bib104) 2003; 23 Marintchev (10.1016/j.molcel.2023.12.019_bib112) 2000; 28 Clark (10.1016/j.molcel.2023.12.019_bib82) 2010; 27 Smith (10.1016/j.molcel.2023.12.019_bib58) 2023; 30 Weber (10.1016/j.molcel.2023.12.019_bib128) 2016; 7 de Murcia (10.1016/j.molcel.2023.12.019_bib60) 1986; 261 Reber (10.1016/j.molcel.2023.12.019_bib33) 2021; 49 Yang (10.1016/j.molcel.2023.12.019_bib145) 2015; 87 Bonfiglio (10.1016/j.molcel.2023.12.019_bib35) 2017; 65 Huambachano (10.1016/j.molcel.2023.12.019_bib68) 2011; 286 Huber (10.1016/j.molcel.2023.12.019_bib67) 2004; 3 Luger (10.1016/j.molcel.2023.12.019_bib2) 1997; 389 Xie (10.1016/j.molcel.2023.12.019_bib30) 2020; 5 Pettersen (10.1016/j.molcel.2023.12.019_bib131) 2021; 30 Kato (10.1016/j.molcel.2023.12.019_bib133) 2011; 108 Gordon (10.1016/j.molcel.2023.12.019_bib21) 2005; 280 Wacker (10.1016/j.molcel.2023.12.019_bib45) 2007; 27 Furukawa (10.1016/j.molcel.2023.12.019_bib119) 2020; 117 Wang (10.1016/j.molcel.2023.12.019_bib126) 2019; 76 Marr (10.1016/j.molcel.2023.12.019_bib153) 2014; 185 Koyama (10.1016/j.molcel.2023.12.019_bib4) 2018; 163 Oshidari (10.1016/j.molcel.2023.12.019_bib54) 2020; 11 Alemasova (10.1016/j.molcel.2023.12.019_bib34) 2019; 47 Leung (10.1016/j.molcel.2023.12.019_bib57) 2020; 30 Gibbs-Seymour (10.1016/j.molcel.2023.12.019_bib71) 2016; 62 Davey (10.1016/j.molcel.2023.12.019_bib91) 2002; 319 Allis (10.1016/j.molcel.2023.12.019_bib27) 2016; 17 Krüger (10.1016/j.molcel.2023.12.019_bib84) 2020; 11 Sørensen (10.1016/j.molcel.2023.12.019_bib148) 2018; 29 Kay (10.1016/j.molcel.2023.12.019_bib136) 1992; 114 Otterstrom (10.1016/j.molcel.2023.12.019_bib20) 2019; 47 Sanulli (10.1016/j.molcel.2023.12.019_bib94) 2019; 575 Tibble (10.1016/j.molcel.2023.12.019_bib51) 2021; 17 Alvarez-Gonzalez (10.1016/j.molcel.2023.12.019_bib114) 1987; 26 Breslin (10.1016/j.molcel.2023.12.019_bib102) 2015; 43 Altmeyer (10.1016/j.molcel.2023.12.019_bib46) 2015; 6 Palazzo (10.1016/j.molcel.2023.12.019_bib86) 2018; 7 Johnson (10.1016/j.molcel.2023.12.019_bib154) 1993; 102 Choy (10.1016/j.molcel.2023.12.019_bib140) 2002; 316 Majumdar (10.1016/j.molcel.2023.12.019_bib146) 2012; 23 McGurk (10.1016/j.molcel.2023.12.019_bib48) 2018; 71 Kilic (10.1016/j.molcel.2023.12.019_bib56) 2019; 38 Hayashi (10.1016/j.molcel.2023.12.019_bib113) 1983; 112 Glasoe (10.1016/j.molcel.2023.12.019_bib142) 1960; 64 Houde (10.1016/j.molcel.2023.12.019_bib150) 2011; 100 Gibson (10.1016/j.molcel.2023.12.019_bib23) 2019; 179 Cannan (10.1016/j.molcel.2023.12.019_bib76) 2017; 292 Abramov (10.1016/j.molcel.2023.12.019_bib93) 2020; 117 Leidecker (10.1016/j.molcel.2023.12.019_bib85) 2016; 12 Sklenar (10.1016/j.molcel.2023.12.019_bib137) 1993; 102 Poirier (10.1016/j.molcel.2023.12.019_bib40) 1982; 79 Chang (10.1016/j.molcel.2023.12.019_bib135) 2017; 1 Allahverdi (10.1016/j.molcel.2023.12.019_bib19) 2011; 39 Langelier (10.1016/j.molcel.2023.12.019_bib106) 2012; 336 Peeples (10.1016/j.molcel.2023.12.019_bib52) 2021; 17 Moore (10.1016/j.molcel.2023.12.019_bib97) 1997; 230 Lyon (10.1016/j.molcel.2023.12.019_bib50) 2021; 22 Hwang (10.1016/j.molcel.2023.12.019_bib141) 1995; 112 Brower-Toland (10.1016/j.molcel.2023.12.019_bib14) 2005; 346 Bacic (10.1016/j.molcel.2023.12.019_bib38) 2021; 10 Chafin (10.1016/j.molcel.2023.12.019_bib77) 2000; 19 Bowman (10.1016/j.molcel.2023.12.019_bib28) 2015; 115 |
| References_xml | – volume: 389 start-page: 251 year: 1997 end-page: 260 ident: bib2 article-title: Crystal structure of the nucleosome core particle at 2.8 Å resolution publication-title: Nature – volume: 28 start-page: 165 year: 2004 end-page: 172 ident: bib90 article-title: An isotope labelling strategy for methyl TROSY spectroscopy publication-title: J. Biomol. NMR – volume: 104 start-page: 1081 year: 2013 end-page: 1088 ident: bib120 article-title: Clipping of flexible tails of histones H3 and H4 affects the structure and dynamics of the nucleosome publication-title: Biophys. J. – volume: 47 start-page: 11250 year: 2019 end-page: 11267 ident: bib61 article-title: Poly(ADP-ribose)-dependent chromatin unfolding facilitates the association of DNA-binding proteins with DNA at sites of damage publication-title: Nucleic Acids Res. – volume: 76 start-page: 646 year: 2019 end-page: 659.e6 ident: bib126 article-title: Histone modifications regulate chromatin compartmentalization by contributing to a phase separation mechanism publication-title: Mol. Cell – volume: 9 start-page: 619 year: 2008 end-page: 631 ident: bib29 article-title: Single-strand break repair and genetic disease publication-title: Nat. Rev. Genet. – volume: 91 start-page: 183 year: 2022 end-page: 195 ident: bib5 article-title: Managing the steady state chromatin landscape by nucleosome dynamics publication-title: Annu. Rev. Biochem. – volume: 7 start-page: 10806 year: 2016 ident: bib128 article-title: Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism publication-title: Nat. Commun. – volume: 30 start-page: 678 year: 2023 end-page: 691 ident: bib58 article-title: HPF1-dependent histone ADP-ribosylation triggers chromatin relaxation to promote the recruitment of repair factors at sites of DNA damage publication-title: Nat. Struct. Mol. Biol. – volume: 115 start-page: 2274 year: 2015 end-page: 2295 ident: bib28 article-title: Post-translational modifications of histones that influence nucleosome dynamics publication-title: Chem. Rev. – volume: 17 start-page: 693 year: 2021 end-page: 702 ident: bib52 article-title: Mechanistic dissection of increased enzymatic rate in a phase-separated compartment publication-title: Nat. Chem. Biol. – volume: 61 start-page: 247 year: 2016 end-page: 259 ident: bib117 article-title: Modulations of DNA contacts by linker histones and post-translational modifications determine the mobility and modifiability of nucleosomal H3 tails publication-title: Mol. Cell – volume: 6 start-page: 31437 year: 2016 ident: bib13 article-title: Distinct roles of histone H3 and H2A tails in nucleosome stability publication-title: Sci. Rep. – volume: 6 start-page: 8088 year: 2015 ident: bib46 article-title: Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose) publication-title: Nat. Commun. – volume: 162 start-page: 1066 year: 2015 end-page: 1077 ident: bib47 article-title: A liquid-to-solid phase transition of the ALS protein FUS accelerated by disease mutation publication-title: Cell – volume: 12 start-page: 998 year: 2016 end-page: 1000 ident: bib85 article-title: Serine is a new target residue for endogenous ADP-ribosylation on histones publication-title: Nat. Chem. Biol. – volume: 81 start-page: 102664 year: 2019 ident: bib110 article-title: XRCC1 protein; form and function publication-title: DNA Repair (Amst) – volume: 65 start-page: 932 year: 2017 end-page: 940.e6 ident: bib35 article-title: Serine ADP-ribosylation depends on HPF1 publication-title: Mol. Cell – volume: 16 start-page: 923 year: 2009 end-page: 929 ident: bib62 article-title: A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation publication-title: Nat. Struct. Mol. Biol. – volume: 274 start-page: 17860 year: 1999 end-page: 17868 ident: bib32 article-title: PARP-2, a novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase publication-title: J. Biol. Chem. – volume: 112 start-page: 275 year: 1995 end-page: 279 ident: bib141 article-title: Water suppression that works. Excitation sculpting using arbitrary wave-forms and pulsed-field gradients publication-title: J. Magn. Reson. A – volume: 27 start-page: 4037 year: 2007 end-page: 4048 ident: bib15 article-title: Histone tails and the H3 alphaN helix regulate nucleosome mobility and stability publication-title: Mol. Cell. Biol. – volume: 179 start-page: 470 year: 2019 end-page: 484.e21 ident: bib23 article-title: Organization of chromatin by intrinsic and regulated phase separation publication-title: Cell – volume: 17 start-page: 487 year: 2016 end-page: 500 ident: bib27 article-title: The molecular hallmarks of epigenetic control publication-title: Nat. Rev. Genet. – volume: 4 start-page: 365 year: 1984 end-page: 386 ident: bib92 article-title: Proteases as structural probes for chromatin: the domain structure of histones publication-title: Biosci. Rep. – volume: 23 start-page: 2140 year: 2012 end-page: 2148 ident: bib146 article-title: Minimizing carry-over in an online pepsin digestion system used for the H/D exchange mass spectrometric analysis of an IgG1 monoclonal antibody publication-title: J. Am. Soc. Mass Spectrom. – volume: 119 start-page: 803 year: 2004 end-page: 814 ident: bib43 article-title: NAD publication-title: Cell – volume: 140 start-page: 4774 year: 2018 end-page: 4777 ident: bib10 article-title: Investigating the dynamics of destabilized nucleosomes using methyl-TROSY NMR publication-title: J. Am. Chem. Soc. – volume: 18 start-page: 610 year: 2017 end-page: 621 ident: bib37 article-title: The multifaceted roles of PARP1 in DNA repair and chromatin remodelling publication-title: Nat. Rev. Mol. Cell Biol. – volume: 575 start-page: 390 year: 2019 end-page: 394 ident: bib94 article-title: HP1 reshapes nucleosome core to promote phase separation of heterochromatin