Development of a liquid-based cytology method for detecting cervical cancer cells using functional gold nanorods
A cytopathology test for cervical cancer diagnosis has been introduced to complement the histopathology test. This study developed a new cervical cancer diagnostic method that complements the existing liquid cytology to reduce the diagnostician’s skill dependence and to improve diagnostic accuracy....
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| Published in | The Korean journal of chemical engineering Vol. 40; no. 2; pp. 369 - 378 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Springer US
01.02.2023
Springer Nature B.V 한국화학공학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0256-1115 1975-7220 |
| DOI | 10.1007/s11814-022-1307-9 |
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| Abstract | A cytopathology test for cervical cancer diagnosis has been introduced to complement the histopathology test. This study developed a new cervical cancer diagnostic method that complements the existing liquid cytology to reduce the diagnostician’s skill dependence and to improve diagnostic accuracy. With the ease of introduction of surface functional groups and their high biocompatibility and stability, gold nanomaterials have been used to diagnose numerous biomolecules. CA125 and p16 markers were chosen as protein markers uniquely present in cervical cancer. Bioconjugation technology was used to form a stable bond between the target antibody and gold nanorods. Antibody-gold nanorods were administered to cervical cancer cells as a factor for optical microscopic analysis. The degree of cancer cell labeling was determined through additional fluorescence microscopy analysis. Additionally, a liquid-based cytology test mimicking the clinical environment was prepared, and the false-positive rate, false-negative rate, and accuracy were determined when the study strategy was implemented. The strategy validated in this study (antibody-gold nanorod-based cervical cancer diagnosis) suggests a method that can reduce the dependence on experts for the cancer cytology and can increase test accuracy. |
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| AbstractList | A cytopathology test for cervical cancer diagnosis has been introduced to complement the histopathology test. This study developed a new cervical cancer diagnostic method that complements the existing liquid cytology to reduce the diagnostician’s skill dependence and to improve diagnostic accuracy. With the ease of introduction of surface functional groups and their high biocompatibility and stability, gold nanomaterials have been used to diagnose numerous biomolecules. CA125 and p16 markers were chosen as protein markers uniquely present in cervical cancer. Bioconjugation technology was used to form a stable bond between the target antibody and gold nanorods. Antibody-gold nanorods were administered to cervical cancer cells as a factor for optical microscopic analysis. The degree of cancer cell labeling was determined through additional fluorescence microscopy analysis. Additionally, a liquid-based cytology test mimicking the clinical environment was prepared, and the false-positive rate, false-negative rate, and accuracy were determined when the study strategy was implemented. The strategy validated in this study (antibody-gold nanorod-based cervical cancer diagnosis) suggests a method that can reduce the dependence on experts for the cancer cytology and can increase test accuracy. KCI Citation Count: 0 A cytopathology test for cervical cancer diagnosis has been introduced to complement the histopathology test. This study developed a new cervical cancer diagnostic method that complements the existing liquid cytology to reduce the diagnostician’s skill dependence and to improve diagnostic accuracy. With the ease of introduction of surface functional groups and their high biocompatibility and stability, gold nanomaterials have been used to diagnose numerous biomolecules. CA125 and p16 markers were chosen as protein markers uniquely present in cervical cancer. Bioconjugation technology was used to form a stable bond between the target antibody and gold nanorods. Antibody-gold nanorods were administered to cervical cancer cells as a factor for optical microscopic analysis. The degree of cancer cell labeling was determined through additional fluorescence microscopy analysis. Additionally, a liquid-based cytology test mimicking the clinical environment was prepared, and the false-positive rate, false-negative rate, and accuracy were determined when the study strategy was implemented. The strategy validated in this study (antibody-gold nanorod-based cervical cancer diagnosis) suggests a method that can reduce the dependence on experts for the cancer cytology and can increase test accuracy. |
| Author | Jeong, Eunseo Choi, Jonghoon Kim, Hayoung Tanaka, Masayoshi Choi, Yonghyun Lee, Sungjun Park, Jongjun |
| Author_xml | – sequence: 1 givenname: Eunseo surname: Jeong fullname: Jeong, Eunseo organization: School of Integrative Engineering, Chung-Ang University – sequence: 2 givenname: Jongjun surname: Park fullname: Park, Jongjun organization: School of Integrative Engineering, Chung-Ang University – sequence: 3 givenname: Hayoung surname: Kim fullname: Kim, Hayoung organization: School of Integrative Engineering, Chung-Ang University – sequence: 4 givenname: Sungjun surname: Lee fullname: Lee, Sungjun organization: School of Integrative Engineering, Chung-Ang University, Feynman Institute of Technology, Nanomedicine Corporation – sequence: 5 givenname: Yonghyun surname: Choi fullname: Choi, Yonghyun organization: School of Integrative Engineering, Chung-Ang University, Feynman Institute of Technology, Nanomedicine Corporation – sequence: 6 givenname: Masayoshi surname: Tanaka fullname: Tanaka, Masayoshi organization: Department of Chemical Science and Engineering, Tokyo Institute of Technology – sequence: 7 givenname: Jonghoon surname: Choi fullname: Choi, Jonghoon email: nanomed@cau.ac.kr organization: School of Integrative Engineering, Chung-Ang University, Feynman Institute of Technology, Nanomedicine Corporation |
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| Snippet | A cytopathology test for cervical cancer diagnosis has been introduced to complement the histopathology test. This study developed a new cervical cancer... |
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| SubjectTerms | Accuracy Antibodies Biocompatibility Biomolecules Biotechnology Cancer Catalysis Cellular biology Cervical cancer Chemistry Chemistry and Materials Science Cytology Diagnosis Diagnostic systems Functional groups Gold Industrial Chemistry/Chemical Engineering Materials Science Medical diagnosis Nanomaterials Nanorods 화학공학 |
| Title | Development of a liquid-based cytology method for detecting cervical cancer cells using functional gold nanorods |
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