Advances in PIWI-piRNA function in female reproduction in mammals

PIWI-interacting RNAs (piRNAs), which associate with PIWI clade Argonaute proteins to form piRNA-induced silencing complexes (piRISCs) in germline cells, are responsible for maintaining genomic integrity and reproductive function through transcriptional or post-transcriptional suppression of transpo...

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Published inActa biochimica et biophysica Sinica Vol. 57; no. 1; pp. 148 - 156
Main Authors Lv, Xiaolong, Zhang, Hongdao, Wu, Ligang
Format Journal Article
LanguageEnglish
Published China China Science Publishing & Media Ltd 15.11.2024
Subjects
Animals
Argonaute Proteins - genetics
Argonaute Proteins - metabolism
Female
fertility
Fertility - genetics
Humans
Male
Mammals - genetics
Mice
oocytes
Oogenesis - genetics
piRNA
PIWI
Piwi-Interacting RNA
Reproduction - genetics
RNA, Small Interfering - genetics
RNA, Small Interfering - metabolism
RNA, Small Interfering - physiology
transposon
transposon
oocytes
PIWI
fertility
piRNA
Online AccessGet full text
ISSN1672-9145
1745-7270
1745-7270
DOI10.3724/abbs.2024195

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Abstract PIWI-interacting RNAs (piRNAs), which associate with PIWI clade Argonaute proteins to form piRNA-induced silencing complexes (piRISCs) in germline cells, are responsible for maintaining genomic integrity and reproductive function through transcriptional or post-transcriptional suppression of transposable elements and regulation of protein-coding genes. Recent discoveries of crucial PIWI-piRNA functions in oogenesis and embryogenesis in golden hamsters suggest an indispensable role in female fertility that has been obscured in the predominant mouse model of PIWI-piRNA pathway regulation. In particular, studies of piRNA expression dynamics, functional redundancies, and compositional variations across mammal species have advanced our understanding of piRNA functions in male and, especially, female reproduction. These findings further support the use of hamsters as a more representative model of piRNA biology in mammals. In addition to discussing these new perspectives, the current review also covers emerging directions for piRNA research, its implications for female fertility, and our fundamental understanding of reproductive mechanisms.
AbstractList PIWI-interacting RNAs (piRNAs), which associate with PIWI clade Argonaute proteins to form piRNA-induced silencing complexes (piRISCs) in germline cells, are responsible for maintaining genomic integrity and reproductive function through transcriptional or post-transcriptional suppression of transposable elements and regulation of protein-coding genes. Recent discoveries of crucial PIWI-piRNA functions in oogenesis and embryogenesis in golden hamsters suggest an indispensable role in female fertility that has been obscured in the predominant mouse model of PIWI-piRNA pathway regulation. In particular, studies of piRNA expression dynamics, functional redundancies, and compositional variations across mammal species have advanced our understanding of piRNA functions in male and, especially, female reproduction. These findings further support the use of hamsters as a more representative model of piRNA biology in mammals. In addition to discussing these new perspectives, the current review also covers emerging directions for piRNA research, its implications for female fertility, and our fundamental understanding of reproductive mechanisms.
PIWI-interacting RNAs (piRNAs), which associate with PIWI clade Argonaute proteins to form piRNA-induced silencing complexes (piRISCs) in germline cells, are responsible for maintaining genomic integrity and reproductive function through transcriptional or post-transcriptional suppression of transposable elements and regulation of protein-coding genes. Recent discoveries of crucial PIWI-piRNA functions in oogenesis and embryogenesis in golden hamsters suggest an indispensable role in female fertility that has been obscured in the predominant mouse model of PIWI-piRNA pathway regulation. In particular, studies of piRNA expression dynamics, functional redundancies, and compositional variations across mammal species have advanced our understanding of piRNA functions in male and, especially, female reproduction. These findings further support the use of hamsters as a more representative model of piRNA biology in mammals. In addition to discussing these new perspectives, the current review also covers emerging directions for piRNA research, its implications for female fertility, and our fundamental understanding of reproductive mechanisms.PIWI-interacting RNAs (piRNAs), which associate with PIWI clade Argonaute proteins to form piRNA-induced silencing complexes (piRISCs) in germline cells, are responsible for maintaining genomic integrity and reproductive function through transcriptional or post-transcriptional suppression of transposable elements and regulation of protein-coding genes. Recent discoveries of crucial PIWI-piRNA functions in oogenesis and embryogenesis in golden hamsters suggest an indispensable role in female fertility that has been obscured in the predominant mouse model of PIWI-piRNA pathway regulation. In particular, studies of piRNA expression dynamics, functional redundancies, and compositional variations across mammal species have advanced our understanding of piRNA functions in male and, especially, female reproduction. These findings further support the use of hamsters as a more representative model of piRNA biology in mammals. In addition to discussing these new perspectives, the current review also covers emerging directions for piRNA research, its implications for female fertility, and our fundamental understanding of reproductive mechanisms.
Author Zhang, Hongdao
Wu, Ligang
Lv, Xiaolong
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CitedBy_id crossref_primary_10_3724_abbs_2024234
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Keywords transposon
oocytes
PIWI
fertility
piRNA
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Snippet PIWI-interacting RNAs (piRNAs), which associate with PIWI clade Argonaute proteins to form piRNA-induced silencing complexes (piRISCs) in germline cells, are...
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SubjectTerms Animals
Argonaute Proteins - genetics
Argonaute Proteins - metabolism
Female
fertility
Fertility - genetics
Humans
Male
Mammals - genetics
Mice
oocytes
Oogenesis - genetics
piRNA
PIWI
Piwi-Interacting RNA
Reproduction - genetics
RNA, Small Interfering - genetics
RNA, Small Interfering - metabolism
RNA, Small Interfering - physiology
transposon
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Title Advances in PIWI-piRNA function in female reproduction in mammals
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