publication-title: Nature – volume: 175 start-page: 1481 year: 2018 end-page: 1491.e13 ident: bib124 article-title: Liquid nuclear condensates mechanically sense and restructure the genome publication-title: Cell – volume: 8 start-page: 127 year: 2015 end-page: 148 ident: bib151 article-title: Analytical aspects of hydrogen exchange mass spectrometry publication-title: Annu. Rev. Anal. Chem. (Palo Alto. Calif) – volume: 131 start-page: 16257 year: 2009 end-page: 16265 ident: bib138 article-title: Selective characterization of microsecond motions in proteins by NMR relaxation publication-title: J. Am. Chem. Soc. – volume: 79 start-page: 3423 year: 1982 end-page: 3427 ident: bib40 article-title: Poly(ADP-ribosyl)ation of polynucleosomes causes relaxation of chromatin structure publication-title: Proc. Natl. Acad. Sci. USA – volume: 27 start-page: 7475 year: 2007 end-page: 7485 ident: bib45 article-title: The DNA binding and catalytic domains of poly(ADP-ribose) polymerase 1 cooperate in the regulation of chromatin structure and transcription publication-title: Mol. Cell. Biol. – volume: 2 start-page: 1685 year: 1983 end-page: 1693 ident: bib59 article-title: Correlation between endogenous nucleosomal hyper(ADP-ribosyl)ation of histone H1 and the induction of chromatin relaxation publication-title: EMBO J. – volume: 10 year: 2021 ident: bib38 article-title: Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome publication-title: eLife – volume: 93 start-page: 102908 year: 2020 ident: bib75 article-title: Human DNA ligases in replication and repair publication-title: DNA Repair (Amst) – volume: 31 start-page: 4623 year: 2011 end-page: 4632 ident: bib79 article-title: Nucleosome disruption by DNA ligase III-XRCC1 promotes efficient base excision repair publication-title: Mol. Cell. Biol. – volume: 64 start-page: 632 year: 1960 end-page: 637 ident: bib143 article-title: Acidity measurements with the glass electrode in H publication-title: J. Phys. Chem. – volume: 46 start-page: 564 year: 2021 end-page: 578 ident: bib83 article-title: Histone tail conformations: a fuzzy affair with DNA publication-title: Trends Biochem. Sci. – volume: 47 start-page: 3811 year: 2019 end-page: 3827 ident: bib34 article-title: Poly(ADP-ribosyl)ation by PARP1: reaction mechanism and regulatory proteins publication-title: Nucleic Acids Res. – volume: 21 start-page: 1286 year: 2019 end-page: 1299 ident: bib53 article-title: Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors publication-title: Nat. Cell Biol. – volume: 29 start-page: 623 year: 2018 end-page: 629 ident: bib144 article-title: Optimization of feasibility stage for hydrogen/deuterium exchange mass spectrometry publication-title: J. Am. Soc. Mass Spectrom. – volume: 327 start-page: 85 year: 2003 end-page: 96 ident: bib100 article-title: Chromatin fiber folding: requirement for the histone H4 N-terminal tail publication-title: J. Mol. Biol. – volume: 117 start-page: 12836 year: 2020 end-page: 12846 ident: bib93 article-title: A methyl-TROSY approach for NMR studies of high-molecular-weight DNA with application to the nucleosome core particle publication-title: Proc. Natl. Acad. Sci. USA – volume: 210 start-page: 229 year: 1989 end-page: 233 ident: bib69 article-title: Zinc-binding domain of poly(ADP-ribose)polymerase participates in the recognition of single strand breaks on DNA publication-title: J. Mol. Biol. – volume: 39 start-page: 1680 year: 2011 end-page: 1691 ident: bib19 article-title: The effects of histone H4 tail acetylations on cation-induced chromatin folding and self-association publication-title: Nucleic Acids Res. – volume: 346 start-page: 135 year: 2005 end-page: 146 ident: bib14 article-title: Specific contributions of histone tails and their acetylation to the mechanical stability of nucleosomes publication-title: J. Mol. Biol. – volume: 27 start-page: 5597 year: 2007 end-page: 5605 ident: bib31 article-title: Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase publication-title: Mol. Cell. Biol. – volume: 27 start-page: 781 year: 2010 end-page: 793 ident: bib82 article-title: Nucleosome positioning, nucleosome spacing and the nucleosome code publication-title: J. Biomol. Struct. Dyn. – volume: 1 start-page: 22 year: 2017 end-page: 25 ident: bib135 article-title: Preparation of calcium competent Escherichia coli and heat-shock transformation publication-title: JEMI Methods – volume: 49 start-page: 8432 year: 2021 end-page: 8448 ident: bib33 article-title: Why structure and chain length matter: on the biological significance underlying the structural heterogeneity of poly(ADP-ribose) publication-title: Nucleic Acids Res. – volume: 13 start-page: 870640 year: 2022 ident: bib6 article-title: Recent advances in investigating functional dynamics of chromatin publication-title: Front. Genet. – volume: 292 start-page: 5227 year: 2017 end-page: 5238 ident: bib76 article-title: The human ligase IIIalpha-XRCC1 protein complex performs DNA nick repair after transient unwrapping of nucleosomal DNA publication-title: J. Biol. Chem. – volume: 48 start-page: 3001 year: 2020 end-page: 3013 ident: bib63 article-title: Poly(ADP-ribosyl)ation mediates early phase histone eviction at DNA lesions publication-title: Nucleic Acids Res. – volume: 26 start-page: 1651 year: 2018 end-page: 1663.e3 ident: bib95 article-title: Hydrogen-deuterium exchange coupled to top- and middle-down mass spectrometry reveals histone tail dynamics before and after nucleosome assembly publication-title: Structure – volume: 62 start-page: 432 year: 2016 end-page: 442 ident: bib71 article-title: HPF1/C4orf27 is a PARP-1-Interacting protein that regulates PARP-1 ADP-ribosylation activity publication-title: Mol. Cell – volume: 117 start-page: 17 year: 2004 end-page: 28 ident: bib111 article-title: The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks publication-title: Cell – volume: 113 start-page: 2412 year: 2016 end-page: 2417 ident: bib147 article-title: Load-dependent destabilization of the gamma-rotor shaft in FOF1 ATP synthase revealed by hydrogen/deuterium-exchange mass spectrometry publication-title: Proc. Natl. Acad. Sci. USA – volume: 87 start-page: 6681 year: 2015 end-page: 6687 ident: bib145 article-title: Recombinant Nepenthesin II for hydrogen/deuterium exchange mass spectrometry publication-title: Anal. Chem. – volume: 36 start-page: 11381 year: 1997 end-page: 11388 ident: bib22 article-title: Hybrid trypsinized nucleosomal arrays: identification of multiple functional roles of the H2A/H2B and H3/H4 N-termini in chromatin fiber compaction publication-title: Biochemistry – volume: 115 start-page: 2255 year: 2015 end-page: 2273 ident: bib3 article-title: Nucleosome structure and function publication-title: Chem. Rev. – volume: 13 start-page: 2638 year: 2022 ident: bib55 article-title: MRNIP condensates promote DNA double-strand break sensing and end resection publication-title: Nat. Commun. – volume: 23 start-page: 5919 year: 2003 end-page: 5927 ident: bib104 article-title: Physical and functional interaction between DNA ligase IIIalpha and poly(ADP-ribose) polymerase 1 in DNA single-strand break repair publication-title: Mol. Cell. Biol. – volume: 18 start-page: 285 year: 2017 end-page: 298 ident: bib109 article-title: Biomolecular condensates: organizers of cellular biochemistry publication-title: Nat. Rev. Mol. Cell Biol. – volume: 7 start-page: 973 year: 2010 end-page: 975 ident: bib129 article-title: Rapid blue-light-mediated induction of protein interactions in living cells publication-title: Nat. Methods – volume: 129 start-page: 11468 year: 2007 end-page: 11479 ident: bib139 article-title: An exchange-free measure of 15N transverse relaxation: an NMR spectroscopy application to the study of a folding intermediate with pervasive chemical exchange publication-title: J. Am. Chem. Soc. – volume: 120 year: 2023 ident: bib9 article-title: Correlating histone acetylation with nucleosome core particle dynamics and function publication-title: Proc. Natl. Acad. Sci. USA – volume: 31 start-page: 5526 year: 2003 end-page: 5533 ident: bib103 article-title: A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage publication-title: Nucleic Acids Res. – volume: 283 start-page: 106767 year: 2022 ident: bib24 article-title: Histone H3 and H4 tails play an important role in nucleosome phase separation publication-title: Biophys. Chem. – volume: 3 start-page: 1103 year: 2004 end-page: 1108 ident: bib67 article-title: PARP-1, PARP-2 and ATM in the DNA damage response: functional synergy in mouse development publication-title: DNA Repair (Amst) – volume: 82 start-page: 969 year: 2022 end-page: 985.e11 ident: bib121 article-title: Poly(ADP-ribose) drives condensation of FUS via a transient interaction publication-title: Mol. Cell – volume: 68 start-page: 847 year: 2017 end-page: 859.e7 ident: bib39 article-title: Mechanistic insights into autoinhibition of the oncogenic chromatin remodeler ALC1 publication-title: Mol. Cell – volume: 38 year: 2019 ident: bib56 article-title: Phase separation of 53BP1 determines liquid-like behavior of DNA repair compartments publication-title: EMBO J. – volume: 114 start-page: 10663 year: 1992 end-page: 10665 ident: bib136 article-title: Pure absorption gradient enhanced heteronuclear single quantum correlation spectroscopy with improved sensitivity publication-title: J. Am. Chem. Soc. – volume: 28 start-page: 2049 year: 2000 end-page: 2059 ident: bib112 article-title: Domain specific interaction in the XRCC1-DNA polymerase beta complex publication-title: Nucleic Acids Res. – volume: 11 start-page: 695 year: 2020 ident: bib54 article-title: DNA repair by Rad52 liquid droplets publication-title: Nat. Commun. – volume: 29 start-page: 538 year: 2009 end-page: 546 ident: bib99 article-title: The H4 tail domain participates in intra- and internucleosome interactions with protein and DNA during folding and oligomerization of nucleosome arrays publication-title: Mol. Cell. Biol. – volume: 26 start-page: 3218 year: 1987 end-page: 3224 ident: bib114 article-title: Characterization of polymers of adenosine diphosphate ribose generated in vitro and in vivo publication-title: Biochemistry – start-page: 205 year: 1990 end-page: 259 ident: bib96 article-title: Polyelectrolyte solutions publication-title: Intorduction to Dynamic Light Scattering by Macromolecules – volume: 83 start-page: 291 year: 2014 end-page: 315 ident: bib88 article-title: Bringing dynamic molecular machines into focus by methyl-TROSY NMR publication-title: Annu. Rev. Biochem. – volume: 3 start-page: 639 year: 2020 ident: bib12 article-title: Dynamic networks observed in the nucleosome core particles couple the histone globular domains with DNA publication-title: Commun. Biol. – volume: 27 start-page: 662 year: 2016 end-page: 668 ident: bib149 article-title: Tuning a high transmission ion guide to prevent gas-phase proton exchange during H/D exchange MS analysis publication-title: J. Am. Soc. Mass Spectrom. – volume: 76 start-page: 595 year: 1979 end-page: 599 ident: bib115 article-title: Structure of poly(adenosine diphosphate ribose): identification of 2′-[1’’-ribosyl-2”-(or 3’’-)(1’’’-ribosyl)]adenosine-5’,5’’,5’’’-tris(phosphate) as a branch linkage publication-title: Proc Natl Acad Sci USA – volume: 12 start-page: 2387 year: 2021 ident: bib11 article-title: Histone dynamics mediate DNA unwrapping and sliding in nucleosomes publication-title: Nat. Commun. – volume: 106 start-page: 687 year: 2006 end-page: 699 ident: bib74 article-title: DNA ligases: structure, reaction mechanism, and function publication-title: Chem. Rev. – volume: 117 start-page: 7566 year: 1995 end-page: 7567 ident: bib101 article-title: Association of biomolecular systems via pulsed field gradient NMR self-diffusion measurements publication-title: J. Am. Chem. Soc. – volume: 547 start-page: 236 year: 2017 end-page: 240 ident: bib125 article-title: Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin publication-title: Nature – volume: 14 start-page: 290 year: 2017 end-page: 296 ident: bib132 article-title: cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination publication-title: Nat. Methods – volume: 60 start-page: 6480 year: 2021 end-page: 6487 ident: bib16 article-title: Histone H4 tails in nucleosomes: a fuzzy interaction with DNA publication-title: Angew. Chem. Int. Ed. Engl. – volume: 7 start-page: e34334 year: 2018 ident: bib86 article-title: Serine is the major residue for ADP-ribosylation upon DNA damage publication-title: eLife – volume: 100 start-page: 2071 year: 2011 end-page: 2086 ident: bib150 article-title: The utility of hydrogen/deuterium exchange mass spectrometry in biopharmaceutical comparability studies publication-title: J. Pharm. Sci. – volume: 325 start-page: 1240 year: 2009 end-page: 1243 ident: bib64 article-title: Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1 publication-title: Science – volume: 337 start-page: 573 year: 2004 end-page: 583 ident: bib70 article-title: Engineering strand-specific DNA nicking enzymes from the type IIS restriction endonucleases BsaI, BsmBI, and BsmAI publication-title: J. Mol. Biol. – volume: 112 start-page: 102 year: 1983 end-page: 107 ident: bib113 article-title: Size and shape of poly(ADP-ribose): examination by gel filtration, gel electrophoresis and electron microscopy publication-title: Biochem. Biophys. Res. Commun. – volume: 13 start-page: 436 year: 2012 end-page: 447 ident: bib1 article-title: New insights into nucleosome and chromatin structure: an ordered state or a disordered affair? publication-title: Nat. Rev. Mol. Cell Biol. – volume: 143 start-page: 3037 year: 2021 end-page: 3042 ident: bib107 article-title: Identifying poly(ADP-ribose)-binding proteins with photoaffinity-based proteomics publication-title: J. Am. Chem. Soc. – volume: 12 year: 2016 ident: bib116 article-title: H3 histone tail conformation within the nucleosome and the impact of K14 acetylation studied using enhanced sampling simulation publication-title: PLoS Comput. Biol. – volume: 185 start-page: 42 year: 2014 end-page: 47 ident: bib153 article-title: Fabrication of carbon films with ∼500nm holes for cryo-EM with a direct detector device publication-title: J. Struct. Biol. – volume: 282 start-page: 32511 year: 2007 end-page: 32519 ident: bib44 article-title: Nucleosomal core histones mediate dynamic regulation of poly(ADP-ribose) polymerase 1 protein binding to chromatin and induction of its enzymatic activity publication-title: J. Biol. Chem. – volume: 17 start-page: 495 year: 2022 end-page: 502 ident: bib7 article-title: Visualizing conformational ensembles of the nucleosome by NMR publication-title: ACS Chem. Biol. – volume: 298 start-page: 211 year: 2000 end-page: 223 ident: bib26 article-title: Effects of core histone tail domains on the equilibrium constants for dynamic DNA site accessibility in nucleosomes publication-title: J. Mol. Biol. – volume: 117 start-page: 19661 year: 2020 end-page: 19663 ident: bib119 article-title: Acetylated histone H4 tail enhances histone H3 tail acetylation by altering their mutual dynamics in the nucleosome publication-title: Proc. Natl. Acad. Sci. USA – volume: 9 start-page: 676 year: 2012 end-page: 682 ident: bib130 article-title: Fiji: an open-source platform for biological-image analysis publication-title: Nat. Methods – volume: 10 start-page: e65773 year: 2021 ident: bib73 article-title: HPF1 and nucleosomes mediate a dramatic switch in activity of PARP1 from polymerase to hydrolase publication-title: eLife – volume: 14 start-page: 1619 year: 2009 end-page: 1626 ident: bib80 article-title: Poly (ADP-ribose) glycohydrolase (PARG) and its therapeutic potential publication-title: Front. Biosci. (Landmark Ed.) – volume: 92 start-page: 2633 year: 2007 end-page: 2645 ident: bib98 article-title: H3 and H4 histone tails play a central role in the interactions of recombinant NCPs publication-title: Biophys. J. – volume: 336 start-page: 728 year: 2012 end-page: 732 ident: bib106 article-title: Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1 publication-title: Science – volume: 280 start-page: 33701 year: 2005 end-page: 33706 ident: bib21 article-title: The core histone N-terminal tail domains function independently and additively during salt-dependent oligomerization of nucleosomal arrays publication-title: J. Biol. Chem. – volume: 71 start-page: 703 year: 2018 end-page: 717.e9 ident: bib48 article-title: Poly(ADP-ribose) prevents pathological phase separation of TDP-43 by promoting liquid demixing and stress granule localization publication-title: Mol. Cell – volume: 30 start-page: 70 year: 2021 end-page: 82 ident: bib131 article-title: UCSF ChimeraX: structure visualization for researchers, educators, and developers publication-title: Protein Sci. – volume: 64 start-page: 188 year: 1960 end-page: 190 ident: bib142 article-title: Use of glass electrodes to measure acidities in deuterium oxide 1,2 publication-title: J. Phys. Chem. – volume: 29 start-page: 2278 year: 2018 end-page: 2281 ident: bib148 article-title: Optimized workflow for selecting peptides for HDX-MS data analyses publication-title: J. Am. Soc. Mass Spectrom. – volume: 102 start-page: 214 year: 1993 end-page: 218 ident: bib154 article-title: Effects of chemical exchange in diffusion-ordered 2D NMR spectra publication-title: J. Magn. Reson. A – volume: 24 start-page: 4387 year: 1996 end-page: 4394 ident: bib108 article-title: XRCC1 polypeptide interacts with DNA polymerase β and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular ‘nick-sensor’ in vitro publication-title: Nucleic Acids Res. – volume: 39 start-page: 6465 year: 2011 end-page: 6474 ident: bib118 article-title: Phosphorylation of histone H3(T118) alters nucleosome dynamics and remodeling publication-title: Nucleic Acids Res. – volume: 7 year: 2018 ident: bib134 article-title: The conformation of the histone H3 tail inhibits association of the BPTF PHD finger with the nucleosome publication-title: eLife – volume: 27 start-page: 1809 year: 2019 end-page: 1821.e5 ident: bib49 article-title: PARP-1 activation directs FUS to DNA damage sites to form PARG-reversible compartments enriched in damaged DNA publication-title: Cell Rep. – volume: 26 start-page: 573 year: 2019 end-page: 581.e5 ident: bib105 article-title: Efficient single-strand break repair requires binding to both poly(ADP-ribose) and DNA by the central BRCT domain of XRCC1 publication-title: Cell Rep. – volume: 30 start-page: 1508 year: 2022 end-page: 1517.e3 ident: bib152 article-title: ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr publication-title: Structure – volume: 52 start-page: 272 year: 2013 end-page: 285 ident: bib36 article-title: Proteome-wide identification of poly(ADP-ribosyl)ation targets in different genotoxic stress responses publication-title: Mol. Cell – volume: 299 start-page: 560 year: 2003 end-page: 562 ident: bib42 article-title: Chromatin loosening by poly(ADP)-ribose polymerase (PARP) at Drosophila puff loci publication-title: Science – volume: 319 start-page: 1097 year: 2002 end-page: 1113 ident: bib91 article-title: Solvent mediated interactions in the structure of the nucleosome core particle at 1.9 a resolution publication-title: J. Mol. Biol. – volume: 21 start-page: 7020 year: 2020 ident: bib122 article-title: Fused in sarcoma (FUS) in DNA repair: tango with poly(ADP-ribose) polymerase 1 and compartmentalisation of damaged DNA publication-title: Int. J. Mol. Sci. – volume: 34 start-page: 3523 year: 2006 end-page: 3532 ident: bib123 article-title: Differential recruitment of DNA ligase I and III to DNA repair sites publication-title: Nucleic Acids Res. – volume: 261 start-page: 7011 year: 1986 end-page: 7017 ident: bib60 article-title: Modulation of chromatin superstructure induced by poly(ADP-ribose) synthesis and degradation publication-title: J. Biol. Chem. – volume: 263 start-page: 3879 year: 1988 end-page: 3883 ident: bib66 article-title: Characterization of human poly(ADP-ribose) polymerase with autoantibodies publication-title: J. Biol. Chem. – volume: 32 start-page: 2490 year: 2012 end-page: 2502 ident: bib81 article-title: Histone ADP-ribosylation facilitates gene transcription by directly remodeling nucleosomes publication-title: Mol. Cell. Biol. – volume: 47 start-page: 8470 year: 2019 end-page: 8484 ident: bib20 article-title: Super-resolution microscopy reveals how histone tail acetylation affects DNA compaction within nucleosomes in vivo publication-title: Nucleic Acids Res. – volume: 276 start-page: 19 year: 1998 end-page: 42 ident: bib65 article-title: New DNA sequence rules for high affinity binding to histone octamer and sequence-directed nucleosome positioning publication-title: J. Mol. Biol. – volume: 19 start-page: 5492 year: 2000 end-page: 5501 ident: bib77 article-title: Human DNA ligase I efficiently seals nicks in nucleosomes publication-title: EMBO J. – volume: 14 start-page: 68 year: 1994 end-page: 76 ident: bib78 article-title: An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III publication-title: Mol. Cell. Biol. – volume: 102 start-page: 241 year: 1993 end-page: 245 ident: bib137 article-title: Gradient-tailored water suppression for 1H-15N HSQC experiments optimized to retain full sensitivity publication-title: J. Magn. Reson. – volume: 43 start-page: 6934 year: 2015 end-page: 6944 ident: bib102 article-title: The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function publication-title: Nucleic Acids Res. – volume: 316 start-page: 101 year: 2002 end-page: 112 ident: bib140 article-title: Distribution of molecular size within an unfolded state ensemble using small-angle X-ray scattering and pulse field gradient NMR techniques publication-title: J. Mol. Biol. – volume: 163 start-page: 85 year: 2018 end-page: 95 ident: bib4 article-title: Structural diversity of the nucleosome publication-title: J. Biochem. – volume: 206 start-page: 451 year: 1989 end-page: 463 ident: bib18 article-title: Use of selectively trypsinized nucleosome core particles to analyze the role of the histone “tails” in the stabilization of the nucleosome publication-title: J. Mol. Biol. – volume: 17 start-page: 615 year: 2021 end-page: 623 ident: bib51 article-title: Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation publication-title: Nat. Chem. Biol. – volume: 125 start-page: 10420 year: 2003 end-page: 10428 ident: bib87 article-title: Cross-correlated relaxation enhanced publication-title: J. Am. Chem. Soc. – volume: 230 start-page: 136 year: 1997 end-page: 139 ident: bib97 article-title: Major role of the histones H3-H4 in the folding of the chromatin fiber publication-title: Biochem. Biophys. Res. Commun. – volume: 291 start-page: 1789 year: 2016 end-page: 1802 ident: bib41 article-title: Poly(ADP-ribosyl)ation-dependent transient chromatin decondensation and histone displacement following laser microirradiation publication-title: J. Biol. Chem. – volume: 9 year: 2017 ident: bib17 article-title: Stabilization of nucleosomes by histone tails and by FACT revealed by spFRET microscopy publication-title: Cancers (Basel) – volume: 428 start-page: 126 year: 2012 end-page: 136 ident: bib72 article-title: Large-scale preparation and characterization of poly(ADP-ribose) and defined length polymers publication-title: Anal. Biochem. – volume: 5 start-page: 227 year: 2020 ident: bib30 article-title: NAD publication-title: Signal Transduct. Target. Ther. – volume: 12 start-page: 46 year: 2005 end-page: 53 ident: bib8 article-title: Rapid spontaneous accessibility of nucleosomal DNA publication-title: Nat. Struct. Mol. Biol. – volume: 30 start-page: 370 year: 2020 end-page: 383 ident: bib57 article-title: Poly(ADP-ribose): a dynamic trigger for biomolecular condensate formation publication-title: Trends Cell Biol. – volume: 286 start-page: 7149 year: 2011 end-page: 7160 ident: bib68 article-title: Double-stranded DNA binding domain of poly(ADP-ribose) polymerase-1 and molecular insight into the regulation of its activity publication-title: J. Biol. Chem. – volume: 14 start-page: 837 year: 2018 end-page: 840 ident: bib127 article-title: Acetylation blocks DNA damage-induced chromatin ADP-ribosylation publication-title: Nat. Chem. Biol. – volume: 611 start-page: 614 year: 2022 end-page: 622 ident: bib25 article-title: Histone H2B.8 compacts flowering plant sperm through chromatin phase separation publication-title: Nature – volume: 108 start-page: 12283 year: 2011 end-page: 12288 ident: bib133 article-title: Architecture of the high mobility group nucleosomal protein 2-nucleosome complex as revealed by methyl-based NMR publication-title: Proc. Natl. Acad. Sci. USA – volume: 22 start-page: 215 year: 2021 end-page: 235 ident: bib50 article-title: A framework for understanding the functions of biomolecular condensates across scales publication-title: Nat. Rev. Mol. Cell Biol. – volume: 11 start-page: 2174 year: 2020 ident: bib84 article-title: Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy publication-title: Nat. Commun. – volume: 9 start-page: 671 year: 2012 end-page: 675 ident: bib155 article-title: NIH Image to ImageJ: 25 years of image analysis publication-title: Nat. Methods – volume: 116 start-page: 56 year: 2020 end-page: 84 ident: bib89 article-title: Methyl TROSY spectroscopy: a versatile NMR approach to study challenging biological systems publication-title: Prog. Nucl. Magn. Reson. Spectrosc. – volume: 26 start-page: 3218 year: 1987 ident: 10.1016/j.molcel.2023.12.019_bib114 article-title: Characterization of polymers of adenosine diphosphate ribose generated in vitro and in vivo publication-title: Biochemistry doi: 10.1021/bi00385a042 – volume: 30 start-page: 678 year: 2023 ident: 10.1016/j.molcel.2023.12.019_bib58 article-title: HPF1-dependent histone ADP-ribosylation triggers chromatin relaxation to promote the recruitment of repair factors at sites of DNA damage publication-title: Nat. Struct. Mol. Biol. doi: 10.1038/s41594-023-00977-x – volume: 10 start-page: e65773 year: 2021 ident: 10.1016/j.molcel.2023.12.019_bib73 article-title: HPF1 and nucleosomes mediate a dramatic switch in activity of PARP1 from polymerase to hydrolase publication-title: eLife doi: 10.7554/eLife.65773 – volume: 325 start-page: 1240 year: 2009 ident: 10.1016/j.molcel.2023.12.019_bib64 article-title: Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1 publication-title: Science doi: 10.1126/science.1177321 – volume: 29 start-page: 2278 year: 2018 ident: 10.1016/j.molcel.2023.12.019_bib148 article-title: Optimized workflow for selecting peptides for HDX-MS data analyses publication-title: J. Am. Soc. Mass Spectrom. doi: 10.1007/s13361-018-2056-1 – volume: 2 start-page: 1685 year: 1983 ident: 10.1016/j.molcel.2023.12.019_bib59 article-title: Correlation between endogenous nucleosomal hyper(ADP-ribosyl)ation of histone H1 and the induction of chromatin relaxation publication-title: EMBO J. doi: 10.1002/j.1460-2075.1983.tb01643.x – volume: 261 start-page: 7011 year: 1986 ident: 10.1016/j.molcel.2023.12.019_bib60 article-title: Modulation of chromatin superstructure induced by poly(ADP-ribose) synthesis and degradation publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)62715-8 – volume: 389 start-page: 251 year: 1997 ident: 10.1016/j.molcel.2023.12.019_bib2 article-title: Crystal structure of the nucleosome core particle at 2.8 Å resolution publication-title: Nature doi: 10.1038/38444 – volume: 27 start-page: 662 year: 2016 ident: 10.1016/j.molcel.2023.12.019_bib149 article-title: Tuning a high transmission ion guide to prevent gas-phase proton exchange during H/D exchange MS analysis publication-title: J. Am. Soc. Mass Spectrom. doi: 10.1007/s13361-015-1330-8 – volume: 27 start-page: 1809 year: 2019 ident: 10.1016/j.molcel.2023.12.019_bib49 article-title: PARP-1 activation directs FUS to DNA damage sites to form PARG-reversible compartments enriched in damaged DNA publication-title: Cell Rep. doi: 10.1016/j.celrep.2019.04.031 – volume: 17 start-page: 495 year: 2022 ident: 10.1016/j.molcel.2023.12.019_bib7 article-title: Visualizing conformational ensembles of the nucleosome by NMR publication-title: ACS Chem. Biol. doi: 10.1021/acschembio.1c00954 – volume: 26 start-page: 1651 year: 2018 ident: 10.1016/j.molcel.2023.12.019_bib95 article-title: Hydrogen-deuterium exchange coupled to top- and middle-down mass spectrometry reveals histone tail dynamics before and after nucleosome assembly publication-title: Structure doi: 10.1016/j.str.2018.08.006 – volume: 30 start-page: 70 year: 2021 ident: 10.1016/j.molcel.2023.12.019_bib131 article-title: UCSF ChimeraX: structure visualization for researchers, educators, and developers publication-title: Protein Sci. doi: 10.1002/pro.3943 – volume: 49 start-page: 8432 year: 2021 ident: 10.1016/j.molcel.2023.12.019_bib33 article-title: Why structure and chain length matter: on the biological significance underlying the structural heterogeneity of poly(ADP-ribose) publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkab618 – volume: 60 start-page: 6480 year: 2021 ident: 10.1016/j.molcel.2023.12.019_bib16 article-title: Histone H4 tails in nucleosomes: a fuzzy interaction with DNA publication-title: Angew. Chem. Int. Ed. Engl. doi: 10.1002/anie.202012046 – volume: 87 start-page: 6681 year: 2015 ident: 10.1016/j.molcel.2023.12.019_bib145 article-title: Recombinant Nepenthesin II for hydrogen/deuterium exchange mass spectrometry publication-title: Anal. Chem. doi: 10.1021/acs.analchem.5b00831 – volume: 8 start-page: 127 year: 2015 ident: 10.1016/j.molcel.2023.12.019_bib151 article-title: Analytical aspects of hydrogen exchange mass spectrometry publication-title: Annu. Rev. Anal. Chem. (Palo Alto. Calif) doi: 10.1146/annurev-anchem-062011-143113 – volume: 336 start-page: 728 year: 2012 ident: 10.1016/j.molcel.2023.12.019_bib106 article-title: Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1 publication-title: Science doi: 10.1126/science.1216338 – volume: 27 start-page: 781 year: 2010 ident: 10.1016/j.molcel.2023.12.019_bib82 article-title: Nucleosome positioning, nucleosome spacing and the nucleosome code publication-title: J. Biomol. Struct. Dyn. doi: 10.1080/073911010010524945 – volume: 68 start-page: 847 year: 2017 ident: 10.1016/j.molcel.2023.12.019_bib39 article-title: Mechanistic insights into autoinhibition of the oncogenic chromatin remodeler ALC1 publication-title: Mol. Cell doi: 10.1016/j.molcel.2017.10.017 – volume: 11 start-page: 695 year: 2020 ident: 10.1016/j.molcel.2023.12.019_bib54 article-title: DNA repair by Rad52 liquid droplets publication-title: Nat. Commun. doi: 10.1038/s41467-020-14546-z – volume: 114 start-page: 10663 year: 1992 ident: 10.1016/j.molcel.2023.12.019_bib136 article-title: Pure absorption gradient enhanced heteronuclear single quantum correlation spectroscopy with improved sensitivity publication-title: J. Am. Chem. Soc. doi: 10.1021/ja00052a088 – volume: 9 start-page: 676 year: 2012 ident: 10.1016/j.molcel.2023.12.019_bib130 article-title: Fiji: an open-source platform for biological-image analysis publication-title: Nat. Methods doi: 10.1038/nmeth.2019 – volume: 117 start-page: 17 year: 2004 ident: 10.1016/j.molcel.2023.12.019_bib111 article-title: The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks publication-title: Cell doi: 10.1016/S0092-8674(04)00206-5 – volume: 291 start-page: 1789 year: 2016 ident: 10.1016/j.molcel.2023.12.019_bib41 article-title: Poly(ADP-ribosyl)ation-dependent transient chromatin decondensation and histone displacement following laser microirradiation publication-title: J. Biol. Chem. doi: 10.1074/jbc.M115.694992 – volume: 29 start-page: 623 year: 2018 ident: 10.1016/j.molcel.2023.12.019_bib144 article-title: Optimization of feasibility stage for hydrogen/deuterium exchange mass spectrometry publication-title: J. Am. Soc. Mass Spectrom. doi: 10.1007/s13361-017-1860-3 – volume: 113 start-page: 2412 year: 2016 ident: 10.1016/j.molcel.2023.12.019_bib147 article-title: Load-dependent destabilization of the gamma-rotor shaft in FOF1 ATP synthase revealed by hydrogen/deuterium-exchange mass spectrometry publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1520464113 – volume: 16 start-page: 923 year: 2009 ident: 10.1016/j.molcel.2023.12.019_bib62 article-title: A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation publication-title: Nat. Struct. Mol. Biol. doi: 10.1038/nsmb.1664 – volume: 299 start-page: 560 year: 2003 ident: 10.1016/j.molcel.2023.12.019_bib42 article-title: Chromatin loosening by poly(ADP)-ribose polymerase (PARP) at Drosophila puff loci publication-title: Science doi: 10.1126/science.1078764 – volume: 327 start-page: 85 year: 2003 ident: 10.1016/j.molcel.2023.12.019_bib100 article-title: Chromatin fiber folding: requirement for the histone H4 N-terminal tail publication-title: J. Mol. Biol. doi: 10.1016/S0022-2836(03)00025-1 – volume: 39 start-page: 1680 year: 2011 ident: 10.1016/j.molcel.2023.12.019_bib19 article-title: The effects of histone H4 tail acetylations on cation-induced chromatin folding and self-association publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkq900 – volume: 263 start-page: 3879 year: 1988 ident: 10.1016/j.molcel.2023.12.019_bib66 article-title: Characterization of human poly(ADP-ribose) polymerase with autoantibodies publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)69007-6 – volume: 292 start-page: 5227 year: 2017 ident: 10.1016/j.molcel.2023.12.019_bib76 article-title: The human ligase IIIalpha-XRCC1 protein complex performs DNA nick repair after transient unwrapping of nucleosomal DNA publication-title: J. Biol. Chem. doi: 10.1074/jbc.M116.736728 – volume: 21 start-page: 7020 year: 2020 ident: 10.1016/j.molcel.2023.12.019_bib122 article-title: Fused in sarcoma (FUS) in DNA repair: tango with poly(ADP-ribose) polymerase 1 and compartmentalisation of damaged DNA publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms21197020 – volume: 47 start-page: 11250 year: 2019 ident: 10.1016/j.molcel.2023.12.019_bib61 article-title: Poly(ADP-ribose)-dependent chromatin unfolding facilitates the association of DNA-binding proteins with DNA at sites of damage publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkz820 – volume: 93 start-page: 102908 year: 2020 ident: 10.1016/j.molcel.2023.12.019_bib75 article-title: Human DNA ligases in replication and repair publication-title: DNA Repair (Amst) doi: 10.1016/j.dnarep.2020.102908 – volume: 282 start-page: 32511 year: 2007 ident: 10.1016/j.molcel.2023.12.019_bib44 article-title: Nucleosomal core histones mediate dynamic regulation of poly(ADP-ribose) polymerase 1 protein binding to chromatin and induction of its enzymatic activity publication-title: J. Biol. Chem. doi: 10.1074/jbc.M705989200 – volume: 79 start-page: 3423 year: 1982 ident: 10.1016/j.molcel.2023.12.019_bib40 article-title: Poly(ADP-ribosyl)ation of polynucleosomes causes relaxation of chromatin structure publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.79.11.3423 – volume: 112 start-page: 275 year: 1995 ident: 10.1016/j.molcel.2023.12.019_bib141 article-title: Water suppression that works. Excitation sculpting using arbitrary wave-forms and pulsed-field gradients publication-title: J. Magn. Reson. A doi: 10.1006/jmra.1995.1047 – volume: 14 start-page: 68 year: 1994 ident: 10.1016/j.molcel.2023.12.019_bib78 article-title: An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III publication-title: Mol. Cell. Biol. – volume: 131 start-page: 16257 year: 2009 ident: 10.1016/j.molcel.2023.12.019_bib138 article-title: Selective characterization of microsecond motions in proteins by NMR relaxation publication-title: J. Am. Chem. Soc. doi: 10.1021/ja906842s – volume: 162 start-page: 1066 year: 2015 ident: 10.1016/j.molcel.2023.12.019_bib47 article-title: A liquid-to-solid phase transition of the ALS protein FUS accelerated by disease mutation publication-title: Cell doi: 10.1016/j.cell.2015.07.047 – volume: 43 start-page: 6934 year: 2015 ident: 10.1016/j.molcel.2023.12.019_bib102 article-title: The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkv623 – volume: 39 start-page: 6465 year: 2011 ident: 10.1016/j.molcel.2023.12.019_bib118 article-title: Phosphorylation of histone H3(T118) alters nucleosome dynamics and remodeling publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkr304 – volume: 5 start-page: 227 year: 2020 ident: 10.1016/j.molcel.2023.12.019_bib30 article-title: NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential publication-title: Signal Transduct. Target. Ther. doi: 10.1038/s41392-020-00311-7 – volume: 83 start-page: 291 year: 2014 ident: 10.1016/j.molcel.2023.12.019_bib88 article-title: Bringing dynamic molecular machines into focus by methyl-TROSY NMR publication-title: Annu. Rev. Biochem. doi: 10.1146/annurev-biochem-060713-035829 – volume: 102 start-page: 214 year: 1993 ident: 10.1016/j.molcel.2023.12.019_bib154 article-title: Effects of chemical exchange in diffusion-ordered 2D NMR spectra publication-title: J. Magn. Reson. A doi: 10.1006/jmra.1993.1093 – volume: 1 start-page: 22 year: 2017 ident: 10.1016/j.molcel.2023.12.019_bib135 article-title: Preparation of calcium competent Escherichia coli and heat-shock transformation publication-title: JEMI Methods – volume: 119 start-page: 803 year: 2004 ident: 10.1016/j.molcel.2023.12.019_bib43 article-title: NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1 publication-title: Cell doi: 10.1016/j.cell.2004.11.002 – volume: 129 start-page: 11468 year: 2007 ident: 10.1016/j.molcel.2023.12.019_bib139 article-title: An exchange-free measure of 15N transverse relaxation: an NMR spectroscopy application to the study of a folding intermediate with pervasive chemical exchange publication-title: J. Am. Chem. Soc. doi: 10.1021/ja072717t – volume: 30 start-page: 370 year: 2020 ident: 10.1016/j.molcel.2023.12.019_bib57 article-title: Poly(ADP-ribose): a dynamic trigger for biomolecular condensate formation publication-title: Trends Cell Biol. doi: 10.1016/j.tcb.2020.02.002 – volume: 100 start-page: 2071 year: 2011 ident: 10.1016/j.molcel.2023.12.019_bib150 article-title: The utility of hydrogen/deuterium exchange mass spectrometry in biopharmaceutical comparability studies publication-title: J. Pharm. Sci. doi: 10.1002/jps.22432 – volume: 286 start-page: 7149 year: 2011 ident: 10.1016/j.molcel.2023.12.019_bib68 article-title: Double-stranded DNA binding domain of poly(ADP-ribose) polymerase-1 and molecular insight into the regulation of its activity publication-title: J. Biol. Chem. doi: 10.1074/jbc.M110.175190 – volume: 4 start-page: 365 year: 1984 ident: 10.1016/j.molcel.2023.12.019_bib92 article-title: Proteases as structural probes for chromatin: the domain structure of histones publication-title: Biosci. Rep. doi: 10.1007/BF01122502 – volume: 64 start-page: 188 year: 1960 ident: 10.1016/j.molcel.2023.12.019_bib142 article-title: Use of glass electrodes to measure acidities in deuterium oxide 1,2 publication-title: J. Phys. Chem. doi: 10.1021/j100830a521 – volume: 64 start-page: 632 year: 1960 ident: 10.1016/j.molcel.2023.12.019_bib143 article-title: Acidity measurements with the glass electrode in H2O-D2O mixtures publication-title: J. Phys. Chem. doi: 10.1021/j100834a026 – volume: 117 start-page: 7566 year: 1995 ident: 10.1016/j.molcel.2023.12.019_bib101 article-title: Association of biomolecular systems via pulsed field gradient NMR self-diffusion measurements publication-title: J. Am. Chem. Soc. doi: 10.1021/ja00133a039 – volume: 428 start-page: 126 year: 2012 ident: 10.1016/j.molcel.2023.12.019_bib72 article-title: Large-scale preparation and characterization of poly(ADP-ribose) and defined length polymers publication-title: Anal. Biochem. doi: 10.1016/j.ab.2012.06.015 – volume: 3 start-page: 639 year: 2020 ident: 10.1016/j.molcel.2023.12.019_bib12 article-title: Dynamic networks observed in the nucleosome core particles couple the histone globular domains with DNA publication-title: Commun. Biol. doi: 10.1038/s42003-020-01369-3 – volume: 23 start-page: 2140 year: 2012 ident: 10.1016/j.molcel.2023.12.019_bib146 article-title: Minimizing carry-over in an online pepsin digestion system used for the H/D exchange mass spectrometric analysis of an IgG1 monoclonal antibody publication-title: J. Am. Soc. Mass Spectrom. doi: 10.1007/s13361-012-0485-9 – volume: 319 start-page: 1097 year: 2002 ident: 10.1016/j.molcel.2023.12.019_bib91 article-title: Solvent mediated interactions in the structure of the nucleosome core particle at 1.9 a resolution publication-title: J. Mol. Biol. doi: 10.1016/S0022-2836(02)00386-8 – volume: 9 start-page: 619 year: 2008 ident: 10.1016/j.molcel.2023.12.019_bib29 article-title: Single-strand break repair and genetic disease publication-title: Nat. Rev. Genet. doi: 10.1038/nrg2380 – volume: 6 start-page: 31437 year: 2016 ident: 10.1016/j.molcel.2023.12.019_bib13 article-title: Distinct roles of histone H3 and H2A tails in nucleosome stability publication-title: Sci. Rep. doi: 10.1038/srep31437 – volume: 230 start-page: 136 year: 1997 ident: 10.1016/j.molcel.2023.12.019_bib97 article-title: Major role of the histones H3-H4 in the folding of the chromatin fiber publication-title: Biochem. Biophys. Res. Commun. doi: 10.1006/bbrc.1996.5903 – volume: 62 start-page: 432 year: 2016 ident: 10.1016/j.molcel.2023.12.019_bib71 article-title: HPF1/C4orf27 is a PARP-1-Interacting protein that regulates PARP-1 ADP-ribosylation activity publication-title: Mol. Cell doi: 10.1016/j.molcel.2016.03.008 – volume: 298 start-page: 211 year: 2000 ident: 10.1016/j.molcel.2023.12.019_bib26 article-title: Effects of core histone tail domains on the equilibrium constants for dynamic DNA site accessibility in nucleosomes publication-title: J. Mol. Biol. doi: 10.1006/jmbi.2000.3644 – volume: 24 start-page: 4387 year: 1996 ident: 10.1016/j.molcel.2023.12.019_bib108 article-title: XRCC1 polypeptide interacts with DNA polymerase β and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular ‘nick-sensor’ in vitro publication-title: Nucleic Acids Res. doi: 10.1093/nar/24.22.4387 – volume: 14 start-page: 1619 year: 2009 ident: 10.1016/j.molcel.2023.12.019_bib80 article-title: Poly (ADP-ribose) glycohydrolase (PARG) and its therapeutic potential publication-title: Front. Biosci. (Landmark Ed.) doi: 10.2741/3329 – volume: 143 start-page: 3037 year: 2021 ident: 10.1016/j.molcel.2023.12.019_bib107 article-title: Identifying poly(ADP-ribose)-binding proteins with photoaffinity-based proteomics publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.0c12246 – volume: 12 start-page: 46 year: 2005 ident: 10.1016/j.molcel.2023.12.019_bib8 article-title: Rapid spontaneous accessibility of nucleosomal DNA publication-title: Nat. Struct. Mol. Biol. doi: 10.1038/nsmb869 – volume: 82 start-page: 969 year: 2022 ident: 10.1016/j.molcel.2023.12.019_bib121 article-title: Poly(ADP-ribose) drives condensation of FUS via a transient interaction publication-title: Mol. Cell doi: 10.1016/j.molcel.2022.01.018 – volume: 30 start-page: 1508 year: 2022 ident: 10.1016/j.molcel.2023.12.019_bib152 article-title: ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr publication-title: Structure doi: 10.1016/j.str.2022.08.008 – volume: 316 start-page: 101 year: 2002 ident: 10.1016/j.molcel.2023.12.019_bib140 article-title: Distribution of molecular size within an unfolded state ensemble using small-angle X-ray scattering and pulse field gradient NMR techniques publication-title: J. Mol. Biol. doi: 10.1006/jmbi.2001.5328 – volume: 206 start-page: 451 year: 1989 ident: 10.1016/j.molcel.2023.12.019_bib18 article-title: Use of selectively trypsinized nucleosome core particles to analyze the role of the histone “tails” in the stabilization of the nucleosome publication-title: J. Mol. Biol. doi: 10.1016/0022-2836(89)90493-2 – volume: 17 start-page: 693 year: 2021 ident: 10.1016/j.molcel.2023.12.019_bib52 article-title: Mechanistic dissection of increased enzymatic rate in a phase-separated compartment publication-title: Nat. Chem. Biol. doi: 10.1038/s41589-021-00801-x – volume: 27 start-page: 5597 year: 2007 ident: 10.1016/j.molcel.2023.12.019_bib31 article-title: Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.02248-06 – volume: 337 start-page: 573 year: 2004 ident: 10.1016/j.molcel.2023.12.019_bib70 article-title: Engineering strand-specific DNA nicking enzymes from the type IIS restriction endonucleases BsaI, BsmBI, and BsmAI publication-title: J. Mol. Biol. doi: 10.1016/j.jmb.2004.02.003 – volume: 175 start-page: 1481 year: 2018 ident: 10.1016/j.molcel.2023.12.019_bib124 article-title: Liquid nuclear condensates mechanically sense and restructure the genome publication-title: Cell doi: 10.1016/j.cell.2018.10.057 – volume: 11 start-page: 2174 year: 2020 ident: 10.1016/j.molcel.2023.12.019_bib84 article-title: Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy publication-title: Nat. Commun. doi: 10.1038/s41467-020-15858-w – volume: 106 start-page: 687 year: 2006 ident: 10.1016/j.molcel.2023.12.019_bib74 article-title: DNA ligases: structure, reaction mechanism, and function publication-title: Chem. Rev. doi: 10.1021/cr040498d – volume: 547 start-page: 236 year: 2017 ident: 10.1016/j.molcel.2023.12.019_bib125 article-title: Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin publication-title: Nature doi: 10.1038/nature22822 – volume: 76 start-page: 595 year: 1979 ident: 10.1016/j.molcel.2023.12.019_bib115 article-title: Structure of poly(adenosine diphosphate ribose): identification of 2′-[1’’-ribosyl-2”-(or 3’’-)(1’’’-ribosyl)]adenosine-5’,5’’,5’’’-tris(phosphate) as a branch linkage publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.76.2.595 – volume: 14 start-page: 837 year: 2018 ident: 10.1016/j.molcel.2023.12.019_bib127 article-title: Acetylation blocks DNA damage-induced chromatin ADP-ribosylation publication-title: Nat. Chem. Biol. doi: 10.1038/s41589-018-0097-1 – volume: 115 start-page: 2255 year: 2015 ident: 10.1016/j.molcel.2023.12.019_bib3 article-title: Nucleosome structure and function publication-title: Chem. Rev. doi: 10.1021/cr500373h – volume: 76 start-page: 646 year: 2019 ident: 10.1016/j.molcel.2023.12.019_bib126 article-title: Histone modifications regulate chromatin compartmentalization by contributing to a phase separation mechanism publication-title: Mol. Cell doi: 10.1016/j.molcel.2019.08.019 – volume: 346 start-page: 135 year: 2005 ident: 10.1016/j.molcel.2023.12.019_bib14 article-title: Specific contributions of histone tails and their acetylation to the mechanical stability of nucleosomes publication-title: J. Mol. Biol. doi: 10.1016/j.jmb.2004.11.056 – volume: 81 start-page: 102664 year: 2019 ident: 10.1016/j.molcel.2023.12.019_bib110 article-title: XRCC1 protein; form and function publication-title: DNA Repair (Amst) doi: 10.1016/j.dnarep.2019.102664 – volume: 23 start-page: 5919 year: 2003 ident: 10.1016/j.molcel.2023.12.019_bib104 article-title: Physical and functional interaction between DNA ligase IIIalpha and poly(ADP-ribose) polymerase 1 in DNA single-strand break repair publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.23.16.5919-5927.2003 – volume: 116 start-page: 56 year: 2020 ident: 10.1016/j.molcel.2023.12.019_bib89 article-title: Methyl TROSY spectroscopy: a versatile NMR approach to study challenging biological systems publication-title: Prog. Nucl. Magn. Reson. Spectrosc. doi: 10.1016/j.pnmrs.2019.09.004 – volume: 7 start-page: 10806 year: 2016 ident: 10.1016/j.molcel.2023.12.019_bib128 article-title: Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism publication-title: Nat. Commun. doi: 10.1038/ncomms10806 – volume: 29 start-page: 538 year: 2009 ident: 10.1016/j.molcel.2023.12.019_bib99 article-title: The H4 tail domain participates in intra- and internucleosome interactions with protein and DNA during folding and oligomerization of nucleosome arrays publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.01343-08 – volume: 210 start-page: 229 year: 1989 ident: 10.1016/j.molcel.2023.12.019_bib69 article-title: Zinc-binding domain of poly(ADP-ribose)polymerase participates in the recognition of single strand breaks on DNA publication-title: J. Mol. Biol. doi: 10.1016/0022-2836(89)90302-1 – volume: 12 start-page: 2387 year: 2021 ident: 10.1016/j.molcel.2023.12.019_bib11 article-title: Histone dynamics mediate DNA unwrapping and sliding in nucleosomes publication-title: Nat. Commun. doi: 10.1038/s41467-021-22636-9 – volume: 112 start-page: 102 year: 1983 ident: 10.1016/j.molcel.2023.12.019_bib113 article-title: Size and shape of poly(ADP-ribose): examination by gel filtration, gel electrophoresis and electron microscopy publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/0006-291X(83)91803-X – volume: 61 start-page: 247 year: 2016 ident: 10.1016/j.molcel.2023.12.019_bib117 article-title: Modulations of DNA contacts by linker histones and post-translational modifications determine the mobility and modifiability of nucleosomal H3 tails publication-title: Mol. Cell doi: 10.1016/j.molcel.2015.12.015 – volume: 47 start-page: 3811 year: 2019 ident: 10.1016/j.molcel.2023.12.019_bib34 article-title: Poly(ADP-ribosyl)ation by PARP1: reaction mechanism and regulatory proteins publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkz120 – volume: 38 year: 2019 ident: 10.1016/j.molcel.2023.12.019_bib56 article-title: Phase separation of 53BP1 determines liquid-like behavior of DNA repair compartments publication-title: EMBO J. doi: 10.15252/embj.2018101379 – volume: 19 start-page: 5492 year: 2000 ident: 10.1016/j.molcel.2023.12.019_bib77 article-title: Human DNA ligase I efficiently seals nicks in nucleosomes publication-title: EMBO J. doi: 10.1093/emboj/19.20.5492 – volume: 185 start-page: 42 year: 2014 ident: 10.1016/j.molcel.2023.12.019_bib153 article-title: Fabrication of carbon films with ∼500nm holes for cryo-EM with a direct detector device publication-title: J. Struct. Biol. doi: 10.1016/j.jsb.2013.11.002 – volume: 115 start-page: 2274 year: 2015 ident: 10.1016/j.molcel.2023.12.019_bib28 article-title: Post-translational modifications of histones that influence nucleosome dynamics publication-title: Chem. Rev. doi: 10.1021/cr500350x – volume: 18 start-page: 610 year: 2017 ident: 10.1016/j.molcel.2023.12.019_bib37 article-title: The multifaceted roles of PARP1 in DNA repair and chromatin remodelling publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm.2017.53 – volume: 274 start-page: 17860 year: 1999 ident: 10.1016/j.molcel.2023.12.019_bib32 article-title: PARP-2, a novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase publication-title: J. Biol. Chem. doi: 10.1074/jbc.274.25.17860 – volume: 92 start-page: 2633 year: 2007 ident: 10.1016/j.molcel.2023.12.019_bib98 article-title: H3 and H4 histone tails play a central role in the interactions of recombinant NCPs publication-title: Biophys. J. doi: 10.1529/biophysj.106.093815 – volume: 9 year: 2017 ident: 10.1016/j.molcel.2023.12.019_bib17 article-title: Stabilization of nucleosomes by histone tails and by FACT revealed by spFRET microscopy publication-title: Cancers (Basel) doi: 10.3390/cancers9010003 – volume: 6 start-page: 8088 year: 2015 ident: 10.1016/j.molcel.2023.12.019_bib46 article-title: Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose) publication-title: Nat. Commun. doi: 10.1038/ncomms9088 – volume: 13 start-page: 870640 year: 2022 ident: 10.1016/j.molcel.2023.12.019_bib6 article-title: Recent advances in investigating functional dynamics of chromatin publication-title: Front. Genet. doi: 10.3389/fgene.2022.870640 – volume: 27 start-page: 4037 year: 2007 ident: 10.1016/j.molcel.2023.12.019_bib15 article-title: Histone tails and the H3 alphaN helix regulate nucleosome mobility and stability publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.02229-06 – volume: 17 start-page: 487 year: 2016 ident: 10.1016/j.molcel.2023.12.019_bib27 article-title: The molecular hallmarks of epigenetic control publication-title: Nat. Rev. Genet. doi: 10.1038/nrg.2016.59 – volume: 36 start-page: 11381 year: 1997 ident: 10.1016/j.molcel.2023.12.019_bib22 article-title: Hybrid trypsinized nucleosomal arrays: identification of multiple functional roles of the H2A/H2B and H3/H4 N-termini in chromatin fiber compaction publication-title: Biochemistry doi: 10.1021/bi970801n – volume: 27 start-page: 7475 year: 2007 ident: 10.1016/j.molcel.2023.12.019_bib45 article-title: The DNA binding and catalytic domains of poly(ADP-ribose) polymerase 1 cooperate in the regulation of chromatin structure and transcription publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.01314-07 – volume: 48 start-page: 3001 year: 2020 ident: 10.1016/j.molcel.2023.12.019_bib63 article-title: Poly(ADP-ribosyl)ation mediates early phase histone eviction at DNA lesions publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkaa022 – volume: 34 start-page: 3523 year: 2006 ident: 10.1016/j.molcel.2023.12.019_bib123 article-title: Differential recruitment of DNA ligase I and III to DNA repair sites publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkl492 – volume: 21 start-page: 1286 year: 2019 ident: 10.1016/j.molcel.2023.12.019_bib53 article-title: Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors publication-title: Nat. Cell Biol. doi: 10.1038/s41556-019-0392-4 – volume: 28 start-page: 2049 year: 2000 ident: 10.1016/j.molcel.2023.12.019_bib112 article-title: Domain specific interaction in the XRCC1-DNA polymerase beta complex publication-title: Nucleic Acids Res. doi: 10.1093/nar/28.10.2049 – volume: 7 year: 2018 ident: 10.1016/j.molcel.2023.12.019_bib134 article-title: The conformation of the histone H3 tail inhibits association of the BPTF PHD finger with the nucleosome publication-title: eLife doi: 10.7554/eLife.31481 – volume: 13 start-page: 2638 year: 2022 ident: 10.1016/j.molcel.2023.12.019_bib55 article-title: MRNIP condensates promote DNA double-strand break sensing and end resection publication-title: Nat. Commun. doi: 10.1038/s41467-022-30303-w – volume: 12 year: 2016 ident: 10.1016/j.molcel.2023.12.019_bib116 article-title: H3 histone tail conformation within the nucleosome and the impact of K14 acetylation studied using enhanced sampling simulation publication-title: PLoS Comput. Biol. doi: 10.1371/journal.pcbi.1004788 – volume: 179 start-page: 470 year: 2019 ident: 10.1016/j.molcel.2023.12.019_bib23 article-title: Organization of chromatin by intrinsic and regulated phase separation publication-title: Cell doi: 10.1016/j.cell.2019.08.037 – volume: 52 start-page: 272 year: 2013 ident: 10.1016/j.molcel.2023.12.019_bib36 article-title: Proteome-wide identification of poly(ADP-ribosyl)ation targets in different genotoxic stress responses publication-title: Mol. Cell doi: 10.1016/j.molcel.2013.08.026 – volume: 140 start-page: 4774 year: 2018 ident: 10.1016/j.molcel.2023.12.019_bib10 article-title: Investigating the dynamics of destabilized nucleosomes using methyl-TROSY NMR publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.8b00931 – volume: 91 start-page: 183 year: 2022 ident: 10.1016/j.molcel.2023.12.019_bib5 article-title: Managing the steady state chromatin landscape by nucleosome dynamics publication-title: Annu. Rev. Biochem. doi: 10.1146/annurev-biochem-032620-104508 – volume: 22 start-page: 215 year: 2021 ident: 10.1016/j.molcel.2023.12.019_bib50 article-title: A framework for understanding the functions of biomolecular condensates across scales publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/s41580-020-00303-z – volume: 120 year: 2023 ident: 10.1016/j.molcel.2023.12.019_bib9 article-title: Correlating histone acetylation with nucleosome core particle dynamics and function publication-title: Proc. Natl. Acad. Sci. USA – volume: 46 start-page: 564 year: 2021 ident: 10.1016/j.molcel.2023.12.019_bib83 article-title: Histone tail conformations: a fuzzy affair with DNA publication-title: Trends Biochem. Sci. doi: 10.1016/j.tibs.2020.12.012 – volume: 31 start-page: 5526 year: 2003 ident: 10.1016/j.molcel.2023.12.019_bib103 article-title: A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkg761 – volume: 7 start-page: e34334 year: 2018 ident: 10.1016/j.molcel.2023.12.019_bib86 article-title: Serine is the major residue for ADP-ribosylation upon DNA damage publication-title: eLife doi: 10.7554/eLife.34334 – volume: 611 start-page: 614 year: 2022 ident: 10.1016/j.molcel.2023.12.019_bib25 article-title: Histone H2B.8 compacts flowering plant sperm through chromatin phase separation publication-title: Nature doi: 10.1038/s41586-022-05386-6 – volume: 32 start-page: 2490 year: 2012 ident: 10.1016/j.molcel.2023.12.019_bib81 article-title: Histone ADP-ribosylation facilitates gene transcription by directly remodeling nucleosomes publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.06667-11 – volume: 125 start-page: 10420 year: 2003 ident: 10.1016/j.molcel.2023.12.019_bib87 article-title: Cross-correlated relaxation enhanced 1H–13C NMR spectroscopy of methyl groups in very high molecular weight proteins and protein complexes publication-title: J. Am. Chem. Soc. doi: 10.1021/ja030153x – volume: 104 start-page: 1081 year: 2013 ident: 10.1016/j.molcel.2023.12.019_bib120 article-title: Clipping of flexible tails of histones H3 and H4 affects the structure and dynamics of the nucleosome publication-title: Biophys. J. doi: 10.1016/j.bpj.2013.01.019 – volume: 12 start-page: 998 year: 2016 ident: 10.1016/j.molcel.2023.12.019_bib85 article-title: Serine is a new target residue for endogenous ADP-ribosylation on histones publication-title: Nat. Chem. Biol. doi: 10.1038/nchembio.2180 – volume: 14 start-page: 290 year: 2017 ident: 10.1016/j.molcel.2023.12.019_bib132 article-title: cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination publication-title: Nat. Methods doi: 10.1038/nmeth.4169 – volume: 163 start-page: 85 year: 2018 ident: 10.1016/j.molcel.2023.12.019_bib4 article-title: Structural diversity of the nucleosome publication-title: J. Biochem. doi: 10.1093/jb/mvx081 – volume: 47 start-page: 8470 year: 2019 ident: 10.1016/j.molcel.2023.12.019_bib20 article-title: Super-resolution microscopy reveals how histone tail acetylation affects DNA compaction within nucleosomes in vivo publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkz593 – start-page: 205 year: 1990 ident: 10.1016/j.molcel.2023.12.019_bib96 article-title: Polyelectrolyte solutions – volume: 117 start-page: 19661 year: 2020 ident: 10.1016/j.molcel.2023.12.019_bib119 article-title: Acetylated histone H4 tail enhances histone H3 tail acetylation by altering their mutual dynamics in the nucleosome publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.2010506117 – volume: 108 start-page: 12283 year: 2011 ident: 10.1016/j.molcel.2023.12.019_bib133 article-title: Architecture of the high mobility group nucleosomal protein 2-nucleosome complex as revealed by methyl-based NMR publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1105848108 – volume: 71 start-page: 703 year: 2018 ident: 10.1016/j.molcel.2023.12.019_bib48 article-title: Poly(ADP-ribose) prevents pathological phase separation of TDP-43 by promoting liquid demixing and stress granule localization publication-title: Mol. Cell doi: 10.1016/j.molcel.2018.07.002 – volume: 102 start-page: 241 year: 1993 ident: 10.1016/j.molcel.2023.12.019_bib137 article-title: Gradient-tailored water suppression for 1H-15N HSQC experiments optimized to retain full sensitivity publication-title: J. Magn. Reson. doi: 10.1006/jmra.1993.1098 – volume: 10 year: 2021 ident: 10.1016/j.molcel.2023.12.019_bib38 article-title: Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome publication-title: eLife doi: 10.7554/eLife.71420 – volume: 65 start-page: 932 year: 2017 ident: 10.1016/j.molcel.2023.12.019_bib35 article-title: Serine ADP-ribosylation depends on HPF1 publication-title: Mol. Cell doi: 10.1016/j.molcel.2017.01.003 – volume: 17 start-page: 615 year: 2021 ident: 10.1016/j.molcel.2023.12.019_bib51 article-title: Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation publication-title: Nat. Chem. Biol. doi: 10.1038/s41589-021-00774-x – volume: 13 start-page: 436 year: 2012 ident: 10.1016/j.molcel.2023.12.019_bib1 article-title: New insights into nucleosome and chromatin structure: an ordered state or a disordered affair? publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm3382 – volume: 283 start-page: 106767 year: 2022 ident: 10.1016/j.molcel.2023.12.019_bib24 article-title: Histone H3 and H4 tails play an important role in nucleosome phase separation publication-title: Biophys. Chem. doi: 10.1016/j.bpc.2022.106767 – volume: 18 start-page: 285 year: 2017 ident: 10.1016/j.molcel.2023.12.019_bib109 article-title: Biomolecular condensates: organizers of cellular biochemistry publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm.2017.7 – volume: 575 start-page: 390 year: 2019 ident: 10.1016/j.molcel.2023.12.019_bib94 article-title: HP1 reshapes nucleosome core to promote phase separation of heterochromatin publication-title: Nature doi: 10.1038/s41586-019-1669-2 – volume: 276 start-page: 19 year: 1998 ident: 10.1016/j.molcel.2023.12.019_bib65 article-title: New DNA sequence rules for high affinity binding to histone octamer and sequence-directed nucleosome positioning publication-title: J. Mol. Biol. doi: 10.1006/jmbi.1997.1494 – volume: 3 start-page: 1103 year: 2004 ident: 10.1016/j.molcel.2023.12.019_bib67 article-title: PARP-1, PARP-2 and ATM in the DNA damage response: functional synergy in mouse development publication-title: DNA Repair (Amst) doi: 10.1016/j.dnarep.2004.06.002 – volume: 28 start-page: 165 year: 2004 ident: 10.1016/j.molcel.2023.12.019_bib90 article-title: An isotope labelling strategy for methyl TROSY spectroscopy publication-title: J. Biomol. NMR doi: 10.1023/B:JNMR.0000013824.93994.1f – volume: 280 start-page: 33701 year: 2005 ident: 10.1016/j.molcel.2023.12.019_bib21 article-title: The core histone N-terminal tail domains function independently and additively during salt-dependent oligomerization of nucleosomal arrays publication-title: J. Biol. Chem. doi: 10.1074/jbc.M507048200 – volume: 7 start-page: 973 year: 2010 ident: 10.1016/j.molcel.2023.12.019_bib129 article-title: Rapid blue-light-mediated induction of protein interactions in living cells publication-title: Nat. Methods doi: 10.1038/nmeth.1524 – volume: 31 start-page: 4623 year: 2011 ident: 10.1016/j.molcel.2023.12.019_bib79 article-title: Nucleosome disruption by DNA ligase III-XRCC1 promotes efficient base excision repair publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.05715-11 – volume: 26 start-page: 573 year: 2019 ident: 10.1016/j.molcel.2023.12.019_bib105 article-title: Efficient single-strand break repair requires binding to both poly(ADP-ribose) and DNA by the central BRCT domain of XRCC1 publication-title: Cell Rep. doi: 10.1016/j.celrep.2018.12.082 – volume: 117 start-page: 12836 year: 2020 ident: 10.1016/j.molcel.2023.12.019_bib93 article-title: A methyl-TROSY approach for NMR studies of high-molecular-weight DNA with application to the nucleosome core particle publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.2004317117 – volume: 9 start-page: 671 year: 2012 ident: 10.1016/j.molcel.2023.12.019_bib155 article-title: NIH Image to ImageJ: 25 years of image analysis publication-title: Nat. Methods doi: 10.1038/nmeth.2089 |
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| Title | Poly(ADP-ribosyl)ation enhances nucleosome dynamics and organizes DNA damage repair components within biomolecular condensates |
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